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The Sympathetic Nervous System in Heart Failure
Open accessAbstract
Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers countermeasures aimed to restore cardiac output. These responses are compensatory at first but eventually become part of the disease process itself leading to further worsening cardiac function. Among these responses is the activation of the sympathetic nervous system (SNS) that provides inotropic support to the failing heart increasing stroke volume, and peripheral vasoconstriction to maintain mean arterial perfusion pressure, but eventually accelerates disease progression affecting survival. Activation of SNS has been attributed to withdrawal of normal restraining influences and enhancement of excitatory inputs including changes in: 1) peripheral baroreceptor and chemoreceptor reflexes; 2) chemical mediators that control sympathetic outflow; and 3) central integratory sites. The interface between the sympathetic fibers and the cardiovascular system is formed by the adrenergic receptors (ARs). Dysregulation of cardiac beta(1)-AR signaling and transduction are key features of heart failure progression. In contrast, cardiac beta(2)-ARs and alpha(1)-ARs may function in a compensatory fashion to maintain cardiac inotropy. Adrenergic receptor polymorphisms may have an impact on the adaptive mechanisms, susceptibilities, and pharmacological responses of SNS. The beta-AR blockers and the inhibitors of the renin-angiotensin-aldosterone axis form the mainstay of current medical management of chronic heart failure. Conversely, central sympatholytics have proved harmful, whereas sympathomimetic inotropes are still used in selected patients with hemodynamic instability. This review summarizes the changes in SNS in heart failure and examines how modulation of SNS activity may affect morbidity and mortality from this syndrome.
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“Decreased cardiac output and the resulting sympathetic vasoconstriction in heart failure stimulates adaptive re-distribution of the systemic circulation, leading to congestion in multiple end organs, including the bowel wall31.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [31]
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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214
Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Bittman, R., Hurley, S., Kleiman, J., & Gatlin, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030207 · Cited by 4,941
The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial
Lechat, P. P., Brunhuber, K., Hofmann, R., Kuhn, P., Nesser, H., Slany, J., Weihs, W., Wiedermann, C. J., Wimmer, H., van Mieghem, W., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11181-9 · Cited by 4,922
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
Packer, M., Bristow, M. R., Cohn, J. N., Colucci, W. S., Fowler, M. B., Gilbert, E. M., & Shusterman, N. H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605233342101 · Cited by 4,649
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,108
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
Cohn, J. N., Archibald, D. G., Ziesche, S., Franciosa, J. A., Harston, W. E., Tristani, F. E., Dunkman, W. B., Jacobs, W., Francis, G. S., Flohr, K. H., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606123142404 · Cited by 2,400
Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
Bristow, M. R., Ginsburg, R., Minobe, W. A., Cubicciotti, R. S., Sageman, W. S., Lurie, K. G., Billingham, M. E., Harrison, D. C., & Stinson, E. B. (1982) · New England Journal of Medicine · doi:10.1056/nejm198207223070401 · Cited by 2,270
Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure
Packer, M., Carver, J. R., Rodeheffer, R. J., Ivanhoe, R. J., DiBianco, R., Zeldis, S. M., Hendrix, G., Bommer, W. J., Elkayam, U., Kukin, M. L., et al. (1991) · New England Journal of Medicine · doi:10.1056/nejm199111213252103 · Cited by 2,218
O'Connor (2009) · doi:10.1001/jama.2009.454 · Cited by 2,173
Poole-Wilson, P. A., Swedberg, K., Cleland, J. G., Di Lenarda, A., Hanrath, P., Komajda, M., Lubsen, J., Lutiger, B., Metra, M., Remme, W. J., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13800-7 · Cited by 1,872
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Flather, M. D., Shibata, M. C., Coats, A. J. S., van Veldhuisen, D. J., Parkhomenko, A. N., Borbola, J., Solal, A. C., Dumitrascu, D. L., Ferrari, R., Lechat, P. P., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi115 · Cited by 1,649
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2000) · JAMA · doi:10.1001/jama.283.15.1967 · Cited by 1,553
Packer, M., Fowler, M. B., Roecker, E. B., Coats, A. J. S., Katus, H. A., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Staiger, C., et al. (2002) · Circulation · doi:10.1161/01.cir.0000035653.72855.bf · Cited by 1,364
Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy
Waagstein, F., Hjalmarson, Å. C., Swedberg, K. B., Bristow, M. R., Gilbert, E. M., Camerini, F., Fowler, M. B., Silver, M. A., Johnson, M. R., & Goss, F. (1993) · The Lancet · doi:10.1016/0140-6736(93)92930-r · Cited by 1,223
International Union of Pharmacology nomenclature of adrenoceptors.
