Inflammation, as Measured by the Erythrocyte Sedimentation Rate, Is an Independent Predictor for the Development of Heart Failure
Open accessAbstract
Objectives Our objective was to explore inflammation, measured as erythrocyte sedimentation rate (ESR), as a predictor for the development of heart failure (HF).Background In recent years, evidence of the importance of inflammation in the pathophysiology of HF has emerged, and various inflammatory markers have been found to predict future HF. Erythrocyte sedimentation rate is an inexpensive and easily accessible marker of systemic inflammation, but to this date it is unknown whether ESR predicts subsequent HF.Methods In a community-based prospective study of 2,314 middle-aged men free from HF, myocardial infarction, and valvular disease at baseline, ESR was analyzed in multivariable models together with established risk factors for HF (hypertension, diabetes, electrocardiographic left ventricular hypertrophy, smoking, obesity, and serum cholesterol) and hematocrit.Results A total of 282 men developed HF during a median follow-up time of 30 years. In Cox proportional hazards analyses, ESR was an independent predictor of HF (hazard ratio 1.46 for highest quartile vs. the lowest, 95% confidence interval 1.04 to 2.06). This observation remained significant when also adjusting for interim myocardial infarction during follow-up.Conclusions Erythrocyte sedimentation rate was a significant predictor of HF, independent of established risk factors for HF, and interim myocardial infarction after three decades of follow-up in a population-based sample of middle-aged men. Our findings indicate that inflammation occurs early in the process leading to HF and that ESR could be used to evaluate this process.
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Several studies have established clear correlations between markers of inflammation and mortality in patients with heart failure.
“Several studies have established clear correlations between markers of inflammation and mortality in patients with heart failure (157, 246).”
From Cardiac remodeling in obesity (2008) · cites this paper as [157]
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- Authors
- Ingelsson, E., Årnlöv, J., Sundström, J., & Lind, L.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Ingelsson, Erik
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 45
- Issue
- 11
- Pages
- 1802-1806
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2128164889
- Cited by
- 69
- References
- 23
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- erythrocyte sedimentation rate, heart failure, inflammation, systemic inflammation, heart failure prediction, myocardial infarction, middle-aged men, cardiovascular risk factors, hematocrit
- MeSH terms
- Blood Sedimentation, Heart Failure, Humans, Inflammation, Male, Middle Aged, Predictive Value of Tests, Sweden, Incidence
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