The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Isolated Quadriceps Training Increases Maximal Exercise Capacity in Chronic Heart Failure
Open accessAbstract
Objectives This study sought to elucidate the mechanisms responsible for the benefits of small muscle mass exercise training in patients with chronic heart failure (CHF).Background How central cardiorespiratory and/or peripheral skeletal muscle factors are altered with small muscle mass training in CHF is unknown.Methods We studied muscle structure, and oxygen (O(2)) transport and metabolism at maximal cycle (whole-body) and knee-extensor exercise (KE) (small muscle mass) in 6 healthy controls and 6 patients with CHF who then performed 8 weeks of KE training (both legs, separately) and repeated these assessments.Results Pre-training cycling and KE peak leg O(2) uptake (Vo(2peak)) were ~17% and ~15% lower, respectively, in the patients compared with controls. Structurally, KE training increased quadriceps muscle capillarity and mitochondrial density by ~21% and ~25%, respectively. Functionally, despite not altering maximal cardiac output, KE training increased maximal O(2) delivery (~54%), arterial-venous O(2) difference (~10%), and muscle O(2) diffusive conductance (D(M)O(2)) (~39%) (assessed during KE), thereby increasing single-leg Vo(2peak) by ~53%, to a level exceeding that of the untrained controls. Post-training, during maximal cycling, O(2) delivery (~40%), arterial-venous O(2) difference (~15%), and D(M)O(2) (~52%) all increased, yielding an increase in Vo(2peak) of ~40%, matching the controls.Conclusions In the face of continued central limitations, clear improvements in muscle structure, peripheral convective and diffusive O(2) transport, and subsequently, O(2) utilization support the efficacy of local skeletal muscle training as a powerful approach to combat exercise intolerance in CHF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In both patients with HF with preserved ejection fraction and those with HFrEF, the peripheral contributions to improved peak V˙o2 with training appear to be attributable largely to improved skeletal muscle function (ie, increased percent skeletal muscle oxidative fibers, mitochondrial volume density, oxidative capacity, capillarity, and muscle blood flow).204–206”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,137
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Cohn, J. N., Levine, T. B., Olivari, M. T., Garberg, V., Lura, D., Francis, G. S., Simon, A. B., & Rector, T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198409273111303 · Cited by 3,125
Effect of carvedilol on survival in severe chronic heart failure
Packer, M., Coats, A. J. S., Fowler, M. B., Katus, H. A., Krum, H., Mohacsi, P., Rouleau, J. L., Tendera, M., Castaigne, A., Roecker, E. B., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105313442201 · Cited by 3,093
Effect of carvedilol on survival in severe chronic heart failure
Packer, M., Coats, A. J. S., & Fowler, M. B. (2001) · ACC Current Journal Review · doi:10.1016/s1062-1458(01)00477-9 · Cited by 1,651
Practical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,563
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,173
Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)
Piepoli, M. F., Davos, C. H., Francis, D. P., & Coats, A. J. S. (2004) · BMJ · doi:10.1136/bmj.37938.645220.ee · Cited by 994
Hambrecht, R., Fiehn, E., Weigl, C., Gielen, S., Hamann, C., Kaiser, R., Yu, J., Adams, V., Niebauer, J., & Schuler, G. C. (1998) · Circulation · doi:10.1161/01.cir.98.24.2709 · Cited by 963
Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure.
Weber, K. T., Kinasewitz, G. T., Janicki, J. S., & Fishman, A. P. (1982) · Circulation · doi:10.1161/01.cir.65.6.1213 · Cited by 913
Alterations of skeletal muscle in chronic heart failure.
Drexler, H., Riede, U. N., Münzel, T. F., König, H., Funke, E., & Just, H. (1992) · Circulation · doi:10.1161/01.cir.85.5.1751 · Cited by 780
MANCINI, D. M., Walter, G., Reichek, N., Lenkinski, R. E., McCully, K. K., Mullen, J. L., & Wilson, J. R. (1992) · Circulation · doi:10.1161/01.cir.85.4.1364 · Cited by 736
Myoglobin O2 desaturation during exercise. Evidence of limited O2 transport.