Bylund, D., Eikenberg, D. C., Hieble, J. P., Langer, S. Z., Lefkowitz, R. J., Minneman, K. P., Molinoff, P. B., Ruffolo, R. R., & TRENDELENBURG, U. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06780-8 · Cited by 1,204
Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure
Bradley, T. D., Logan, A. G., Kimoff, R. J., Sériès, F., Morrison, D., Ferguson, K., Belenkie, I., Pfeifer, M., Fleetham, J., Hanly, P., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051001 · Cited by 1,189
Ingelman‐Sundberg, M., Sim, S. C., Gomez, A. V., & Rodríguez‐Antona, C. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.004 · Cited by 1,180
Cuffe, M. S. (2002) · JAMA · doi:10.1001/jama.287.12.1541 · Cited by 1,179
A Trial of the Beta-Blocker Bucindolol in Patients with Advanced Chronic Heart Failure
The Beta-Blocker Evaluation of Survival Trial Investigators (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442202 · Cited by 1,005
A family of hyperpolarization-activated mammalian cation channels
Ludwig, A., Zong, X., Jeglitsch, M., Hofmann, F. B., & Biel, M. (1998) · Nature · doi:10.1038/31255 · Cited by 944
Modulation of neurotransmitter release by presynaptic autoreceptors
Starke, K., Göthert, M., & Kilbinger, H. J. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.3.864 · Cited by 927
Mechanisms and Models in Heart Failure
Mann, D. L., & Bristow, M. R. (2005) · Circulation · doi:10.1161/circulationaha.104.500546 · Cited by 885
Left Ventricular Assist Device and Drug Therapy for the Reversal of Heart Failure
Birks, E. J., Tansley, P., Hardy, J. P., George, R. S., Bowles, C. T., Burke, M. M., Banner, N. R., Khaghani, A., & Yacoub, M. H. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa053063 · Cited by 882
Lyon, A. R., Rees, P. S. C., Prasad, S. K., Poole-Wilson, P. A., & Harding, S. E. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1066 · Cited by 873
Adrenergic effects on the biology of the adult mammalian cardiocyte.
Mann, D. L., Kent, R. L., Parsons, B., & Cooper, G. (1992) · Circulation · doi:10.1161/01.cir.85.2.790 · Cited by 865
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794
What Is the Role of β-Adrenergic Signaling in Heart Failure?
Lohse, M. J., Engelhardt, S. H., & Eschenhagen, T. (2003) · Circulation Research · doi:10.1161/01.res.0000102042.83024.ca · Cited by 789
Abraham, W. T., Adams, K. F., Fonarow, G. C., Costanzo, M. R., Berkowitz, R. L., LeJemtel, T. H., Cheng, M. L., & Wynne, J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.051 · Cited by 737
MANCINI, D. M., Walter, G., Reichek, N., Lenkinski, R. E., McCully, K. K., Mullen, J. L., & Wilson, J. R. (1992) · Circulation · doi:10.1161/01.cir.85.4.1364 · Cited by 736
Communal, C., Singh, K., Pimentel, D. R., & Colucci, W. S. (1998) · Circulation · doi:10.1161/01.cir.98.13.1329 · Cited by 690
Angelini, P. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1235 · Cited by 686
Arzt, M. E., Floras, J. S., Logan, A. G., Kimoff, R. J., Sériès, F., Morrison, D., Ferguson, K. A., Belenkie, I., Pfeifer, M., Fleetham, J. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.683482 · Cited by 674
- Australia/New Zealand Heart Failure Research Collaborative Group (20190096) (1997) · The Lancet · doi:10.1016/s0140-6736(97)80008-6 · Cited by 610
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Dodge‐Kafka, K. L., Soughayer, J. S., Paré, G. C., Michel, J. J. C., Langeberg, L. K., Kapiloff, M. S., & Scott, J. D. (2005) · Nature · doi:10.1038/nature03966 · Cited by 577
Assessment of Autonomic Function in Cardiovascular Disease
Lahiri, M. K., Kannankeril, P. J., & Goldberger, J. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.038 · Cited by 571
Bradley, T. D., & Floras, J. S. (2003) · Circulation · doi:10.1161/01.cir.0000061757.12581.15 · Cited by 566
(2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.002 · Cited by 557
Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure.
