Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats
Open accessAbstract
Objectives The purpose of this study was to investigate whether liposomal adenosine has stronger cardioprotective effects and fewer side effects than free adenosine.Background Liposomes are nanoparticles that can deliver various agents to target tissues and delay degradation of these agents. Liposomes coated with polyethylene glycol (PEG) prolong the residence time of drugs in the blood. Although adenosine reduces the myocardial infarct (MI) size in clinical trials, it also causes hypotension and bradycardia.Methods We prepared PEGylated liposomal adenosine (mean diameter 134 +/- 21 nm) by the hydration method. In rats, we evaluated the myocardial accumulation of liposomes and MI size at 3 h after 30 min of ischemia followed by reperfusion.Results The electron microscopy and ex vivo bioluminescence imaging showed the specific accumulation of liposomes in ischemic/reperfused myocardium. Investigation of radioisotope-labeled adenosine encapsulated in PEGylated liposomes revealed a prolonged blood residence time. An intravenous infusion of PEGylated liposomal adenosine (450 microg/kg/min) had a weaker effect on blood pressure and heart rate than the corresponding dose of free adenosine. An intravenous infusion of PEGylated liposomal adenosine (450 microg/kg/min) for 10 min from 5 min before the onset of reperfusion significantly reduced MI size (29.5 +/- 6.5%) compared with an infusion of saline (53.2 +/- 3.5%, p < 0.05). The antagonist of adenosine A(1), A(2a), A(2b), or A(3) subtype receptor blocked cardioprotection observed in the PEGylated liposomal adenosine-treated group.Conclusions An infusion as PEGylated liposomes augmented the cardioprotective effects of adenosine against ischemia/reperfusion injury and reduced its unfavorable hemodynamic effects. Liposomes are promising for developing new treatments for acute MI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PEGylated liposome-dependent adenosine delivery shows effective cardioprotection by delivering more adequate adenosine concentration in ischemic myocardium rat model than free adenosine.
“In this regard, PEGylated liposome-dependent adenosine delivery shows effective cardioprotection by delivering a more adequate adenosine concentration in the ischemic myocardium rat model than does free adenosine.159”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [159]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Papahadjopoulos, D., Allen, T. M., Gabizón, A., Mayhew, E. G., Matthay, K. K., Huang, S. K., Lee, K. D., Woodle, M. C., Lasiç, D. D., & Redemann, C. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11460 · Cited by 1,621 · see citing works
Ross, A. M., Gibbons, R. J., Stone, G. W., Kloner, R. A., & Alexander, R. W. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.061 · Cited by 608 · see citing works
Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction
Mahaffey, K. W., Puma, J. A., Barbagelata, A., DiCarli, M. F., Leesar, M. A., Browne, K. F., Eisenberg, P. R., Bolli, R., Casas, A. C., Molina‐Viamonte, V., et al. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00418-0 · Cited by 551 · see citing works
Adenosine, adenosine receptors and myocardial protection An updated overview
Mubagwa, K. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00358-3 · Cited by 311 · see citing works
Doxorubicin in sterically stabilized liposomes
Lasiç, D. D. (1996) · Nature · doi:10.1038/380561a0 · Cited by 309 · see citing works
Postconditioning reduces infarct size via adenosine receptor activation by endogenous adenosine
Kin, H., Zatta, A. J., LOFYE, M., AMERSON, B., Halkos, M. E., Kerendi, F., ZHAO, Z., Guyton, R. A., Headrick, J., & Vinten‐Johansen, J. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.015 · Cited by 297 · see citing works
Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo
Bullard, A. J., Govewalla, P., & Yellon, D. M. (2005) · Basic Research in Cardiology · doi:10.1007/s00395-005-0537-4 · Cited by 170 · see citing works
Animal models for the study of adenosine receptor function
Yaar, R., Jones, M. R., Chen, J., & Ravid, K. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20138 · Cited by 152 · see citing works
Dauber, I. M., VanBenthuysen, K. M., McMurtry, I. F., Wheeler, G. S., Lesnefsky, E. J., Horwitz, L. D., & Weil, J. V. (1990) · Circulation Research · doi:10.1161/01.res.66.4.986 · Cited by 149 · see citing works
Norton, E. D., Jackson, E. K., Turner, M. B., Virmani, R., & Forman, M. B. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90643-a · Cited by 111 · see citing works
Role of Adenosine as Adjunctive Therapy in Acute Myocardial Infarction
Forman, M. B., Stone, G. W., & Jackson, E. K. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00116.x · Cited by 98 · see citing works
Preconditioning prevents chronic reperfusion-induced coronary endothelial dysfunction in rats
Kaeffer, N., Richard, V. J., François, A., Lallemand, F., Henry, J., & Thuillez, C. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.3.h842 · Cited by 89 · see citing works
Adenosine Receptor Subtypes Mediating Coronary Vasodilation in Rat Hearts
Hinschen, A. K., Rose’Meyer, R. B., & Headrick, J. P. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200301000-00010 · Cited by 78 · see citing works
Vinten‐Johansen, J. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9024-3 · Cited by 75 · see citing works
Brief ischemia-reperfusion induces stunning of endothelium in canine coronary artery.
