Molecular Mechanisms in Heart Failure

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

Gottlieb, R. A., Burleson, K. O., Kloner, R. A., Babior, B., & Engler, R. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117504 · Cited by 1,442 · see citing works

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

Laufs, U., & Liao, J. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.24266 · Cited by 1,035 · see citing works

Apoptosis in Ischemic and Reperfused Rat Myocardium

Fliss, H., & Gattinger, D. A. (1996) · Circulation Research · doi:10.1161/01.res.79.5.949 · Cited by 801 · see citing works

The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy

Knöll, R., Hoshijima, M., Hoffman, H. M., Person, V., Lorenzen-Schmidt, I., Bang, M.-L., Hayashi, T., Shiga, N., Yasukawa, H., Schaper, W., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01226-6 · Cited by 786 · see citing works

The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

Bueno, O. F., Windt, L. J. D., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6341 · Cited by 774 · see citing works

A mechanistic role for cardiac myocyte apoptosis in heart failure

Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765 · see citing works

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

Krown, K. A., Pagé, M., Nguyen, C., Zechner, D., Gutierrez, V., Comstock, K. L., Glembotski, C. C., Quintana, P. J. E., & Sabbadini, R. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119114 · Cited by 728 · see citing works

CCN proteins: multifunctional signalling regulators

Perbal, B. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15172-0 · Cited by 704 · see citing works

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

Carmeliet, P., Ng, Y., Nuyens, D., Theilmeier, G., Brusselmans, K., Cornelissen, I., Ehler, E., Kakkar, V. V., Stalmans, I., Mattot, V., et al. (1999) · Nature Medicine · doi:10.1038/8379 · Cited by 679 · see citing works

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

Hirota, H., Chen, J., Betz, U. A. K., Rajewsky, K., Gu, Y., Ross, J., Müller, W., & Chien, K. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80729-1 · Cited by 652 · see citing works

The Giant Protein Titin

Granzier, H. L. M., & Labeit, S. (2004) · Circulation Research · doi:10.1161/01.res.0000117769.88862.f8 · Cited by 650 · see citing works

Protein kinase cascades in the regulation of cardiac hypertrophy

Dorn, G. W., & Force, T. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24178 · Cited by 637 · see citing works

Uric Acid and Survival in Chronic Heart Failure: Validation and Application in Metabolic, Functional, and Hemodynamic Staging

Anker, S. D., Doehner, W., Rauchhaus, M., Sharma, R., Francis, D., Knosalla, C., Davos, C. H., Cicoira, M., Shamim, W., Kemp, M., et al. (2003) · Circulation · doi:10.1161/01.cir.0000065637.10517.a0 · Cited by 593 · see citing works

In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction

Morishita, R., Sugimoto, T., Aoki, M., Kida, I., Tomita, N., Moriguchi, A., Maeda, K., Sawa, Y., Kaneda, Y., Higaki, J., et al. (1997) · Nature Medicine · doi:10.1038/nm0897-894 · Cited by 584 · see citing works

Increased myocardial NADPH oxidase activity in human heart failure

Heymes, C., Bendall, J. K., Ratajczak, P., Cave, A. C., Samuel, J., Hasenfuss, G. P., & Shah, A. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00471-6 · Cited by 582 · see citing works

Interleukin-6 Spillover in the Peripheral Circulation Increases With the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients With Congestive Heart Failure

Tsutamoto, T., 久永, 智., Wada, A., Maeda, K., Ohnishi, M., 深井, 大., Mabuchi, N., Sawaki, M., & Kinoshita, M. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00494-4 · Cited by 563 · see citing works

Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

Torella, D., Rota, M., Nurzyńska, D., Musso, E., Monsen, A., Shiraishi, I., Zias, E. A., Walsh, K., Rosenzweig, A., Sussman, M. A., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000117306.10142.50 · Cited by 538 · see citing works

Pivotal Role of a gp91 phox -Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice

Bendall, J. K., Cave, A. C., Heymes, C., Gall, N. P., & Shah, A. M. (2002) · Circulation · doi:10.1161/hc0302.103712 · Cited by 531 · see citing works

Vascular Oxidative Stress and Endothelial Dysfunction in Patients With Chronic Heart Failure