Dzau, V. J., Colucci, W. S., Hollenberg, N. K., & Williams, G. H. (1981) · Circulation · doi:10.1161/01.cir.63.3.645 · Cited by 532
Small, K. M., Wagoner, L. E., Levin, A. M., Kardia, S. L. R., & Liggett, S. B. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020803 · Cited by 524
Bradley, T. D., & Floras, J. S. (2003) · Circulation · doi:10.1161/01.cir.0000061758.05044.64 · Cited by 522
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
Hein, L., Altman, J. D., & Kobilka, B. K. (1999) · Nature · doi:10.1038/46040 · Cited by 518
Cellular basis of abnormal calcium transients of failing human ventricular myocytes
Piacentino, V., Weber, C. R., Chen, X., Weisser-Thomas, J., Margulies, K. B., Bers, D. M., & Houser, S. R. (2003) · Circulation Research · doi:10.1161/01.res.0000062469.83985.9b · Cited by 477
Parasympathetic Nervous System and Heart Failure
Olshansky, B., Sabbah, H. N., Hauptman, P. J., & Colucci, W. S. (2008) · Circulation · doi:10.1161/circulationaha.107.760405 · Cited by 460
Green, S. A., Cole, G., Jacinto, M. T., Innis, M. A., & Liggett, S. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49434-9 · Cited by 457
Liggett, S. B., Mialet‐Perez, J., Thaneemit-Chen, S., Weber, S. A., Greene, S. M., Hodne, D., Nelson, B., Morrison, J., DOMANSKI, M. J., Wagoner, L. E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509937103 · Cited by 452
β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
Noma, T., Lemaire, A., Prasad, S. V. N., Barki‐Harrington, L., Tilley, D. G., Chen, J., Corvoisier, P. L., Violin, J. D., Wei, H., Lefkowitz, R. J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31901 · Cited by 450
Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla
Ernsberger, P. R., Meeley, M. P., Mann, J. J., & Reis, D. J. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90125-7 · Cited by 445
Kingwell, B. A., Thompson, J. M., Kaye, D. M., McPherson, G. A., Jennings, G., & Esler, M. (1994) · Circulation · doi:10.1161/01.cir.90.1.234 · Cited by 401
Gauthier, C., Leblais, V., Kobzik, L., Trochu, J., Khandoudi, N., Bril, A., Balligand, J., & Marec, H. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2191 · Cited by 396
Early and Delayed Consequences of β 2 -Adrenergic Receptor Overexpression in Mouse Hearts
Liggett, S. B., Tepe, N. M., Lorenz, J. N., Canning, A. M., Jantz, T. D., Mitarai, S., Yatani, A., & Dorn, G. W. (2000) · Circulation · doi:10.1161/01.cir.101.14.1707 · Cited by 395
Sistonen, J., Sajantila, A., Lao, Ó., Corander, J., Barbujani, G., & Fuselli, S. (2007) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000239974.69464.f2 · Cited by 394
NADPH oxidases and angiotensin II receptor signaling
Garrido, A. M., & Griendling, K. K. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.003 · Cited by 391
Myocardial imaging with a radioiodinated norepinephrine storage analog.
Wieland, D. M., Brown, L. E., Rogers, W. L., Worthington, K. C., Wu, J. L., Clinthorne, N. H., Otto, C. A., Swanson, D. P., & Beierwaltes, W. H. (1981) · PubMed · Cited by 387
Cohn, J. N., Pfeffer, M. A., Rouleau, J. L., Sharpe, N., Swedberg, K. B., Straub, M., Wiltse, C. G., Wright, T. J., & for the MOXCON Investigators (2003) · European Journal of Heart Failure · doi:10.1016/s1388-9842(03)00163-6 · Cited by 382
Ferguson, D. W., Berg, W. J., Sanders, J. S., ROACH, P. J., Kempf, J. S., & Kienzle, M. G. (1989) · Circulation · doi:10.1161/01.cir.80.1.65 · Cited by 380
Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli
Mori, H., Ishikawa, S., Kojima, S., Hayashi, J., Watanabe, Y., Hoffman, J. I. E., & Okino, H. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.2.192 · Cited by 377
Moniotte, S., Kobzik, L., Féron, O., Trochu, J., Gauthier, C., & Balligand, J. (2001) · Circulation · doi:10.1161/01.cir.103.12.1649 · Cited by 341
Willenheimer, R. B., van Veldhuisen, D. J., Silke, B., Erdmann, E., Folláth, F., Krum, H., Ponikowski, P. P., Skene, A. M., van de Ven, L., Verkenne, P., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.582320 · Cited by 341
Mialet‐Perez, J., Rathz, D. A., Petrashevskaya, N. N., Hahn, H. S., Wagoner, L. E., Schwartz, A., Dorn, G. W., & Liggett, S. B. (2003) · Nature Medicine · doi:10.1038/nm930 · Cited by 333
A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure
Liggett, S. B., Cresci, S., Kelly, R. J., Syed, F. M., Matkovich, S. J., Hahn, H. S., Diwan, A., Martini, J. S., Sparks, L., Parekh, R. R., et al. (2008) · Nature Medicine · doi:10.1038/nm1750 · Cited by 322
Knowlton, K. U., Michel, M. C., Itani, M., Shubeita, H. E., Ishihara, K., Brown, J. H., & Chien, K. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82267-0 · Cited by 301
Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man.