Kim, Y., Fomsgaard, J. S., Heim, K. F., Ramwell, P. W., Thomas, G. R., Kagan, E., Moore, S., Coughlin, S. S., Kuwahara, M., & Analouei, A. R. (1992) · Circulation · doi:10.1161/01.cir.85.4.1473 · Cited by 72 · see citing works
Time course of coronary endothelial healing after injury due to ischemia and reperfusion.
Horwitz, L. D., Kaufman, D., Keller, M. W., & Kong, Y. (1994) · Circulation · doi:10.1161/01.cir.90.5.2439 · Cited by 69 · see citing works
Encapsulation of Chicken Egg Yolk Immunoglobulin G (IgY) by Liposomes
Shimizu, M., Miwa, Y., Hashimoto, K., & Goto, A. (1993) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.57.1445 · Cited by 68 · see citing works
Self-citationCanyon, S. J., & Dobson, G. P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00273.2004 · Cited by 60 · see citing works
Cardioprotection With Adenosine A2 Receptor Activation at Reperfusion
Xu, Z., Mueller, R. A., Park, S.-S., Boysen, P. G., Cohen, M. V., & Downey, J. M. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000188161.57018.29 · Cited by 36 · see citing works
Hannon, J. P., Tigani, B., Wolber, C., Williams, I., Mazzoni, L., Howes, C., & Fozard, J. R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704516 · Cited by 28 · see citing works
Kasuya, T., Jung, J., Kadoya, H., Matsuzaki, T., Tatematsu, K., Okajima, T., Miyoshi, E., Tanizawa, K., & Kuroda, S. (2008) · Human Gene Therapy · doi:10.1089/hum.2008.037 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- min Mean blood pressure (mm Hg) Lp-Ado ϩ 8SPT 120 Ϯ 6 113 Ϯ 4 112 Ϯ 6 112 Ϯ 5 107 Ϯ 6 102 Ϯ 8 109 Ϯ 7 Lp-Ado ϩ DPCPX 130 Ϯ 6 105 Ϯ 4 121 Ϯ 4 100 Ϯ 10 122 Ϯ 6 120 Ϯ 6 111 Ϯ 4 Lp-Ado ϩ SCH58261 132 Ϯ 2 9 8 Ϯ 12 99 Ϯ 8 110 Ϯ 8 118 Ϯ 10 113 Ϯ 10 109 Ϯ 6 Lp-Ado ϩ MRS1754 130 Ϯ 3 9 5 Ϯ 12 106 Ϯ 8 105 Ϯ 10 100 Ϯ 10 96 Ϯ 10 99 Ϯ 7 Lp-Ado ϩ MRS1523 130 Ϯ 2 109 Ϯ 8 104 Ϯ 8 105 Ϯ 9 100 Ϯ 9 101 Ϯ 10 104 Ϯ 6 Heart rate (beats/min) Lp-Ado ϩ 8SPT 404 Ϯ 17 385 Ϯ 10 374 Ϯ 8 396 Ϯ 8 389 Ϯ 9 383 Ϯ 8 385 Ϯ 9 Lp-Ado ϩ DPCPX 396 Ϯ 24 380 Ϯ 11 399 Ϯ 9 398 Ϯ 12 385 Ϯ 9 382 Ϯ 9 380 Ϯ 7 Lp-Ado ϩ SCH58261 393 Ϯ 14 399 Ϯ 15 381 Ϯ 9 395 Ϯ 15 376 Ϯ 9 373 Ϯ 9 385 Ϯ 7 Lp-Ado ϩ MRS1754 398 Ϯ 14 392 Ϯ 11 401 Ϯ 9 379 Ϯ 15 378 Ϯ 9 374 Ϯ 9 377 Ϯ 7 Lp-Ado ϩ MRS1523 396 Ϯ 9 390 Ϯ 11 390 Ϯ 11 392 Ϯ 10 373 Ϯ 9 391 Ϯ 7 388 Ϯ 11 Values were expressed as mean Ϯ SEM. ءp Ͻ 0.05 versus baseline. Lp-Ado ϭ PEGylated liposomal adenosine; PEG ϭ polyethylene glycol; Vehicle ϭ PEGylated liposomes. 715 JACC Vol. 53, No. 8, 2009 Takahama et al. February 24, 2009:709-17 Drug Delivery System Targeting Injured Myocardium REFERENCES
- Yaar R, Jones MR, Chen JF, Ravid K. Animal models for the study of adenosineÅreceptor function. J Cell Physiol 2005;202:9 -20.
