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The Sympathetic Nervous System in Heart Failure
Open accessAbstract
Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers countermeasures aimed to restore cardiac output. These responses are compensatory at first but eventually become part of the disease process itself leading to further worsening cardiac function. Among these responses is the activation of the sympathetic nervous system (SNS) that provides inotropic support to the failing heart increasing stroke volume, and peripheral vasoconstriction to maintain mean arterial perfusion pressure, but eventually accelerates disease progression affecting survival. Activation of SNS has been attributed to withdrawal of normal restraining influences and enhancement of excitatory inputs including changes in: 1) peripheral baroreceptor and chemoreceptor reflexes; 2) chemical mediators that control sympathetic outflow; and 3) central integratory sites. The interface between the sympathetic fibers and the cardiovascular system is formed by the adrenergic receptors (ARs). Dysregulation of cardiac beta(1)-AR signaling and transduction are key features of heart failure progression. In contrast, cardiac beta(2)-ARs and alpha(1)-ARs may function in a compensatory fashion to maintain cardiac inotropy. Adrenergic receptor polymorphisms may have an impact on the adaptive mechanisms, susceptibilities, and pharmacological responses of SNS. The beta-AR blockers and the inhibitors of the renin-angiotensin-aldosterone axis form the mainstay of current medical management of chronic heart failure. Conversely, central sympatholytics have proved harmful, whereas sympathomimetic inotropes are still used in selected patients with hemodynamic instability. This review summarizes the changes in SNS in heart failure and examines how modulation of SNS activity may affect morbidity and mortality from this syndrome.
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“Decreased cardiac output and the resulting sympathetic vasoconstriction in heart failure stimulates adaptive re-distribution of the systemic circulation, leading to congestion in multiple end organs, including the bowel wall31.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [31]
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Cites
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F., Remme, W. J., Cody, R., Castaigne, A., Perez, A., Palensky, J., & Wittes, J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411001 · Cited by 9,214
Pitt, B., Remme, W., Zannad, F., Neaton, J., Martinez, F., Roniker, B., Bittman, R., Hurley, S., Kleiman, J., & Gatlin, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030207 · Cited by 4,941
The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial
Lechat, P. P., Brunhuber, K., Hofmann, R., Kuhn, P., Nesser, H., Slany, J., Weihs, W., Wiedermann, C. J., Wimmer, H., van Mieghem, W., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11181-9 · Cited by 4,922
The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure
Packer, M., Bristow, M. R., Cohn, J. N., Colucci, W. S., Fowler, M. B., Gilbert, E. M., & Shusterman, N. H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605233342101 · Cited by 4,649
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,108
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Pitt, B., Zannad, F. M., Remme, W. J., Cody, R. J., Castaigne, A., Pérez, A. J. P., Palensky, J., & Wittes, J. T. (2000) · Survey of Anesthesiology · doi:10.1097/00132586-200006000-00059 · Cited by 2,927
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
Cohn, J. N., Archibald, D. G., Ziesche, S., Franciosa, J. A., Harston, W. E., Tristani, F. E., Dunkman, W. B., Jacobs, W., Francis, G. S., Flohr, K. H., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606123142404 · Cited by 2,400
Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
Bristow, M. R., Ginsburg, R., Minobe, W. A., Cubicciotti, R. S., Sageman, W. S., Lurie, K. G., Billingham, M. E., Harrison, D. C., & Stinson, E. B. (1982) · New England Journal of Medicine · doi:10.1056/nejm198207223070401 · Cited by 2,270
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Nakata, T., Nakajima, K., Yamashina, S., Yamada, T., Momose, M., Kasama, S., Matsui, T., Matsuo, S., Travin, M. I., & Jacobson, A. F. (2013) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2013.02.007 · Cited by 206
