Statins to reduce risk of depression
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Statins may decrease the activity of the enzyme indoleamine 2,3-dioxygenase, which is induced by IFN-gamma, leading to the cleavage of tryptophan, a precursor of serotonin and melatonin, as well as the production of neurotoxic tryptophan catabolites.
“Furthermore, statins may decrease the activity of the enzyme indoleamine 2,3-dioxygenase [175], which is induced by IFN-γ, leading to the cleavage of the essential amino acid tryptophan, a precursor of serotonin and melatonin, as well as the production of neurotoxic tryptophan catabolites [176].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [175]
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Youssef, S., Stüve, O., Patarroyo, J. C., Ruiz, P. J., Radosevich, J. L., Hur, E. M., Bravo, M., Mitchell, D. J., Sobel, R. A., Steinman, L., et al. (2002) · Nature · doi:10.1038/nature01158 · Cited by 1,094 · see citing works
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Self-citationNeopterin production, tryptophan degradation, and mental depression—What is the link?
Widner, B., Laich, A., Sperner‐Unterweger, B., Ledochowski, M., & Fuchs, D. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00006-5 · Cited by 231 · see citing works
Self-citationImmune activation and degradation of tryptophan in coronary heart disease
Wirleitner, B., Rudzite, V., Neurauter, G., Murr, C., Kalnins, U., Ērglis, A., Trušinskis, K., & Fuchs, D. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01186.x · Cited by 190 · see citing works
Self-citationLong-term statin use and psychological well-being
Young‐Xu, Y., Chan, K. A., Liao, J. K., Ravid, S., & Blatt, C. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00785-x · Cited by 139 · see citing works
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Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works
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Sokalska, A., & Dulęba, A. J. (2011) · doi:10.1002/9781444398519.ch36
- Authors
- Wirleitner, B., Sperner-Unterweger, B., & Fuchs, D.
- Affiliations
- Universität Innsbruck (AT)
- Corresponding author
- Fuchs, Dietmar
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 43
- Issue
- 6
- Pages
- 1132
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2071388013
- Cited by
- 14
- References
- 6
- Citations by year
- 2023: 1 · 2022: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- statins, depression, long-term statin use, psychological outcomes, lipid-lowering therapy
- MeSH terms
- Coronary Disease, Depressive Disorder, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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