The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Resistin, Adiponectin, and Risk of Heart Failure
Open accessAbstract
Objective We tested the association of the adipokines resistin and adiponectin with incident heart failure. Background Abnormal concentrations of adipokines may partially explain the association between obesity and heart failure. Methods We related circulating adipokine concentrations to the incidence of heart failure in 2,739 participants in the Framingham Offspring Study. Results During six years of follow-up, 58 participants developed new-onset heart failure. In proportional hazards models (adjusting for age, sex, blood pressure, antihypertensive treatment, diabetes, smoking, total/HDL cholesterol ratio, prevalent coronary heart disease, valvular heart disease, left ventricular hypertrophy and estimated glomerular filtration rate) using the lowest third of the resistin distribution as the referent, the hazard ratios (HRs) for heart failure in the middle and top thirds were 2.89 (95% confidence interval 1.05–7.92) and 4.01 (1.52–10.57), respectively (P=0.004 for trend). Additional adjustment for body mass index, insulin resistance (measured with the homeostasis model), C-reactive protein and B-type natriuretic peptide did not substantively weaken this association (multivariable HRs 2.62 and 3.74, P=0.007). In the maximally-adjusted model, each standard deviation increment in resistin (7.45 ng/ml) was associated with a 26% increase in heart failure risk (95% CI -1–60%). Concentrations of adiponectin were not associated with heart failure (multivariable HRs 0.87 and 0.97, P=0.9). Conclusions Elevated circulating concentrations of resistin were associated with incident heart failure, even after accounting for prevalent coronary heart disease, obesity, and for measures of insulin resistance and inflammation. The findings suggest a role for resistin in human disease and a novel pathway to heart failure.
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Self-citationBody-Mass Index and Mortality in a Prospective Cohort of U.S. Adults
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Self-citationObesity and the risk of heart failure
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Self-citationLipotoxic heart disease in obese rats: Implications for human obesity
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Self-citationHeart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Self-citationHeart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
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Metadata
- Authors
- Frankel, D. S., Vasan, R. S., D'Agostino, R. B., Benjamin, E. J., Levy, D., Wang, T. J., & Meigs, J. B.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 53
- Issue
- 9
- Pages
- 754-762
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W57547456
- Cited by
- 255
- References
- 13
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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