Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation: The DECAAF Study

Marrouche, Nassir F.; Wilber, David; Hindricks, Gerhard; Jais, Pierre; Akoum, Nazem; Marchlinski, Francis; Kholmovski, Eugene; Burgon, Nathan; Hu, Nan; Mont, Lluis; Deneke, Thomas; Duytschaever, Mattias; Neumann, Thomas; Mansour, Moussa; Mahnkopf, Christian; Herweg, Bengt; Daoud, Emile; Wissner, Erik; Bansmann, Paul; Brachmann, Johannes

doi:10.1001/jama.2014.3

Cited by 1,473Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmias

Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation: The DECAAF Study

Marrouche, Nassir F., Wilber, David, Hindricks, Gerhard, Jais, Pierre, Akoum, Nazem, Marchlinski, Francis, Kholmovski, Eugene, Burgon, Nathan +12 more·2014·JAMA

DOI 10.1001/jama.2014.3

Open this paper in CoChat — free account

Abstract

IMPORTANCE: Left atrial fibrosis is prominent in patients with atrial fibrillation (AF). Extensive atrial tissue fibrosis identified by delayed enhancement magnetic resonance imaging (MRI) has been associated with poor outcomes of AF catheter ablation. OBJECTIVE: To characterize the feasibility of atrial tissue fibrosis estimation by delayed enhancement MRI and its association with subsequent AF ablation outcome. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, prospective, observational cohort study of patients diagnosed with paroxysmal and persistent AF (undergoing their first catheter ablation) conducted between August 2010 and August 2011 at 15 centers in the United States, Europe, and Australia. Delayed enhancement MRI images were obtained up to 30 days before ablation. MAIN OUTCOMES AND MEASURES: Fibrosis quantification was performed at a core laboratory blinded to the participating center, ablation approach, and procedure outcome. Fibrosis blinded to the treating physicians was categorized as stage 1 (<10% of the atrial wall), 2 (≥10%-<20%), 3 (≥20%-<30%), and 4 (≥30%). Patients were followed up for recurrent arrhythmia per current guidelines using electrocardiography or ambulatory monitor recording and results were analyzed at a core laboratory. Cumulative incidence of recurrence was estimated by stage at days 325 and 475 after a 90-day blanking period (standard time allowed for arrhythmias related to ablation-induced inflammation to subside) and the risk of recurrence was estimated (adjusting for 10 demographic and clinical covariates). RESULTS: Atrial tissue fibrosis estimation by delayed enhancement MRI was successfully quantified in 272 of 329 enrolled patients (57 patients [17%] were excluded due to poor MRI quality). There were 260 patients who were followed up after the blanking period (mean [SD] age of 59.1 [10.7] years, 31.5% female, 64.6% with paroxysmal AF). For recurrent arrhythmia, the unadjusted overall hazard ratio per 1% increase in left atrial fibrosis was 1.06 (95% CI, 1.03-1.08; P < .001). Estimated unadjusted cumulative incidence of recurrent arrhythmia by day 325 for stage 1 fibrosis was 15.3% (95% CI, 7.6%-29.6%); stage 2, 32.6% (95% CI, 24.3%-42.9%); stage 3, 45.9% (95% CI, 35.5%-57.5%); and stage 4, 51.1% (95% CI, 32.8%-72.2%) and by day 475 was 15.3% (95% CI, 7.6%-29.6%), 35.8% (95% CI, 26.2%-47.6%), 45.9% (95% CI, 35.6%-57.5%), and 69.4% (95% CI, 48.6%-87.7%), respectively. Similar results were obtained after covariate adjustment. The addition of fibrosis to a recurrence prediction model that includes traditional clinical covariates resulted in an improved predictive accuracy with the C statistic increasing from 0.65 to 0.69 (risk difference of 0.05; 95% CI, 0.01-0.09). CONCLUSIONS AND RELEVANCE: Among patients with AF undergoing catheter ablation, atrial tissue fibrosis estimated by delayed enhancement MRI was independently associated with likelihood of recurrent arrhythmia. The clinical implications of this association warrant further investigation.

Integrity signals

Registry

Crossref · 10.1001/jama.2014.3

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The rhythm outcome after catheter ablation of atrial fibrillation is difficult to predict in individual patients.
“The rhythm outcome after catheter ablation of AF is difficult to predict in individual patients.173,227,713,728”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [173]

