Differential regulation of EHD3 in human and mammalian heart failure
Open accessAbstract
Electrical and structural remodeling during the progression of cardiovascular disease is associated with adverse outcomes subjecting affected patients to overt heart failure (HF) and/or sudden death. Dysfunction in integral membrane protein trafficking has long been linked with maladaptive electrical remodeling. However, little is known regarding the molecular identity or function of these intracellular targeting pathways in the heart. Eps15 homology domain-containing (EHD) gene products (EHD1-4) are polypeptides linked with endosomal trafficking, membrane protein recycling, and lipid homeostasis in a wide variety of cell types. EHD3 was recently established as a critical mediator of membrane protein trafficking in the heart. Here, we investigate the potential link between EHD3 function and heart disease. Using four different HF models including ischemic rat heart, pressure overloaded mouse heart, chronic pacing-induced canine heart, and non-ischemic failing human myocardium we provide the first evidence that EHD3 levels are consistently increased in HF. Notably, the expression of the Na/Ca exchanger (NCX1), targeted by EHD3 in heart is similarly elevated in HF. Finally, we identify a molecular pathway for EHD3 regulation in heart failure downstream of reactive oxygen species and angiotensin II signaling. Together, our new data identify EHD3 as a previously unrecognized component of the cardiac remodeling pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Regulation of EHD3 plays a role in a molecular pathway related to heart failure.
“Regulation of EHD3 plays a role in a molecular pathway related to heart failure (Gudmundsson et al., 2012).”
From Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears (2014) · cites this paper as Gudmundsson et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Rockman, H. A., Ross, R. S., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., Ross, J., & Chien, K. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.18.8277 · Cited by 807 · see citing works
RetractedTHE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS
Sadoshima, J., & Izumo, S. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.551 · Cited by 868 · see citing works
McMurray, J. J. V., & Pfeffer, M. A. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66621-4 · Cited by 834 · see citing works
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772 · see citing works
Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure.
Studer, R., Reinecke, H., Bilger, J., Thomas Eschenhagen, A., Böhm, M., Hasenfuss, G. P., Just, H., Holtz, J., & Drexler, H. (1994) · Circulation Research · doi:10.1161/01.res.75.3.443 · Cited by 633 · see citing works
Bendall, J. K., Cave, A. C., Heymes, C., Gall, N. P., & Shah, A. M. (2002) · Circulation · doi:10.1161/hc0302.103712 · Cited by 531 · see citing works
Activation of NADPH Oxidase During Progression of Cardiac Hypertrophy to Failure
Li, J., Gall, N. P., Grieve, D., Chen, M., & Shah, A. M. (2002) · Hypertension · doi:10.1161/01.hyp.0000032031.30374.32 · Cited by 517 · see citing works
Valdivia, C. R., Chu, W. W., Pu, J., Foell, J. D., Haworth, R. A., Wolff, M. R., Kamp, T. J., & Makielski, J. C. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.12.012 · Cited by 441 · see citing works
Byrne, J., Grieve, D., Bendall, J. K., Li, J., Gove, C. D., Lambeth, J. D., Cave, A. C., & Shah, A. M. (2003) · Circulation Research · doi:10.1161/01.res.0000099504.30207.f5 · Cited by 411 · see citing works
T-Tubule Remodeling During Transition From Hypertrophy to Heart Failure
