Fibroblast Growth Factor 23 and Risk of Incident Stroke in Community-Living Adults
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Background and Purpose—: Fibroblast growth factor 23 (FGF23) is a hormone that regulates phosphorus and vitamin D metabolism. Elevated FGF23 concentrations are associated with excess risk of cardiovascular disease. Associations of FGF23 with stroke outcomes are less clear. Methods—: Using a case–cohort study design, we examined the association of baseline plasma FGF23 concentrations with incident stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a cohort of black and white adults aged ≥45 years. FGF23 was measured in 615 participants who developed incident stroke (cases) and in 936 participants randomly selected from the REGARDS cohort (comparison subcohort). Results—: In multivariable-adjusted models, higher calcium and phosphorus concentrations, lower estimated glomerular filtration rate and higher urine albumin excretion were independently associated with higher FGF23. There was no statistically significant association of FGF23 with risk of all-cause stroke in Cox models adjusted for demographic factors and established stroke risk factors (hazard ratio comparing fourth with first quartile 1.19; 95% confidence interval, 0.78–1.82). In prespecified models stratified by stroke subtypes, there was a graded association of FGF23 with risk of cardioembolic stroke in fully adjusted models (quartile 1, reference; quartile 2 hazard ratio, 1.48; 95% confidence interval, 0.63–3.47; quartile 3 hazard ratio, 1.99; 95% confidence interval, 0.89–4.44; quartile 4 hazard ratio, 2.52; 95% confidence interval, 1.08–5.91). There were no statistically significant associations of FGF23 with other ischemic stroke subtypes or with hemorrhagic strokes. Conclusions—: Higher FGF23 concentrations were associated with higher risk of cardioembolic but not with other stroke subtypes in community-dwelling adults. Additional studies should delineate reasons for these findings.
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In women aged <65 years with lone AF, the rate of thromboembolism varies widely, from 0.1-0.2% annual stroke risk in a Swedish study to 1.24/100 person-years in a Danish study.
“Notably, a nationwide register study of >120,000 individuals with AF in Denmark found a rate of thromboembolism as high as 1.24/100 person–years among women aged < 65 years with lone AF at 1-year follow-up.86 In contrast, however, a Swedish nationwide study of >140,000 individuals with AF showed that the annual stroke risk for women with AF who were aged <65 years was 0.1–0.2%.85”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [86]
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- Authors
- Panwar, B., Jenny, N. S., Howard, V. J., Wadley, V. G., Muntner, P., Kissela, B. M., Judd, S. E., & Gutiérrez, O. M.
- Affiliations
- University of Vermont (US)
- From the Departments of Medicine (B.P., V.G.W., P.M., O.M.G.), Epidemiology (V.J.H., P.M., O.M.G.), and Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Pathology, University of Vermont, Burlington (N.S.J.); and Department of Neurology, University of Cincinnati, OH (B.M.K.).
- Venue
- Stroke
- Published
- 2015-02
- Volume
- 46
- Issue
- 2
- Pages
- 322-328
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC4308535
- OpenAlex
- W2043955249
- Cited by
- 65
- References
- 38
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 7 · 2015: 8
- FWCI
- 7.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR001425, UL1TR000077)
- National Institute of Diabetes and Digestive and Kidney Diseases (R03DK095005)
- National Institute of Neurological Disorders and Stroke (U01NS041588, R01NS041588, R01NS080850)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Keywords
- fibroblast growth factor 23, incident stroke, cardioembolic stroke, ischemic stroke subtypes, hemorrhagic stroke, phosphorus metabolism, vitamin D metabolism, calcium, estimated glomerular filtration rate, urinary albumin excretion, REGARDS study, community-dwelling adults
- MeSH terms
- Fibroblast Growth Factor-23, Aged, Aged, 80 and over, Female, Fibroblast Growth Factors, Humans, Male, Middle Aged, Population Surveillance, Risk Factors, Cohort Studies, Biomarkers, Incidence, Stroke
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