The Statistical Analysis of Failure Time Data.
Aitkin, M. A., Kalbfleisch, J. D., & Prentice, R. L. (1981) · Biometrics · doi:10.2307/2530581 · Cited by 9,875 · see citing works
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,875 · see citing works
Self-citation
Atrial Fibrillation Begets Atrial Fibrillation
WIJFFELS, M. C. E. F., Kirchhof, C. J. H. J., Dorland, R., & Allessie, M. A. (1995) · Circulation · doi:10.1161/01.cir.92.7.1954 · Cited by 3,500 · see citing works
2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H., Kuck, K. H., Cappato, R., Brugada, J., Camm, A. J., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., DiMarco, J., et al. (2012) · Europace · doi:10.1093/europace/eus027 · Cited by 2,722 · see citing works
Self-citation
Relationship of MRI Delayed Contrast Enhancement to Irreversible Injury, Infarct Age, and Contractile Function
Kim, R. J., Fieno, D. S., Parrish, T. B., Harris, K. R., Chen, E.-L., Simonetti, O. P., Bundy, J. M., Finn, J. P., Klocke, F. J., & Judd, R. M. (1999) · Circulation · doi:10.1161/01.cir.100.19.1992 · Cited by 2,583 · see citing works
The Statistical Analysis of Failure Time Data
Klein, J. P., Kalbfleisch, J. D., & Prentice, R. L. (1982) · Technometrics · doi:10.1080/00401706.1982.10487769 · Cited by 2,248 · see citing works
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Calkins, H., Kuck, K., Cappato, R., Brugada, J., Camm, A., Chen, S.-A., Crijns, H., Damiano, R., Davies, D., Dimarco, J., et al. (2012) · Journal of interventional cardiac electrophysiology · doi:10.1007/s10840-012-9672-7 · Cited by 1,959 · see citing works
Self-citation
Electrical, contractile and structural remodeling during atrial fibrillation
Allessie, M. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00258-4 · Cited by 1,455 · see citing works
Promotion of Atrial Fibrillation by Heart Failure in Dogs
Li, D., Fareh, S., Leung, T. K., & Nattel, S. (1999) · Circulation · doi:10.1161/01.cir.100.1.87 · Cited by 1,343 · see citing works
Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation: A Randomized Controlled Trial
Wilber, D. J., Pappone, C., Neuzil, P., De Paola, A., Marchlinski, F., Natale, A., Macle, L., Daoud, E. G., Calkins, H., Hall, B., et al. (2010) · JAMA · doi:10.1001/jama.2009.2029 · Cited by 1,170 · see citing works
Self-citation
Detection and Quantification of Left Atrial Structural Remodeling With Delayed-Enhancement Magnetic Resonance Imaging in Patients With Atrial Fibrillation
Oakes, R. S., Badger, T. J., Kholmovski, E. G., AKOUM, N. W., Burgon, N. S., Fish, E. N., Blauer, J. J. E., Rao, S. N., DiBella, E., Segerson, N. M., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.811877 · Cited by 1,123 · see citing works
Self-citation
Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial
Wazni, O. M., Marrouche, N. F., Martin, D. O., Verma, A., Bhargava, M., Saliba, W., Bash, D., Schweikert, R., Brachmann, J., Gunther, J., et al. (2005) · JAMA · doi:10.1001/jama.293.21.2634 · Cited by 1,121 · see citing works
Self-citation
Chronic Rapid Atrial Pacing
Morillo, C. A., Klein, G. J., Jones, D. L., & Guiraudon, C. M. (1995) · Circulation · doi:10.1161/01.cir.91.5.1588 · Cited by 1,046 · see citing works
Catheter Ablation for Paroxysmal Atrial Fibrillation
Oral, H., Scharf, C., Chugh, A., HALL, B. W., Cheung, P. W., Good, E. D., Veerareddy, S., Pelosi, F., & Morady, F. (2003) · Circulation · doi:10.1161/01.cir.0000095796.45180.88 · Cited by 896 · see citing works
Catheter Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation
Jaı̈s, P., CAUCHEMEZ, B., Macle, L., Daoud, E. G., Khairy, P., Subbiah, R. N., Hocini, M., Extramiana, F., Sacher, F., Bordachar, P., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772582 · Cited by 889 · see citing works
Self-citation
The Statistical Analysis of Failure Time Data
Borgan, Ø. (2003) · Journal of the American Statistical Association · doi:10.1198/jasa.2003.s310 · Cited by 810 · see citing works
Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis
Ganesan, A. N., Shipp, N. J., Brooks, A. G., Kuklik, P., Lau, D. H., Lim, H. S., Sullivan, T., Roberts‐Thomson, K. C., & Sanders, P. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004549 · Cited by 800 · see citing works
Catheter Ablation of Long‐Lasting Persistent Atrial Fibrillation: Clinical Outcome and Mechanisms of Subsequent Arrhythmias
Haı̈ssaguerre, M., Hocini, M., Sanders, P., Sacher, F., Rotter, M., Takahashi, Y., Rostock, T., Hsu, L., Bordachar, P., Reuter, S., et al. (2005) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2005.00308.x · Cited by 755 · see citing works
Corrigendum to: ‘Guidelines for the management of atrial fibrillation’ [European Heart Journal (2010) 31, 2369–2429 and EP-Europace (2010) 12, 1360–1420]
Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., Prendergast, B., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq512 · Cited by 555 · see citing works
Self-citation
Contrast-enhanced magnetic resonance imaging of myocardium at risk
Fieno, D. S., Kim, R. J., Chen, E.-L., Lomasney, J. W., Klocke, F. J., & Judd, R. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00958-x · Cited by 542 · see citing works
Structural Abnormalities in Atrial Walls Are Associated With Presence and Persistency of Atrial Fibrillation But Not With Age
Platonov, P. G., Mitrofanova, L. B., Orshanskaya, V., & Ho, S. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.05.061 · Cited by 496 · see citing works
Assessing the Direct Costs of Treating Nonvalvular Atrial Fibrillation in the United States
Coyne, K. S., Paramore, C., Grandy, S., Mercader, M. A., Reynolds, M. W., & ZIMETBAUM, P. J. (2006) · Value in Health · doi:10.1111/j.1524-4733.2006.00124.x · Cited by 422 · see citing works
Atrial Fibrosis Helps Select the Appropriate Patient and Strategy in Catheter Ablation of Atrial Fibrillation: A DE-MRI Guided Approach
AKOUM, N. W., Daccarett, M., McGann, C. J., Segerson, N. M., VERGARA, G., Kuppahally, S. S., Badger, T. J., Burgon, N. S., Haslam, T. S., Kholmovski, E. G., et al. (2010) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2010.01876.x · Cited by 358 · see citing works
Self-citation
Atrial fibrosis and the mechanisms of atrial fibrillation
Everett, T. H., & Olgin, J. E. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.12.040 · Cited by 338 · see citing works
Detection of Pulmonary Vein and Left Atrial Scar after Catheter Ablation with Three-dimensional Navigator-gated Delayed Enhancement MR Imaging: Initial Experience1
Peters, D. C., Wylie, J. V., Hauser, T. H., Kissinger, K. V., Botnar, R. M., Essebag, V., Josephson, M. E., & Manning, W. J. (2007) · Radiology · doi:10.1148/radiol.2433060417 · Cited by 336 · see citing works
Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: Implications for disease progression and response to catheter ablation
Mahnkopf, C., Badger, T. J., Burgon, N. S., Daccarett, M., Haslam, T. S., Badger, C. T., McGann, C. J., AKOUM, N. W., Kholmovski, E. G., MacLeod, R., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.06.030 · Cited by 334 · see citing works
Self-citation
New Magnetic Resonance Imaging-Based Method for Defining the Extent of Left Atrial Wall Injury After the Ablation of Atrial Fibrillation
McGann, C. J., Kholmovski, E. G., Oakes, R. S., Blauer, J. J. E., Daccarett, M., Segerson, N. M., Airey, K. J., AKOUM, N. W., Fish, E. N., Badger, T. J., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.062 · Cited by 329 · see citing works
Self-citation
Assessment of Conventional Cardiovascular Risk Factors and Multiple Biomarkers for the Prediction of Incident Heart Failure and Atrial Fibrillation
Smith, J. G., Newton‐Cheh, C., Almgren, P., Struck, J., Morgenthaler, N. G., Bergmann, A., Platonov, P. G., Hedblad, B., Engström, G., Wang, T. J., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.049 · Cited by 311 · see citing works
Influence of Systolic and Diastolic Blood Pressure on the Risk of Incident Atrial Fibrillation in Women
Conen, D., Tedrow, U. B., Koplan, B. A., Glynn, R. J., Buring, J. E., & Albert, C. M. (2009) · Circulation · doi:10.1161/circulationaha.108.830042 · Cited by 308 · see citing works
Complications of atrial fibrillation ablation in a high-volume center in 1,000 procedures: still cause for concern?
DAGRES, N., HINDRICKS, G., KOTTKAMP, H., SOMMER, P., GASPAR, T., BODE, K., ARYA, A., HUSSER, D., RALLIDIS, L. S., KREMASTINOS, D. T., et al. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2009.01493.x · Cited by 279 · see citing works
Self-citation
Atrial Electrophysiologic Remodeling: Another Vicious Circle?
Allessie, M. A. (1998) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1998.tb00114.x · Cited by 239 · see citing works
Evaluation of Left Atrial Lesions After Initial and Repeat Atrial Fibrillation Ablation
Badger, T. J., Daccarett, M., AKOUM, N. W., Adjei-Poku, Y. A., Burgon, N. S., Haslam, T. S., Kalvaitis, S., Kuppahally, S. S., Vergara, G., McMullen, L., et al. (2010) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.868356 · Cited by 213 · see citing works
Self-citation
Long-Term Clinical Results of 2 Different Ablation Strategies in Patients With Paroxysmal and Persistent Atrial Fibrillation
Gaïta, F., Caponi, D., Scaglione, M., Montefusco, A., Corleto, A., Monte, F. D., Coin, D., Donna, P. D., & Giustetto, C. (2008) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.108.774885 · Cited by 211 · see citing works
Clinical and echocardiographic features of intermittent atrial fibrillation that predict recurrent atrial fibrillation
Flaker, G. C., The Stroke Prevention in Atrial Fibrillation (SPAF) Investigators, Fletcher, K. A., Rothbart, R. M., Halperin, J. L., & Hart, R. G. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80100-3 · Cited by 156 · see citing works
Blood Pressure Control and Risk of Incident Atrial Fibrillation
Thomas, M. C., Dublin, S., Kaplan, R. C., Glazer, N. L., Lumley, T., Longstreth, W. T., Jr., Smith, N. L., Psaty, B. M., Siscovick, D. S., & Heckbert, S. R. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.248 · Cited by 143 · see citing works
Late recurrent arrhythmias after ablation of atrial fibrillation: Incidence, mechanisms, and treatment
Kobza, R., Hindricks, G., Tanner, H., Schirdewahn, P., Dorszewski, A., Piorkowski, C., Gerds‐Li, J., & Kottkamp, H. (2004) · Heart Rhythm · doi:10.1016/j.hrthm.2004.08.009 · Cited by 136 · see citing works
Self-citation
Assessing Myocardial Viability and Infarct Transmurality With Left Ventricular Electromechanical Mapping in Patients With Stable Coronary Artery Disease
Perin, E. C., Silva, G. V., Sarmento‐Leite, R., Sousa, A., Howell, M., Muthupillai, R., Lambert, B., Vaughn, W. K., & Flamm, S. D. (2002) · Circulation · doi:10.1161/01.cir.0000026394.01888.18 · Cited by 134 · see citing works
Radiofrequency Ablation vs Antiarrhythmic Drugs as First-line Treatment of Symptomatic Atrial Fibrillation: A Randomized Trial
Waldo, A. L. (2006) · Yearbook of Cardiology · doi:10.1016/s0145-4145(07)70267-8 · Cited by 96 · see citing works
Advanced left-atrial fibrosis is associated with unsuccessful maze operation for valvular atrial fibrillation
Kainuma, S., Masai, T., Yoshitatsu, M., Miyagawa, S., Yamauchi, T., Takeda, K., Morii, E., & Sawa, Y. (2011) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2010.11.008 · Cited by 60 · see citing works
Radiofrequency Ablation as Initial Therapy in Paroxysmal Atrial Fibrillation
Nielsen, J. C., Johannessen, A. C., Raatikainen, P. M. J., Hindricks, G., Walfridsson, H., Kongstad, O., Pehrson, S. M., Englund, A., Hartikainen, J. E. K., Mortensen, L. S., et al. (2014) · Survey of Anesthesiology · doi:10.1097/sa.0000000000000031 · Cited by 54 · see citing works
Self-citation
Updated National Multicenter Registry on Procedural Safety of Catheter Ablation for Atrial Fibrillation
Bertaglia, E., Stabile, G., Pappone, A., Themistoclakis, S., Tondo, C., Sanctis, V. D., Soldati, E., Tritto, M. V., Solimene, F., Grimaldi, M., et al. (2013) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12194 · Cited by 48 · see citing works
Radiofrequency Ablation as Initial Therapy in Paroxysmal Atrial Fibrillation
Mehra, R., & Benjamin, E. J. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1214193 · Cited by 13 · see citing works