Sisson, J. C., Shapiro, B., MEYERS, L., Mallette, S., Mangner, T. J., Wieland, D. M., Glowniak, J. V., Sherman, P., & Beierwaltes, W. H. (1987) · PubMed · Cited by 286
Verberne, H. J., Brewster, L. M., Somsen, G. A., & van Eck‐Smit, B. L. F. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn113 · Cited by 274
Vallbo, Å. B., Hagbarth, K. E., & Wallin, B. G. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00470.2003 · Cited by 273
Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography.
Schwaiger, M., Kalff, V., Rosenspire, K. C., Haka, M. S., Molina, E., Hutchins, G. D., Deeb, M., Wolfe, E., & Wieland, D. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.457 · Cited by 240
Packer, M., Medina, N., & Yushak, M. (1984) · Circulation · doi:10.1161/01.cir.70.6.1038 · Cited by 233
Tamaki, S., Yamada, T., Okuyama, Y., Morita, T., Sanada, S., Tsukamoto, Y., Masuda, M., Okuda, K., Iwasaki, Y., Yasui, T., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.10.025 · Cited by 232
Levin, M. C., Marullo, S., Muntaner, O., Andersson, B., & Magnusson, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200681200 · Cited by 231
Cardiac neuronal hierarchy in health and disease
Armour, J. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2004 · Cited by 229
Börjesson, M. (2000) · European Heart Journal · doi:10.1053/euhj.1999.1994 · Cited by 209
The MERIT-HF Study Group, White, H. L., de Boer, R. A., Maqbool, A., Greenwood, D. C., van Veldhuisen, D. J., Cuthbert, R., Ball, S. G., Hall, A. S., & Balmforth, A. J. (2003) · European Journal of Heart Failure · doi:10.1016/s1388-9842(03)00044-8 · Cited by 199
Contemporary Use of Digoxin in the Management of Cardiovascular Disorders
Gheorghiade, M., van Veldhuisen, D. J., & Colucci, W. S. (2006) · Circulation · doi:10.1161/circulationaha.105.560110 · Cited by 194
Grassi, G., Seravalle, G., Quarti-Trevano, F., Dell'Oro, R., Arenare, F., Spaziani, D., & Mancia, G. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.121467 · Cited by 194
Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure
Krum, H., Bigger, T., Goldsmith, R. L., & Packer, M. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)00417-o · Cited by 185
Li, Y.-F., Wang, W., Mayhan, W. G., & Patel, K. P. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00338.2004 · Cited by 182
Despa, S. I., Bossuyt, J., Han, F., Ginsburg, K. S., Jia, L.-G., Kutchai, H. C., Tucker, A. L., & Bers, D. M. (2005) · Circulation Research · doi:10.1161/01.res.0000176532.97731.e5 · Cited by 180
Wuttke, H., Rau, T., Heide, R., Bergmann, K., Böhm, M., Weil, J., Werner, D., & Thomas Eschenhagen, A. (2002) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2002.127111 · Cited by 175
Terra, S. G., Hamilton, K. K., Pauly, D. F., Lee, C. R., Patterson, J. H., Adams, K. F., Schofield, R. S., Belgado, B. S., Hill, J. A., Aranda, J. M., et al. (2005) · Pharmacogenetics and Genomics · doi:10.1097/01213011-200504000-00006 · Cited by 173
Systemic and coronary effects of intravenous milrinone and dobutamine in congestive heart failure
Grose, R., Strain, J. E., Greenberg, M. A., & LeJemtel, T. H. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80231-5 · Cited by 160
Gao, L., Wang, W., Liu, D., & Zucker, I. H. (2007) · Circulation · doi:10.1161/circulationaha.106.677989 · Cited by 150
Nerve Growth Factor Modulates Synaptic Transmission between Sympathetic Neurons and Cardiac Myocytes
Lockhart, S. T., Turrigiano, G. G., & Birren, S. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09573.1997 · Cited by 145
Neri, M., Cerretani, D., Fiaschi, A. I., Pasini, L. F., Lazzerini, P. E., Maffione, A. B., Micheli, L., Bruni, G., Nencini, C., Giorgi, G., et al. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00009.x · Cited by 141
Engelhardt, S. H., Böhm, M., Erdmann, E., & Lohse, M. J. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00425-4 · Cited by 138
Huang, Y., Wright, C. D., Merkwan, C. L., Baye, N. L., Liang, Q., Simpson, P. C., & O’Connell, T. D. (2007) · Circulation · doi:10.1161/circulationaha.106.664862 · Cited by 138
Heart-brain interactions in cardiac arrhythmias: role of the autonomic nervous system.