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Roy, B., & Ghatak, S. K. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20130181 · Cited by 87
Chen, W., Xiong, X., Chen, Q., Li, Y., Kang, Y., & Zhu, G. (2015) · Acta Physiologica · doi:10.1111/apha.12447 · Cited by 82
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He, X., Zhao, M. F., Bi, X., Sun, L., Yu, X., Zhao, M., & Zang, W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13010 · Cited by 81
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Rizas, K. D., McNitt, S. A., Hamm, W., Maßberg, S., Kääb, S., Zaręba, W., Couderc, J., & Bauer, A. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx161 · Cited by 82
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Conte, M., Petraglia, L., Poggio, P., Valerio, V., Cabaro, S., Campana, P., Comentale, G., Attena, E., Russo, V., Pilato, E., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.844266 · Cited by 84
Role of the Carotid Body in the Pathophysiology of Heart Failure
Schultz, H. D., Marcus, N. J., & Río, R. D. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0368-x · Cited by 79
Willis, B. C., Salazar-Cantú, A., Silva‐Platas, C., Fernández-Sada, E., Villegas, C., Argaiz, E. R., Gonzalez-Serrano, P., Sánchez, L. A., Guerrero-Beltrán, C. E., Garcı́a, N., et al. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00734.2013 · Cited by 81
Ageing, the autonomic nervous system and arrhythmia: From brain to heart
Chadda, K. R., Ajijola, O. A., Vaseghi, M., Shivkumar, K., Huang, C. L.-H., & Jeevaratnam, K. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.005 · Cited by 77
Use of β-Blockers in Pulmonary Hypertension
Perros, F., de Man, F. S., Bogaard, H. J., Antigny, F., Simonneau, G., Bonnet, S., Provencher, S., Galiè, N., & Humbert, M. J. C. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003703 · Cited by 77
Risk Stratification for Sudden Cardiac Death in Non-Ischaemic Dilated Cardiomyopathy
Akhtar, M. M., & Elliot, P. M. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1236-3 · Cited by 77
Neural Mechanisms in Cardiovascular Health and Disease
Ziegler, K. A., Engelhardt, S. H., Carnevale, D., McAlpine, C. S., Guzik, T. J., Dimmeler, S., & Świrski, F. K. (2025) · Circulation Research · doi:10.1161/circresaha.125.325580 · Cited by 89
Andersson, C., Gaal, L. V., Caterson, I. D., Weeke, P. E., James, W. P. T., Couthino, W., Finer, N., Sharma, A. M., Maggioni, A. P., & Torp-Pedersen, C. T. (2012) · Diabetologia · doi:10.1007/s00125-012-2584-3 · Cited by 77
The relationship of stress and blood pressure effectors.
Ayada, C., Toru, Ü., & Korkut, Y. (2015) · Europe PMC (PubMed Central) · Cited by 80
Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications
Carnevale, D. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00678-w · Cited by 77
Metadata
- Authors
- Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., & Butler, J.
- Affiliations
- University Hospital of Larissa (GR)
- Emory University (US)
- AHEPA University Hospital (GR)
- Corresponding author
- Butler, Javed
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 54
- Issue
- 19
- Pages
- 1747-1762
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2097757382
- Cited by
- 978
- References
- 171
- Citations by year
- 2026: 40 · 2025: 44 · 2024: 69 · 2023: 46 · 2022: 74 · 2021: 54 · 2020: 59 · 2019: 77 · 2018: 59 · 2017: 62 · 2016: 71 · 2015: 66 · 2014: 63 · 2013: 58 · 2012: 61
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- heart failure, sympathetic nervous system, sympathetic activation, left ventricular dysfunction, beta1-adrenergic receptor, beta2-adrenergic receptor, alpha1-adrenoceptors, baroreflex, chemoreceptor reflex, beta-blockers, renin-angiotensin-aldosterone system inhibitors, cardiac inotropy, disease progression
- MeSH terms
- Adrenergic alpha-Antagonists, Adrenergic beta-Antagonists, Cardiotonic Agents, Digoxin, Heart Failure, Hemodynamics, Humans, Parasympathetic Nervous System, Polymorphism, Genetic, Receptors, Adrenergic, Renin-Angiotensin System, Sympathetic Nervous System, Sympatholytics, Sympathomimetics, Randomized Controlled Trials as Topic, Exercise Tolerance, Receptors, Adrenergic, alpha-1, Receptors, Adrenergic, beta-2
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