Flagged first, then by citations

Sorted by citations

2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS).
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J., Blomström-Lundqvist, C., Boriani, G., Castellá, M., Dan, G., Dilaveris, P. E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 2,605 · see citing works
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Self-citation
2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
Gelder, I. C. V., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., Potter, T. J. R. D., Dwight, J., Guasti, L., Hanke, T., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae176 · Cited by 3,338 · see citing works
Self-citation
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A. M., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001193 · Cited by 2,989 · see citing works
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.05.012 · Cited by 2,771 · see citing works
Self-citation
Epidemiology of Atrial Fibrillation in the 21st Century
Kornej, J., Börschel, C. S., Benjamin, E. J., & Schnabel, R. B. (2020) · Circulation Research · doi:10.1161/circresaha.120.316340 · Cited by 1,550 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Self-citation
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
Calkins, H. G., Hindricks, G., Cappato, R., Kim, Y., Saad, E., Aguinaga, L., Akar, J. G., Badhwar, V., Brugada, J., Camm, A. J., et al. (2017) · EP Europace · doi:10.1093/europace/eux274 · Cited by 1,191 · see citing works
Self-citation
2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation
Joglar, J. A., Chung, M. K., Armbruster, A. L., Benjamin, E. J., Chyou, J. Y., Cronin, E. M., Deswal, A., Eckhardt, L. L., Goldberger, Z. D., Gopinathannair, R., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.017 · Cited by 933 · see citing works
EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.028 · Cited by 785 · see citing works
Self-citation
EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · EP Europace · doi:10.1093/europace/euw161 · Cited by 782 · see citing works
Self-citation
2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation
Tzeis, S. E., Gerstenfeld, E. P., Kalman, J. M., Saad, E., Shamloo, A. S., Andrade, J. G., Barbhaiya, C. R., Baykaner, T., Bovéda, S., Calkins, H. G., et al. (2024) · EP Europace · doi:10.1093/europace/euae043 · Cited by 692 · see citing works
Self-citation
Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction
Thomas, L., Marwick, T. H., Popescu, B. A., Donal, E., & Badano, L. P. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.059 · Cited by 662 · see citing works
Cardiac Fibrosis in Patients With Atrial Fibrillation
Dzeshka, M. S., Lip, G. Y. H., Snezhitskiy, V. А., & Shantsila, E. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.06.1313 · Cited by 557 · see citing works
Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy
Nattel, S., Heijman, J., Zhou, L., & Dobrev, D. (2020) · Circulation Research · doi:10.1161/circresaha.120.316363 · Cited by 448 · see citing works
Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation
Marrouche, N. F., Wazni, O. M., McGann, C., Greene, T., Dean, J. M., Dagher, L., Kholmovski, E. G., MANSOUR, M. C., Marchlinski, F. E., Wilber, D. J., et al. (2022) · JAMA · doi:10.1001/jama.2022.8831 · Cited by 433 · see citing works
Self-citation
Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts
Hansen, B. J., Zhao, J., Csepe, T. A., Moore, B. T., Li, N., Jayne, L. A., Kalyanasundaram, A., Lim, P., Bratasz, A., Powell, K. A., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv233 · Cited by 411 · see citing works
Left Atrial Reverse Remodeling
Thomas, L., & Abhayaratna, W. P. (2017) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.11.003 · Cited by 392 · see citing works
Mechanisms of atrial fibrillation
Wijesurendra, R. S., & Casadei, B. (2019) · Heart · doi:10.1136/heartjnl-2018-314267 · Cited by 366 · see citing works
EACVI/EHRA Expert Consensus Document on the role of multi-modality imaging for the evaluation of patients with atrial fibrillation
Donal, E., Lip, G. Y. H., Galderisi, M., Goette, A., Shah, D. C., Marwan, M., Léderlin, M., Mondillo, S., Edvardsen, T., Sitges, M., et al. (2016) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jev354 · Cited by 342 · see citing works
Self-citation
Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS)
Goette, A., Corradi, D., Dobrev, D., Aguinaga, L., Cabrera, J. Á., Chugh, S. S., de Groot, J. R., Soulat-Dufour, L., Fenelon, G., Hatem, S. N., et al. (2024) · EP Europace · doi:10.1093/europace/euae204 · Cited by 341 · see citing works
Self-citation
2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation
Tzeis, S. E., Gerstenfeld, E. P., Kalman, J. M., Saad, E., Shamloo, A. S., Andrade, J. G., Barbhaiya, C. R., Baykaner, T., Bovéda, S., Calkins, H. G., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.03.017 · Cited by 312 · see citing works
Self-citation
Ablation of Persistent Atrial Fibrillation Targeting Low-Voltage Areas With Selective Activation Characteristics
Jadidi, A., Lehrmann, H., Keyl, C., Sorrel, J., Markstein, V., Minners, J., Park, C., Denis, A., Jaı̈s, P., Hocini, M., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.002962 · Cited by 304 · see citing works
Computationally guided personalized targeted ablation of persistent atrial fibrillation
Boyle, P. M., Zghaib, T., Zahid, S., Ali, R. L., Deng, D., Franceschi, W. H., Hakim, J. B., Murphy, M. J., Prakosa, A., Zimmerman, S. L., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0437-9 · Cited by 304 · see citing works
Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern
Zahid, S., Cochet, H., Boyle, P. M., Schwarz, E. L., Whyte, K. N., Vigmond, E. J., Dubois, R., Hocini, M., Haı̈ssaguerre, M., Jaı̈s, P., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw073 · Cited by 294 · see citing works
Cardiac Fibroblast Diversity
Tallquist, M. D. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034527 · Cited by 276 · see citing works
Atrial fibrillation and cardiac fibrosis
Sohns, C., & MARROUCHE, N. F. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz786 · Cited by 272 · see citing works
Self-citation
Atrial Fibrillation
Chung, M. K., Refaat, M. M., Shen, W.-K., Kutyifa, V., Cha, Y., Biase, L. D., Baranchuk, A. M., Lampert, R., Natale, A., Fisher, J. D., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.02.025 · Cited by 257 · see citing works
Catheter ablation for atrial fibrillation: current indications and evolving technologies
Parameswaran, R., Al‐Kaisey, A., & Kalman, J. M. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00451-x · Cited by 251 · see citing works
Early Rhythm Control Therapy in Patients With Atrial Fibrillation and Heart Failure
