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Cited by 212Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryHormonal and reproductive studies

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Subclinical Hypothyroidism Is Associated With Increased Risk for All-Cause and Cardiovascular Mortality in Adults

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Tseng, Fen-Yu, Lin, Wen-Yuan, Lin, Cheng-Chieh, Lee, Long-Teng, Li, Tsai-Chung, Sung, Pei-Kun, Huang, Kuo-Chin·2012·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2012.03.047
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Abstract

Objectives This study sought to evaluate the relationship between subclinical hypothyroidism (SCH) and all-cause and cardiovascular disease (CVD) mortality.Background SCH may increase the risks of hypercholesterolemia and atherosclerosis. The associations between SCH and all-cause or CVD mortality are uncertain, on the basis of the results of previous studies.Methods A baseline cohort of 115,746 participants without a history of thyroid disease, ≥20 years of age, was recruited in Taiwan. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.0 to 19.96 mIU/l with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47 to 4.9 mIU/l. Cox proportional hazards regression analysis was used to estimate the relative risks (RRs) of death from all-cause and CVD for adults with SCH during a 10-year follow-up period.Results There were 3,669 deaths during the follow-up period; 680 deaths were due to CVD. Compared with subjects with euthyroidism, after adjustment for age, sex, body mass index, diabetes, hypertension, dyslipidemia, smoking, alcohol consumption, betel nut chewing, physical activity, income, and education level, the RRs (95% confidence interval) of deaths from all-cause and CVD among subjects with SCH were 1.30 (1.02 to 1.66), and 1.68 (1.02 to 2.76), respectively.Conclusions Adult Taiwanese with SCH had an increased risk for all-cause mortality and CVD death.

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  1. Chen, 1976, Studies on the effect of salt iodization on endemic goiter, Taiwan, J Formos Med Assoc, 75, 471

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Metadata

Authors
Tseng, F.-Y., Lin, W.-Y., Lin, C.-C., Lee, L.-T., Li, T.-C., Sung, P.-K., & Huang, K.-C.
Affiliations
  • National Taiwan University (TW)
  • China Medical University (TW)
  • Asia University (TW)
  • National Taiwan University Hospital (TW)
Corresponding author
Huang, Kuo-Chin
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2012-08
Volume
60
Issue
8
Pages
730-737
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2012.03.047
OpenAlex
W2081641269
Cited by
212
References
52
Citations by year
2026: 5 · 2025: 7 · 2024: 30 · 2023: 15 · 2022: 15 · 2021: 10 · 2020: 12 · 2019: 13 · 2018: 17 · 2017: 12 · 2016: 15 · 2015: 18 · 2014: 23 · 2013: 19 · 2012: 1
FWCI
15.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Taiwan Department of Health Clinical Trial and Research Center (DOH101-TD-B-111-004)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
subclinical hypothyroidism, all-cause mortality, cardiovascular mortality, thyroid-stimulating hormone, euthyroidism, cardiovascular disease, hypercholesterolemia, atherosclerosis, Taiwanese adults
MeSH terms
Adult, Age Factors, Aged, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Hyperlipidemias, Hypertension, Hypothyroidism, Male, Middle Aged, Surveys and Questionnaires, Research Design, Risk Factors, Sex Factors, Taiwan, Thyrotropin, Cohort Studies, Biomarkers, Body Mass Index, Proportional Hazards Models, Diabetes Complications

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