Cited by
Sorted by citations
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease.
Minamino, T., Komuro, I., & Kitakaze, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.227819 · Cited by 469 · see citing works
Self-citationER stress in cardiovascular disease
Minamino, T., & Kitakaze, M. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.10.026 · Cited by 456 · see citing works
Self-citationPerspectives and opportunities for nanomedicine in the management of atherosclerosis
Lobatto, M. E., Fuster, V., Fayad, Z. A., & Mulder, W. J. M. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3578 · Cited by 423 · see citing works
Sanada, S., Komuro, I., & Kitakaze, M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00553.2011 · Cited by 383 · see citing works
Self-citationHe, W., Kapate, N., Shields, C. W., & Mitragotri, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.12.001 · Cited by 237 · see citing works
Nakano, Y., Matoba, T., Tokutome, M., Funamoto, D., Katsuki, S., Ikeda, G., Nagaoka, K., Ishikita, A., Nakano, K., Koga, J., et al. (2016) · Scientific Reports · doi:10.1038/srep29601 · Cited by 125 · see citing works
Nagaoka, K., Matoba, T., Mao, Y., Nakano, Y., Ikeda, G., Egusa, S., Tokutome, M., Nagahama, R., Nakano, K., Sunagawa, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132451 · Cited by 113 · see citing works
Cell‐Based Drug Delivery and Use of Nano‐and Microcarriers for Cell Functionalization
Timin, A. S., Litvak, M. M., Gorin, D. A., Atochina‐Vasserman, E. N., Atochin, D. N., & Sukhorukov, G. B. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700818 · Cited by 112 · see citing works
Cardioprotection From Ischemia/Reperfusion Injury
Minamino, T. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-0132 · Cited by 111 · see citing works
Self-citationFerreira, M. P. A., Ranjan, S. K., Kinnunen, S. M., Correia, A., Talman, V., Mäkilä, E. M., Barrios‐Lopez, B., Kemell, M., Balasubramanian, V., Salonen, J., et al. (2017) · Small · doi:10.1002/smll.201701276 · Cited by 105 · see citing works
Anti-inflammatory Nanomedicine for Cardiovascular Disease
Katsuki, S., Matoba, T., Koga, J., Nakano, K., & Egashira, K. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00087 · Cited by 96 · see citing works
Electrospun PVA Fibers for Drug Delivery: A Review
Zahra, F. T., Quick, Q., & Mu, R. R. (2023) · Polymers · doi:10.3390/polym15183837 · Cited by 95 · see citing works
Zhang, S., Wang, J., & Pan, J. (2016) · Drug Delivery · doi:10.1080/10717544.2016.1223218 · Cited by 93 · see citing works
Ferreira, M. P. A., Talman, V., Torrieri, G., Liu, D., Marques, G., Moslova, K., Liu, Z., Pinto, J. F., Hirvonen, J. J., Ruskoaho, H. J., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201705134 · Cited by 85 · see citing works
Nanoparticle-Mediated Drug Delivery System for Cardiovascular Disease
Matoba, T., & Egashira, K. (2014) · International Heart Journal · doi:10.1536/ihj.14-150 · Cited by 83 · see citing works
Paulis, L. E. M., Geelen, T., Kuhlmann, M. T., Coolen, B. F., Schäfers, M. A., Nicolay, K., & Strijkers, G. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.06.035 · Cited by 81 · see citing works
Role of Endoplasmic Reticulum Stress in Atherosclerosis and Diabetic Macrovascular Complications
Chistiakov, D. A., Sobenin, I., Orekhov, A., & Bobryshev, Y. (2014) · BioMed Research International · doi:10.1155/2014/610140 · Cited by 74 · see citing works
Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities
Hajipour, M. J., Mehrani, M., Abbasi, S. H., Amin, A., Kassaian, S. E., Garbern, J. C., Caracciolo, G., Zanganeh, S., Chitsazan, M., Aghaverdi, H., et al. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00323 · Cited by 77 · see citing works
Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles
Galagudza, M. M., Korolev, D. V., Николаевич, П. В., Naumisheva, Сергеевич, У. И., Grigorova, & Shlyakhto, E. V. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s29511 · Cited by 75 · see citing works
Nanoparticle Based Treatment for Cardiovascular Diseases
Gupta, P., Garcia, E., Sarkar, A., Kapoor, S., Rafiq, K., Chand, H. S., & Jayant, R. D. (2018) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x18666180508113253 · Cited by 62 · see citing works
Nanoplumbers: biomaterials to fight cardiovascular diseases
Dormont, F., Varna, M., & Couvreur, P. (2017) · Materials Today · doi:10.1016/j.mattod.2017.07.008 · Cited by 60 · see citing works
Galagudza, M. M. (2010) · International Journal of Nanomedicine · doi:10.2147/ijn.s8719 · Cited by 59 · see citing works
Nanomedical Theranostics in Cardiovascular Disease
Tang, J., Lobatto, M. E., Read, J. C., Mieszawska, A. J., Fayad, Z. A., & Mulder, W. J. M. (2011) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-011-9120-6 · Cited by 58 · see citing works
Micro- and Nanoparticles for Treating Cardiovascular Disease
Suarez, S. L., Almutairi, A., & Christman, K. (2015) · Biomaterials Science · doi:10.1039/c4bm00441h · Cited by 51 · see citing works
Skourtis, D., Stavroulaki, D., Athanasiou, V., Fragouli, P. G., & Iatrou, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121160 · Cited by 55 · see citing works
Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss
Hoque, J., Shih, Y.-R. V., Zeng, Y., Newman, H., Sangaj, N. S., Arjunji, N., & Varghese, S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120819 · Cited by 54 · see citing works
Adenosine-associated delivery systems
Kazemzadeh‐Narbat, M., Annabi, N., Tamayol, A., Öklü, R., Ghanem, A., & Khademhosseini, A. (2015) · Journal of drug targeting · doi:10.3109/1061186x.2015.1058803 · Cited by 53 · see citing works
Targeting fibrosis in the failing heart with nanoparticles
Passaro, F., Tocchetti, C. G., Spinetti, G., Paudice, F., Ambrosone, L., Costagliola, C., Cacciatore, F., Abete, P., & Testa, G. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.004 · Cited by 51 · see citing works
Zheng, Y., Zhang, H., Hu, Y., Bai, L., & Xue, J. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s176404 · Cited by 48 · see citing works
Takahama, H., Shigematsu, H., Asai, T., Matsuzaki, T., Sanada, S., Fu, H. Y., Okuda, K., Yamato, M., Asanuma, H., Asano, Y., et al. (2013) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-012-6437-6 · Cited by 46 · see citing works
Self-citationHeart-Targeted Nanoscale Drug Delivery Systems
Liu, M., Li, M., Wang, G., Liu, X., Liu, D., Peng, H., & Wang, Q. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.1894 · Cited by 46 · see citing works
Cheng, X., Cheng, G., Xing, X., Yin, C., Cheng, Y., Zhou, X. M., Jiang, S., Tao, F., Deng, H., & Li, Z. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.048 · Cited by 45 · see citing works
Liposome technology for cardiovascular disease treatment and diagnosis
Bowey, K., Tanguay, J., & Tabrizian, M. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.647908 · Cited by 45 · see citing works
Pharmacological modulation of mitochondrial calcium homeostasis
Arduíno, D. M., & Perocchi, F. (2018) · The Journal of Physiology · doi:10.1113/jp274959 · Cited by 44 · see citing works
Serebruany, V. L. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.09.017 · Cited by 43 · see citing works
Tran, B. H., Yu, Y., Chang, L., Tan, B., Jia, W., Xiong, Y., Dai, T., Zhong, R. M., Zhang, W., Le, V. M., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s216667 · Cited by 43 · see citing works
An antioxidant nanozyme for targeted cardiac fibrosis therapy post myocardial infarction
