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A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Open accessAbstract
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial signaling were shown to be specifically altered in heart failure with preserved ejection fraction (HFPEF). A new paradigm for HFPEF development is therefore proposed, which identifies a systemic proinflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations. The new paradigm presumes the following sequence of events in HFPEF: 1) a high prevalence of comorbidities such as overweight/obesity, diabetes mellitus, chronic obstructive pulmonary disease, and salt-sensitive hypertension induce a systemic proinflammatory state; 2) a systemic proinflammatory state causes coronary microvascular endothelial inflammation; 3) coronary microvascular endothelial inflammation reduces nitric oxide bioavailability, cyclic guanosine monophosphate content, and protein kinase G (PKG) activity in adjacent cardiomyocytes; 4) low PKG activity favors hypertrophy development and increases resting tension because of hypophosphorylation of titin; and 5) both stiff cardiomyocytes and interstitial fibrosis contribute to high diastolic left ventricular (LV) stiffness and heart failure development. The new HFPEF paradigm shifts emphasis from LV afterload excess to coronary microvascular inflammation. This shift is supported by a favorable Laplace relationship in concentric LV hypertrophy and by all cardiac chambers showing similar remodeling and dysfunction. Myocardial remodeling in HFPEF differs from heart failure with reduced ejection fraction, in which remodeling is driven by loss of cardiomyocytes. The new HFPEF paradigm proposes comorbidities, plasma markers of inflammation, or vascular hyperemic responses to be included in diagnostic algorithms and aims at restoring myocardial PKG activity.
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“The lessened secretion of inflammatory adipocytokines might act to alleviate coronary endothelial inflammation with secondary beneficial effects on microvascular rarefaction and myocardial fibrosis, 2 important mechanisms in the pathogenesis of HFpEF.46–48”
From Effects of Tirzepatide on the Clinical Trajectory of Patients With Heart Failure, Preserved Ejection Fraction, and Obesity (2025) · cites this paper as [48]
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“Obesity and diabetes create a pro-inflammatory state and promote endothelial and coronary microvascular dysfunction. 1,7,8”
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“Obesity, diabetes, and HF result in pro-inflammatory states, 7,31-34 and each are risk factors for infectious disease complications, an important cause of morbidity and mortality in these patient groups.”
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“Inflammation due to sarcopenic obesity results in reduced NO, cyclic guanosine monophosphate (cGMP), and protein kinase G (PKG) activity in cardiomyocytes, leading to LV hypertrophy and stiffness [120].”
From Sarcopenic obesity, insulin resistance, and their implications in cardiovascular and metabolic consequences (2020) · cites this paper as [120]
In the citing paper
“Inhibition of systemic metabolic inflammation with glucose-lowering drugs is thought to enhance endothelial and cardiomyocyte function”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [70]
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“Indirectly, through a paracrine endothelial signaling, hyperglycemia causes a mitochondrial hyper-production of superoxide, with impaired activation of endothelial nitric oxide synthase.”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [67]
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“As a result, the impaired bioavailability in nitric oxide impairs its downstream cGMP protein kinase G (PKG) pathway in cardiomyocytes which become hypertrophied and stiffened [65,67].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [67]
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Cites
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886
Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure
