The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Adenosine-Mediated Effects of Ticagrelor
Open accessAbstract
This review constitutes a critical evaluation of recent publications that have described an additional mode of action of the P2Y12 receptor antagonist ticagrelor. The effect is mediated by inhibition of the adenosine transporter ENT1 (type 1 equilibrative nucleoside transporter), which provides protection for adenosine from intracellular metabolism, thus increasing its concentration and biological activity, particularly at sites of ischemia and tissue injury where it is formed. Understanding the mode of action of ticagrelor is of particular interest given that its clinical profile, both in terms of efficacy and adverse events, differs from that of thienopyridine P2Y12 antagonists.
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Citations
Cites
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
Wallentin, L., Becker, R. C., Budaj, A., Cannon, C. P., Emanuelsson, H., Held, C., Horrow, J., Husted, S., James, S., Katus, H., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904327 · Cited by 7,117
Prasugrel versus clopidogrel in patients with acute coronary syndromes
Wiviott, S. D., Braunwald, E., McCabe, C. H., Montalescot, G., Ruzyllo, W., Gottlieb, S., Neumann, F.-J., Ardissino, D., De Servi, S., Murphy, S. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa0706482 · Cited by 6,790 · cited 5×
“Prasugrel was also superior to clopidogrel in preventing the same composite endpoint in patients with ACS who underwent PCI in the TRITON trial (4).”
BackgroundMethodInfluentialTurnover of adenosine in plasma of human and dog blood
Moser, G. H., Schrader, J., & Deussen, A. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.256.4.c799 · Cited by 529
The Role of Monocytes in Angiogenesis and Atherosclerosis
Jaipersad, A. S., Lip, G. Y. H., Silverman, S., & Shantsila, E. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.019 · Cited by 451
Regulation of Inflammation by Adenosine
Haskó, G., & Cronstein, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00085 · Cited by 367
Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes
Belardinelli, L., Shryock, J. C., Song, Y., Wang, D., & Srinivas, M. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.5.7896004 · Cited by 289
Ticagrelor Increases Adenosine Plasma Concentration in Patients With an Acute Coronary Syndrome
Bonello, L., Laine, M., Kipson, N., Mancini, J., Helal, O., Fromonot, J., Gariboldi, V., Condo, J., Thuny, F., Frere, C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.067 · Cited by 283
Absorption, Distribution, Metabolism, and Excretion of Ticagrelor in Healthy Subjects
Teng, R., Oliver, S., Hayes, M. A., & Butler, K. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.032250 · Cited by 264
Regulation of Neutrophil Function by Adenosine
Barletta, K. E., Ley, K., & Mehrad, B. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.226845 · Cited by 260
Mustafa, S. J., Morrison, R. R., Teng, B., & Pelleg, A. (2009) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-540-89615-9_6 · Cited by 251
Cited by
Antiplatelet therapy after percutaneous coronary intervention
Angiolillo, D. A., Galli, M., Collet, J.-P., Kastrati, A., & O'Donoghue, M. O. (2022) · EuroIntervention · doi:10.4244/eij-d-21-00904 · Cited by 299
Adenosine and adenosine receptors in the pathogenesis and treatment of rheumatic diseases
Cronstein, B. N., & Sitkovsky, M. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.178 · Cited by 258
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Loffredo, G., Rinaldi, L., Catalini, C., Gjeloshi, K., Albanese, G., Di Martino, A., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10092274 · Cited by 98
Adenosine and Adenosine Receptor-Mediated Action in Coronary Microcirculation
Zhang, Y., Wernly, B., Cao, X., Mustafa, S. J., Tang, Y., & Zhou, Z. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00859-7 · Cited by 71
Metadata
- Authors
- Cattaneo, M., Schulz, R., & Nylander, S.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 63
- Issue
- 23
- Pages
- 2503-2509
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W136622145
- Cited by
- 312
- References
- 50
- FWCI
- 23.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