Rillig, A., Magnussen, C., Ozga, A., Suling, A. I., Brandes, A., BREITHARDT, G. E., Camm, A. J., Crijns, H. J. G. M., Eckardt, L., Elvan, A., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.056323 · Cited by 249 · see citing works
Evaluating the Atrial Myopathy Underlying Atrial Fibrillation
Goldberger, J. J., Arora, R., Green, D., Greenland, P., Lee, D. C., Lloyd‐Jones, D. M., Markl, M., Ng, J., & Shah, S. J. (2015) · Circulation · doi:10.1161/circulationaha.115.016795 · Cited by 244 · see citing works
Atrial Myopathy
Shen, M. J., Arora, R., & Jalife, J. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.05.005 · Cited by 243 · see citing works
The role of obesity in atrial fibrillation
Nalliah, C. J., Sanders, P., Kottkamp, H., & Kalman, J. M. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv486 · Cited by 240 · see citing works
Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation
Zuo, K., Li, J., Li, K., Hu, C., Gao, Y., Chen, M., Hu, R., Liu, Y., Chi, H., Wang, H., et al. (2019) · GigaScience · doi:10.1093/gigascience/giz058 · Cited by 235 · see citing works
Atrial Cardiomyopathy
Guichard, J.-B., & Nattel, S. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.06.033 · Cited by 226 · see citing works
Sinus Node and Atrial Arrhythmias
John, R. M., & Kumar, S. (2016) · Circulation · doi:10.1161/circulationaha.116.018011 · Cited by 219 · see citing works
Predicting atrial fibrillation ablation outcome: The CAAP-AF score
Winkle, R. A., Jarman, J. W. E., Mead, R. H., Engel, G., Kong, M. H., Fleming, W., & Patrawala, R. A. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.07.018 · Cited by 214 · see citing works
Fibrotic Atrial Cardiomyopathy, Atrial Fibrillation, and Thromboembolism
Hirsh, B. J., Copeland-Halperin, R. S., & Halperin, J. L. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.557 · Cited by 214 · see citing works
Comorbidity of atrial fibrillation and heart failure
Ling, L., Kistler, P. M., Kalman, J. M., SCHILLING, R. J., & Hunter, R. J. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.191 · Cited by 213 · see citing works
Structure and Function of the Left Atrium and Left Atrial Appendage
Delgado, V., Biase, L. D., Leung, M., Romero, J. E., Tops, L. F., Casadei, B., MARROUCHE, N. F., & Bax, J. J. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.10.063 · Cited by 213 · see citing works
Self-citation
Artificial Intelligence and Machine Learning in Arrhythmias and Cardiac Electrophysiology
Feeny, A. K., Chung, M. K., Madabhushi, A., Attia, Z. I., Čikeš, M., Firouznia, M., Friedman, P. A., Kalscheur, M. M., Kapa, S., Narayan, S. M., et al. (2020) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.007952 · Cited by 210 · see citing works
Left atrial function: evaluation by strain analysis
Gan, G. C. H., Ferkh, A., Boyd, A. C., & Thomas, L. (2018) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.06.08 · Cited by 203 · see citing works
Benchmark for Algorithms Segmenting the Left Atrium From 3D CT and MRI Datasets
Tobon‐Gomez, C., Geers, A. J., Peters, J., Weese, J., Pinto, K., Karim, R., Ammar, M., Daoudi, A., Margeta, J., Sandoval, Z., et al. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2398818 · Cited by 200 · see citing works
Age, Atrial Fibrillation, and Structural Heart Disease Are the Main Determinants of Left Atrial Fibrosis Detected by Delayed‐Enhanced Magnetic Resonance Imaging in a General Cardiology Population
COCHET, H., MOURIES, A., NIVET, H., SACHER, F., DERVAL, N., DENIS, A., MERLE, M., RELAN, J., HOCINI, M., HAÏSSAGUERRE, M., et al. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12651 · Cited by 199 · see citing works
Prospective, multicenter validation of a clinical risk score for left atrial arrhythmogenic substrate based on voltage analysis: DR-FLASH score
Kosiuk, J., Dinov, B., Kornej, J., Acou, W., Schönbauer, R., Fiedler, L., Buchta, P., Myrda, K., Gąsior, M., Poloński, L., et al. (2015) · Heart Rhythm · doi:10.1016/j.hrthm.2015.07.003 · Cited by 199 · see citing works
Self-citation
The State of the Art
Morin, D. P., Bernard, M. L., Madias, C. A., Rogers, P. A., Thihalolipavan, S., & Estes, N. A. M. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.08.022 · Cited by 196 · see citing works
Association of Left Atrial Function and Left Atrial Enhancement in Patients With Atrial Fibrillation
Habibi, M., Lima, J. A. C., Khurram, I. M., Zimmerman, S. L., Zipunnikov, V. M., Fukumoto, K., SPRAGG, D. D., Ashikaga, H., Rickard, J., Marine, J. E., et al. (2015) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.114.002769 · Cited by 195 · see citing works
Left Atrial Fibrosis and Risk of Cerebrovascular and Cardiovascular Events in Patients With Atrial Fibrillation
King, J. B., Azadani, P. N., Suksaranjit, P., Bress, A. P., Witt, D. M., Han, F. T., Chelu, M. G., Silver, M. A., BISKUPIAK, J. E., Wilson, B. D., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.07.758 · Cited by 195 · see citing works
Self-citation
Individually tailored vs. standardized substrate modification during radiofrequency catheter ablation for atrial fibrillation: a randomized study
Kircher, S., Arya, A., Altmann, D., Rolf, S., Bollmann, A., Sommer, P., Dagres, N., Richter, S., Breithardt, O. A., Dinov, B., et al. (2017) · EP Europace · doi:10.1093/europace/eux310 · Cited by 195 · see citing works
Self-citation
Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis
Hakalahti, A., Biancari, F., Nielsen, J. C., & Raatikainen, M. J. P. (2015) · Europace · doi:10.1093/europace/euu376 · Cited by 191 · see citing works
STABLE-SR (Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm) for the Treatment of Nonparoxysmal Atrial Fibrillation
Yang, B., Jiang, C., Lin, Y., Yang, G., Chu, H., Cai, H., Lu, F., Zhan, X., Xu, J., Wang, X., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005405 · Cited by 183 · see citing works
Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference
Schnabel, R. B., Marinelli, E. A., Arbelo, E., Boriani, G., Bovéda, S., Buckley, C. M., Camm, A. J., Casadei, B., Chua, W., Dagres, N., et al. (2022) · EP Europace · doi:10.1093/europace/euac062 · Cited by 182 · see citing works
Self-citation
Catheter Ablation of Nonparoxysmal Atrial Fibrillation Using Electrophysiologically Guided Substrate Modification During Sinus Rhythm After Pulmonary Vein Isolation
Yang, G., Yang, B., Wei, Y., Zhang, F., Ju, W., Chen, H., Li, M., Gu, K., Lin, Y., Wang, B., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003382 · Cited by 177 · see citing works
Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure
Denham, N. C., Pearman, C. M., Caldwell, J. L., Madders, G. W. P., Eisner, D. A., Trafford, A. W., & Dibb, K. M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01380 · Cited by 174 · see citing works
Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications
