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Cited by 487

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The Pathologic Continuum of Diabetic Vascular Disease

Open access
Orasanu, Gabriela, Plutzky, Jorge·2009·Journal of the American College of Cardiology

Abstract

Hyperglycemia can promote vascular complications by multiple mechanisms, with formation of advanced glycation endproducts (AGEs) and increased oxidative stress proposed to contribute to both macrovascular and microvascular complications. Many of the earliest pathologic responses to hyperglycemia are manifest in the vascular cells that directly encounter elevated blood glucose levels. In the macrovasculature, these include endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). In the microvasculature, these include ECs, pericytes (in retinopathy), and podocytes (in renal disease). Additionally, neovascularization arising from the vasa vasorum may promote atherosclerotic plaque progression and contribute to plaque rupture, thereby interconnecting macro- and microangiopathy.

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Registry

Crossref · 10.1016/j.jacc.2008.09.055

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Metadata

Authors
Orasanu, G., & Plutzky, J.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2009-02
Volume
53
Issue
5
Pages
S35-S42
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2132080783
Cited by
487
References
7
FWCI
17.73
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Pathologic Continuum of Diabetic Vascular Disease. https://app.cochat.ai/papers/10.1016/j.jacc.2008.09.055
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Orasanu, G., & Plutzky, J. (2009). The Pathologic Continuum of Diabetic Vascular Disease. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2008.09.055

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.