AUGMENTATION OF FLUOXETINE WITH LOVASTATIN FOR TREATING MAJOR DEPRESSIVE DISORDER, A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED-CLINICAL TRIAL: Lovastatin for Treating Depression
Abstract
BACKGROUNDS: There are contradictory evidence about the effect of statins on depression. This 6-week-randomized placebo-controlled clinical trial assessed the efficacy and safety of lovastatin as an adjuvant agent for treating major depressive disorder (MDD). METHODS: The participants were 68 patients with MDD according to DSM-IV diagnostic criteria. The sample was randomly allocated into fluoxetine (up to 40 mg/day) plus lovastatin (30 mg/day) group or fluoxetine plus placebo group. Hamilton Depression Rating scale was used to measure depression score at baseline, week 2, and week 6. RESULTS: Both groups showed a significant decrease of depression score on the Hamilton Depression scale. However, the treatment group decreased depression score more than placebo group [12.8(6.3) vs. 8.2(4.0), t = 3.4, df = 60, P < .001]. Any serious adverse effect was not found. DISCUSSION: These results suggest that lovastatin as an adjuvant treatment may be effective for treating patients with MDD.
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In an RCT, participants with major depressive disorder allocated to lovastatin augmentation showed a significant reduction in HDRS scores compared with a placebo group.
“By the end of this trial, the group allocated to lovastatin augmentation showed a significant reduction in HDRS scores compared with those measured for a placebo group.”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [172]
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- Authors
- Ghanizadeh, A., & Hedayati, A.
- Affiliations
- Shiraz University of Medical Sciences (IR)
- Fasa University of Medical Sciences (IR)
- Corresponding author
- Ghanizadeh, Ahmad
- Venue
- Depression and Anxiety
- Publisher
- Hindawi Limited
- Published
- 2013-09-30
- Volume
- 30
- Issue
- 11
- Pages
- 1084-1088
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W1901734004
- Cited by
- 81
- References
- 32
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 5 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 5
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, fluoxetine, lovastatin, statins, adjuvant therapy, antidepressant augmentation, Hamilton Depression Rating Scale, drug safety
- MeSH terms
- Adult, Major Depressive Disorder, Double-Blind Method, Drug Synergism, Drug Therapy, Combination, Fluoxetine, Humans, Lovastatin, Placebos, Psychiatric Status Rating Scales, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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