Richardson, R. S., Noyszewski, E. A., Kendrick, K. F., Leigh, J. S., & Wagner, P. D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118237 · Cited by 647
Self-citationExercise training in patients with chronic heart failure: Fig 1: Authors' reply
Piepoli, M. F., & Francis, D. P. (2004) · BMJ · doi:10.1136/bmj.328.7441.711-b · Cited by 472
Effect of barbiturates on ‘quantal’ synaptic transmission in spinal motoneurones
Weakly, J. N. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008898 · Cited by 432
Jones, P. R., & Pearson, J. (1969) · PubMed · Cited by 430
Skeletal Muscle Function and Its Relation to Exercise Tolerance in Chronic Heart Failure
Harrington, D., Anker, S. D., Chua, T. P., Webb-Peploe, K., Ponikowski, P. P., Poole-Wilson, P. A., & Coats, A. J. S. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00381-1 · Cited by 400
Dynamic knee extension as model for study of isolated exercising muscle in humans
Andersen, P., Adams, R. P., Sjøgaard, G., Thorboe, A., & Saltin, B. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.5.1647 · Cited by 385
The effects of exercise training on sympathetic neural activation in advanced heart failure
Roveda, F., Middlekauff, H. R., Rondon, M. U. P. B., Reis, S. F., Souza, M., Nastari, L., Barretto, A. C. P., Krieger, E. M., & Negrão, C. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00831-3 · Cited by 333
van Tol, B., Huijsmans, R. J., Kroon, D. W., Schothorst, M., & Kwakkel, G. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.02.013 · Cited by 308
New ideas on limitations to VO2max.
Wagner, P. D. (2000) · PubMed · Cited by 243
Self-citationEvidence of O2 supply-dependentV˙ o 2 max in the exercise-trained human quadriceps
Richardson, R. S., Grassi, B., Gavin, T. P., Haseler, L. J., Tagore, K. S., Roca, J., & Wagner, P. D. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.1048 · Cited by 234
Self-citationEffects of hyperoxia on maximal leg O2 supply and utilization in men
Knight, D. R., Schaffartzik, W., Poole, D. C., Hogan, M. C., Bebout, D. E., & Wagner, P. D. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.6.2586 · Cited by 232
Self-citationLimited Maximal Exercise Capacity in Patients With Chronic Heart Failure
Esposito, F., Mathieu-Costello, O. A., Shabetai, R. W., Wagner, P. D., & Richardson, R. S. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.11.086 · Cited by 212
Self-citationExercise adaptation attenuates VEGF gene expression in human skeletal muscle
Richardson, R. S., Wagner, H. E., Mudaliar, S. R. D., Saucedo, E., Henry, R. R., & Wagner, P. D. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.2.h772 · Cited by 205
Self-citationVascular and metabolic response to isolated small muscle mass exercise: effect of age
Lawrenson, L., Poole, J. G., Kim, J. H., Brown, C., Patel, P. M., & Richardson, R. S. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00135.2003 · Cited by 174
Self-citationMagnusson, G., Gordon, A., Kaijser, L., Sylvén, C., Isberg, B., Karpakka, J., & Saltin, B. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015001 · Cited by 155
Massie, B. M., Simonini, A. A., Sahgal, P., Wells, L., & Dudley, G. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00416-5 · Cited by 140
Richardson, T., Kindig, C. A., Musch, T. I., & Poole, D. C. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00308.2003 · Cited by 131
Capillary tortuosity and degree of contraction or extension of skeletal muscles
Mathieu-Costello, O. A. (1987) · Microvascular Research · doi:10.1016/0026-2862(87)90010-0 · Cited by 129
Tyni‐Lenné, R., Dencker, K., Gordon, A., Jansson, E., & Sylvén, C. (2001) · European Journal of Heart Failure · doi:10.1016/s1388-9842(00)00087-8 · Cited by 120
Wadley, G. D., Lee, R. S., Canny, B. J., Wasuntarawat, C., Chen, Z. P., Hargreaves, M., Kemp, B. E., & McConell, G. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2005 · Cited by 111
Poole, D. C., & Mathieu-Costello, O. A. (1996) · Microcirculation · doi:10.3109/10739689609148286 · Cited by 108
Norepinephrine spillover from skeletal muscle during exercise in humans: role of muscle mass
Savard, G. K., Richter, E. A., Strange, S., Kiens, B., Christensen, N. J., & Saltin, B. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.6.h1812 · Cited by 107
Haseler, L. J., Lin, A., & Richardson, R. S. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01321.2003 · Cited by 92
