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Structural Abnormalities in Atrial Walls Are Associated With Presence and Persistency of Atrial Fibrillation But Not With Age
Open accessAbstract
Objectives The purpose of this study was to assess the association between structural changes in human atria, age, and history of atrial fibrillation (AF).Background Development of fibrosis in atrial walls is associated with deterioration of atrial conduction and predisposes to AF in experiment. Human data, however, are scarce, and whether fibrosis is a cause or consequence of AF is not known.Methods Medical records for consecutive autopsies were checked for AF history and duration. Atrial specimens from 30 patients (ages 64 ± 12 years) were collected in 3 equal age-matched groups as patients without AF history, with paroxysmal AF, or with permanent AF. Tissue samples were obtained at the level of superior pulmonary veins, inferior pulmonary veins, center of posterior left atrial wall, terminal crest, and Bachmann's bundle. Histology sections were assessed for extent of fibrosis, fatty tissues, and inflammatory infiltration at each location.Results No correlation was observed between age and fibrosis at any location. Fibrosis extent and fatty infiltration were twofold to threefold higher at all locations in patients with history of AF and correlated with lymphomononuclear infiltration. Patients with permanent AF had greater fibrosis extent than did patients with paroxysmal AF.Conclusions In post-mortem material, structural changes in the atria were not associated with age, but were significantly correlated with presence of AF and its severity. Our findings suggest that age-related changes per se are unlikely to be the sole cause of advanced fibrosis underlying AF.
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“A number of observational studies have demonstrated the association between female sex and risk of AF-related stroke and thromboembolism (Supplementary Table S6).”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [68]
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“most studies report an increased risk of stroke in women.68–71”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [68]
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Cites
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,924
Self-citationEpidemiologic Features of Chronic Atrial Fibrillation
Kannel, W. B., Abbott, R. D., Savage, D. D., & McNamara, P. M. (1982) · New England Journal of Medicine · doi:10.1056/nejm198204293061703 · Cited by 2,304
Histological Substrate of Atrial Biopsies in Patients With Lone Atrial Fibrillation
Frustaci, A., Chimenti, C., Bellocci, F., Morgante, E., Russo, M. A., & Maseri, A. (1997) · Circulation · doi:10.1161/01.cir.96.4.1180 · Cited by 1,400
C-Reactive Protein Elevation in Patients With Atrial Arrhythmias
Chung, M. K., Martin, D. O., Sprecher, D. L., Wazni, O. M., KANDERIAN, A. S., Carnes, C. A., Bauer, J. A., TCHOU, P. J., Niebauer, M. J., Natale, A., et al. (2001) · Circulation · doi:10.1161/hc4901.101760 · Cited by 1,386
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343
Oakes, R. S., Badger, T. J., Kholmovski, E. G., AKOUM, N. W., Burgon, N. S., Fish, E. N., Blauer, J. J. E., Rao, S. N., DiBella, E., Segerson, N. M., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.811877 · Cited by 1,123
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046
Variants conferring risk of atrial fibrillation on chromosome 4q25
Gudbjartsson, D. F., Arnar, D. O., Helgadottir, A., Gretarsdottir, S., Holm, H., Sigurdsson, A., Jonasdottir, A., Baker, A., Thorleifsson, G., Kristjansson, K., et al. (2007) · Nature · doi:10.1038/nature06007 · Cited by 955
Left Atrial Strain and Strain Rate in Patients With Paroxysmal and Persistent Atrial Fibrillation
Kuppahally, S. S., AKOUM, N. W., Burgon, N. S., Badger, T. J., Kholmovski, E. G., Vijayakumar, S., Rao, S. N., Blauer, J. J. E., Fish, E. N., DiBella, E., et al. (2010) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.109.865683 · Cited by 707
Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., Prendergast, B., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq512 · Cited by 555
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
Benjamin, E. J., Rice, K. M., Arking, D. E., Pfeufer, A., van Noord, C., Smith, A. V., Schnabel, R. B., Bis, J. C., Boerwinkle, E., Sinner, M. F., et al. (2009) · Nature Genetics · doi:10.1038/ng.416 · Cited by 390
Mahnkopf, C., Badger, T. J., Burgon, N. S., Daccarett, M., Haslam, T. S., Badger, C. T., McGann, C. J., AKOUM, N. W., Kholmovski, E. G., MacLeod, R., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.06.030 · Cited by 334
McGann, C. J., Kholmovski, E. G., Oakes, R. S., Blauer, J. J. E., Daccarett, M., Segerson, N. M., Airey, K. J., AKOUM, N. W., Fish, E. N., Badger, T. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.062 · Cited by 329
Electrophysiologic studies in atrial fibrillation
Cosío, F. G., Palacios, J., Vidal, J. M., Cocina, E. G., Gómez‐Sánchez, M. Á., & Tamargo, L. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80022-8 · Cited by 311
de Luna, A. B., Cladellas, M., Oter, R., TORNER, P., Soldevila, J. G., Vicens Martí, C., RIVERA, I., & Iturralde, P. (1988) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a062407 · Cited by 299
Smith, J. G., Platonov, P. G., Hedblad, B., Engström, G., & Melander, O. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-009-9404-1 · Cited by 275
Self-citationRecruitment of Immune Cells Across Atrial Endocardium in Human Atrial Fibrillation
Yamashita, T., Sekiguchi, A., Iwasaki, Y., Date, T., Sagara, K., Tanabe, H., Suma, H., Sawada, H., & Aizawa, T. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-0644 · Cited by 197
Determinants and consequences of atrial fibrosis in patients undergoing open heart surgery
Goette, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00251-1 · Cited by 179
Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis
Anyukhovsky, E. P. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00271-7 · Cited by 160
Provocation of coronary spasm by dopamine in patients with active variant angina pectoris.