Cohn, J. N., Archibald, D. G., Ziesche, S., Franciosa, J. A., Harston, W. E., Tristani, F. E., Dunkman, W. B., Jacobs, W., Francis, G. S., Flohr, K. H., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198606123142404 · Cited by 2,400
Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure
Taylor, A. L., Ziesche, S., Yancy, C., Carson, P., D'Agostino, R., Ferdinand, K., Taylor, M., Adams, K., Sabolinski, M., Worcel, M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042934 · Cited by 1,773
Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
Ganau, A., Devereux, R. B., Roman, M. J., SIMONE, G. D., Pickering, T. G., Saba, P. S., Vargiu, P., Simongini, I., & LARAGH, J. H. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90617-v · Cited by 1,594
Zile, M. R., Baicu, C. F., & Gaasch, W. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032566 · Cited by 1,577
Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
Lam, C. S. P., Roger, V. L., Rodeheffer, R. J., Borlaug, B. A., Enders, F., & Redfield, M. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.051 · Cited by 1,345
Torre-Amione, G., Kapadia, S., Benedict, C., Oral, H., Young, J. B., & Mann, D. L. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00589-7 · Cited by 1,211
Solomon, S. D., Zile, M. R., Pieske, B. M., Voors, A. A., Shah, A. M., Kraigher‐Krainer, E., Shi, V. C., Bransford, T. L., Takeuchi, M., Gong, J., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61227-6 · Cited by 1,171
GISSI-HF investigators (2008) · The Lancet · doi:10.1016/s0140-6736(08)61240-4 · Cited by 1,106
Yancy, C. W., Lopatin, M., Stevenson, L. W., De Marco, T., & Fonarow, G. C. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.09.022 · Cited by 927
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Takimoto, E., Champion, H. C., Li, M., Belardi, D. F., Ren, S. V., Rodríguez, E. R., Bedja, D., Gabrielson, K. L., Wang, Y., & Kass, D. A. (2005) · Nature Medicine · doi:10.1038/nm1175 · Cited by 902
The Progression of Hypertensive Heart Disease
Drazner, M. H. (2011) · Circulation · doi:10.1161/circulationaha.108.845792 · Cited by 844
Trends in Patients Hospitalized With Heart Failure and Preserved Left Ventricular Ejection Fraction
Steinberg, B. A., Zhao, X., Heidenreich, P. A., Peterson, E. D., Bhatt, D. L., Cannon, C. P., Hernandez, A. F., & Fonarow, G. C. (2012) · Circulation · doi:10.1161/circulationaha.111.080770 · Cited by 776
Global Cardiovascular Reserve Dysfunction in Heart Failure With Preserved Ejection Fraction
Borlaug, B. A., Olson, T. P., Lam, C. S. P., Flood, K. S., Lerman, A., Johnson, B. D., & Redfield, M. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.077 · Cited by 733
van Heerebeek, L., Hamdani, N., Handoko, M. L., Falcao-Pires, I., Musters, R. J., Kupreishvili, K., Ijsselmuiden, A. J. J., Schalkwijk, C. G., Bronzwaer, J. G. F., Diamant, M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.728550 · Cited by 723
Self-citationBrutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
Ather, S., Chan, W., Bozkurt, B., Aguilar, D. A., Ramasubbu, K., Zachariah, A., Wehrens, X. H. T., & Deswal, A. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.11.040 · Cited by 692
Edelmann, F., Gelbrich, G., Düngen, H., Fröhling, S., Wachter, R., Stahrenberg, R., Binder, L., Töpper, A., Lashki, D. J., Schwarz, S., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.054 · Cited by 677
Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure
van Heerebeek, L., Borbély, A., Niessen, H. W. M., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Linke, W. A., Laarman, G. J., & Paulus, W. J. (2006) · Circulation · doi:10.1161/circulationaha.105.587519 · Cited by 655
Self-citationWestermann, D., Lindner, D., Kasner, M., Zietsch, C., Savvatis, K., Escher, F., von Schlippenbach, J., Skurk, C., Steendijk, P., Riad, A., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.931451 · Cited by 644
Self-citationAltered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus
Shenouda, S. M., Widlansky, M. E., Chen, K., Xu, G., Holbrook, M., Tabit, C. E., Hamburg, N. M., Frame, A. A., Caiano, T. L., Kluge, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.014506 · Cited by 570
Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
Guazzi, M., Vicenzi, M., Arena, R. A., & Guazzi, M. D. (2011) · Circulation · doi:10.1161/circulationaha.110.983866 · Cited by 556
Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction
van Heerebeek, L., Hamdani, N., Falcão‐Pires, I., Leite-Moreira, A. F., Begieneman, M. P. V., Bronzwaer, J. G. F., van der Velden, J., Stienen, G. J. M., Laarman, G. J., Somsen, G. A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.076075 · Cited by 545
Self-citationCardiomyocyte stiffness in diastolic heart failure
Borbély, A., van der Velden, J., Papp, Z., Bronzwaer, J. G. F., Edes, I., Stienen, G. J. M., & Paulus, W. J. (2005) · Circulation · doi:10.1161/01.cir.0000155257.33485.6d · Cited by 536
Self-citationZile, M. R., Gottdiener, J. S., Hetzel, S. J., McMurray, J. J., Komajda, M., McKelvie, R., Baicu, C. F., Massie, B. M., & Carson, P. E. (2011) · Circulation · doi:10.1161/circulationaha.110.011031 · Cited by 517
Calderone, A., Thaik, C. M., Takahashi, N., Chang, D. L. F., & Colucci, W. S. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119883 · Cited by 489
Inflammatory Markers and Incident Heart Failure Risk in Older Adults
Kalogeropoulos, A., Georgiopoulou, V., Psaty, B. M., Rodondi, N., Smith, A. L., Harrison, D. G., Liu, Y., Hoffmann, U., Bauer, D. C., Newman, A. B., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.045 · Cited by 478
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430
Left Ventricular Structural Remodeling in Health and Disease
Gaasch, W. H., & Zile, M. R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.022 · Cited by 430
Krüger, M., Kötter, S., Grützner, A., Lang, P. M., Andresen, C., Redfield, M. M., Butt, E., dos Remedios, C. G., & Linke, W. A. (2008) · Circulation Research · doi:10.1161/circresaha.108.184408 · Cited by 408
Guazzi, M., Vicenzi, M., Arena, R. A., & Guazzi, M. D. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.944694 · Cited by 382
Borbély, A., Falcão‐Pires, I., van Heerebeek, L., Hamdani, N., Edes, I. F., Gavina, C., Leite-Moreira, A. F., Bronzwaer, J. G. F., Papp, Z., van der Velden, J., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.193326 · Cited by 369
Self-citationHaass, M., Kitzman, D. W., Anand, I. S., Miller, A., Zile, M. R., Massie, B. M., & Carson, P. E. (2011) · Circulation: Heart Failure · doi:10.1161/circheartfailure.110.959890 · Cited by 366
Haykowsky, M. J., Brubaker, P. H., Stewart, K. P., Morgan, T. M., Eggebeen, J., & Kitzman, D. W. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.02.055 · Cited by 358
Phan, T. T., Abozguia, K., Shivu, G. N., Mahadevan, G., Ahmed, I., Williams, L. K., Dwivedi, G., Patel, K., Paul Steendijk, A., Ashrafian, H., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.012 · Cited by 339
Effects of Vasodilation in Heart Failure With Preserved or Reduced Ejection Fraction
Schwartzenberg, S., Redfield, M. M., From, A. M., Sorajja, P., Nishimura, R. A., & Borlaug, B. A. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.09.062 · Cited by 330
Kašner, M., Westermann, D., López, B., Gaub, R., Escher, F., Kühl, U., Schultheiß, H., & Tschöpe, C. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.024 · Cited by 330
Self-citationLam, C. S. P., Lyass, A., Kraigher‐Krainer, E., Massaro, J. M., Lee, D. S., Ho, J. E., Levy, D. A., Redfield, M. M., Pieske, B. M., Benjamin, E. J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.979203 · Cited by 317
Statin Therapy May Be Associated With Lower Mortality in Patients With Diastolic Heart Failure
Fukuta, H., Sane, D. C., Brucks, S., & Little, W. C. (2005) · Circulation · doi:10.1161/circulationaha.104.519876 · Cited by 298
Thenappan, T., Shah, S. J., Gomberg-Maitland, M., Collander, B., Vallakati, A., Shroff, P., & Rich, S. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.958801 · Cited by 289
Akiyama, E., Sugiyama, S., Matsuzawa, Y., Konishi, M., Suzuki, H., Nozaki, T., Ohba, K., Matsubara, J., Maeda, H., Horibata, Y., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.036 · Cited by 283
PKC Phosphorylation of Titin’s PEVK Element