Lau, D. H., Schotten, U., Mahajan, R., Antic, N. A., Hatem, S. N., Pathak, R. K., Hendriks, J., Kalman, J. M., & Sanders, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv375 · Cited by 171 · see citing works
Translational Challenges in Atrial Fibrillation
Heijman, J., Guichard, J.-B., Dobrev, D., & Nattel, S. (2018) · Circulation Research · doi:10.1161/circresaha.117.311081 · Cited by 165 · see citing works
Diagnosis-to-Ablation Time and Recurrence of Atrial Fibrillation Following Catheter Ablation
Chew, D. S., Black‐Maier, E., Loring, Z., Noseworthy, P. A., Packer, D. L., Exner, D. V., Mark, D. B., & Piccini, J. P. (2020) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.119.008128 · Cited by 164 · see citing works
Cardiac Magnetic Resonance–Measured Left Atrial Volume and Function and Incident Atrial Fibrillation
Habibi, M., Samiei, S., Ambale‐Venkatesh, B., Opdahl, A., Helle-Valle, T. M., Zareian, M., de Almeida, A. L. C., Choi, E., Wu, C. O., Alonso, Á., et al. (2016) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.115.004299 · Cited by 157 · see citing works
Management of Atrial Fibrillation Across the Spectrum of Heart Failure With Preserved and Reduced Ejection Fraction
Reddy, Y. N. V., Borlaug, B. A., & Gersh, B. J. (2022) · Circulation · doi:10.1161/circulationaha.122.057444 · Cited by 157 · see citing works
Catheter ablation in patients with persistent atrial fibrillation
Kirchhof, P. F., & Calkins, H. G. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw260 · Cited by 156 · see citing works
Left atrial fibrosis quantification by late gadolinium-enhanced magnetic resonance: a new method to standardize the thresholds for reproducibility
Benito, E. M., Carlosena-Remírez, A., Guasch, E., Prat, S., Perea, R. J., Figueras, R., Borràs, R., Andreu, D., Arbelo, E., Tolosana, J. M., et al. (2016) · EP Europace · doi:10.1093/europace/euw219 · Cited by 156 · see citing works
Self-citation
Quantification of the cryoablation zone demarcated by pre- and postprocedural electroanatomic mapping in patients with atrial fibrillation using the 28-mm second-generation cryoballoon
Kenigsberg, D. N., Martin, N., Lim, H. W., Kowalski, M., & Ellenbogen, K. A. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.11.012 · Cited by 154 · see citing works
Novel Risk Markers and Risk Assessments for Cardiovascular Disease
Thomas, M. R., & Lip, G. Y. H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309955 · Cited by 154 · see citing works
Age and sex differences in atrial fibrosis among patients with atrial fibrillation
AKOUM, N. W., Mahnkopf, C., Kholmovski, E. G., Brachmann, J., & MARROUCHE, N. F. (2017) · EP Europace · doi:10.1093/europace/eux260 · Cited by 154 · see citing works
Self-citation
Assessment of Left Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging
Siebermair, J., Kholmovski, E. G., & MARROUCHE, N. F. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.07.004 · Cited by 152 · see citing works
Self-citation
Circumferential Pulmonary Vein Isolation Plus Low-Voltage Area Modification in Persistent Atrial Fibrillation
Yang, G., Zheng, L., Jiang, C., Fan, J., Liu, X., Zhan, X., Li, J., Wang, L., Yang, H. Y., Zhu, W., et al. (2022) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2022.03.012 · Cited by 149 · see citing works
EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication
Goette, A., Kalman, J. M., Aguinaga, L., Akar, J. G., Cabrera, J. Á., Chen, S. A., Chugh, S. S., Corradi, D., d’Ávila, A., Dobrev, D., et al. (2016) · Journal of Arrhythmia · doi:10.1016/j.joa.2016.05.002 · Cited by 148 · see citing works
Self-citation
Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options
Sha, R., Baines, O., Hayes, A., Tompkins, K., Kalla, M., Holmes, A. P., O’Shea, C., & Pavlović, D. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.032277 · Cited by 145 · see citing works
Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment
Fabritz, L., Guasch, E., Antoniades, C. A., Bardinet, I., Benninger, G., Betts, T. R., Brand, E., BREITHARDT, G. E., Suchánková, G., Camm, A. J., et al. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.194 · Cited by 142 · see citing works
Self-citation
Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation
Haı̈ssaguerre, M., Shah, A. J., Cochet, H., Hocini, M., Dubois, R., Efimov, I. R., Vigmond, E. J., Bernus, O., & Trayanova, N. A. (2016) · The Journal of Physiology · doi:10.1113/jp270617 · Cited by 142 · see citing works
Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation
Ahlberg, G., Refsgaard, L., Lundegaard, P. R., Andreasen, L., Ranthe, M. F., Linscheid, N., Nielsen, J. B., Melbye, M., Haunsø, S., Sajadieh, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06618-y · Cited by 142 · see citing works
Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging and Catheter Ablation of Atrial Fibrillation: 5‐Year Follow‐Up Data
Chelu, M. G., King, J. B., Kholmovski, E. G., Ma, J., Gal, P., Marashly, Q., Aljuaid, M., Kaur, G., Silver, M. A., Johnson, K. A., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.006313 · Cited by 141 · see citing works
Self-citation
Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis
Lau, D. H., Linz, D., Schotten, U., Mahajan, R., Sanders, P., & Kalman, J. M. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.119 · Cited by 136 · see citing works
Atrial Fibrosis and Conduction Slowing in the Left Atrial Appendage of Patients Undergoing Thoracoscopic Surgical Pulmonary Vein Isolation for Atrial Fibrillation
Krul, S. P. J., Berger, W. R., Smit, N. W., van Amersfoorth, S. C. M., Driessen, A. H. G., van Boven, W. J., Fiolet, J. W. T., van Ginneken, A. C. G., van der Wal, A. C., de Bakker, J. M. T., et al. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.001752 · Cited by 135 · see citing works
Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms
Roney, C. H., Bayer, J. D., Zahid, S., Meo, M., Boyle, P. M., Trayanova, N. A., Haı̈ssaguerre, M., Dubois, R., Cochet, H., & Vigmond, E. J. (2016) · EP Europace · doi:10.1093/europace/euw365 · Cited by 134 · see citing works
Development and validation of a risk score for predicting atrial fibrillation recurrence after a first catheter ablation procedure – ATLAS score
Mesquita, J., Ferreira, A. J. M., Cavaco, D., Costa, F. M., Carmo, P., Marques, H., Morgado, F., Mendes, M., & Adragão, P. (2017) · EP Europace · doi:10.1093/europace/eux265 · Cited by 132 · see citing works
Magnetic resonance imaging of atrial fibrosis: redefining atrial fibrillation to a syndrome
Gal, P., & MARROUCHE, N. F. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv514 · Cited by 129 · see citing works
Self-citation
Atrial Substrate and Triggers of Paroxysmal Atrial Fibrillation in Patients With Obstructive Sleep Apnea
