Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy
Open accessAbstract
Objectives The aim of this study was to examine the characteristics of non-sustained ventricular tachycardia (NSVT) episodes during Holter monitoring and to determine their relationship to age and prognosis.Background It has been suggested that NSVT is only of prognostic importance in patients with hypertrophic cardiomyopathy (HCM) when repetitive, prolonged, or associated with symptoms.Methods We studied 531 patients with HCM (323 male, 39 +/- 15 years). All underwent ambulatory electrocardiogram monitoring (41 +/- 11 h).Results A total of 104 patients (19.6%) had NSVT. The proportion of patients with NSVT increased with age (p = 0.008). Maximum left ventricular wall thickness and left atrial size were greater in patients with NSVT. Mean follow-up was 70 +/- 40 months. Sixty-eight patients died, 32 from sudden cardiac death (SCD). Twenty-one patients received an implantable cardioverter defibrillator (ICD). There were four appropriate ICD discharges. In patients < or =30 years (but not >30), five-year freedom from sudden death was lower in those with NSVT (77.6% [95% confidence interval (CI): 59.8 to 95.4] vs. 94.1% [95% CI: 90.2 to 98.0]; p = 0.003). There was no relation between the duration, frequency, or rate of NSVT runs and prognosis at any age. The odds ratio of sudden death in patients < or =30 years of age with NSVT was 4.35 (95% CI: 1.54 to 12.28; p = 0.006) compared with 2.16 (95% CI: 0.82 to 5.69; p = 0.1) in patients >30 years of age.Conclusions Non-sustained ventricular tachycardia is associated with a substantial increase in sudden death risk in young patients with HCM. A relation between the frequency, duration, and rate of NSVT episodes could not be demonstrated.
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Up to 30% of HCM patients present with NSVT episodes on Holter monitoring.
“Up to 30% of HCM patients present with NSVT episodes on Holter monitoring”
From 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry (2017) · cites this paper as Monserrat et al., 2003
The NSVT characteristics section reports that 104 of 531 HCM patients (19.6%) had NSVT during their initial Holter recording. This supports the claim that Holter monitoring detects NSVT in HCM patients, but the paper does not establish the stated figure of up to 30%. (LLM, conf=0.88)
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- Authors
- Monserrat, L., Elliott, P. M., Gimeno, J. R., Sharma, S., Penas-Lado, M., & McKenna, W. J.
- Affiliations
- St George's, University of London (GB)
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 42
- Issue
- 5
- Pages
- 873-879
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2107752854
- Cited by
- 541
- References
- 18
- Citations by year
- 2026: 7 · 2025: 28 · 2024: 23 · 2023: 21 · 2022: 13 · 2021: 31 · 2020: 38 · 2019: 19 · 2018: 34 · 2017: 31 · 2016: 23 · 2015: 32 · 2014: 27 · 2013: 26 · 2012: 19
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- non-sustained ventricular tachycardia, hypertrophic cardiomyopathy, sudden cardiac death, prognosis, age, left ventricular wall thickness, left atrial size, implantable cardioverter-defibrillator, Holter monitoring, young patients
- MeSH terms
- Adolescent, Adult, Aged, Cardiomyopathy, Hypertrophic, Echocardiography, Electrocardiography, Exercise Test, Female, Follow-Up Studies, Heart Rate, Humans, London, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, Biomarkers, Electrocardiography, Ambulatory, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Death, Sudden, Cardiac, Tachycardia, Ventricular, Hypertrophy, Left Ventricular, Age Distribution, Risk Assessment
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