Hidalgo, C. G., Hudson, B. D., Bogomolovas, J., Zhu, Y., Anderson, B., Greaser, M. L., Labeit, S., & Granzier, H. L. M. (2009) · Circulation Research · doi:10.1161/circresaha.109.198465 · Cited by 263
LeWinter, M. M., & Granzier, H. L. M. (2010) · Circulation · doi:10.1161/circulationaha.109.860171 · Cited by 260
Tschöpe, C., Bock, C. –., Kasner, M., Noutsias, M., Westermann, D., Schwimmbeck, P. L., Pauschinger, M., Poller, W. C., Kühl, U., Kandolf, R., et al. (2005) · Circulation · doi:10.1161/01.cir.0000155615.68924.b3 · Cited by 258
Self-citationCirculating Biomarkers of Collagen Metabolism in Cardiac Diseases
López, B., González, A., & Dı́ez, J. (2010) · Circulation · doi:10.1161/circulationaha.109.912774 · Cited by 258
Vascular Inflammation in Obesity and Sleep Apnea
Jelić, S., Lederer, D. J., Adams, T., Padeletti, M., Colombo, P. C., Factor, P. H., & Jemtel, T. H. L. (2010) · Circulation · doi:10.1161/circulationaha.109.900357 · Cited by 255
Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
Silberman, G. A., Fan, T. M., Liu, H., Jiao, Z., Xiao, H., Lovelock, J. D., Boulden, B. M., Widder, J. D., Fredd, S., Bernstein, K. E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.883777 · Cited by 254
Anand, I. S., Rector, T. S., Cleland, J. G. F., Kuskowski, M. A., McKelvie, R. S., Persson, H., McMurray, J. J. V., Zile, M. R., Michel Komajda, N., Massie, B. M., et al. (2011) · Circulation Heart Failure · doi:10.1161/circheartfailure.111.962654 · Cited by 249
Inflammation and metabolic dysfunction: links to cardiovascular diseases
Taube, A., Schlich, R., Sell, H., Eckardt, K., & Eckel, J. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00907.2011 · Cited by 246
Falcão‐Pires, I., Hamdani, N., Borbély, A., Gavina, C., Schalkwijk, C. G., van der Velden, J., van Heerebeek, L., Stienen, G. J. M., Niessen, H. W. M., Leite-Moreira, A. F., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.025270 · Cited by 239
Self-citationTreatment of Heart Failure With Normal Ejection Fraction
Paulus, W. J., & van Ballegoij, J. J. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.06.067 · Cited by 236
Self-citationMcMurray, J. J. V., Carson, P. E., Michel Komajda, N., McKelvie, R. S., Zile, M. R., Ptaszynska, A., Staiger, C., Donovan, J. M., & Massie, B. M. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.12.010 · Cited by 223
Antoniades, C., Bakogiannis, C., Leeson, P., Guzik, T. J., Zhang, M.-H., Tousoulis, D., Antonopoulos, A. S., Demosthenous, M., Marinou, K., Hale, A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.985150 · Cited by 219
Collier, P. H., Watson, C. J., Voon, V., Phelan, D. M. J., Jan, A., Mak, G. J., Martos, R., Baugh, J. A., Ledwidge, M. T., & McDonald, K. (2011) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfr079 · Cited by 213
Mohammed, S. F., Borlaug, B. A., Roger, V. L., Mirzoyev, S. A., Rodeheffer, R. J., Chirinos, J. A., & Redfield, M. M. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.968594 · Cited by 213
Stritzke, J., Markus, M. R. P., Duderstadt, S., Lieb, W., Luchner, A., Döring, A., Keil, U., Hense, H., & Schunkert, H. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.034 · Cited by 205
Davis, B. R., Kostis, J. B., Simpson, L. M., Black, H. R., Cushman, W. C., Einhorn, P. T., Farber, M. A., Ford, C. E., Levy, D. A., Massie, B. M., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.762229 · Cited by 204
Fukuda, N., Wu, Y., Nair, P., & Granzier, H. L. M. (2005) · The Journal of General Physiology · doi:10.1085/jgp.200409177 · Cited by 198
Chronic Inhibition of cGMP Phosphodiesterase 5A Improves Diabetic Cardiomyopathy
Giannetta, E., Isidori, A. M., Galea, N., Carbone, I., Mandosi, E., Vizza, C. D., Naro, F., Morano, S., Fedele, F., & Lenzi, A. (2012) · Circulation · doi:10.1161/circulationaha.111.063412 · Cited by 186
Bishu, K. G., Hamdani, N., Mohammed, S. F., Krüger, M., Ohtani, T., Ogut, O., Brozovich, F. V., Burnett, J. C. J., Linke, W. A., & Redfield, M. M. (2011) · Circulation · doi:10.1161/circulationaha.111.048520 · Cited by 186
Campbell, R. T., Jhund, P. S., Castagno, D., Hawkins, N. M., Petrie, M. C., & McMurray, J. J. V. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.064 · Cited by 180