Landmesser, U., Spiekermann, S., Dikalov, S., Tatge, H., Wilke, R., Kohler, C., Harrison, D. G., Hornig, B., & Drexler, H. (2002) · Circulation · doi:10.1161/01.cir.0000041431.57222.af · Cited by 517 · see citing works

Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

Urbanek, K., Rota, M., Cascapera, S., Bearzi, C., Nascimbene, A., Angelis, A. D., Hosoda, T., Chimenti, S., Baker, M., Limana, F., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000183733.53101.11 · Cited by 513 · see citing works

Calcineurin?NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

Molkentin, J. D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.021 · Cited by 498 · see citing works

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

Takemoto, M., Node, K., Hironori Nakagami, A., Liao, Y., Grimm, M. F., Takemoto, Y., Kitakaze, M., & Liao, J. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13350 · Cited by 490 · see citing works

Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

Antos, C. L., McKinsey, T. A., Frey, N., Kutschke, W. J., McAnally, J., Shelton, J. M., Richardson, J. A., Hill, J. A., & Olson, E. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231619298 · Cited by 477 · see citing works

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Russo, M. A., Gu, Y., Dalton, N. D., Chung, C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172376399 · Cited by 461 · see citing works

Elevated Levels of 8-iso-Prostaglandin F2αin Pericardial Fluid of Patients With Heart Failure

Mallat, Z., Philip, I., Lebret, M., Chatel, D., Maclouf, J., & Tedgui, A. (1998) · Circulation · doi:10.1161/01.cir.97.16.1536 · Cited by 453 · see citing works

Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy

Cappola, T. P., Kass, D. A., Nelson, G. S., Berger, R. D., Rosas, G. O., Kobeissi, Z. A., Marbán, E., & Hare, J. M. (2001) · Circulation · doi:10.1161/hc4501.098928 · Cited by 436 · see citing works

Simvastatin Versus Ezetimibe

Landmesser, U., Bahlmann, F. H., Mueller, M. F., Spiekermann, S., Kirchhoff, N., Schulz, S., Manes, C., Fischer, D., de Groot, K., Fliser, D., et al. (2005) · Circulation · doi:10.1161/01.cir.0000164260.82417.3f · Cited by 425 · see citing works

Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment

Maack, C., Kartes, T., Kilter, H., Schäfers, H., Nickenig, G., Böhm, M., & Laufs, U. (2003) · Circulation · doi:10.1161/01.cir.0000091084.46500.bb · Cited by 424 · see citing works

Statin-Induced Improvement of Endothelial Progenitor Cell Mobilization, Myocardial Neovascularization, Left Ventricular Function, and Survival After Experimental Myocardial Infarction Requires Endothelial Nitric Oxide Synthase

Landmesser, U., Engberding, N., Bahlmann, F. H., Schaefer, A., Wiencke, A., Heineke, A., Spiekermann, S., Hilfiker‐Kleiner, D., Templin, C., Kotlarz, D., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143232.67642.7a · Cited by 423 · see citing works

Short-Term Statin Therapy Improves Cardiac Function and Symptoms in Patients With Idiopathic Dilated Cardiomyopathy

Node, K., Fujita, M., Kitakaze, M., Hori, M., & Liao, J. K. (2003) · Circulation · doi:10.1161/01.cir.0000084539.58092.de · Cited by 415 · see citing works

Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure

Katz, S. D., Hryniewicz, K. M., Hriljac, I., Balidemaj, K., Dimayuga, C. A., Hudaihed, A., & Yasskiy, A. (2005) · Circulation · doi:10.1161/01.cir.0000153349.77489.cf · Cited by 408 · see citing works

Conditional switching of VEGF provides new insights into adult neovascularization and pro‐angiogenic therapy

Dor, Y., Djonov, V., Abramovitch, R., Itin, A., Fishman, G. I., Carmeliet, P., Goelman, G., & Keshet, E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.8.1939 · Cited by 389 · see citing works

Vitamin C Improves Endothelial Function of Conduit Arteries in Patients With Chronic Heart Failure

Hornig, B., Arakawa, N., Kohler, C., & Drexler, H. (1998) · Circulation · doi:10.1161/01.cir.97.4.363 · Cited by 389 · see citing works

