Ethnic Differences in Left Ventricular Remodeling in Highly-Trained Athletes
Open accessAbstract
Objectives The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes.Background The upper limits of left ventricular hypertrophy (LVH) are established in white athletes and aid the differentiation of physiologic LVH from hypertrophic cardiomyopathy (HCM). However, there are few data regarding LV remodeling in black athletes, in whom deaths from HCM are more prevalent.Methods Between 2003 and 2007, 300 nationally ranked black male athletes (mean age 20.5 years) underwent 12-lead electrocardiogram and 2-dimensional echocardiography. The results were compared with 150 black and white sedentary individuals and 300 highly-trained white male athletes matched for age, size, and sport.Results Black athletes exhibited greater LV wall thickness and cavity size compared with sedentary black and white individuals. Black athletes had greater LV wall thickness compared with white athletes (11.3 +/- 1.6 mm vs. 10 +/- 1.5 mm; p < 0.001). In absolute terms, 54 black athletes (18%) had LV wall thickness >12 mm compared with 12 white athletes (4%), and 3% of black athletes exhibited LV wall thickness >/=15 mm compared with none of the white athletes. Black athletes with LVH displayed an enlarged LV cavity and normal diastolic function.Conclusions Black athletes develop a greater magnitude of LVH compared with white athletes; therefore, extrapolation of conclusions derived from white athletes has the potential of generating false-positive diagnoses of HCM in black athletes.
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Black athletes with left ventricular hypertrophy have a higher prevalence of ST-segment elevations and deep T-wave inversions.
“Black athletes with left ventricular hypertrophy had a higher prevalence of ST-segment elevations and deep T-wave inversions.11”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [11]
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- Authors
- Basavarajaiah, S., Boraita, A., Whyte, G., Wilson, M., Carby, L., Shah, A., & Sharma, S.
- Affiliations
- King's College Hospital (GB)
- University Hospital Lewisham (GB)
- Corresponding author
- Sharma, Sanjay
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 51
- Issue
- 23
- Pages
- 2256-2262
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1432820760
- Cited by
- 333
- References
- 35
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 15 · 2023: 12 · 2022: 15 · 2021: 16 · 2020: 16 · 2019: 15 · 2018: 22 · 2017: 13 · 2016: 14 · 2015: 27 · 2014: 16 · 2013: 21 · 2012: 34
- FWCI
- 18.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Keywords
- left ventricular remodeling, left ventricular hypertrophy, Black athletes, ethnic differences, hypertrophic cardiomyopathy, athlete's heart, left ventricular wall thickness, left ventricular dimensions, diastolic function, false-positive diagnosis, highly trained athletes
- MeSH terms
- Adolescent, Adult, Algorithms, Black or African American, Cardiomyopathy, Hypertrophic, Heart Ventricles, Humans, Male, Surveys and Questionnaires, Reference Values, Sports, Ultrasonography, United States, Case-Control Studies, Hypertrophy, Left Ventricular, Ventricular Remodeling, White People
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