Gu, Z., Liu, X., Qi, Z., Zhou, F., Jiang, Y., Huang, Y.-T., Wang, Y., Wu, L., & Yang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03047-6 · Cited by 42 · see citing works
Passive targeting of lipid‐based nanoparticles to mouse cardiac ischemia–reperfusion injury
Geelen, T., Paulis, L. E. M., Coolen, B. F., Nicolay, K., & Strijkers, G. J. (2012) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.1501 · Cited by 37 · see citing works
Torrieri, G., Ferreira, M. P. A., Shahbazi, M., Talman, V., Karhu, S. T., Pohjolainen, L., Carvalho, C., Pinto, J. F., Hirvonen, J. J., Ruskoaho, H. J., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202109032 · Cited by 37 · see citing works
Internalization of paramagnetic phosphatidylserine-containing liposomes by macrophages
Geelen, T., Yeo, S. Y., Paulis, L. E. M., Starmans, L. W. E., Nicolay, K., & Strijkers, G. J. (2012) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-10-37 · Cited by 36 · see citing works
Liposomes in Diagnosis and Treatment of Cardiovascular Disorders
Levchenko, T. S., Hartner, W. C., & Torchilin, V. P. (2012) · Methodist DeBakey Cardiovascular Journal · doi:10.14797/mdcj-8-1-36 · Cited by 36 · see citing works
Recent advances in magnetoliposome for heart drug delivery
Namdari, M., Cheraghi, M., Negahdari, B., Eatemadi, A., & Daraee, H. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1299159 · Cited by 35 · see citing works
Sy, J. C., & Davis, M. E. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9210-x · Cited by 34 · see citing works
Lougiakis, N., Papapetropoulos, A., Gikas, E. E., Toumpas, S., Efentakis, P., Wedmann, R., Ζώγα, Α., Zhou, Z., Iliodromitis, E. K., Skaltsounis, A., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01223 · Cited by 34 · see citing works
Sugasini, D., & Lokesh, B. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1736-1 · Cited by 29 · see citing works
Thant, Y., Wang, Q., Wei, C., Liu, J., Zhang, K., Bao, R., Zhu, Q., Weng, W., Yu, Q., Zhu, Y., et al. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102808 · Cited by 31 · see citing works
Advance cardiac nanomedicine by targeting the pathophysiological characteristics of heart failure
Lin, C., Gao, H., & Ouyang, L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.002 · Cited by 30 · see citing works
Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
Yajima, S., Miyagawa, S., Fukushima, S., Sakai, Y., Iseoka, H., Harada, A., Isohashi, K., Horitsugi, G., Mori, Y., Shiozaki, M., et al. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.12.006 · Cited by 28 · see citing works
Lin, X., Yao, C., Shi, X., Shen, L., De-sheng, X., & Feng, Y. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s73462 · Cited by 28 · see citing works
Chen, A., Mesfin, J. M., Gianneschi, N. C., & Christman, K. L. (2023) · Advanced Materials · doi:10.1002/adma.202300603 · Cited by 26 · see citing works
Fu, H., Li, X. A., & Tan, J. (2018) · Oncology Letters · doi:10.3892/ol.2018.7922 · Cited by 26 · see citing works
The Potential for Nanotechnology to Improve Delivery of Therapy to the Acute Ischemic Heart
Evans, C. W., Iyer, K. S., & Hool, L. C. (2016) · Nanomedicine · doi:10.2217/nnm.16.7 · Cited by 23 · see citing works
Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart
Mukhamadiyarov, R. А., Сенокосова, Е. А., Сергеевич, К. С., Voevoda, D. V., Pyshnaya, I. A., Ivanov, V. V., Lewis, M., & Халиулин, И. Г. (2018) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000606 · Cited by 22 · see citing works
Chitosan nanoparticles as adenosine carriers
Kazemzadeh‐Narbat, M., Reid, M., Brooks, M. S., & Ghanem, A. (2015) · Journal of Microencapsulation · doi:10.3109/02652048.2015.1046517 · Cited by 22 · see citing works