Anter, E., Di Biase, L., Contreras-Valdes, F. M., Gianni, C., Mohanty, S., Tschabrunn, C. M., Viles-Gonzalez, J. F., Leshem, E., Buxton, A. E., Kulbak, G., et al. (2017) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.117.005407 · Cited by 127 · see citing works
Implications of Inflammation and Fibrosis in Atrial Fibrillation Pathophysiology
Harada, M., & Nattel, S. (2021) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2020.11.002 · Cited by 126 · see citing works
Pathophysiology, Echocardiographic Diagnosis, and Treatment of Atrial Functional Mitral Regurgitation
Farhan, S., Silbiger, J. J., Halperin, J. L., Zhang, L., Dukkipati, S. R., Vogel, B., Kini, A. S., Sharma, S. K., & Lerakis, S. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.09.046 · Cited by 126 · see citing works
Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling
McDowell, K. S., Zahid, S., Vadakkumpadan, F., Blauer, J. J. E., MacLeod, R., & Trayanova, N. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117110 · Cited by 125 · see citing works
Impact of Voltage Mapping to Guide Whether to Perform Ablation of the Posterior Wall in Patients With Persistent Atrial Fibrillation
Cutler, M. J., Johnson, J. R., Abozguia, K., Rowan, S. B., LEWIS, W., Costantini, O., Natale, A., & Ziv, O. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12830 · Cited by 125 · see citing works
Catheter ablation of atrial fibrillation: an update
Haegeli, L., & Calkins, H. G. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu291 · Cited by 123 · see citing works
Pulmonary Vein Reconnection No Longer Occurs in the Majority of Patients After a Single Pulmonary Vein Isolation Procedure
Pooter, J. D., Strisciuglio, T., Haddad, M. E., Wolf, M., Phlips, T., Vandekerckhove, Y. R., Tavernier, R., Knecht, S., & Duytschaever, M. F. (2019) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.11.020 · Cited by 123 · see citing works
Self-citation
2019 APHRS expert consensus statement on three‐dimensional mapping systems for tachycardia developed in collaboration with HRS, EHRA, and LAHRS
Kim, Y., Chen, S., Ernst, S., Guzmán, C., Han, S., Kalarus, Z. F., Labadet, C., Lin, Y.-J., Lo, L., Nogami, A., et al. (2020) · Journal of Arrhythmia · doi:10.1002/joa3.12308 · Cited by 121 · see citing works
MRI Assessment of Ablation‐Induced Scarring in Atrial Fibrillation: Analysis from the DECAAF Study
AKOUM, N. W., Wilber, D. J., Hindricks, G., Jaı̈s, P., Cates, J. E., Marchlinski, F. E., Kholmovski, E. G., Burgon, N. S., HU, N., Mont, L., et al. (2015) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12650 · Cited by 119 · see citing works
Self-citation
Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation
Cochet, H., Dubois, R., Yamashita, S., Al-Jefairi, N., Berte, B., Sellal, J., Hooks, D. A., Frontera, A., Amraoui, S., Zemoura, A., et al. (2017) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.07.019 · Cited by 118 · see citing works
Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy
Calenda, B. W., Fuster, V., Halperin, J. L., & Granger, C. B. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.106 · Cited by 116 · see citing works
Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference
Kotecha, D., BREITHARDT, G. E., Camm, A. J., Lip, G. Y. H., Schotten, U., Ahlsson, A., Arnar, D. O., Atar, D., Auricchio, A., Bax, J. J., et al. (2018) · EP Europace · doi:10.1093/europace/eux318 · Cited by 115 · see citing works
Self-citation
The Duration of the Amplified Sinus-P-Wave Identifies Presence of Left Atrial Low Voltage Substrate and Predicts Outcome After Pulmonary Vein Isolation in Patients With Persistent Atrial Fibrillation
Jadidi, A., Müller‐Edenborn, B., Chen, J., Keyl, C., Weber, R., Allgeier, J., Weidmann, Z. M., Trenk, D., Neumann, F., Lehrmann, H., et al. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2017.12.001 · Cited by 115 · see citing works
Associations of electrocardiographic P-wave characteristics with left atrial function, and diffuse left ventricular fibrosis defined by cardiac magnetic resonance: The PRIMERI Study
Win, T. T., Ambale‐Venkatesh, B., Volpe, G. J., Mewton, N., Rizzi, P., Sharma, R. K., Strauss, D. G., Lima, J. A. C., & Tereshchenko, L. G. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.09.044 · Cited by 114 · see citing works
Atrial Arrhythmias in Pulmonary Hypertension: Pathogenesis, Prognosis and Management
Wanamaker, B. L., CASCINO, T. M., McLaughlin, V. V., Oral, H., Latchamsetty, R., & Siontis, K. C. (2018) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2018.3.2 · Cited by 113 · see citing works
Left Atrial LGE and Arrhythmia Recurrence Following Pulmonary Vein Isolation for Paroxysmal and Persistent AF
Khurram, I. M., Habibi, M., İpek, E. G., Chrispin, J., Yang, E., Fukumoto, K., Dewire, J., SPRAGG, D. D., Marine, J. E., Berger, R. D., et al. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2015.10.015 · Cited by 111 · see citing works
Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management
Ma, J., Chen, Q., & Ma, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16350 · Cited by 111 · see citing works
Predicting Atrial Fibrillation Recurrence by Combining Population Data and Virtual Cohorts of Patient-Specific Left Atrial Models
Roney, C. H., Sim, I., Yu, J., Beach, M., Mehta, A., Solis-Lemus, J. A., Kotadia, I., Whitaker, J., Corrado, C., Razeghi, O., et al. (2022) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.121.010253 · Cited by 106 · see citing works
Association Between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation
Khurram, I. M., Maqbool, F., Berger, R. D., Marine, J. E., SPRAGG, D. D., Ashikaga, H., Zipunnikov, V. M., Kass, D. A., Calkins, H. G., Nazarian, S., et al. (2016) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003163 · Cited by 104 · see citing works
Slow Conduction in the Border Zones of Patchy Fibrosis Stabilizes the Drivers for Atrial Fibrillation: Insights from Multi-Scale Human Atrial Modeling
Morgan, R., Colman, M. A., Chubb, H., Seemann, G., & Aslanidi, O. V. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00474 · Cited by 104 · see citing works
Low‐voltage areas detected by high‐density electroanatomical mapping predict recurrence after ablation for paroxysmal atrial fibrillation
Vlachos, K. G., Efremidis, M., Letsas, Κ. P., Bazoukis, G., Martin, R. I. R., Kalafateli, M., Lioni, L., Georgopoulos, S., Saplaouras, A., Efremidis, T., et al. (2017) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13321 · Cited by 104 · see citing works
High-Power Radiofrequency Catheter Ablation of Atrial Fibrillation
Baher, A. A., Kheirkhahan, M., Rechenmacher, S. J., Marashly, Q., Kholmovski, E. G., Siebermair, J., Acharya, M. M., Aljuaid, M., Morris, A. K., Kaur, G., et al. (2018) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2018.07.017 · Cited by 103 · see citing works
Self-citation