Zipes, D. P. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.suppl_2.s94 · Cited by 137
Fraga, R. F., Franco, F. G. M., Roveda, F., de Matos, L. D. N. J., Braga, A., Rondon, M. U. P. B., Rotta, D. R., Brum, P. C., Barretto, A. C. P., Middlekauff, H. R., et al. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.03.003 · Cited by 136
Inotropes in the management of acute heart failure
Petersen, J. W., & Felker, G. M. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0000296273.72952.39 · Cited by 133
MECHANISMS OF SYMPATHETIC ACTIVATION IN HEART FAILURE
Watson, A., Hood, S., & May, C. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04523.x · Cited by 131
Sehnert, A. J., Daniels, S. E., Elashoff, M. R., Wingrove, J. A., Burrow, C. R., Horne, B. D., Muhlestein, J. B., Donahue, M., Liggett, S. B., Anderson, J. L., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.022 · Cited by 127
de Groote, P., Helbecque, N., Lamblin, N., Hermant, X., Fadden, E. P. M., Hossein-Foucher, C., Amouyel, P., Dallongeville, J., & Bauters, C. (2005) · Pharmacogenetics and Genomics · doi:10.1097/01213011-200503000-00001 · Cited by 124
Fu, Y. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.039 · Cited by 121
Adaptations in autonomic function during exercise training in heart failure
Negrão, C. E., & Middlekauff, H. R. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9057-7 · Cited by 121
Feldman, D. S., Carnes, C. A., Abraham, W. T., & Bristow, M. R. (2005) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0309 · Cited by 120
Quigg, R. J., Rocco, M. B., Gauthier, D. F., Creager, M. A., Hartley, L. H., & Colucci, W. S. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90183-6 · Cited by 120
Backs, J., Haunstetter, A., Gerber, S. H., Metz, J., Borst, M. M., Strasser, R. H., Kübler, W., & Haass, M. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1319 · Cited by 113
Jacobson, A. F., Lombard, J., Banerjee, G., & Camici, P. G. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-008-9008-2 · Cited by 112
Ernsberger, P. R., Meeley, M. P., & Reis, D. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91409-6 · Cited by 112
Magnusson, Y., Levin, M. C., Eggertsen, R., Nyström, E., Mobini, R., Schaufelberger, M., & ANDERSSON, B. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.06.004 · Cited by 111
Effect of long-term enalapril therapy on neurohormones in patients with left ventricular dysfunction
Benedict, C. R., Francis, G. S., Shelton, B. J., Johnstone, D. E., Kubo, S. H., Kirlin, P. C., Nicklas, J. M., Liang, C., Konstam, M. A., Greenberg, B., et al. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80748-6 · Cited by 110
Skeberdis, V. A., Gendvilienė, V., Zablockaitė, D., Treinys, R., Mačianskienė, R., Bogdelis, A., Jurevičius, J., & Fischmeister, R. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32519 · Cited by 109
Region-Specific Neuropeptide Y Overflows at Rest and During Sympathetic Activation in Humans
Morris, M. J., Cox, H. S., Lambert, G. W., Kaye, D. M., Jennings, G., Meredith, I. T., & Esler, M. (1997) · Hypertension · doi:10.1161/01.hyp.29.1.137 · Cited by 107
Sympathetic Activation in Heart Failure and Its Treatment With β-Blockade
Pepper, G. S., & Lee, R. W. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.3.225 · Cited by 104
Massie, B. M., Berk, M. R., Brozena, S. C., Elkayam, U., Plehn, J. F., Kukin, M. L., Packer, M., Murphy, B. E., Neuberg, G. W., & Steingart, R. M. (1993) · Circulation · doi:10.1161/01.cir.88.2.492 · Cited by 101
Wang, H., Huang, B. S., Ganten, D., & Leenen, F. H. H. (2004) · Circulation Research · doi:10.1161/01.res.0000120864.21172.5a · Cited by 99
Sulakhe, P. V., & Vo, X. T. (1995) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076569 · Cited by 96
Angiotensin II stimulates norepinephrine uptake in hypothalamus-brain stem neuronal cultures
Sumners, C., & Raizada, M. K. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.2.c236 · Cited by 95
