Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial
Abstract
Background The beneficial effects of beta-blockers on long-term outcome after acute myocardial infarction were shown before the introduction of thrombolysis and angiotensin-converting-enzyme (ACE) inhibitors. Generally, the patients recruited to these trials were at low risk: few had heart failure, and none had measurements of left-ventricular function taken. We investigated the long-term efficacy of carvedilol on morbidity and mortality in patients with left-ventricular dysfunction after acute myocardial infarction treated according to current evidence-based practice. Methods In a multicentre, randomised, placebo-controlled trial, 1959 patients with a proven acute myocardial infarction and a left-ventricular ejection fraction of Findings Although there was no difference between the carvedilol and placebo groups in the number of patients with the primary endpoint (340 [35%] vs 367 [37%], hazard ratio 0.92 [95% CI 0.80-1.07]), all-cause mortality alone was lower in the carvedilol group than in the placebo group (116 [12%] vs 151 [15%], 0.77 [0.60-0.98], p=0.03). Cardiovascular mortality, non-fatal myocardial infarctions, and all-cause mortality or non-fatal myocardial infarction were also lower on carvedilol than on placebo. Interpretation In patients treated long-term after an acute myocardial infarction complicated by left-ventricular systolic dysfunction, carvedilol reduced the frequency of all-cause and cardiovascular mortality, and recurrent, non-fatal myocardial infarcti…
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In the CAPRICORN study, treatment with carvedilol reduced mortality by 23% in people with a history of MI and reduced LVEF.
“Treatment with carvedilol reduced mortality by 23%, and there was a 14% risk reduction for heart failure hospitalization.”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [282]
In the CAPRICORN study, treatment with carvedilol reduced heart failure hospitalization by 14%.
“and there was a 14% risk reduction for heart failure hospitalization.”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [282]
In the CAPRICORN study, treatment with carvedilol reduced mortality by 23% and reduced heart failure hospitalization risk by 14% in people with a history of MI and reduced LVEF.
“Treatment with carvedilol reduced mortality by 23%, and there was a 14% risk reduction for heart failure hospitalization.”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [279]
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- Authors
- Dargie, H. J.
- Affiliations
- Western Infirmary (GB)
- Corresponding author
- H. J. Dargie
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 357
- Issue
- 9266
- Pages
- 1385-1390
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W21478844
- Cited by
- 1,837
- References
- 1
- Citations by year
- 2026: 43 · 2025: 67 · 2024: 47 · 2023: 44 · 2022: 58 · 2021: 51 · 2020: 71 · 2019: 64 · 2018: 60 · 2017: 72 · 2016: 69 · 2015: 71 · 2014: 59 · 2013: 82 · 2012: 77
- FWCI
- 61.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- carvedilol, beta-blockers, acute myocardial infarction, left ventricular systolic dysfunction, all-cause mortality, cardiovascular mortality, reinfarction, heart failure, ACE inhibitors, long-term outcomes
- MeSH terms
- Carvedilol, Adrenergic beta-Antagonists, Adult, Aged, Aged, 80 and over, Carbazoles, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Myocardial Infarction, Propanolamines, Treatment Outcome, Ventricular Dysfunction, Left, Endpoint Determination
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