Non-invasive assessment of aortic stiffness and blood pressure in young Turner syndrome patients
Abstract
Background Females with Turner syndrome (TS) carry an elevated risk of aortic dissection. The objective of the study was to assess the biophysical properties of the aorta and ambulatory blood pressure (BP) in females with TS and compare these findings to those in healthy female age-matched controls. Methods This was a prospective cohort study including subjects aged 8-25 years. Utilizing two-dimensional (2D) echocardiography and Doppler, proximal aortic dimensions were measured and biophysical properties of the aorta were calculated including pulse wave velocity (PWV), arterial pressure-strain elastic modulus and stiffness index. Resting BP was measured and ambulatory blood pressure monitoring (ABPM) was performed. Results Of 23 TS patients and 46 controls (median age 16.3 years), aortic annulus, sinus of Valsalva and sinotubular (ST) junction diameters, as well as left ventricular (LV) mass, were significantly greater in TS patients compared with controls when scaled for height2.7, but not for body surface area (BSA), although ascending aorta diameter was greater when scaled for both. Median PWV was faster in TS patients compared to controls (451 vs. 360 cm/s) while arterial pressure-strain elastic modulus and stiffness index were similar. Resting BP was abnormal in seven out of 22 patients and ABPM was abnormal in 16 out of 21 patients. Conclusions Young patients with TS had dilated proximal aortas when scaled for height2.7 and stiffer aortas when compared with healthy female age-matched controls. Moreover, resting BP underdiagnosed pre-hypertension and hypertension compared to ABPM. These findings are consistent with the presence of a primary aortopathy in TS.
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Proximal aortic stiffness is frequently increased in TS, even if the aorta is not dilated and the aortic valve is tricuspid.
“Proximal aortic stiffness is frequently increased in TS, even if the aorta is not dilated and the aortic valve is tricuspid.462-465”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [465]
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Self-citation
- Authors
- Fox, D. A., Kang, K. T., Potts, J. E., Bradley, T. J., Stewart, L. L., Dionne, J. M., & Sandor, G. G. S.
- Affiliations
- University of British Columbia (CA)
- University of Saskatchewan (CA)
- Corresponding author
- Fox, Danya A.
- ORCID
- Venue
- Journal of Pediatric Endocrinology and Metabolism
- Publisher
- Walter de Gruyter GmbH
- Published
- 2019-05-27
- Volume
- 32
- Issue
- 5
- Pages
- 489-498
- ISSN
- 0334-018X (ISSN-L)
- 2191-0251
- OpenAlex
- W2943754195
- Cited by
- 9
- References
- 51
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 4
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- Turner syndrome, aortic stiffness, aortic dilatation, pulse wave velocity, stiffness index, ambulatory blood pressure monitoring, hypertension, prehypertension, aortopathy, aortic annulus, sinotubular junction, left ventricular mass, young women
- MeSH terms
- Adolescent, Adult, Aorta, Blood Pressure, Child, Echocardiography, Female, Follow-Up Studies, Humans, Male, Prognosis, Prospective Studies, Turner Syndrome, Case-Control Studies, Risk Assessment, Blood Pressure Monitoring, Ambulatory, Young Adult, Vascular Stiffness
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