Sheng, W., Guo, A., Chen, B., Kutschke, W. J., Xie, Y., Zimmerman, K., Weiss, R. M., Anderson, M. E., Cheng, H., & Song, L. (2010) · Circulation Research · doi:10.1161/circresaha.109.212324 · Cited by 395 · see citing works
Self-citationHill, M. F., & Singal, P. K. (1996) · PubMed · Cited by 360 · see citing works
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling
Daumke, O., Lundmark, R., Vallis, Y., Martens, S., Butler, P. J. G., & McMahon, H. T. (2007) · Nature · doi:10.1038/nature06173 · Cited by 317 · see citing works
van Oort, R. J., McCauley, M. D., Dixit, S. S., Pereira, L., Yang, Y., Respress, J. L., Wang, Q., Almeida, A. C. D., Skapura, D. G., Anderson, M. E., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.982298 · Cited by 310 · see citing works
Self-citationCaplan, S., Naslavsky, N., Hartnell, L. M., Lodge, R., Polishchuk, R., Donaldson, J. G., & Bonifacino, J. S. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2557 · Cited by 301 · see citing works
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling
Grant, B. D., Zhang, Y., Paupard, M., Lin, S. X. H., Hall, D. H., & Hirsh, D. (2001) · Nature Cell Biology · doi:10.1038/35078549 · Cited by 269 · see citing works
Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling
Xie, L., Chen, F., Karagueuzian, H. S., & Weiss, J. N. (2008) · Circulation Research · doi:10.1161/circresaha.108.183475 · Cited by 265 · see citing works
Enhanced Ca 2+ Release and Na/Ca Exchange Activity in Hypertrophied Canine Ventricular Myocytes
Sipido, K. R., Volders, P. G. A., de Groot, S. H. M., Verdonck, F., de Werf, F. V., Wellens, H. J. J., & Vos, M. A. (2000) · Circulation · doi:10.1161/01.cir.102.17.2137 · Cited by 263 · see citing works
Mohler, P. J., Davis, J. Q., & Bennett, V. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030423 · Cited by 244 · see citing works
Self-citationModulation of Vascular Smooth Muscle Signaling by Reactive Oxygen Species
Lyle, A. N., & Griendling, K. K. (2006) · Physiology · doi:10.1152/physiol.00004.2006 · Cited by 239 · see citing works
Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?
Sipido, K. R. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00470-9 · Cited by 214 · see citing works
Malhotra, R., Sadoshima, J., Brosius, F. C., & Izumo, S. (1999) · Circulation Research · doi:10.1161/01.res.85.2.137 · Cited by 201 · see citing works
Interactions between EHD Proteins and Rab11-FIP2: A Role for EHD3 in Early Endosomal Transport
Naslavsky, N., Rahajeng, J., Sharma, M., Jović, M., & Caplan, S. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-05-0466 · Cited by 184 · see citing works
Progression of heart failure after myocardial infarction in the rat
Francis, J., Weiss, R. M., Wei, S., Johnson, A. K., & Felder, R. B. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.5.r1734 · Cited by 178 · see citing works
Self-citationIncreased Nox2 expression in human cardiomyocytes after acute myocardial infarction
Krijnen, P. A. J., Meischl, C., Hack, C. E., Meijer, C. J. L. M., Visser, C. A., Roos, D., & Niessen, H. W. M. (2003) · Journal of Clinical Pathology · doi:10.1136/jcp.56.3.194 · Cited by 176 · see citing works
Molecular Mechanisms in Heart Failure
Hilfiker-Kleiner, D., Landmesser, U., & Drexler, H. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.007 · Cited by 151 · see citing works
Kaprielian, R., Wickenden, A. D., Kassiri, Z., Parker, T. G., Liu, P. P., & Backx, P. H. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0229z.x · Cited by 148 · see citing works
Mechanisms of EHD/RME‐1 Protein Function in Endocytic Transport
Grant, B. D., & Caplan, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00834.x · Cited by 147 · see citing works