Life and Death of Cardiac Stem Cells

Anversa, P., Kajstura, J., Leri, A., & Bolli, R. (2006) · Circulation · doi:10.1161/circulationaha.105.595181 · Cited by 385 · see citing works

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury

Hilfiker-Kleiner, D., Hilfiker, A., Fuchs, M., Kaminski, K., Schaefer, A., Schieffer, B., Hillmer, A., Schmiedl, A., Ding, Z., Podewski, E., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000134921.50377.61 · Cited by 385 · see citing works

Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor

Sivasubramanian, N., Coker, M. L., Kurrelmeyer, K. M., MacLellan, W. R., DeMayo, F. J., Spinale, F. G., & Mann, D. L. (2001) · Circulation · doi:10.1161/hc3401.093154 · Cited by 382 · see citing works

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

Giordano, F. J., Gerber, H., Williams, S., van Bruggen, N., Bunting, S., Ruiz‐Lozano, P., Gu, Y., Nath, A. K., Huang, Y., Hickey, R. P., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091415198 · Cited by 370 · see citing works

Endothelial Dysfunction in Chronic Myocardial Infarction Despite Increased Vascular Endothelial Nitric Oxide Synthase and Soluble Guanylate Cyclase Expression

Bauersachs, J. K., Bouloumié, A., Fraccarollo, D., Hu, K., Busse, R., & Ertl, G. (1999) · Circulation · doi:10.1161/01.cir.100.3.292 · Cited by 360 · see citing works

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age

Jacoby, J. J., Kalinowski, A., Liu, M.-G., Zhang, S. S.-M., Gao, Q., Chai, G.-X., Ji, L., Iwamoto, Y., Li, E., Schneider, M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2134694100 · Cited by 357 · see citing works

NO/redox disequilibrium in the failing heart and cardiovascular system

Hare, J. M., & Stamler, J. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524459 · Cited by 356 · see citing works

Induction of Cyclooxygenase-2 and Activation of Nuclear Factor-κB in Myocardium of Patients With Congestive Heart Failure

Wong, S. C. Y., Fukuchi, M., Melnyk, P. M., Rodger, I. W., & Giaid, A. (1998) · Circulation · doi:10.1161/01.cir.98.2.100 · Cited by 323 · see citing works

Treatment With Dimethylthiourea Prevents Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction in Mice

Kinugawa, S., Tsutsui, H., Hayashidani, S., Ide, T., Suematsu, N., Satoh, S., Utsumi, H., & Takeshita, A. (2000) · Circulation Research · doi:10.1161/01.res.87.5.392 · Cited by 323 · see citing works

Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death

Fischer, D., Rossa, S. D., Landmesser, U., Spiekermann, S., Engberding, N., Hornig, B., & Drexler, H. (2004) · European Heart Journal · doi:10.1093/eurheartj/ehi001 · Cited by 320 · see citing works

Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice

Scherrer‐Crosbie, M., Ullrich, R., Bloch, K. D., Nakajima, H., Nasseri, B., Aretz, H. T., Lindsey, M. L., Vançon, A.-C., Huang, P. L., Lee, R. T., et al. (2001) · Circulation · doi:10.1161/hc3601.094298 · Cited by 309 · see citing works

Death begets failure in the heart

Foo, R., Mani, K. M., & Kitsis, R. N. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24569 · Cited by 307 · see citing works

Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., Acetis, M. D., Vecchione, C., Marino, G., Altruda, F., et al. (2002) · Nature Medicine · doi:10.1038/nm805 · Cited by 295 · see citing works

A decade of discoveries in cardiac biology

Olson, E. N. (2004) · Nature Medicine · doi:10.1038/nm0504-467 · Cited by 292 · see citing works

Immune Activation in Chronic Heart Failure

Torre‐Amione, G. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.006 · Cited by 283 · see citing works

Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes

Fiedler, B., Lohmann, S. M., Smolenski, A., Linnemüller, S., Pieske, B. M., Schröder, F., Molkentin, J. D., Drexler, H., & Wollert, K. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162100799 · Cited by 276 · see citing works

Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy

Kunisada, K., Negoro, S., Tone, E., Funamoto, M., Osugi, T., Yamada, S., Okabe, M., Kishimoto, T., & Yamauchi‐Takihara, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.315 · Cited by 274 · see citing works

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase

Negoro, S., Kunisada, K., Fujio, Y., Funamoto, M., Darville, M. I., Eizirik, D. L., Osugi, T., Izumi, M., Oshima, Y., Nakaoka, Y., et al. (2001) · Circulation · doi:10.1161/hc3401.095947 · Cited by 252 · see citing works

Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models

Liang, Q. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.10.001 · Cited by 239 · see citing works

Activation of gp130 Transduces Hypertrophic Signals via STAT3 in Cardiac Myocytes

Kunisada, K., Tone, E., Fujio, Y., Matsui, H., Yamauchi‐Takihara, K., & Kishimoto, T. (1998) · Circulation · doi:10.1161/01.cir.98.4.346 · Cited by 236 · see citing works

Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction

Negoro, S. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00138-3 · Cited by 234 · see citing works

Cardiomyocyte-Specific Overexpression of Nitric Oxide Synthase 3 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy After Myocardial Infarction

Janssens, S. P., Pokreisz, P., Schoonjans, L., Pellens, M., Vermeersch, P., Tjwa, M., Jans, P., Scherrer‐Crosbie, M., Picard, M. H., Szelid, Z., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000126497.38281.23 · Cited by 231 · see citing works

Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice

Jones, S. P., Greer, J. J. M., van Haperen, R., Duncker, D. J., de Crom, R., & Lefer, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0837428100 · Cited by 229 · see citing works

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress

Frey, N., Barrientos, T., Shelton, J. M., Frank, D., Rütten, H., Gehring, D., Kühn, C., Lutz, M., Rothermel, B. A., Bassel‐Duby, R., et al. (2004) · Nature Medicine · doi:10.1038/nm1132 · Cited by 223 · see citing works

Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice

Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J. H., Dorn, G. W., Armstrong, R. C., & Kitsis, R. N. (2003) · Circulation · doi:10.1161/01.cir.0000101920.72665.58 · Cited by 222 · see citing works

Altered intracellular Ca2+ handling in heart failure

Yano, M., Ikeda, Y., & Matsuzaki, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24159 · Cited by 218 · see citing works

Allopurinol Attenuates Left Ventricular Remodeling and Dysfunction After Experimental Myocardial Infarction

Engberding, N., Spiekermann, S., Schaefer, A., Heineke, A., Wiencke, A., Müller, M. F., Fuchs, M., Hilfiker‐Kleiner, D., Hornig, B., Drexler, H., et al. (2004) · Circulation · doi:10.1161/01.cir.0000144303.24894.1c · Cited by 209 · see citing works

Increased Reactive Oxygen Species Production and Functional Alterations in Antioxidant Enzymes in Human Failing Myocardium

Sam, F., Kerstetter, D. L., Pimental, D. R., Mulukutla, S. R., Tabaee, A., Bristow, M. R., Colucci, W. S., & Sawyer, D. B. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.01.007 · Cited by 196 · see citing works

Mineralocorticoid Receptor Inhibition Ameliorates the Transition to Myocardial Failure and Decreases Oxidative Stress and Inflammation in Mice With Chronic Pressure Overload

Kuster, G. M., Kotlyar, E., Rude, M. K., Siwik, D. A., Liao, R., Colucci, W. S., & Sam, F. (2005) · Circulation · doi:10.1161/01.cir.0000153800.09920.40 · Cited by 194 · see citing works

Integrin signalling: The tug-of-war in heart hypertrophy

Brancaccio, M., Hirsch, E., Notte, A., Selvetella, G., Lembo, G., & Tarone, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.015 · Cited by 187 · see citing works

Aldosterone Synthase Inhibitor Ameliorates Angiotensin II–Induced Organ Damage

Fiebeler, A., Nussberger, J., Shagdarsuren, E., Rong, S., Hilfenhaus, G., Al‐Saadi, N., Dechend, R., Wellner, M., Meiners, S., Maser‐Gluth, C., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.521625 · Cited by 182 · see citing works