DeGeorge, B. R., Gao, E., Boucher, M., Vinge, L. E., Martini, J. S., Raake, P. W. J., Chuprun, J. K., Harris, D. M., Kim, G. W., Soltys, S., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.752618 · Cited by 90
Todd, G. L., Baroldi, G., Pieper, G. M., Clayton, F. C., & Eliot, R. S. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80064-x · Cited by 89
Chen, L., Meyers, D. E., Javorsky, G., Burstow, D. J., Lolekha, P., Lucas, M., Semmler, A., Francis, S. M. S., Fong, K. M., Yang, I. A., et al. (2007) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282ef7354 · Cited by 89
Antiadrenergic Therapy of Chronic Heart Failure
Bristow, M. R. (2003) · Circulation · doi:10.1161/01.cir.0000054530.87613.36 · Cited by 89
Morimoto, A., Hasegawa, H., Cheng, H.-J., Little, W. C., & Cheng, C. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01045.2003 · Cited by 88
Parasympathetic Control of Cardiac Sympathetic Activity
Azevedo, E. R., & Parker, J. D. (1999) · Circulation · doi:10.1161/01.cir.100.3.274 · Cited by 86
Brain Mechanisms Contributing to Sympathetic Hyperactivity and Heart Failure
Leenen, F. H. H. (2007) · Circulation Research · doi:10.1161/circresaha.107.158261 · Cited by 85
Sandilands, A., O’Shaughnessy, K. M., & Brown, M. J. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705030 · Cited by 82
Cardiac 1-adrenergic drive in pathological remodelling
Woodcock, E. A., Du, X.-J., Reichelt, M. E., & Graham, R. M. (2007) · Cardiovascular Research · doi:10.1093/cvr/cvm078 · Cited by 82
Rozec, B. R., Erfanian, M., Laurent, K., Trochu, J., & Gauthier, C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.057 · Cited by 80
Goldsmith, R. L., Bigger, J. T., Bloomfield, D. M., Krum, H., Steinman, R. C., Sackner‐Bernstein, J., & Packer, M. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00616-4 · Cited by 80
Neurohumoral Pathways in Heart Failure With Preserved Systolic Function
Hogg, K. J., & McMurray, J. J. V. (2005) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2005.02.001 · Cited by 76
Effect of α1-adrenergic receptors in cardiac pathophysiology
Shannon, R. P., & Chaudhry, M. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.05.017 · Cited by 74
Effect of Sympathoinhibition on Exercise Performance in Patients With Heart Failure
Lang, C. C., Rayos, G. H., Chomsky, D. B., Wood, A. J. J., & Wilson, J. R. (1997) · Circulation · doi:10.1161/01.cir.96.1.238 · Cited by 73
Pharmacokinetics and Metabolism of Bisoprolol Enantiomers in Humans
Horikiri, Y., Suzuki, T., & Mizobe, M. (1998) · Journal of Pharmaceutical Sciences · doi:10.1021/js970316d · Cited by 71
Osadchii, O. E., Norton, G. R., McKECHNIE, R. E., Deftereos, D., & Woodiwiss, A. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00740.2006 · Cited by 71
Soppa, G. K. R., Lee, J., Stagg, M. A., Felkin, L. E., Barton, P. J. R., Siedlecka, U., Youssef, S., Yacoub, M. H., & Terracciano, C. M. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvm106 · Cited by 70
Biolo, A., Clausell, N., dos Santos, K. G., Salvaro, R. G., Ashton‐Prolla, P., Borges, A. P., & Rohde, L. E. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.04.070 · Cited by 67
Du, X., Gao, X. J., Kiriazis, H., MOORE, X., MING, Z., Su, Y. R., Finch, A. M., Hannan, R. D., Dart, A. M., & GRAHAM, R. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.015 · Cited by 66
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology
Kaumann, A. J., & Molenaar, P. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.03.009 · Cited by 65
Clenbuterol Increases Lean Muscle Mass but Not Endurance in Patients With Chronic Heart Failure
Kamalakkannan, G., Petrilli, C. M., George, I., LaManca, J. J., McLaughlin, B. T., Shane, E. J., MANCINI, D. M., & Maybaum, S. W. (2008) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2008.01.013 · Cited by 64
Catecholamine-mediated constrictor effects of aldosterone on vascular smooth muscle
Weber, M. A., & Purdy, R. E. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90441-6 · Cited by 63
