Cited by 212Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

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Subclinical Hypothyroidism Is Associated With Increased Risk for All-Cause and Cardiovascular Mortality in Adults

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Tseng, Fen-Yu, Lin, Wen-Yuan, Lin, Cheng-Chieh, Lee, Long-Teng, Li, Tsai-Chung, Sung, Pei-Kun, Huang, Kuo-Chin·2012·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2012.03.047

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Abstract

Objectives This study sought to evaluate the relationship between subclinical hypothyroidism (SCH) and all-cause and cardiovascular disease (CVD) mortality.Background SCH may increase the risks of hypercholesterolemia and atherosclerosis. The associations between SCH and all-cause or CVD mortality are uncertain, on the basis of the results of previous studies.Methods A baseline cohort of 115,746 participants without a history of thyroid disease, ≥20 years of age, was recruited in Taiwan. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.0 to 19.96 mIU/l with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47 to 4.9 mIU/l. Cox proportional hazards regression analysis was used to estimate the relative risks (RRs) of death from all-cause and CVD for adults with SCH during a 10-year follow-up period.Results There were 3,669 deaths during the follow-up period; 680 deaths were due to CVD. Compared with subjects with euthyroidism, after adjustment for age, sex, body mass index, diabetes, hypertension, dyslipidemia, smoking, alcohol consumption, betel nut chewing, physical activity, income, and education level, the RRs (95% confidence interval) of deaths from all-cause and CVD among subjects with SCH were 1.30 (1.02 to 1.66), and 1.68 (1.02 to 2.76), respectively.Conclusions Adult Taiwanese with SCH had an increased risk for all-cause mortality and CVD death.

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The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033
Serum TSH, T 4 , and Thyroid Antibodies in the United States Population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279
The Colorado Thyroid Disease Prevalence Study
Canaris, G. J., Manowitz, N. R., Mayor, G., & Ridgway, E. C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.526 · Cited by 2,824
THE SPECTRUM OF THYROID DISEASE IN A COMMUNITY: THE WHICKHAM SURVEY
Tunbridge, W. M. G., Evered, D. C., Hall, R., Appleton, D. R., BREWIS, M., CLARK, F., Evans, J. G., Young, E. T., Bird, T., & Smith, P. (1977) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1977.tb01340.x · Cited by 2,665
Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management
Surks, M. I., Ortiz, E., Daniels, G. H., Sawin, C. T., Col, N. F., Cobin, R. H., Franklyn, J. A., Hershman, J. M., Burman, K. D., Denke, M. A., et al. (2004) · JAMA · doi:10.1001/jama.291.2.228 · Cited by 1,800
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study
Hak, A. E., Pols, H. A. P., Visser, T. J., Drexhage, H. A., Hofman, A., & Witteman, J. C. M. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-132-4-200002150-00004 · Cited by 1,336
Thyroid Disease and the Heart
Klein, I., & Danzi, S. (2007) · Circulation · doi:10.1161/circulationaha.106.678326 · Cited by 1,324
Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality
Rodondi, N., den Elzen, W. P. J., Bauer, D. C., Cappola, A. R., Razvi, S., Walsh, J. P., Åsvold, B. O., Iervasi, G., Imaizumi, M., Collet, T.-H., et al. (2010) · JAMA · doi:10.1001/jama.2010.1361 · Cited by 1,216
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Gussekloo, J. (2004) · JAMA · doi:10.1001/jama.292.21.2591 · Cited by 899

Show all 52 references

Research works printed but not linked: 1

Chen, 1976, Studies on the effect of salt iodization on endemic goiter, Taiwan, J Formos Med Assoc, 75, 471

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Sohn, S. Y., Seo, G. H., & Chung, J. H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.680647 · Cited by 21
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Li, J., Li, Y., Shi, X., Teng, D., Teng, X., Teng, W., & Shan, Z. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-064613 · Cited by 17
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Holley, M., Razvi, S., Farooq, M. S., Dew, R., Maxwell, I., & Wilkes, S. (2024) · Systematic Reviews · doi:10.1186/s13643-024-02548-7 · Cited by 17
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Aksoy, N., Yeler, M. T., Ayan, N. N., Özkeskin, A., Özkan, Z., & Serin, O. (2015) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.316.7560 · Cited by 15
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Mazur, P. K., Sokołowski, G., Hubalewska–Dydejczyk, A., Płaczkiewicz‐Jankowska, E., & Undas, A. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.05.041 · Cited by 17
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Tsou, M.-T. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab028 · Cited by 13
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Inoue, K., Guo, R., Lee, M. L., Neverova, N. V., Ebrahimi, R., Currier, J. W., Bashir, M. T., & Leung, A. M. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.030511 · Cited by 13
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Aldossari, K. K., Al-Ghamdi, S. H., Alzahrani, J. M., Jammah, A. A., Alanazi, B. G., Albriek, A. Z., & Alanazi, M. A. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22983 · Cited by 12
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Krysiak, R. G., Gilowski, W., Szkróbka, W., & Okopień, B. (2014) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12095 · Cited by 12
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Wu, K., Zhao, M., Ma, C., Zhang, H., Liu, X., Zhou, L., Zhao, J., Gao, L., & Wang, D. (2016) · Scandinavian Journal of Immunology · doi:10.1111/sji.12507 · Cited by 12
Serum H-FABP levels in patients with hypothyroidism
Güneş, F., Aşık, M., Temız, A., Vural, A., Şen, H., Binnetoğlu, E., Bozkurt, N., Tekeli, Z., Erbağ, G., Ükinç, K., et al. (2014) · Wiener klinische Wochenschrift · doi:10.1007/s00508-014-0612-7 · Cited by 11
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Tuliani, T. A., Shenoy, M. H., Belgrave, K., Deshmukh, A. J., Pant, S., Hilliard, A. A., & Afonso, L. (2017) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.04.022 · Cited by 10
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Authors: Tseng, F.-Y., Lin, W.-Y., Lin, C.-C., Lee, L.-T., Li, T.-C., Sung, P.-K., & Huang, K.-C.
Affiliations: National Taiwan University (TW)
China Medical University (TW)
Asia University (TW)
National Taiwan University Hospital (TW)
Corresponding author: Huang, Kuo-Chin
ORCID: Tseng, Fen-Yu
Lin, Wen-Yuan
Lin, Cheng-Chieh
Lee, Long-Teng
Li, Tsai-Chung
Huang, Kuo-Chin
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2012-08
Volume: 60
Issue: 8
Pages: 730-737
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2012.03.047
OpenAlex: W2081641269
Cited by: 212
References: 52
Citations by year: 2026: 5 · 2025: 7 · 2024: 30 · 2023: 15 · 2022: 15 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 17 · 2017: 12 · 2016: 15 · 2015: 18 · 2014: 23 · 2013: 19 · 2012: 1
FWCI: 15.52
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 428 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: Taiwan Department of Health Clinical Trial and Research Center (DOH101-TD-B-111-004)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: subclinical hypothyroidism, all-cause mortality, cardiovascular mortality, thyroid-stimulating hormone, euthyroidism, cardiovascular disease, hypercholesterolemia, atherosclerosis, Taiwanese adults
MeSH terms: Adult, Age Factors, Aged, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Hyperlipidemias, Hypertension, Hypothyroidism, Male, Middle Aged, Surveys and Questionnaires, Research Design, Risk Factors, Sex Factors, Taiwan, Thyrotropin, Cohort Studies, Biomarkers, Body Mass Index, Proportional Hazards Models, Diabetes Complications

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Subclinical Hypothyroidism Is Associated With Increased Risk for All-Cause and Cardiovascular Mortality in Adults

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