Ichikawa, K., Asai, T., Shimizu, K., Yonezawa, S., Urakami, T., Miyauchi, H., Kawashima, H., Ishida, T., Kiwada, H., & Oku, N. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.02.002 · Cited by 22 · see citing works
Self-citationDevelopment of a novel one-step production system for injectable liposomes under GMP
Araki, R., Matsuzaki, T., Nakamura, A., Nakatani, D., Sanada, S., Fu, H. Y., Okuda, K., Yamato, M., Tsuchida, S., Sakata, Y., et al. (2017) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2017.1290106 · Cited by 20 · see citing works
Self-citationHydrogel delivery of purinergic enzymes improves cardiac ischemia/reperfusion injury
Sayegh, M. N., Cooney, K. A., Han, W. M., Cicka, M., Strobel, F. H., Wang, L., Garcı́a, A. J., & Levit, R. D. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.02.001 · Cited by 19 · see citing works
Al‐Darraji, A., Donahue, R. R., Tripathi, H., Peng, H., Levitan, B. M., Chelvarajan, L., Haydar, D., Gao, E., Henson, D. M., Gensel, J. C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73593-0 · Cited by 19 · see citing works
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats
Okuda, K., Fu, H. Y., Matsuzaki, T., Araki, R., Tsuchida, S., Veeraveedu, P. T., Fukuta, T., Asai, T., Yamato, M., Sanada, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160944 · Cited by 19 · see citing works
Self-citationMultimodality imaging demonstrates trafficking of liposomes preferentially to ischemic myocardium
Lipinski, M. J., Albelda, M. T., Frias, J. C., Anderson, S. A., Luger, D., Westman, P. C., Escarcega, R. O., Hellinga, D. G., Waksman, R., Arai, A. E., et al. (2016) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2016.01.003 · Cited by 18 · see citing works
Остроушко, А. А., Grzhegorzhevskii, K. V., Medvedeva, S. Y., Гетте, И. Ф., Тонкушина, М. О., Гагарин, И. Д., & Danilova, I. G. (2021) · Nanosystems Physics Chemistry Mathematics · doi:10.17586/2220-8054-2021-12-1-81-112 · Cited by 17 · see citing works
Kure, T., & Sakai, H. (2017) · Langmuir · doi:10.1021/acs.langmuir.6b04643 · Cited by 17 · see citing works
Drug Delivery and Nanoformulations for the Cardiovascular System.
Geldenhuys, W. J., Khayat, M. T. A., Yun, J., & Nayeem, M. A. (2017) · PubMed · Cited by 16 · see citing works
Lin, X., Yao, C., Wu, F., Shen, L., Feng, Y., & Wang, L. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s89445 · Cited by 15 · see citing works
Naoghare, P. K., Kwon, H. T., & Song, J. M. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.07.020 · Cited by 15 · see citing works
Han, D., Wang, F., & Shen, D. (2024) · Theranostics · doi:10.7150/thno.99961 · Cited by 14 · see citing works
Adjuvant Cardioprotection in Cardiac Surgery: Update
Wagner, R., Piler, P., Ахнафович, Г. З., Maruyama, J., Maruyama, K., Nicovsky, J., & Kružliak, P. (2014) · BioMed Research International · doi:10.1155/2014/808096 · Cited by 14 · see citing works
Sonin, D. L., Korolev, D. V., Николаевич, П. В., Борисовна, Н. Е., Pochkaeva, E. I., Vasyutina, M. L., & Galagudza, M. M. (2015) · Drug Delivery · doi:10.3109/10717544.2015.1069421 · Cited by 14 · see citing works
St. Petersburg, Russian Federation
Trumbull, N. (2011) · Cities · doi:10.1016/j.cities.2011.05.003 · Cited by 14 · see citing works
Bejarano, J., Rojas, A., Ramírez‐Sagredo, A., Riveros, A. L., Morales-Zavala, F., Flores, Y., Riquelme, J. A., Guzmán, F., Araya, E., Chiong, M., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.002 · Cited by 14 · see citing works
Scalone, G., Coviello, I., Barone, L., Pisanello, C., Sestito, A., Lanza, G. A., & Crea, F. (2009) · Heart · doi:10.1136/hrt.2009.178178 · Cited by 14 · see citing works
Adenosine and lipids: A forced marriage or a love match?
