CoChat
Sign Up
Cited by 177Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies

Moon, Shinje, Kim, Min Joo, Yu, Jae Myung, Yoo, Hyung Joon, Park, Young Joo·2018·Thyroid
DOI 10.1089/thy.2017.0414
Open this paper in CoChat — free account

Abstract

Objectives: To determine the impact of subclinical hypothyroidism (SCH) on the risk of cardiovascular disease (CVD) and all-cause mortality, a comprehensive meta-analysis was performed according to the age or coexisting CVD risk status of the participants. Methods: Studies regarding the association of SCH with all-cause mortality from PubMed and Embase databases were included. The pooled relative risk (RR) of CVD and all-cause mortality was calculated using the Mantel–Haenszel method. A subgroup analysis of participants with high CVD risk was conducted, including history of coronary, cerebral, or peripheral artery disease; dilated cardiomyopathy; heart failure; atrial fibrillation; venous thromboembolism; diabetes mellitus; or chronic kidney disease. Results: In total, 35 eligible articles incorporating 555,530 participants were included. SCH was modestly associated with CVD and all-cause mortality (RR for CVD = 1.33 [confidence interval (CI) 1.14–1.54]; RR for all-cause mortality = 1.20 [CI 1.07–1.34]). However, the association was not observed in participants aged ≥65 years. Subgroup analysis showed that participants with SCH and high CVD risk showed a significantly higher risk of all-cause mortality (RR for CVD = 2.20 [CI 1.28–3.77]; RR for all-cause mortality = 1.66 [CI 1.41–1.94]), whereas those with SCH and low CVD risk did not. Additional subgroup analysis of six studies with a mean participant age of ≥65 years and high CVD risk showed a significant high risk of all-cause mortality in the SCH group (RR = 1.41 [CI 1.08–1.85]; I2 = 0%). Conclusions: SCH is associated with an increased CVD risk and all-cause mortality, particularly in participants with high CVD risk.

Integrity signals

Registry

Crossref · 10.1089/thy.2017.0414

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The relationship between subclinical hypothyroidism and overall mortality is conflicting, although the two meta-analyses with larger number of studies suggest increased risk in younger subjects.

    “The relationship between SC-HT and overall mortality is more conflicting although the two meta-analyses [11, 25] which considered a larger number of studies suggest an increased risk in younger subjects (Fig. 1, Panels A and C).”

    From Thyroid and heart, a clinically relevant relationship (2021) · cites this paper as [25]

  • The association between subclinical hypothyroidism and increased risk of MACE was significant only for younger subjects (<65 years) with higher cardiovascular risk, unlike older individuals (>65 years).

    “Furthermore, the association between SC-HT and increased risk of MACE was found to be significant only for younger subjects (< 65 years) with a higher CV risk, unlike older individuals (> 65 years) (Fig. 1, Panel B) [25].”

    From Thyroid and heart, a clinically relevant relationship (2021) · cites this paper as [25]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Moon, S., Kim, M. J., Yu, J. M., Yoo, H. J., & Park, Y. J.
Affiliations
  • Hallym University (KR)
  • Seoul National University (KR)
Corresponding author
Park, Young Joo
ORCID
Venue
Thyroid
Publisher
SAGE Publications
Published
2018-09
Volume
28
Issue
9
Pages
1101-1110
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
DOI
10.1089/thy.2017.0414
OpenAlex
W2811575556
Cited by
175
References
64
Citations by year
2026: 12 · 2025: 16 · 2024: 22 · 2023: 47 · 2022: 17 · 2021: 25 · 2020: 25 · 2019: 9 · 2018: 2
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Thyroid (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, cardiovascular disease, all-cause mortality, cardiovascular risk, older adults, high cardiovascular risk, thyroid function
MeSH terms
Aged, Cardiovascular Diseases, Female, Humans, Hypothyroidism, Male, Middle Aged, Prognosis, Prospective Studies, Risk, Incidence, Survival Rate, Seveso Accidental Release

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review