Crea, F., Chierchia, S. L., Kaski, J. C., Davies, G. J., Margonato, A., Miran, D. O., & Maseri, A. (1986) · Circulation · doi:10.1161/01.cir.74.2.262 · Cited by 129
Chen, M., Chang, J., Liu, W., Yang, C., Chen, Y., Tsai, T., Wang, Y., & Pan, K. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.05.038 · Cited by 128
Corradi, D., Callegari, S., Benussi, S., Maestri, R., Pastori, P., Nascimbene, S., Bosio, S., Dorigo, E., Grassani, C., Rusconi, R., et al. (2005) · Human Pathology · doi:10.1016/j.humpath.2005.07.018 · Cited by 113
Sinner, M. F., Pfeufer, A., Akyol, M., Beckmann, B.-M., Hinterseer, M., Wacker, A., Perz, S., Sauter, W., Illig, T., Näbauer, M., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehm619 · Cited by 107
Swartz, M. F., Fink, G. W., Lutz, C. J., Taffet, S. M., Berenfeld, O., Vikstrom, K. L., Kasprowicz, K., Bhatta, L., Puskás, F., Kalifa, J., et al. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.06.018 · Cited by 103
Gramley, F., Lorenzen, J., Knackstedt, C., Rana, O. R., Saygili, E., Frechen, D., Stanzel, S. F., Pezzella, F., Koellensperger, E., Weiß, C. H., et al. (2008) · AGE · doi:10.1007/s11357-008-9077-9 · Cited by 83
Platonov, P. G., Carlson, J., Ingemansson, M., Roijer, A., Hansson, A., Chireĭkin, L. V., & Olsson, S. B. (2000) · EP Europace · doi:10.1053/eupc.1999.0072 · Cited by 83
Self-citationRelationship between atrial histopathology and atrial fibrillation after coronary bypass surgery
Mariscalco, G., Engström, K. G., Ferrarese, S., Cozzi, G., Bruno, V. D., Sessa, F., & Sala, A. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.01.040 · Cited by 70
How structurally normal are human atria in patients with atrial fibrillation?
Becker, A. E. (2004) · Heart Rhythm · doi:10.1016/j.hrthm.2004.09.009 · Cited by 46
Platonov, P. G. (2001) · EP Europace · doi:10.1053/eupc.2001.0150 · Cited by 36
Self-citationAltered Interatrial Conduction Detected in MADIT II Patients Bound to Develop Atrial Fibrillation
Holmqvist, F., Platonov, P. G., Carlson, J., Zaręba, W., Moss, A. J., & for the MADIT II Investigators (2009) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2009.00309.x · Cited by 32
Self-citation
Cited by
Sorted by citations
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,794
Marrouche, N. F., Wilber, D., Hindricks, G., Jais, P., Akoum, N., Marchlinski, F., Kholmovski, E., Burgon, N., Hu, N., Mont, L., et al. (2014) · JAMA · doi:10.1001/jama.2014.3 · Cited by 1,473
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · EP Europace · doi:10.1093/europace/eux274 · Cited by 1,203
Tzeis, S. E., Gerstenfeld, E. P., Kalman, J. M., Saad, E., Shamloo, A. S., Andrade, J. G., Barbhaiya, C. R., Baykaner, T., Bovéda, S., Calkins, H. G., et al. (2024) · EP Europace · doi:10.1093/europace/euae043 · Cited by 724
Brundel, B. J. J. M., Ai, X., Hills, M. T., Kuipers, M. F., Lip, G. Y. H., & de Groot, N. M. S. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00347-9 · Cited by 545
Metadata
- Authors
- Platonov, P. G., Mitrofanova, L. B., Orshanskaya, V., & Ho, S. Y.
- Affiliations
- Lund University (SE)
- Royal Brompton Hospital (GB)
- Corresponding author
- Platonov, Pyotr G.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 58
- Issue
- 21
- Pages
- 2225-2232
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2062105156
- Cited by
- 496
- References
- 31
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 38 · 2023: 42 · 2022: 44 · 2021: 44 · 2020: 39 · 2019: 39 · 2018: 36 · 2017: 43 · 2016: 36 · 2015: 30 · 2014: 20 · 2013: 22 · 2012: 14
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- Lund University Hospital
- Swedish Heart-Lung Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- atrial fibrillation, atrial fibrosis, age, paroxysmal atrial fibrillation, permanent atrial fibrillation, fatty infiltration, pulmonary veins, left atrial wall, Bachmann's bundle, atrial conduction
- MeSH terms
- Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Biopsy, Needle, Female, Fibrosis, Follow-Up Studies, Heart Atria, Heart Diseases, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Disease Progression
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