Walseng, E., Bakke, O., & Roche, P. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801070200 · Cited by 132 · see citing works
Jović, M., Naslavsky, N., Rapaport, D., Horowitz, M., & Caplan, S. (2007) · Journal of Cell Science · doi:10.1242/jcs.03383 · Cited by 125 · see citing works
Guilherme, A., Soriano, N. A., Furcinitti, P. S., & Czech, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401918200 · Cited by 123 · see citing works
George, M., Ying, G., Rainey, M. A., Solomon, A., Parikh, P. T., Gao, Q., Band, V., & Band, H. (2007) · BMC Cell Biology · doi:10.1186/1471-2121-8-3 · Cited by 115 · see citing works
Self-citationA Role for EHD4 in the Regulation of Early Endosomal Transport
Sharma, M., Naslavsky, N., & Caplan, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00732.x · Cited by 113 · see citing works
Fukui, T., Yoshiyama, M., Hanatani, A., Omura, T., Yoshikawa, J., & Abe, Y. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4493 · Cited by 108 · see citing works
Xiao, C.-Y., Chen, M., Zsengellér, Z. K., Li, H., Kiss, L., Kollai, M., & Szabó, C. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.077164 · Cited by 106 · see citing works
Pohl, U., Smith, J. S., Tachibana, I., Ueki, K., Lee, H. K., Ramaswamy, S., Wu, Q., Mohrenweiser, H. W., Jenkins, R. B., & Louis, D. N. (2000) · Genomics · doi:10.1006/geno.1999.6087 · Cited by 91 · see citing works
EHD1—An EH-Domain-Containing Protein with a Specific Expression Pattern
Mintz, L., Galperin, E., Pasmanik‐Chor, M., Tulzinsky, S., Bromberg, Y., Kozak, C. A., Joyner, A. L., Fein, A., & Horowitz, M. (1999) · Genomics · doi:10.1006/geno.1999.5800 · Cited by 89 · see citing works
Na+-Ca2+ Exchanger Remodeling in Pressure Overload Cardiac Hypertrophy
Wang, Z., Nolan, B., Kutschke, W. J., & Hill, J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100544200 · Cited by 88 · see citing works
Nishijima, Y., Sridhar, A., Bonilla, I. M., Velayutham, M., Khan, M., Terentyeva, R., Li, C., Kuppusamy, P., Elton, T. S., Terentyev, D. A., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr087 · Cited by 81 · see citing works
Self-citationObscurin Targets Ankyrin-B and Protein Phosphatase 2A to the Cardiac M-line
Cunha, S. R., & Mohler, P. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806050200 · Cited by 81 · see citing works
Self-citationTilley, D. G., & Rockman, H. A. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.3.417 · Cited by 77 · see citing works
Blume, J. J., Halbach, A., Behrendt, D., Paulsson, M., & Plomann, M. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.10.006 · Cited by 74 · see citing works
EH Domain Proteins Regulate Cardiac Membrane Protein Targeting
Gudmundsson, H., Hund, T. J., Wright, P. J., Kline, C. F., Snyder, J. S., Qian, L., Koval, O. M., Cunha, S. R., George, M., Rainey, M. A., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.216713 · Cited by 69 · see citing works
Self-citationFrancis, J., Weiss, R. M., Johnson, A. K., & Felder, R. B. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00376.2002 · Cited by 66 · see citing works
Self-citationMolecular Cloning and Characterization of MT-ACT48, a Novel Mitochondrial Acyl-CoA Thioesterase
Poupon, V., Bègue, B., Gagnon, J., Dautry‐Varsat, A., Cerf–Bensussan, N., & Benmerah, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19188 · Cited by 34 · see citing works
Canine Nonischemic Left Ventricular Dysfunction: A Model of Chronic Human Cardiomyopathy
Nishijima, Y., Feldman, D. S., Bonagura, J. D., Özkanlar, Y., Jenkins, P. J., Lacombe, V. A., Abraham, W. T., Hamlin, R. L., & Carnes, C. A. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.05.006 · Cited by 33 · see citing works