Rouquette, M., Lepêtre‐Mouelhi, S., & Couvreur, P. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.005 · Cited by 13 · see citing works
Combined ROS Sensitive PEG-PPS-PEG with Peptide Agonist for Effective Target Therapy in Mouse Model
Xiang, P., Liu, Q., Jing, W., Wang, Y., & Yu, H. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s471036 · Cited by 11 · see citing works
Cohen, M. V., & Downey, J. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.016 · Cited by 11 · see citing works
Zhou, H., Zhang, J., Jin, Q., Liu, G., Long, Y., Duan, M., & Xia, Q. (2013) · Materials Letters · doi:10.1016/j.matlet.2013.07.057 · Cited by 10 · see citing works
Prolonged cardioprotective effect of pyridostigmine encapsulated in liposomes
Vidal, A. T., Guimarães, H. N., de Paula, D. C. C., Frézard, F., Silva-Barcellos, N. M., & Grabe‐Guimarães, A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.011 · Cited by 10 · see citing works
Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease
Pylypenko, D., Горбач, Т. В., & Krasnopolsky, Y. М. (2021) · Biotechnologia · doi:10.5114/bta.2020.100420 · Cited by 10 · see citing works
Wang, J., Yu, L., Zhou, A., Liu, J., Wang, K., Luo, Y., & Wang, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091520 · Cited by 11 · see citing works
Xing, F., Han, H., He, Y., Zhang, Y., Jing, L., Xu, Z., & Xi, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2490501 · Cited by 10 · see citing works
Passive and Active Target Delivery of Drugs to Ischemic Myocardium
Galagudza, M. M., Korolev, D. V., Sonin, D. L., Alexandrov, I. V., Минасян, С. М., Николаевич, П. В., Kirpicheva, E. B., Papayan, G. V., & Сергеевич, У. И. (2011) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-011-1466-x · Cited by 9 · see citing works
Li, D., & Zhang, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126153 · Cited by 8 · see citing works
MicroRNA delivery based on nanoparticles of cardiovascular diseases
Wang, N., Chen, C., Ren, J., & Dai, D. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04821-0 · Cited by 8 · see citing works
Yue, T., Xiong, S., Zheng, D., Wang, Y., Long, P., Yang, J., Danzeng, D., Gao, H. J., Wen, X., Li, X., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.988683 · Cited by 8 · see citing works
Assessment of Squalene-Adenosine Nanoparticles in Two Rodent Models of Cardiac Ischemia-Reperfusion
Brusini, R., Tran, N. L. L., Cailleau, C., Domergue, V., Nicolas, V., Dormont, F., Calet, S., Cajot, C., Jouran, A., Lepêtre‐Mouelhi, S., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071790 · Cited by 8 · see citing works
Passive targeting of ischemic myocardium with the use of silica nanoparticles
Galagudza, M. M., Korolev, D. V., Sonin, D. L., Александров, И. В., Николаевич, П. В., Papayan, G. V., & Shlyakhto, E. V. (2010) · Nanotechnologies in Russia · doi:10.1134/s1995078010110145 · Cited by 7 · see citing works
Messerschmidt, V. L., Chintapula, U. K., Kuriakose, A. E., Laboy-Segarra, S. L., Truong, T. T. D., Kydd, L. A., Jaworski, J. W., Pan, Z., Sadek, H. A., Nguyen, K. T., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.707897 · Cited by 7 · see citing works
Tu, S., Shen, C., Bai, X., Zhang, H., Amraii, S. A., & Dai, D. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.111104 · Cited by 6 · see citing works
Mahmoud, D. M., El‐Ela, F. I. A., Fouad, A. G., Belal, A., Ali, M. A. M., Ghoneim, M. M., Almeheyawi, R. N., Attia, M. E., & Mahmoud, T. M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124395 · Cited by 6 · see citing works
Therapy Against Ischemic Injury
Guarini, G., Huqi, A., Capozza, P., Morrone, D., Donati, F., & Marzilli, M. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319250008 · Cited by 6 · see citing works
Nanoparticle delivery of cardioprotective therapies.