The Role of Atrial Fibrosis Detected by Delayed - Enhancement MRI in Atrial Fibrillation Ablation
Kis, Z., Hendriks, A. A., Muka, T., Bramer, W. M., Kovács, I., & Szili‐Törok, T. (2018) · Current Medical Imaging Formerly Current Medical Imaging Reviews · doi:10.2174/1573405614666180806130327 · Cited by 11 · see citing works
Left Atrial Fibrosis and Recurrent Arrhythmia
Tops, L. F., & Schalij, M. J. (2014) · JAMA · doi:10.1001/jama.2014.5184 · Cited by 1 · see citing works
Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation
Marrouche, N. F., Wazni, O. M., McGann, C., Greene, T., Dean, J. M., Dagher, L., Kholmovski, E. G., MANSOUR, M. C., Marchlinski, F. E., Wilber, D. J., et al. (2022) · JAMA · doi:10.1001/jama.2022.8831 · Cited by 433 · see citing works
Self-citation
Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging and Catheter Ablation of Atrial Fibrillation: 5‐Year Follow‐Up Data
Chelu, M. G., King, J. B., Kholmovski, E. G., Ma, J., Gal, P., Marashly, Q., Aljuaid, M., Kaur, G., Silver, M. A., Johnson, K. A., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.006313 · Cited by 141 · see citing works
Self-citation
Early recurrence of atrial fibrillation after catheter ablation with left atrial fibrosis identified at cardiac magnetic resonance by late gadolinium enhancement
Totaro, A., Casavecchia, G., Gravina, M., Ieva, R., Santoro, F., Grimaldi, M., Pellegrino, P. L., Macarini, L., Biase, M. D., & Brunetti, N. D. (2016) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944715623232 · Cited by 3 · see citing works