Increased Plasma Norepinephrine Levels During Prazosin Therapy for Severe Congestive Heart Failure
Colucci, W. S., Williams, G. H., & D, E. B. M. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-3-452 · Cited by 59
β-adrenergic signaling in heart failure—adapt or die
Thomas Eschenhagen, A. (2008) · Nature Medicine · doi:10.1038/nm0508-485 · Cited by 59
Khayat, R., Abraham, W. T., Patt, B. T., Roy, M., Hua, K., & Jarjoura, D. G. (2008) · CHEST Journal · doi:10.1378/chest.08-0346 · Cited by 57
Ruttanaumpawan, P., Gilman, M., Usui, K., Floras, J. S., & Bradley, T. D. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282fb81ed · Cited by 56
Blockade of β1- and desensitization of β2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis
Brouri, F., Hanoun, N., Médiani, O., Saurini, F., Hamon, M., Vanhoutte, P. M., & Lechat, P. P. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.063 · Cited by 54
Cardiovascular reflexes mediated by sympathetic afferent fibers
Malliani, A., Pagani, M., Pizzinelli, P., Furlan, R., & Guzzetti, S. (1983) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(83)90082-6 · Cited by 53
Nechwatal, R., Duck, C., & Gruber, G. (2002) · Zeitschrift für Kardiologie · doi:10.1007/s003920200034 · Cited by 52
Critical role of CNS effects of aldosterone in cardiac remodeling post-myocardial infarction in rats
LAL, A., VEINOT, J., & Leenen, F. H. H. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.004 · Cited by 52
Ventricular myocardial catecholamines in primates.
Pierpont, G. L., DeMaster, E. G., Reynolds, S., Pederson, J. E., & Cohn, J. N. (1985) · PubMed · Cited by 52
Perrino, C., Prasad, S. V. N., Patel, M. M., Wolf, M. J., & Rockman, H. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.062 · Cited by 51
Khan, M. H., & Sinoway, L. I. (2000) · Heart Failure Reviews · doi:10.1023/a:1009802308872 · Cited by 46
Adams, V. (2007) · Frontiers in bioscience · doi:10.2741/2680 · Cited by 44
Leineweber, K., Wangemann, T., Giessler, C., Bruck, H., Dhein, S., Kostelka, M., Mohr, F., Silber, R.-E., & Brodde, O.-E. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02168-x · Cited by 43
Autonomic innervation of the heart.
Stee, E. W. V. (1978) · Environmental Health Perspectives · doi:10.1289/ehp.7826151 · Cited by 42
Karayannis, G., Kitsios, G. D., Kotidis, H., & Triposkiadis, F. K. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9021-6 · Cited by 39
Self-citationPrevention of diminished parasympathetic control of the heart in experimental heart failure
Bibevski, S., & Dunlap, M. E. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00430.2004 · Cited by 39
Zhao, X. L., Gutiérrez, L. M., Chang, C., & Hosey, M. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1024 · Cited by 38
Sensitization of vagal cardiopulmonary baroreflex by chronic digoxin
Thames, M. D., Miller, B. D., & Abboud, F. M. (1982) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1982.243.5.h815 · Cited by 37
Reducing the Risk of Sudden Death in Heart Failure With β-Blockers
Adamson, P. B., & Gilbert, E. M. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.213 · Cited by 36
Esler, M. D., Jennings, G., Johns, J., Burke, F., Little, P. J., & Leonard, P. (1984) · PubMed · Cited by 36
Acute and Short-Term Effects of Clonidine in Heart Failure
Giles, T. D., Thomas, M. G., Quiroz, A. C., Rice, J. C., Plauche, W. E., & Sander, G. E. (1987) · Angiology · doi:10.1177/000331978703800707 · Cited by 35
Kubo, T., Parker, J. D., Azevedo, E. R., Atchison, D. J., Newton, G. E., Picton, P. E., & Floras, J. S. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.10.012 · Cited by 33
Regitz‐Zagrosek, V., Leuchs, B., Bossaller, C., Sehested, J., Rappolder, M., & Fleck, E. (1991) · European Heart Journal · doi:10.1093/eurheartj/12.suppl_d.171 · Cited by 32
β-Adrenergic signal transduction following carvedilol treatment in hypertensive cardiac hypertrophy
Böhm, M. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00099-6 · Cited by 28
Is digoxin a drug of the past?
