Cited by 9Cardiovascular Health and Disease PreventionAortic Disease and Treatment ApproachesConnective tissue disorders research

Non-invasive assessment of aortic stiffness and blood pressure in young Turner syndrome patients

Fox, Danya A., Kang, Kristopher T., Potts, James E., Bradley, Timothy J., Stewart, Laura L., Dionne, Janis M., Sandor, George G.S.·2019·Journal of Pediatric Endocrinology and Metabolism

Abstract

Background Females with Turner syndrome (TS) carry an elevated risk of aortic dissection. The objective of the study was to assess the biophysical properties of the aorta and ambulatory blood pressure (BP) in females with TS and compare these findings to those in healthy female age-matched controls. Methods This was a prospective cohort study including subjects aged 8-25 years. Utilizing two-dimensional (2D) echocardiography and Doppler, proximal aortic dimensions were measured and biophysical properties of the aorta were calculated including pulse wave velocity (PWV), arterial pressure-strain elastic modulus and stiffness index. Resting BP was measured and ambulatory blood pressure monitoring (ABPM) was performed. Results Of 23 TS patients and 46 controls (median age 16.3 years), aortic annulus, sinus of Valsalva and sinotubular (ST) junction diameters, as well as left ventricular (LV) mass, were significantly greater in TS patients compared with controls when scaled for height2.7, but not for body surface area (BSA), although ascending aorta diameter was greater when scaled for both. Median PWV was faster in TS patients compared to controls (451 vs. 360 cm/s) while arterial pressure-strain elastic modulus and stiffness index were similar. Resting BP was abnormal in seven out of 22 patients and ABPM was abnormal in 16 out of 21 patients. Conclusions Young patients with TS had dilated proximal aortas when scaled for height2.7 and stiffer aortas when compared with healthy female age-matched controls. Moreover, resting BP underdiagnosed pre-hypertension and hypertension compared to ABPM. These findings are consistent with the presence of a primary aortopathy in TS.

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Crossref · 10.1515/jpem-2018-0346

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Authors
Fox, D. A., Kang, K. T., Potts, J. E., Bradley, T. J., Stewart, L. L., Dionne, J. M., & Sandor, G. G. S.
Affiliations
  • University of British Columbia (CA)
  • University of Saskatchewan (CA)
Corresponding author
Fox, Danya A.
Venue
Journal of Pediatric Endocrinology and Metabolism
Published
2019-05-27
Volume
32
Issue
5
Pages
489-498
ISSN
  • 0334-018X (ISSN-L)
  • 2191-0251
OpenAlex
W2943754195
Cited by
9
References
51
Citations by year
2026: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 4
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pediatric Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Keywords
Turner syndrome, aortic stiffness, aortic dilatation, pulse wave velocity, stiffness index, ambulatory blood pressure monitoring, hypertension, prehypertension, aortopathy, aortic annulus, sinotubular junction, left ventricular mass, young women
MeSH terms
Adolescent, Adult, Aorta, Blood Pressure, Child, Echocardiography, Female, Follow-Up Studies, Humans, Male, Prognosis, Prospective Studies, Turner Syndrome, Case-Control Studies, Risk Assessment, Blood Pressure Monitoring, Ambulatory, Young Adult, Vascular Stiffness

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