Self-citationProteomic Remodeling of Mitochondria in Heart Failure
Hollander, J. M., Baseler, W. A., & Dabkowski, E. R. (2011) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2011.00254.x · Cited by 27 · see citing works
Role of the Na/Ca Exchanger in Arrhythmias in Compensated Hypertrophy
Sipido, K. R., Volders, P. G. A., Schoenmakers, M., de Groot, S. H. M., Verdonck, F., & Vos, M. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04773.x · Cited by 24 · see citing works
Weisser-Thomas, J., Kubo, H., Hefner, C. A., Gaughan, J. P., McGowan, B. S., Ross, R. S., Meyer, M., DILLMANN, W. H., & Houser, S. R. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.01.004 · Cited by 21 · see citing works
Current Understanding of the Mechanism and Role of ROS in Angiotensin II Signal Transduction
Suzuki, H., Frank, G. D., Utsunomiya, H., Higuchi, S., & Eguchi, S. (2006) · Current Pharmaceutical Biotechnology · doi:10.2174/138920106776597667 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears
Liu, S., Lorenzen, E. D., Fumagalli, M., Li, B., Harris, K., Xiong, Z., Zhou, L., Korneliussen, T. S., Somel, M., Babbitt, C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.054 · Cited by 411 · see citing works
Spectrin- and Ankyrin-Based Membrane Domains and the Evolution of Vertebrates
Bennett, V., & Lorenzo, D. N. (2013) · Current topics in membranes · doi:10.1016/b978-0-12-417027-8.00001-5 · Cited by 159 · see citing works
Glynn, P., Musa, H., Wu, X., Unudurthi, S. D., Little, S. C., Qian, L., Wright, P. J., Radwański, P., Györke, S., Mohler, P. J., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.015218 · Cited by 118 · see citing works
Self-citationBennett, V., & Lorenzo, D. N. (2015) · Current topics in membranes · doi:10.1016/bs.ctm.2015.10.001 · Cited by 97 · see citing works
Molecular Mechanisms Underlying Cardiac Protein Phosphatase 2A Regulation in Heart
DeGrande, S. T., Little, S. C., Nixon, D. J., Wright, P., Snyder, J. S., Dun, W., Murphy, N. P., Kılıç, A., Higgins, R. S. D., Binkley, P. F., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426957 · Cited by 92 · see citing works
Self-citationPlasma Membrane Repair in Health and Disease
Demonbreun, A. R., & McNally, E. M. (2015) · Current topics in membranes · doi:10.1016/bs.ctm.2015.10.006 · Cited by 67 · see citing works
Membrane fusion in muscle development and repair
Demonbreun, A. R., Biersmith, B. H., & McNally, E. M. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.026 · Cited by 60 · see citing works
EHD3-Dependent Endosome Pathway Regulates Cardiac Membrane Excitability and Physiology
Curran, J. W., Makara, M. A., Little, S. C., Musa, H., Liu, B., Wu, X., Polina, I. A., Alecusan, J. S., Wright, P., Li, J., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.304149 · Cited by 39 · see citing works
Self-citationBhattacharyya, S., Rainey, M. A., Arya, P., Mohapatra, B. C., Mushtaq, I., Dutta, S., George, M., Storck, M. D., McComb, R. D., Muirhead, D. E., et al. (2016) · Scientific Reports · doi:10.1038/srep20727 · Cited by 36 · see citing works
Self-citationWang, X., Chen, X., Dobrev, D., & Li, N. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-021-02515-4 · Cited by 36 · see citing works
Cardiomyocyte damage control in heart failure and the role of the sarcolemma
Kitmitto, A., Baudoin, F., & Cartwright, E. J. (2019) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-019-09539-5 · Cited by 30 · see citing works
Ankyrin-B Protein in Heart Failure
Kashef, F., Li, J., Wright, P., Snyder, J. S., Suliman, F., Kılıç, A., Higgins, R. S. D., Anderson, M. E., Binkley, P. F., Hund, T. J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.368415 · Cited by 28 · see citing works
