Impact of diabetes on cardiovascular disease: an update
Open accessAbstract
Cardiovascular diseases are the most prevalent cause of morbidity and mortality among patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated atherosclerosis and increased cardiovascular risk in this population are poorly understood. It has been suggested that an association between hyperglycemia and intracellular metabolic changes can result in oxidative stress, low‐grade inflammation, and endothelial dysfunction. Recently, epigenetic factors by different types of reactions are known to be responsible for the interaction between genes and environment and for this reason can also account for the association between diabetes and cardiovascular disease. The impact of clinical factors that may coexist with diabetes such as obesity, dyslipidemia, and hypertension are also discussed. Furthermore, evidence that justify screening for subclinical atherosclerosis in asymptomatic patients is controversial and is also matter of this review. The purpose of this paper is to describe the association between poor glycemic control, oxidative stress, markers of insulin resistance, and of low‐grade inflammation that have been suggested as putative factors linking diabetes and cardiovascular disease.
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Individuals with diabetes suffer from a higher risk of cardiovascular diseases compared to those without diabetes, which is associated with a number of common risk factors such as age, obesity, smoking, hypertension, and dyslipidemia.
“Individuals with diabetes suffer from a higher risk of cardiovascular diseases compared to those without diabetes, which is associated with a number of common risk factors such as age, obesity, smoking, hypertension, and dyslipidemia (113).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [113]
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Flagged first, then by citations
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- Authors
- Matheus, A. S. D. M., Tannus, L. R. M., Cobas, R. A., Palma, C. C. S., Negrato, C. A., & Gomes, M. D. B.
- Affiliations
- Universidade do Estado do Rio de Janeiro (BR)
- Corresponding author
- Matheus, Alessandra Saldanha de Mattos
- Venue
- International Journal of Hypertension
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 2013
- Issue
- 1
- Pages
- 653789-653789
- ISSN
- 2090-0384 (ISSN-L)
- 2090-0392
- PMC
- PMC3603160
- OpenAlex
- W1991511572
- Cited by
- 547
- References
- 154
- Citations by year
- 2026: 25 · 2025: 57 · 2024: 64 · 2023: 61 · 2022: 45 · 2021: 54 · 2020: 52 · 2019: 57 · 2018: 48 · 2017: 30 · 2016: 16 · 2015: 15 · 2014: 17 · 2013: 5
- FWCI
- 13.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Hypertension (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- diabetes mellitus, cardiovascular disease, type 1 diabetes, type 2 diabetes, atherosclerosis, hyperglycemia, oxidative stress, low-grade inflammation, endothelial dysfunction, epigenetics, insulin resistance, obesity, dyslipidemia, hypertension, glycemic control
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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