Low-Sodium Dietary Approaches to Stop Hypertension Diet Reduces Blood Pressure, Arterial Stiffness, and Oxidative Stress in Hypertensive Heart Failure With Preserved Ejection Fraction
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Recent studies suggest that oxidative stress and vascular dysfunction contribute to heart failure with preserved ejection fraction (HFPEF). In salt-sensitive HFPEF animal models, diets low in sodium and high in potassium, calcium, magnesium, and antioxidants attenuate oxidative stress and cardiovascular damage. We hypothesized that the sodium-restricted Dietary Approaches to Stop Hypertension diet (DASH/SRD) would have similar effects in human hypertensive HFPEF. Thirteen patients with treated hypertension and compensated HFPEF consumed the DASH/SRD for 21 days (all food/most beverages provided). The DASH/SRD reduced clinic systolic (155–138 mm Hg; P =0.02) and diastolic blood pressure (79–72 mm Hg; P =0.04), 24-hour ambulatory systolic (130–123 mm Hg; P =0.02) and diastolic blood pressure (67–62 mm Hg; P =0.02), and carotid-femoral pulse wave velocity (12.4–11.0 m/s; P =0.03). Urinary F2-isoprostanes decreased by 31% (209–144 pmol/mmol Cr; P =0.02) despite increased urinary aldosterone excretion. The reduction in urinary F2-isoprostanes closely correlated with the reduction in urinary sodium excretion on the DASH/SRD. In this cohort of HFPEF patients with treated hypertension, the DASH/SRD reduced systemic blood pressure, arterial stiffness, and oxidative stress. These findings are characteristic of salt-sensitive hypertension, a phenotype present in many HFPEF animal models and suggest shared pathophysiological mechanisms linking these 2 conditions. Further dietary modification studies could provide insights into the development and progression of hypertensive HFPEF.
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Multiple observational studies suggest that a DASH diet reduces heart failure incidence.
“Multiple observational studies suggest that a DASH diet reduces heart failure incidence214–217.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [215]
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The Dietary Approaches to Stop Hypertension (DASH) Diet Pattern and Incident Heart Failure
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Is there a clinical role for oxidative stress biomarkers in atherosclerotic diseases?
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Current Perspectives on Systemic Hypertension in Heart Failure with Preserved Ejection Fraction
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The Framingham Study on Cardiovascular Disease Risk and Stress-Defenses: A Historical Review
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Lifestyle interventions in cardiometabolic HFpEF: dietary and exercise modalities
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Malnutrition in pulmonary arterial hypertension
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Sodium Restriction in Heart Failure: Benefit or Harm?
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Urinary Sodium Excretion and Ambulatory Blood Pressure Findings in Patients With Hypertension
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Nutrition as Treatment Modality in Heart Failure
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Hypertension as a Road to Treatment of Heart Failure with Preserved Ejection Fraction
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Dietary Interventions for Heart Failure in Older Adults: Re-emergence of the Hedonic Shift
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Heart Failure With Preserved Ejection Fraction: Prevention and Management
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Dietary Interventions in Heart Failure With Preserved Ejection Fraction
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Self-citationHypertension in the Geriatric Population
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Heart Failure and a Plant-Based Diet. A Case-Report and Literature Review
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Update on Heart Failure with Preserved Ejection Fraction
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Heart Failure with Preserved Ejection Fraction
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- Authors
- Hummel, S. L., Seymour, E. M., Brook, R. D., Kolias, T. J., Sheth, S. S., Rosenblum, H. R., Wells, J. M., & Weder, A. B.
- Affiliations
- University of Michigan (US)
- Venue
- Hypertension
- Published
- 2012-11
- Volume
- 60
- Issue
- 5
- Pages
- 1200-1206
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3522520
- OpenAlex
- W2154944643
- Cited by
- 161
- References
- 44
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 13 · 2018: 18 · 2017: 11 · 2016: 8 · 2015: 16 · 2014: 19 · 2013: 17
- FWCI
- 15.49
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Michigan
- U.S. Public Health Service (UL1R000433)
- National Heart, Lung, and Blood Institute (K23HL109176)
- National Center for Research Resources (UL1RR024986)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- heart failure with preserved ejection fraction, Dietary Approaches to Stop Hypertension diet, sodium restriction, blood pressure reduction, arterial stiffness, pulse wave velocity, oxidative stress, F2-isoprostanes, sodium excretion, aldosterone, salt-sensitive hypertension, dietary intervention
- MeSH terms
- Aged, Aged, 80 and over, Blood Pressure, Diet, Sodium-Restricted, Female, Heart Failure, Humans, Hypertension, Male, Middle Aged, Sodium, Time Factors, Treatment Outcome, Oxidative Stress, F2-Isoprostanes, Vascular Stiffness
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