New Targets to Treat the Structural Remodeling of the Myocardium
González, A., Ravassa, S., Beaumont, J., López, B., & Dı́ez, J. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.058 · Cited by 176
Matsubara, J., Sugiyama, S., Nozaki, T., Sugamura, K., Konishi, M., Ohba, K., Matsuzawa, Y., Akiyama, E., Yamamoto, E., Sakamoto, K., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.018 · Cited by 175
Heart Failure With Preserved Ejection Fraction
Shah, S. J., & Gheorghiade, M. (2008) · JAMA · doi:10.1001/jama.300.4.431 · Cited by 172
Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole
Chaturvedi, R. R., Herron, T., Simmons, R., Shore, D., Kumar, P., Sethia, B., Chua, F., Vassiliadis, E., & Kentish, J. C. (2010) · Circulation · doi:10.1161/circulationaha.109.850677 · Cited by 167
Rajapakse, A. G., Yepuri, G., Carvas, J. M., Stein, S., Matter, C. M., Scerri, I., Ruffieux, J., Montani, J., Ming, X., & Yang, Z. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019237 · Cited by 164
Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation
Diwan, A., Wansapura, J. P., Syed, F. M., Matkovich, S. J., Lorenz, J. N., & Dorn, G. W. (2008) · Circulation · doi:10.1161/circulationaha.107.727073 · Cited by 164
Ho, J. E., Gona, P. N., Pencina, M. J., Tu, J. V., Austin, P. C., Vasan, R. S., Kannel, W. B., D’Agostino, R. B., Lee, D. S., & Levy, D. A. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs070 · Cited by 161
Hummel, S. L., Seymour, E. M., Brook, R. D., Kolias, T. J., Sheth, S. S., Rosenblum, H. R., Wells, J. M., & Weder, A. B. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.202705 · Cited by 161
Ramasubbu, K., Estep, J. D., White, D. L., Deswal, A. M., & Mann, D. L. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.009 · Cited by 151
Shahin, Y., Khan, J. A., Samuel, N., & Chetter, I. C. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.02.044 · Cited by 144
Selby, D. E., Palmer, B. M., LeWinter, M. M., & Meyer, M. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.069 · Cited by 137
The Dynamic Interaction Between Matrix Metalloproteinase Activity and Adverse Myocardial Remodeling
Janicki, J. S., Brower, G. L., Gardner, J. D., Chancey, A. L., & Stewart, J. A. (2004) · Heart Failure Reviews · doi:10.1023/b:hrev.0000011392.03037.7e · Cited by 131
Vascular Oxidative Stress: The Common Link in Hypertensive and Diabetic Vascular Disease
Cohen, R. A., & Tong, X. (2010) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181d89670 · Cited by 129
Edelmann, F., Stahrenberg, R., Gelbrich, G., Durstewitz, K., Angermann, C. E., Düngen, H., Scheffold, T., Zugck, C., Maisch, B., Regitz‐Zagrosek, V., et al. (2011) · Clinical Research in Cardiology · doi:10.1007/s00392-011-0305-4 · Cited by 127
Oxidative Stress and Apoptosis in Heart Failure Progression
Hare, J. M. (2001) · Circulation Research · doi:10.1161/res.89.3.198 · Cited by 122
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Metadata
- Authors
- Paulus, W. J., & Tschöpe, C.
- Affiliations
- Amsterdam Cardiovascular Sciences (NL)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Paulus, Walter J.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 62
- Issue
- 4
- Pages
- 263-271
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W164205712
- Cited by
- 3,564
- References
- 99
- Citations by year
- 2026: 351 · 2025: 334 · 2024: 320 · 2023: 298 · 2022: 331 · 2021: 364 · 2020: 348 · 2019: 253 · 2018: 225 · 2017: 228 · 2016: 222 · 2015: 148 · 2014: 117 · 2013: 19
- FWCI
- 28.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure with preserved ejection fraction, systemic inflammation, comorbidities, nitric oxide bioavailability, protein kinase G, cardiomyocyte hypertrophy, diastolic dysfunction, left ventricular stiffness, interstitial fibrosis, cardiac remodeling, Laplace law, obesity, diabetes mellitus, chronic obstructive pulmonary disease, salt-sensitive hypertension
- MeSH terms
- Animals, Coronary Circulation, Endothelium, Vascular, Heart Failure, Humans, Inflammation, Microcirculation, Myocardium, Stroke Volume, Comorbidity, Ventricular Remodeling
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