Self-citationAdaptation of the transcriptional response to resistance exercise over 4 weeks of daily training
Viggars, M. R., Sutherland, H., Lanmüller, H., Schmoll, M., Bijak, M., & Jarvis, J. C. (2022) · The FASEB Journal · doi:10.1096/fj.202201418r · Cited by 26 · see citing works
Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis
Wang, X., Song, J., Yuan, Y., Li, L., Abu-Taha, I., Heijman, J., Sun, L. T., Dobrev, S., Kamler, M., Xie, L., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322213 · Cited by 27 · see citing works
Dysfunction of the β2-spectrin-based pathway in human heart failure
Smith, S. A., Hughes, L. D., Kline, C. F., Kempton, A. N., Dorn, L. E., Curran, J. W., Makara, M. A., Webb, T. R., Wright, P., Voigt, N., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00875.2015 · Cited by 25 · see citing works
Self-citationAnkyrin-G Participates in INa Remodeling in Myocytes from the Border Zones of Infarcted Canine Heart
Dun, W., Lowe, J. S., Wright, P., Hund, T. J., Mohler, P. J., & Boyden, P. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078087 · Cited by 24 · see citing works
Self-citationDefects in Cytoskeletal Signaling Pathways, Arrhythmia, and Sudden Cardiac Death
Smith, S. A., Curran, J. W., Hund, T. J., & Mohler, P. J. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00122 · Cited by 23 · see citing works
Self-citationThe Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
Sienkiewicz‐Szłapka, E., Fiedorowicz, E., Król-Grzymała, A., Kordulewska, N. K., Rozmus, D., Cieślińska, A., & Grzybowski, A. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115865 · Cited by 20 · see citing works
Roof, S. R., Boslett, J. J., Russell, D., del Rio, C. L., Alecusan, J., Zweier, J. L., Ziolo, M. T., Hamlin, R. L., Mohler, P. J., & Curran, J. (2015) · Acta Physiologica · doi:10.1111/apha.12607 · Cited by 20 · see citing works
Self-citationUse of Whole Exome Sequencing for the Identification of I to ‐Based Arrhythmia Mechanism and Therapy
Sturm, A. C., Kline, C. F., Glynn, P., Johnson, B. L., Curran, J. W., Kılıç, A., Higgins, R. S. D., Binkley, P. F., Janssen, P. M. L., Weiss, R., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001762 · Cited by 18 · see citing works
Self-citationKline, C. F., & Mohler, P. J. (2013) · Current topics in membranes · doi:10.1016/b978-0-12-417027-8.00004-0 · Cited by 17 · see citing works
Self-citationCurran, J. W., Musa, H., Kline, C. F., Makara, M. A., Little, S. C., Higgins, J. D. D., Hund, T. J., Band, H., & Mohler, P. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646893 · Cited by 16 · see citing works
Self-citationCypher, L. R., Bielecki, T. A., Huang, L., An, W., Iseka, F., Tom, E. C., Storck, M. D., Hoppe, A. D., Band, V., & Band, H. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.05.013 · Cited by 16 · see citing works
Self-citationEndosome-based protein trafficking and Ca2+ homeostasis in the heart
Curran, J. W., Makara, M. A., & Mohler, P. J. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00034 · Cited by 14 · see citing works
Self-citationAltered regulation of cardiac ankyrin repeat protein in heart failure
Kempton, A. N., Cefalu, M., Justice, C. N., Baich, T. M., Derbala, M. H., Canan, B. D., Janssen, P. M. L., Mohler, P. J., & Smith, S. A. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00514 · Cited by 13 · see citing works
Self-citationEHD1 and RUSC2 Control Basal Epidermal Growth Factor Receptor Cell Surface Expression and Recycling
Tom, E. C., Mushtaq, I., Mohapatra, B. C., Luan, H., Bhat, A. M., Zutshi, N., Chakraborty, S., Islam, N., Arya, P., Bielecki, T. A., et al. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00434-19 · Cited by 14 · see citing works