Self-citationRosenblatt, J. D., Kuzon, W. M., Plyley, M. J., Pynn, B. R., & McKee, N. H. (1987) · Stain Technology · doi:10.3109/10520298709107973 · Cited by 84
Tyni‐Lenné, R., Gordon, A., Jensen‐Urstad, M., Dencker, K., Jansson, E., & Sylvén, C. (1999) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(99)91334-9 · Cited by 71
Effects of FIO2 on leg ??VO2 during cycle ergometry in sedentary subjects
S, J. C., Marrades, R. M., Roca, J., Barberà, J. A., Orlando Díaz, P., Masclans, J. R., Rodriguez‐Roisin, R., & Wagner, P. D. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199805000-00009 · Cited by 66
Self-citationMeasurement of cardiac output during exercise by open-circuit acetylene uptake
Barker, R. C., Hopkins, S. R., Kellogg, N., Olfert, I. M., Brutsaert, T. D., Gavin, T. P., Entin, P. L., Rice, A. J., & Wagner, P. D. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.4.1506 · Cited by 66
Self-citationIncreased fiber capillarization in flight muscle of finch at altitude
Mathieu-Costello, O., Agey, P. J., Wu, L., Szewczak, J. M., & MacMillen, R. E. (1998) · Respiration Physiology · doi:10.1016/s0034-5687(97)00119-9 · Cited by 64
Lawrenson, L., Hoff, J., & Richardson, R. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01070.2003 · Cited by 62
Self-citationMathieu-Costello, O. A., Agey, P. J., Wu, L., Hang, J., & Adair, T. H. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.3.904 · Cited by 56
Pulmonary and Peripheral Gas Exchange in Health and Disease
Roca, J., Rodríguez-Roisin, R., & Wagner, P. D. (2000) · Cited by 48
Self-citationGordon, A., Tyni‐Lenné, R., Jansson, E., Kaijser, L., Theodorsson-Norheim, E., & Sylvén, C. (1997) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(97)90002-6 · Cited by 37
Effect of sampling site on femoral venous blood gas values
Agustí, A. G. N., Roca, J., Barberà, J. A., Casademont, J., Rodríguez-Roisin, R., & Wagner, P. D. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.4.2018 · Cited by 17
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kitzman, D. W., Brubaker, P. H., Herrington, D. M., Morgan, T. M., Stewart, K. P., Hundley, W. G., Abdelhamed, A., & Haykowsky, M. J. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.033 · Cited by 369
Cardiac Rehabilitation for Patients With Heart Failure
Bozkurt, B., Fonarow, G. C., Goldberg, L. R., Guglin, M. E., Josephson, R., Forman, D. E., Lin, G., Lindenfeld, J. M., O’Connor, C., Panjrath, G. S., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.030 · Cited by 375
Forman, D. E., Arena, R., Boxer, R., Dolansky, M. A., Eng, J. J., Fleg, J. L., Haykowsky, M., Jahangir, A., Kaminsky, L. A., Kitzman, D. W., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000483 · Cited by 319
Zenith, L., Meena, N., Ramadi, A., Yavari, M., Harvey, A. K., Carbonneau, M., Ma, M. M., Abraldeṣ, J. G., Paterson, D. I., Haykowsky, M. J., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.016 · Cited by 241
Haykowsky, M. J., Tomczak, C. R., Scott, J. M., Paterson, D. I., & Kitzman, D. W. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00049.2015 · Cited by 195
Metadata
- Authors
- Esposito, F., Reese, V., Shabetai, R., Wagner, P. D., & Richardson, R. S.
- Affiliations
- University of Milan (IT)
- University of Utah (US)
- University of California San Diego (US)
- Corresponding author
- Esposito, Fabio
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 58
- Issue
- 13
- Pages
- 1353-1362
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC3180857
- OpenAlex
- W1948975945
- Cited by
- 175
- References
- 44
- Citations by year
- 2026: 13 · 2025: 6 · 2024: 10 · 2023: 11 · 2022: 15 · 2021: 18 · 2020: 13 · 2019: 17 · 2018: 11 · 2017: 13 · 2016: 13 · 2015: 12 · 2014: 9 · 2013: 6 · 2012: 7
- FWCI
- 19.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health, National Heart, Lung, and Blood Institute (HL 09183)
- Tobacco-Related Disease Research Program (15RT-0100)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- chronic heart failure, quadriceps, exercise capacity, oxygen transport, muscle capillarity, mitochondrial density, arteriovenous oxygen difference, exercise intolerance
- MeSH terms
- Biological Transport, Active, Biopsy, Blood Flow Velocity, Exercise Test, Follow-Up Studies, Cardiac Catheterization, Heart Failure, Humans, Male, Microscopy, Electron, Middle Aged, Mitochondria, Muscle, Oxygen, Oxygen Consumption, Severity of Illness Index, Stroke Volume, Exercise Tolerance, Disease Progression, Quadriceps Muscle
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