Méndez‐Fernández, A., Cabrera-Fuentes, H. A., Velmurugan, B., Irei, J. S., Boisvert, W. A., Lu, S., & Hausenloy, D. J. (2020) · PubMed · Cited by 6 · see citing works
Innovative Lipid-Based Nanobiotechnology: Diagnostics and Medicine
Seo, S. E., Kim, K. H., Singh, S., Chen, J.-S., Iijima, S., Cheng, C., Ryu, Y., Song, H. S., Li, W., & Kwon, O. S. (2026) · ACS Nano · doi:10.1021/acsnano.5c16718 · Cited by 5 · see citing works
Applications of nanoparticles in cardiovascular imaging and therapeutics
Oey, O., & Sunjaya, A. P. (2022) · Asian Cardiovascular and Thoracic Annals · doi:10.1177/02184923221087003 · Cited by 5 · see citing works
The Emergence of Nanotechnology in the Prognosis and Treatment of Myocardial Infarctions
Sharma, I., Bhardwaj, S., Karwasra, R., Kaushik, D., & Sharma, S. (2023) · Recent Patents on Nanotechnology · doi:10.2174/1872210517666230721123453 · Cited by 7 · see citing works
Lipids and Liposomes in the Enhancement of Health and Treatment of Disease
Young, S. A., & Smith, T. (2015) · InTech eBooks · doi:10.5772/59665 · Cited by 3 · see citing works
Nanomedicine in Cardiovascular Diseases: Emerging Diagnostic and Therapeutic Potential
Sureddi, R. K., & Mehta, J. L. (2011) · Journal of Nanotechnology in Engineering and Medicine · doi:10.1115/1.4005490 · Cited by 3 · see citing works
Development of a liposomal drug delivery system for the treatment of ischemic stroke
Fukuta, T., Asai, T., & Oku, N. (2015) · Drug Delivery System · doi:10.2745/dds.30.309 · Cited by 3 · see citing works
Self-citationManagement by Objectives: A Consultant's Viewpoint.
Mahler, W. R. (1972) · Training and development journal · Cited by 3 · see citing works
Drug Delivery Systems and Cardiovascular Disease
Wang, X., Liang, X., Duan, J., Chen, Y., Li, H., Liu, K., & Yang, J. (2024) · Springer eBooks · doi:10.1007/978-981-19-7712-1_4 · Cited by 2 · see citing works
Eeda, V., Hedrick, A. F., Pranay, A., Humphries, K. M., Heidenreich, E., & Awasthi, V. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125841 · Cited by 2 · see citing works
- Authors
- Takahama, H., Minamino, T., Asanuma, H., Fujita, M., Asai, T., Wakeno, M., Sasaki, H., Kikuchi, H., Hashimoto, K., Oku, N., Asakura, M., Kim, J., Takashima, S., Komamura, K., Sugimachi, M., Mochizuki, N., & Kitakaze, M.
- Affiliations
- National Cerebral and Cardiovascular Center (JP)
- The University of Osaka (JP)
- Shizuoka University (JP)
- Daiichi-Sankyo (Japan) (JP)
- Corresponding author
- Minamino, Tetsuo
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 53
- Issue
- 8
- Pages
- 709-717
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2048350889
- Cited by
- 129
- References
- 21
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 3 · 2021: 11 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 11 · 2016: 6 · 2015: 11 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Cardiovascular Research Foundation
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- PEGylated liposomes, myocardial ischemia-reperfusion injury, cardioprotection, myocardial infarct size, adenosine receptor antagonists, drug delivery, blood residence time, acute myocardial infarction
- MeSH terms
- Adenosine, Animals, Blood Pressure, Cardiotonic Agents, Dose-Response Relationship, Drug, Drug Carriers, Fluorescence, Infusions, Intravenous, Liposomes, Male, Myocardial Infarction, Myocardium, Polyethylene Glycols, Vasodilator Agents, Myocardial Reperfusion Injury, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
