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Cited by 324

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Fibroblast Growth Factor-23 and Death, Heart Failure, and Cardiovascular Events in Community-Living Individuals

Open access
Ix, Joachim H., Katz, Ronit, Kestenbaum, Bryan R., de Boer, Ian H., Chonchol, Michel, Mukamal, Kenneth J., Rifkin, Dena, Siscovick, David S., Sarnak, Mark J., Shlipak, Michael G.·2012·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2012.03.040
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Abstract

Objective To determine the associations of FGF23 with death, HF, and CVD and investigate the influence of CKD in a general community-living population. Background FGF23 increases renal phosphorus excretion and inhibits vitamin D activation. In ESRD, high FGF23 levels are associated with mortality. The associations of FGF23 with death, heart failure (HF), and cardiovascular disease (CVD) in teh general population are unknown. Methods Plasma FGF23 was measured in 3,107 community-living persons ≥ 65 years in 1996–97, and participants were followed through 2008. HF and CVD events were adjudicated by a panel of experts. Associations of FGF23 with each outcome were evaluated using Cox proportional hazards models, and we tested whether associations differed by CKD status. Results Both lower eGFR and higher urine ACR were associated with high FGF23 at baseline. During 10.5 years (median) follow-up, there were 1,730 deaths, 697 incident HF events, and 797 incident CVD events. Although high FGF23 concentrations were associated with each outcome in combined analyses, the associations were consistently stronger for those with CKD (P interactions all < 0.006). In the CKD group (n=1,128), the highest FGF23 quartile had adjusted hazards ratios (HR) of 1.87 (1.47, 2.38) for all-cause death, 1.94 (1.32, 2.83) for incident HF, and 1.49 (1.02, 2.18) for incident CVD events compared to the lowest quartile. Corresponding HRs in those without CKD (n=1,979) were 1.29 (1.05, 1.59), 1.37 (0.99, 1.89), and 1.07 (0.79, 1.45). Conclusions FGF23, a hormone involved in phosphorous and vitamin D homeostasis, is independently associated with all-cause death and incident HF in community-living older persons. These associations appear stronger in persons with CKD.

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Metadata

Authors
Ix, J. H., Katz, R., Kestenbaum, B. R., de Boer, I. H., Chonchol, M., Mukamal, K. J., Rifkin, D., Siscovick, D. S., Sarnak, M. J., & Shlipak, M. G.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2012-07
Volume
60
Issue
3
Pages
200-207
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2012.03.040
OpenAlex
W1803609188
Cited by
324
References
43
FWCI
25.96
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Fibroblast Growth Factor-23 and Death, Heart Failure, and Cardiovascular Events in Community-Living Individuals. https://app.cochat.ai/papers/10.1016/j.jacc.2012.03.040
The paper
Ix, J. H., Katz, R., Kestenbaum, B. R., de Boer, I. H., Chonchol, M., Mukamal, K. J., Rifkin, D., Siscovick, D. S., Sarnak, M. J., & Shlipak, M. G. (2012). Fibroblast Growth Factor-23 and Death, Heart Failure, and Cardiovascular Events in Community-Living Individuals. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2012.03.040

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.