The Imbalance Between Oxygen Demand and Supply as a Potential Mechanism in the Pathophysiology of Heart Failure: The Role of Microvascular Growth and Abnormalities

de Boer, R. A., Pinto, Y. M., & van Veldhuisen, D. J. (2003) · Microcirculation · doi:10.1038/sj.mn.7800188 · Cited by 180 · see citing works

C-reactive protein and interleukin-6 in vascular disease

Rattazzi, M., Puato, M., Faggin, E., Bertipaglia, B., Zambon, A., & Pauletto, P. (2003) · Journal of Hypertension · doi:10.1097/00004872-200310000-00002 · Cited by 179 · see citing works

Fas receptor signaling inhibits glycogen synthase kinase 3β and induces cardiac hypertrophy following pressure overload

Badorff, C., Ruetten, H., Mueller, S., Stahmer, M., Gehring, D., Jung, F., Ihling, C. H., Zeiher, A. M., & Dimmeler, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13779 · Cited by 174 · see citing works

Gq Signaling in Cardiac Adaptation and Maladaptation

Dorn, G. W. (1999) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(99)00004-3 · Cited by 174 · see citing works

Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes.

Kodama, H., Fukuda, K., Pan, J.-K., Makino, S., Baba, A., Hori, S., & Ogawa, S. (1997) · Circulation Research · doi:10.1161/01.res.81.5.656 · Cited by 168 · see citing works

Flow-Mediated Vasodilation Predicts Outcome in Patients With Chronic Heart Failure

Meyer, B., Mörtl, D., Strecker, K., Hülsmann, M., Kulemann, V., Neunteufl, T., Pacher, R., & Berger, R. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.060 · Cited by 165 · see citing works

Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc

Heineke, J., Ruetten, H., Willenbockel, C., Gross, S. C., Naguib, M., Schaefer, A., Kempf, T., Hilfiker‐Kleiner, D., Caroni, P., Kraft, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405488102 · Cited by 165 · see citing works

Suppressor of cytokine signaling-3 is a biomechanical stress–inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways

Yasukawa, H., Hoshijima, M., Gu, Y., Nakamura, T., Pradervand, S., Hanada, T., Hanakawa, Y., Yoshimura, A., ROSS, J. R., & Chien, K. R. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13939 · Cited by 164 · see citing works

Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence

Selvetella, G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.04.031 · Cited by 157 · see citing works

Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat

Iemitsu, M., Miyauchi, T., Maeda, S., Sakai, S., Kobayashi, T., FUJII, N. L., Miyazaki, H., Matsuda, M., & Yamaguchi, I. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.6.r2029 · Cited by 157 · see citing works

Alterations in Janus Kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) Signaling in Patients With End-Stage Dilated Cardiomyopathy

Podewski, E. K., Hilfiker‐Kleiner, D., Hilfiker, A., Morawietz, H., Lichtenberg, A., Wollert, K. C., & Drexler, H. (2003) · Circulation · doi:10.1161/01.cir.0000057545.82749.ff · Cited by 155 · see citing works

Sustained activation of nuclear factor kappa B and activator protein 1 in chronic heart failure

Frantz, S. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00723-x · Cited by 155 · see citing works

Cardiac-specific Activation of Signal Transducer and Activator of Transcription 3 Promotes Vascular Formation in the Heart

Osugi, T., Oshima, Y., Fujio, Y., Funamoto, M., Yamashita, A., Negoro, S., Kunisada, K., Izumi, M., Nakaoka, Y., Hirota, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108246200 · Cited by 152 · see citing works

Long-Term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction

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Role of interleukin‐6 for left ventricular remodeling and survival after experimental myocardial infarction

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Polyamines in Cardiac Physiology and Disease~!2009-10-19~!2009-11-30~!2010-06-14~!

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PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts

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Myocardial Cell Signaling During the Transition to Heart Failure

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Attractor landscape analysis of the cardiac signaling network reveals mechanism-based therapeutic strategies for heart failure

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Bone Marrow SSEA1+ Cells Support the Myocardium in Cardiac Pressure Overload

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Cardiac sensory afferents modulate susceptibility to anxio‐depressive behaviour in a mouse model of chronic heart failure

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