Paravalvular Leak After Transcatheter Aortic Valve Replacement
Open accessAbstract
Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of methods for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.
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The most notable complication of TAVR has been paravalvular aortic regurgitation.
“The most notable has been paravalvular aortic regurgitation234–236.”
From Calcific aortic stenosis (2016) · cites this paper as [235]
The association between moderate or severe paravalvular aortic regurgitation and increased mortality is clearly established.
“The association between moderate or severe paravalvular aortic regurgitation and increased mortality has been clearly established”
From Calcific aortic stenosis (2016) · cites this paper as [235]
Some studies suggest that the adverse association between paravalvular aortic regurgitation and mortality extends to mild regurgitation.
“with some studies even suggesting that this adverse association extends to mild regurgitation235;237;238.”
From Calcific aortic stenosis (2016) · cites this paper as [235]
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Flagged first, then by citations
Research works printed but not linked: 4
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- [65]65. Schultz CJ, Weustink A, Piazza N, et al. Geometry and degree of apposition of the CoreValve revalving system with multislice com- 1135 JACC Vol. 61, No. 11, 2013
- [66]66. Généreux et al. March 19, 2013:1125-36 Paravalvular Leak After TAVR puted tomography after implantation in patients with aortic stenosis. J Am Coll Cardiol 2009;54:911-8.
- [74]74. Vavuranakis M, Vrachatis D, Stefanadis C. CoreValve aortic biopros- thesis: repositioning techniques. J Am Coll Cardiol Intv 2010;3: 565-6.
Cited by
Sorted by citations
Popma, J. J., Adams, D. H., Reardon, M. J., Yakubov, S. J., Kleiman, N. S., Heimansohn, D., Hermiller, J., Hughes, G. C., Harrison, J. K., Coselli, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.556 · Cited by 1,040 · see citing works
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Self-citationPerioperative Results and Complications in 15,964 Transcatheter Aortic Valve Replacements
Walther, T., Hamm, C. W., Schuler, G., Berkowitsch, A., Kötting, J., Mangner, N., Mudra, H., Beckmann, A., Cremer, J., Welz, A., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.03.034 · Cited by 402 · see citing works
Ripley, B., Kelil, T., Cheezum, M. K., Goncalves, A., Di Carli, M. F., Rybicki, F. J., Steigner, M., Mitsouras, D., & Blankstein, R. (2016) · Journal of Cardiovascular Computed Tomography · doi:10.1016/j.jcct.2015.12.004 · Cited by 205 · see citing works
- Authors
- Généreux, P., Head, S. J., Hahn, R., Daneault, B., Kodali, S., Williams, M. R., van Mieghem, N. M., Alu, M. C., Serruys, P. W., Kappetein, A. P., & Leon, M. B.
- Affiliations
- NewYork–Presbyterian Hospital (US)
- Erasmus MC (NL)
- Corresponding author
- Leon, Martin B.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 61
- Issue
- 11
- Pages
- 1125-1136
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2125431183
- Cited by
- 447
- References
- 96
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 18 · 2023: 18 · 2022: 20 · 2021: 23 · 2020: 28 · 2019: 34 · 2018: 39 · 2017: 42 · 2016: 38 · 2015: 64 · 2014: 60 · 2013: 30 · 2012: 1
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Edwards Lifesciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Keywords
- paravalvular leak, transcatheter aortic valve implantation, aortic valve disease, post-TAVR complications, late mortality
- MeSH terms
- Aortic Valve, Cardiac Catheterization, Heart Valve Prosthesis, Humans, Postoperative Complications, Prosthesis Design, Heart Valve Prosthesis Implantation
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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