Self-citationBhattacharyya, S. S., & Pucadyil, T. J. (2020) · Protein Science · doi:10.1002/pro.3860 · Cited by 12 · see citing works
Putative functional genes in idiopathic dilated cardiomyopathy
Nair, N. U., Das, A., Amit, U., Robinson, W., Park, S. G., Basu, M., Lugo, A., Leor, J., Ruppin, E., & Hannenhalli, S. S. (2018) · Scientific Reports · doi:10.1038/s41598-017-18524-2 · Cited by 9 · see citing works
Implantable Cardiovascular Sensors and Computers: Interventional Heart Failure Strategies
Smith, S. A., & Abraham, W. T. (2012) · Current Cardiology Reports · doi:10.1007/s11886-012-0294-6 · Cited by 8 · see citing works
Self-citationEHD4 is a novel regulator of urinary water homeostasis
Rahman, S. S., Moffitt, A. E. J., Trease, A. J., Foster, K. W., Storck, M. D., Band, H., & Boesen, E. I. (2017) · The FASEB Journal · doi:10.1096/fj.201601182rr · Cited by 3 · see citing works
Self-citationAlur, V. C., Vastrad, B. M., Raju, V., Vastrad, C. M., & Kotrashetti, S. (2025) · Discover Endocrinology and Metabolism · doi:10.1007/s44417-025-00003-2 · Cited by 2 · see citing works
Vastrad, B. M., & Vastrad, C. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.24.469869 · Cited by 2 · see citing works
Requirement of EHD Family of Endocytic Recycling Regulators for T-Cell Functions
Iseka, F. (2017) · DigitalCommons@UNMC
(2013) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328360f5be
Shotton, R., Campbell, A. E., Baričević-Jones, I., Reed, R., Kelsall, J., Williams, J., Mellor, H. R., Unwin, R. D., & Linton, K. (2026) · Cardio-Oncology · doi:10.1186/s40959-026-00484-0
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Frisby, D., Misri, G., Naslavsky, N., & Caplan, S. (2026) · Traffic · doi:10.1111/tra.70039
Phosphatase regulation in cardiovascular physiology and disease
DeGrande, S. T. (2012) · doi:10.17077/etd.or34zt15
- Authors
- Gudmundsson, H., Curran, J., Kashef, F., Snyder, J. S., Smith, S. A., Vargas-Pinto, P., Bonilla, I. M., Weiss, R. M., Anderson, M. E., Binkley, P., Felder, R. B., Carnes, C. A., Band, H., Hund, T. J., & Mohler, P. J.
- Affiliations
- University of Iowa (US)
- The Ohio State University Wexner Medical Center (US)
- University of Nebraska Medical Center (US)
- ORCID
- Venue
- Journal of Molecular and Cellular Cardiology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 52
- Issue
- 5
- Pages
- 1183-1190
- ISSN
- 0022-2828 (ISSN-L)
- PMC
- PMC3360944
- OpenAlex
- W2094785789
- Cited by
- 37
- References
- 50
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Journal of Molecular and Cellular Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl083422-11, UL1TR000090)
- National Heart, Lung, and Blood Institute (HL-079031, HL089836, F32HL114252, HL62494, HL084583, R01HL084583, HL70250, R00HL096805, R01-HL-083422, K99HL096805, R01HL073986, HL-083422, R01HL079031, R01HL113001, R01HL089836, HL096805, R01HL070250, HL073986, R01HL062494)
- National Cancer Institute (CA 116552, R01CA099163, CA105489, R01CA105489, CA 87986, R01CA087986, R01CA116552, CA 99163)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- EHD3, heart failure, Eps15 homology domain, membrane protein trafficking, Na+/Ca2+ exchanger, NCX1, cardiac remodeling, reactive oxygen species, angiotensin II signaling, endosomal trafficking, myocardial ischemia, pressure overload
- MeSH terms
- Angiotensin II, Animals, Carrier Proteins, Cells, Cultured, Dogs, Gene Expression Regulation, Heart Failure, Heart Ventricles, Humans, Male, Mice, Inbred C57BL, Case-Control Studies, Rats, Sprague-Dawley, Reactive Oxygen Species, NADPH Oxidases, Sodium-Calcium Exchanger, Myocytes, Cardiac, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
