The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Safety and Efficacy of Sertraline for Depression in Patients With Heart Failure
Open accessAbstract
Objectives The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo.Background Depression is common among HF patients. It is associated with increased hospitalization and mortality.Methods The SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial was a randomized, double-blind, placebo-controlled trial of sertraline 50 to 200 mg/day versus matching placebo for 12 weeks. All participants also received nurse-facilitated support. Eligible patients were age 45 years or older with HF (left ventricular ejection fraction < or =45%, New York Heart Association functional class II to IV) and clinical depression (Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition criteria for current major depressive disorder). Those with significant cognitive impairment, psychosis, recent alcohol or drug dependence, bipolar or severe personality disorder, active suicidal ideation, and current antipsychotic or antidepressant medications were excluded. Primary end points were change in depression severity (Hamilton Depression Rating Scale total score) and composite cardiovascular status at 12 weeks.Results A total of 469 patients were randomized (n = 234 sertraline, n = 235 placebo). The mean +/- SE change from baseline to 12 weeks in the Hamilton Depression Rating Scale total score was -7.1 +/- 0.5 (sertraline) and -6.8 +/- 0.5 (placebo) (p < 0.001 from baseline, p = 0.89 between groups, mean change between groups -0.4; 95% confidence interval: -1.7 to 0.92). The proportions whose composite cardiovascular score worsened, improved, or was unchanged were 29.9%, 40.6%, and 29.5%, respectively, in the sertraline group and 31.1%, 43.8%, and 25.1%, respectively, in the placebo group (p = 0.78).Conclusions Sertraline was safe in patients with significant HF. However, treatment with sertraline compared with placebo did not provide greater reduction in depression or improved cardiovascular status among patients with HF and depression. (Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure [SADHART-CHF]; NCT00078286).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Treating low mood can be done safely with pharmacological treatments such as selective serotonin reuptake inhibitors, 105 whereas tricyclic antidepressants and monoamine oxidase inhibitors should be avoided because of the increased risk of arrhythmias or hypotension. 106”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [105]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Other controlled trials have demonstrated modest improvements associated with SSRIs in patients with heart disease on surrogate markers, including heart rate variability 179 and mental stress-induced myocardial ischemia, 180 although other studies have found no such effect on clinical events or other markers. 179,181”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [181]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
Heart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008
Dickstein, K., Authors Task Force Members, Solal, A. C., Filippatos, G. S., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.08.005 · Cited by 3,535
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140
Authors Task Force Members, Dickstein, K., Solal, A. C., Filippatos, G., McMurray, J. J. V., Ponikowski, P. P., Poole-Wilson, P. A., Strömberg, A., van Veldhuisen, D. J., Atar, D., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn309 · Cited by 2,710
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251
The Seattle Heart Failure Model
Levy, W. C., Mozaffarian, D., Linker, D. T., Sutradhar, S., Anker, S. D., Cropp, A. B., Anand, I. S., Maggioni, A. P., Burton, P. B. J., Sullivan, M. D., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.584102 · Cited by 2,024
Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis
Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J. (2010) · JAMA · doi:10.1001/jama.2009.1943 · Cited by 2,009
Pfeffer, M. A., Swedberg, K. B., Granger, C. B., Held, P., McMurray, J. J. V., Michelson, E. L., Olofsson, B., Östergren, J., & Yusuf, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14282-1 · Cited by 1,895
Rutledge, T., Reis, V. A., Linke, S. E., Greenberg, B. H., & Mills, P. J. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.055 · Cited by 1,513
Research works printed but not linked: 1
- Nair, 1999, Depression, coronary events, platelet inhibition, and serotonin reuptake inhibitors, Am J Cardiol, 84, 321
Cited by
Sorted by citations
Items 501–534 of 534
Control de síntomas en individuos con insuficiencia cardiaca avanzada en Cuidados Paliativos
Serje, D. A. E. (2024) · Enfermería en cardiología: revista científica e informativa de la Asociación Española de Enfermería en Cardiología · doi:10.59322/91.6786.yr5
Belenkov, Y. N., Mareev, V. Y., Ageev, F. T., & Begrambekova, Y. L. (2024) · Kardiologiia · doi:10.18087/cardio.2024.11.n2779
Jabeen, T., Todd, E., Gauci, S., Wootton, R. E., Marx, W., Ashtree, D. N., Zhang, D. J., West, E. C., Davoodian, N., Bastawy, E. M., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5134441
(2025) · Elsevier eBooks · doi:10.1016/b978-3-437-21835-4.00116-5
Prescribing sleep, provoking harm? rethinking Z-drugs in heart failure
Fauvel, C., & Simova, I. I. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf277
Mental Health in the Adult Solid Organ Transplant Recipient
Lenti, G., Karnik, A. N., & Soeprono, T. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-98076-3_12
Heart Failure With Comorbidities
Li, Y., & Liang, M. (2025) · Cardiology Discovery · doi:10.1097/cd9.0000000000000172
Patient Education and Self-Management for Heart Failure
Sun, N., Ma, Y., Cao, R., & Cao, F. (2025) · Cardiology Discovery · doi:10.1097/cd9.0000000000000171
Wachter, R., & Laufs, U. (2025) · Springer eBooks · doi:10.1007/978-3-662-69938-6_11
Correll, C. U., Purushottamahanti, P., Subramaniam, K., Bayan, B., Cook, J., Palmer, E. O. C., Yeow, J., & Lipunova, N. (2026) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s563433
Ilardi, D. L., Zaidi, A. N., Calderon, J., Choi, J. J., Kasparian, N. A., Pike, N. A., Plotkin, D., Smorra, C., Woodhouse, K., Gurvitz, M. Z., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.042921
Besteiro, B., Ribeirinho-Soares, P., Elias, C., Vale, C., PINTO, C., Vieira, J. T., Matos, M. M., Brito, M. T., Matias, P., Gomes, F., et al. (2026) · Heart Lung and Circulation · doi:10.1016/j.hlc.2025.10.007
Tripathi, S. M., Chutia, P., Shahi, M. K., Supranjali, S., Shukla, R., & Roy, R. B. (2026) · Neurodegenerative Disease Management · doi:10.1080/17582024.2026.2637429
Palliative Care in Heart Failure: A Practical Approach
Lawless, M., & Thomas, H. E. (2026) · British Journal of Hospital Medicine · doi:10.31083/bjhm50736
Šustar, A., Nadalin, S., & Pivac, N. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111677
Chang, S. R., & Grysman, N. (2026) · Springer eBooks · doi:10.1007/978-3-032-15772-0_5
Abdelwahab, S. İ., Taha, M. M. E., Farasani, A. M., Moshi, J. M., Assiri, A., Alshahrani, S., Jali, A. M., Sahli, K. A., Qadri, M. M., Alaajam, F., et al. (2026) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2026.103354 · Cited by 1
Lee, S. E., Cho, H., Lee, K.-S., Bak, M., Bae, D., Kim, D. R., Yoo, S. H., Kim, S., Lee, S. E., Kim, H. J., et al. (2026) · International Journal of Heart Failure · doi:10.36628/ijhf.2026.0037
Hartsell, S. E., Drakos, S. G., Boucher, R. E., Sarwal, A., Fang, J. C., Wei, G., Takyi, A., Bissada, G., Shen, J., & Beddhu, S. (2026) · Kidney Medicine · doi:10.1016/j.xkme.2026.101390