Pervaiz, M. H., Dickinson, M. G., & Yamani, M. (2006) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.73.9.821 · Cited by 27
(2005) · European Journal of Heart Failure Supplements · doi:10.1016/s1567-4215(05)80454-0 · Cited by 24
Xu, X.-L., Zang, W., Lü, J., Kang, X., Li, M., & Yu, X. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.04.005 · Cited by 24
Diagnostic and prognostic imaging of the cardiac sympathetic nervous system
Link, J. M., & Caldwell, J. H. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1150 · Cited by 23
Triposkiadis, F., Giamouzis, G., Kelepeshis, G. A., Sitafidis, G., Skoularigis, J. S., & Demopoulos, V. (2007) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp45071 · Cited by 20
Self-citationα2-adrenerge Rezeptoren: Molekulare Struktur und In-vivo-Funktion
Hein, L. (2001) · Zeitschrift für Kardiologie · doi:10.1007/s003920170107 · Cited by 17
Triposkiadis, F. K., Dalampiras, P., Kelepeshis, G. A., Skoularigis, J. S., & Sitafidis, G. (2008) · International Journal of Clinical Pharmacology and Therapeutics · doi:10.5414/cpp46136 · Cited by 13
Self-citationFujimaki, M. (1994) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07557-9 · Cited by 11
O'Connor, C., Anand, I., Fiuzat, M., Plehn, J. F., Gottlieb, S. S., Silver, M. A., Lindenfeld, J., Miller, A., White, M., Robertson, A. C., et al. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.06.184 · Cited by 9
Chemello, D., Rohde, L. E. P., Pimentel, M., Zimerman, L. I., de Abreu, L. P., Gonzalez, V., da Rosa, P. R., Dalsasso, E. R., & Clausell, N. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.06.319 · Cited by 4
742 Peak Endocardial Acceleration mirrors Left Ventricular dP/dt in CRT optimization
(2005) · European Journal of Heart Failure Supplements · doi:10.1016/s1567-4215(05)80452-7 · Cited by 3
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Mitochondrial function as a therapeutic target in heart failure
Brown, D. A., Perry, J. B., Allen, M. E., Sabbah, H. N., Stauffer, B. L., Shaikh, S. R., Cleland, J. G. F., Colucci, W. S., Butler, J., Voors, A. A., et al. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.203 · Cited by 829
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Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789
Pathophysiology of Takotsubo Syndrome
Pelliccia, F., Kaski, J. C., Crea, F., & Camici, P. G. (2017) · Circulation · doi:10.1161/circulationaha.116.027121 · Cited by 743
Adrenergic Nervous System in Heart Failure
Lymperopoulos, A., Rengo, G., & Koch, W. J. (2013) · Circulation Research · doi:10.1161/circresaha.113.300308 · Cited by 632
Non-invasive Vagus Nerve Stimulation in Healthy Humans Reduces Sympathetic Nerve Activity
Clancy, J. A., Mary, D., Witte, K. K., Greenwood, J. P., Deuchars, S. A., & Deuchars, J. (2014) · Brain stimulation · doi:10.1016/j.brs.2014.07.031 · Cited by 582
Metadata
- Authors
- Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., & Butler, J.
- Affiliations
- University Hospital of Larissa (GR)
- Emory University (US)
- AHEPA University Hospital (GR)
- Corresponding author
- Butler, Javed
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 54
- Issue
- 19
- Pages
- 1747-1762
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2097757382
- Cited by
- 978
- References
- 171
- Citations by year
- 2026: 40 · 2025: 44 · 2024: 69 · 2023: 46 · 2022: 74 · 2021: 54 · 2020: 59 · 2019: 77 · 2018: 59 · 2017: 62 · 2016: 71 · 2015: 66 · 2014: 63 · 2013: 58 · 2012: 61
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- heart failure, sympathetic nervous system, sympathetic activation, left ventricular dysfunction, beta1-adrenergic receptor, beta2-adrenergic receptor, alpha1-adrenoceptors, baroreflex, chemoreceptor reflex, beta-blockers, renin-angiotensin-aldosterone system inhibitors, cardiac inotropy, disease progression
- MeSH terms
- Adrenergic alpha-Antagonists, Adrenergic beta-Antagonists, Cardiotonic Agents, Digoxin, Heart Failure, Hemodynamics, Humans, Parasympathetic Nervous System, Polymorphism, Genetic, Receptors, Adrenergic, Renin-Angiotensin System, Sympathetic Nervous System, Sympatholytics, Sympathomimetics, Randomized Controlled Trials as Topic, Exercise Tolerance, Receptors, Adrenergic, alpha-1, Receptors, Adrenergic, beta-2
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