Cited by 447Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesInfective Endocarditis Diagnosis and Management

Paravalvular Leak After Transcatheter Aortic Valve Replacement

Open access
Généreux, Philippe, Head, Stuart J., Hahn, Rebecca, Daneault, Benoit, Kodali, Susheel, Williams, Mathew R., van Mieghem, Nicolas M., Alu, Maria C. +3 more·2013·Journal of the American College of Cardiology

Abstract

Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of methods for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.

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Crossref · 10.1016/j.jacc.2012.08.1039

Cites

96 of 96 references verified0 citation errors · 0 not checkable

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  • The most notable complication of TAVR has been paravalvular aortic regurgitation.

    “The most notable has been paravalvular aortic regurgitation234–236.”

    From Calcific aortic stenosis (2016) · cites this paper as [235]

  • The association between moderate or severe paravalvular aortic regurgitation and increased mortality is clearly established.

    “The association between moderate or severe paravalvular aortic regurgitation and increased mortality has been clearly established”

    From Calcific aortic stenosis (2016) · cites this paper as [235]

  • Some studies suggest that the adverse association between paravalvular aortic regurgitation and mortality extends to mild regurgitation.

    “with some studies even suggesting that this adverse association extends to mild regurgitation235;237;238.”

    From Calcific aortic stenosis (2016) · cites this paper as [235]

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Research works printed but not linked: 4

  1. [24]24. Webb JG, Altwegg L, Boone RH, et al. Transcatheter aortic valve implantation: impact on clinical and valve-related outcomes. Circula- tion 2009;119:3009 -16.
  2. [65]65. Schultz CJ, Weustink A, Piazza N, et al. Geometry and degree of apposition of the CoreValve revalving system with multislice com- 1135 JACC Vol. 61, No. 11, 2013
  3. [66]66. Généreux et al. March 19, 2013:1125-36 Paravalvular Leak After TAVR puted tomography after implantation in patients with aortic stenosis. J Am Coll Cardiol 2009;54:911-8.
  4. [74]74. Vavuranakis M, Vrachatis D, Stefanadis C. CoreValve aortic biopros- thesis: repositioning techniques. J Am Coll Cardiol Intv 2010;3: 565-6.

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Authors
Généreux, P., Head, S. J., Hahn, R., Daneault, B., Kodali, S., Williams, M. R., van Mieghem, N. M., Alu, M. C., Serruys, P. W., Kappetein, A. P., & Leon, M. B.
Affiliations
  • NewYork–Presbyterian Hospital (US)
  • Erasmus MC (NL)
Corresponding author
Leon, Martin B.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2013-03
Volume
61
Issue
11
Pages
1125-1136
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2125431183
Cited by
447
References
96
Citations by year
2026: 14 · 2025: 18 · 2024: 18 · 2023: 18 · 2022: 20 · 2021: 23 · 2020: 28 · 2019: 34 · 2018: 39 · 2017: 42 · 2016: 38 · 2015: 64 · 2014: 60 · 2013: 30 · 2012: 1
FWCI
10.91
Type
journal article
Language
en
Open access
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders
Edwards Lifesciences
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
  • Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Keywords
paravalvular leak, transcatheter aortic valve implantation, aortic valve disease, post-TAVR complications, late mortality
MeSH terms
Aortic Valve, Cardiac Catheterization, Heart Valve Prosthesis, Humans, Postoperative Complications, Prosthesis Design, Heart Valve Prosthesis Implantation

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