Authors: Marrouche, N. F., Wilber, D., Hindricks, G., Jais, P., Akoum, N., Marchlinski, F., Kholmovski, E., Burgon, N., Hu, N., Mont, L., Deneke, T., Duytschaever, M., Neumann, T., Mansour, M., Mahnkopf, C., Herweg, B., Daoud, E., Wissner, E., Bansmann, P., & Brachmann, J.
Affiliations: University of Utah (US)
Loyola University Medical Center (US)
Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
University of Barcelona, Barcelona, Spain
Corresponding author: Marrouche, Nassir F.
ORCID: Marrouche, Nassir F.
Wilber, David
Hindricks, Gerhard
Akoum, Nazem
Marchlinski, Francis
Kholmovski, Eugene
Deneke, Thomas
Duytschaever, Mattias
Neumann, Thomas
Mansour, Moussa
Herweg, Bengt
Daoud, Emile
Wissner, Erik
Bansmann, Paul
Brachmann, Johannes
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2014-02-05
Volume: 311
Issue: 5
Pages: 498
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.2014.3
OpenAlex: W2150866578
Cited by: 1,473
References: 42
Citations by year: 2026: 122 · 2025: 111 · 2024: 125 · 2023: 122 · 2022: 154 · 2021: 126 · 2020: 137 · 2019: 126 · 2018: 108 · 2017: 119 · 2016: 96 · 2015: 77 · 2014: 45 · 2013: 2
FWCI: 76.46
Type: journal article
Language: en
Open access: closed
Locations: JAMA (publishedVersion, public-domain)
PubMed (publishedVersion)
Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion)
RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: atrial fibrillation, left atrial fibrosis, delayed enhancement MRI, cardiac magnetic resonance imaging, catheter ablation, fibrosis quantification, recurrent arrhythmia, paroxysmal atrial fibrillation, persistent atrial fibrillation, ablation outcome prediction, fibrosis staging
MeSH terms: Aged, Atrial Fibrillation, Female, Fibrosis, Heart Atria, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Recurrence, Risk, Incidence, Treatment Outcome, Catheter Ablation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Association of Atrial Tissue Fibrosis Identified by Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation: The DECAAF Study

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks