The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Diabetes and Its Effect on Bone and Fracture Healing
Open accessAbstract
Diabetes mellitus is a metabolic disorder that increases fracture risk, interferes with bone formation, and impairs fracture healing. Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) both increase fracture risk and have several common features that affect the bone including hyperglycemia and increased advanced glycation end product (AGE) formation, reactive oxygen species (ROS) generation, and inflammation. These factors affect both osteoblasts and osteoclasts leading to increased osteoclasts and reduced numbers of osteoblasts and bone formation. In addition to fracture healing, T1DM and T2DM impair bone formation under conditions of perturbation such as bacteria-induced periodontal bone loss by increasing osteoblast apoptosis and reducing expression of factors that stimulate osteoblasts such as BMPs and growth factors.
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Cites
Oxidative stress and diabetic complications
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Role of oxidative stress in diabetic complications: a new perspective on an old paradigm.
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Oxidative damage to DNA in diabetes mellitus
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Self-citationOxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB
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Cited by
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
Saul, D., & Khosla, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac008 · Cited by 185
Effects of anti-diabetic drugs on fracture risk: a systematic review and network meta-analysis
Zhang, Y.-S., Zheng, Y.-D., Yuan, Y., Chen, S.-C., & Xie, B.-C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.735824 · Cited by 117
TNFα contributes to diabetes impaired angiogenesis in fracture healing
Lim, J. C., Ko, K. I., Mattos, M., Fang, M., Zhang, C., Feinberg, D., Sindi, H., Li, S., Alblowi, J., Kayal, R. A., et al. (2017) · Bone · doi:10.1016/j.bone.2017.02.014 · Cited by 91
Self-citationKhajuria, D. K., Reider, I., Kamal, F., Norbury, C. C., & Elbarbary, R. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1250309 · Cited by 15
Dietary calcium and serum 25OHD protect Chinese women from type 2 diabetes
FENG, L., HU, Z., & WANG, Q. (2017) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.63.222 · Cited by 9
Metadata
- Authors
- Jiao, H., Xiao, E., & Graves, D. T.
- Venue
- Current Osteoporosis Reports
- Published
- 2015-08-09
- Volume
- 13
- Issue
- 5
- Pages
- 327-335
- ISSN
- 1544-1873 (ISSN-L)
- 1544-2241
- OpenAlex
- W1048885802
- Cited by
- 522
- References
- 102
- FWCI
- 16.62
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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