Psychological Scars and Physical Consequences: Linking PTSD to Cardiovascular Health
Corker, A., Oh, G., & DeLeon‐Pennell, K. Y. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10783-7
Cen, K., Liang, X.-L., & Zhang, M.-L. (2026) · World Journal of Psychiatry · doi:10.5498/wjp.v16.i6.116288
Pilarski, B., Suchodolski, A., Florek, S., Szulik, M., & Pudlo, R. (2026) · Current problems in cardiology · doi:10.1016/j.cpcardiol.2026.103385
Li, D., Yang, Y., Zhang, Y., Yue, J., Dong, B., & Ge, M. (2026) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.70160
Titscher, G., Albus, C., Boll-Klatt, A., Hilke, K., Kleinschmidt, J., Köllner, V., Princip, M., von Känel, R., Herrmann‐Lingen, C., Titscher, G., et al. (2026) · Springer eBooks · doi:10.1007/978-3-662-72956-4_8
Design and Baseline Characteristics of CONCORD, a Trial of Novel Therapies for Depression in CKD
McAdams, M. C., Gregg, L. P., Carmody, T., Trombello, J. M., Goodman, L. C., Dubovsky, A. N., Abdulrahman, R. A., Roehm, B. A., Shastri, S., Tuttle, K. R., et al. (2026) · Kidney International Reports · doi:10.1016/j.ekir.2026.107034
Neurocardiology: Brain–Heart Interactions in the Heart
Wang, W., Jia, H., Han, H., & Song, J. (2026) · MedComm · doi:10.1002/mco2.70935
Angeli, F., Armillotta, M., Bergamaschi, L., & Pizzi, C. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15186967
Depression and anxiety in vascular dementia: an update
Jellinger, K. A. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03304-y
Diretriz Brasileira de Insuficiência Cardíaca – 2026
Simões, M. V., Moura, L. Z., Martins, S. M., Mourilhe‐Rocha, R., Danzmann, L. C., Neto, J. A. D. F., Marcondes‐Braga, F. G., de Oliveira, M. T., de Albuquerque, D. C., Freitas, A. F., et al. (2026) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20260830
Diretriz Brasileira de Cardiogeriatria – 2026
Helber, I., Zanon, J. C. D. C., Peixoto, J. M., Caixeta, A. M., Nussbacher, A., de Oliveira, D. C., de Freitas, E. V., Cintra, F. D., Garcia, J. S., Miranda, R. D., et al. (2026) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20260795
Zalewska, M., Nowak, K. W., Kościanek, J., Nessler, J., & Zalewski, J. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15207893
Abbes, A. B. (2026) · Studies in Psychology Estudios de Psicología · doi:10.1177/02109395261485760
Tan, Y., Zhang, Y., Yuan, L., Huang, F., Cheng, Y., & Cheng, F. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1976656
Depression and Heart Failure With Preserved Ejection Fraction: An Inflammatory Perspective
Chen, H., Zhang, N., Feng, Y., Tao, M., & Geng, C. (2026) · Depression and Anxiety · doi:10.1155/da/7169650
Metadata
- Authors
- O'Connor, C. M., Jiang, W., Kuchibhatla, M., Silva, S. G., Cuffe, M. S., Callwood, D. D., Zakhary, B., Stough, W. G., Arias, R. M., Rivelli, S. K., & Krishnan, R.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- Virginia Research Institute (US)
- Campbell University (US)
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 56
- Issue
- 9
- Pages
- 692-699
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC3663330
- OpenAlex
- W1608367062
- Cited by
- 535
- References
- 36
- Citations by year
- 2026: 29 · 2025: 23 · 2024: 21 · 2023: 28 · 2022: 35 · 2021: 27 · 2020: 40 · 2019: 49 · 2018: 35 · 2017: 39 · 2016: 42 · 2015: 36 · 2014: 23 · 2013: 38 · 2012: 37
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- Pfizer, Inc.
- NIMH
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- sertraline, heart failure, depression, major depressive disorder, antidepressants, cardiovascular events, drug safety, depression severity
- MeSH terms
- Aged, Antidepressive Agents, Chronic Disease, Depression, Female, Heart Failure, Humans, Male, Middle Aged, Sertraline
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
