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Should Atrial Fibrillation Patients With 1 Additional Risk Factor of the CHA2DS2-VASc Score (Beyond Sex) Receive Oral Anticoagulation?
Open accessAbstract
Background Although the CHA2DS2-VASc (congestive heart failure, hypertension, age 75 years or older, diabetes mellitus, previous stroke or transient ischemic attack, vascular disease, age 65 to 74 years, female) score is recommended by both American and European guidelines for stroke risk stratification in atrial fibrillation (AF), the treatment recommendations for a CHA2DS2-VASc score of 1 are less clear.Objectives This study aimed to investigate the risk of ischemic stroke in patients with a single additional stroke risk factor (i.e., CHA2DS2-VASc score = 1 [males] or 2 [females]) and the impact of different component risk factors.Methods We used the National Health Insurance Research Database in Taiwan. Among 186,570 AF patients not on antiplatelet or anticoagulant therapy, we evaluated males with a CHA2DS2-VASc score of 1 and females with a CHA2DS2-VASc score of 2. The clinical endpoint was the occurrence of ischemic stroke.Results Among 12,935 male AF patients with a CHA2DS2-VASc score of 1, 1,858 patients (14.4%) experienced ischemic stroke during follow-up (5.2 ± 4.3 years), with an annual stroke rate of 2.75%. Ischemic stroke risk ranged from 1.96%/year for men with vascular disease to 3.50%/year for those 65 to 74 years of age. For 7,900 females with AF and a CHA2DS2-VASc score of 2, 14.9% experienced ischemic stroke for an annual stroke rate of 2.55%. Ischemic stroke risk increased from 1.91%/year for women with hypertension to 3.34%/year for those 65 to 74 years of age.Conclusions Not all risk factors in CHA2DS2-VASc score carry an equal risk, with age 65 to 74 years associated with the highest stroke rate. Oral anticoagulation should be considered for AF patients with 1 additional stroke risk factor given their high risk of ischemic stroke.
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“In many of these patients, anticoagulation seems to provide a clinical benefit.[371][372][373][374][375]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [372]
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Cites
Dabigatran versus warfarin in patients with atrial fibrillation
Connolly, S. J., Ezekowitz, M. D., Yusuf, S., Eikelboom, J., Oldgren, J., Parekh, A., Pogue, J., Reilly, P. A., Themeles, E., Varrone, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905561 · Cited by 11,215
Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
Patel, M. R., Mahaffey, K. W., Garg, J., Pan, G., Singer, D. E., Hacke, W., Breithardt, G., Halperin, J. L., Hankey, G. J., Piccini, J. P., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1009638 · Cited by 9,430
Apixaban versus warfarin in patients with atrial fibrillation
Granger, C. B., Alexander, J. H., McMurray, J. J. V., Lopes, R. D., Hylek, E. M., Hanna, M., Al-Khalidi, H. R., Ansell, J., Atar, D., Avezum, A., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1107039 · Cited by 8,943
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,145
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,924
Edoxaban versus warfarin in patients with atrial fibrillation
Giugliano, R. P., Ruff, C. T., Braunwald, E., Murphy, S. A., Wiviott, S. D., Halperin, J. L., Waldo, A. L., Ezekowitz, M. D., Weitz, J. I., Špinar, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1310907 · Cited by 5,164
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · EP Europace · doi:10.1093/europace/eus305 · Cited by 3,823
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs253 · Cited by 2,929
Olesen, J. B., Lip, G. Y. H., Hansen, M. L., Hansen, P. R., Tolstrup, J. S., Lindhardsen, J., Selmer, C., Ahlehoff, O., Olsen, A.-M. S., Gislason, G. H., et al. (2011) · BMJ · doi:10.1136/bmj.d124 · Cited by 1,428
Stroke Severity in Atrial Fibrillation
Lin, H., Wolf, P. A., Kelly‐Hayes, M., Beiser, A., Kase, C. S., Benjamin, E. J., & D’Agostino, R. B. (1996) · Stroke · doi:10.1161/01.str.27.10.1760 · Cited by 1,412
Validation of the national health insurance research database with ischemic stroke cases in Taiwan
Cheng, C.-L., Kao, Y., Lin, S.-J., Lee, C.-H., & Lai, M. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2087 · Cited by 1,242
Biase, L. D., Santangeli, P., Anselmino, M., Mohanty, P. K., Salvetti, I., Gili, S., Horton, R., Sánchez, J., Bai, R., Mohanty, S., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.032 · Cited by 876
2012 Focused Update of the ESC Guidelines for the Management of Atrial Fibrillation
Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., & Kirchhof, P. F. (2012) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2012.11.003 · Cited by 687
Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy
Hart, R. G., Pearce, L. A., Rothbart, R. M., McAnulty, J. H., ASINGER, R. W., & Halperin, J. L. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00489-1 · Cited by 662
Accuracy of diabetes diagnosis in health insurance claims data in Taiwan.
Lin, C.-C., Lai, M., Syu, C.-Y., Chang, S.-C., & Tseng, F. (2005) · PubMed · Cited by 508
Piccini, J. P., Stevens, S. R., Chang, Y., Singer, D. E., Lokhnygina, Y. V., Go, A. S., Patel, M. R., Mahaffey, K. W., Halperin, J. L., BREITHARDT, G. E., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.107128 · Cited by 503
Olesen, J. B., Torp-Pedersen, C. T., Hansen, M. L., & Lip, G. Y. H. (2012) · Thrombosis and Haemostasis · doi:10.1160/th12-03-0175 · Cited by 484
Hohnloser, S. H., Pajitnev, D., Pogue, J. M., Healey, J. S., Pfeffer, M. A., Yusuf, S., & Connolly, S. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.076 · Cited by 459
Singer, D. E., Chang, Y., Borowsky, L. H., Fang, M. C., Pomernacki, N. K., Udaltsova, N. V., Reynolds, K., & Go, A. S. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000250 · Cited by 408
Daccarett, M., Badger, T. J., AKOUM, N. W., Burgon, N. S., Mahnkopf, C., Vergara, G., Kholmovski, E. G., McGann, C. J., Parker, D. L., Brachmann, J., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.049 · Cited by 386
Validating the diagnosis of acute ischemic stroke in a National Health Insurance claims database
Hsieh, C., Chen, C., Li, C., & Lai, M. (2013) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2013.09.009 · Cited by 382
Banerjee, A., Lane, D. A., Torp-Pedersen, C. T., & Lip, G. Y. H. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-11-0784 · Cited by 300
Eckman, M. H., Singer, D. E., Rosand, J. M., & Greenberg, S. M. (2010) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.110.958108 · Cited by 280
Roldán, V., Marín, F. R., Manzano‐Fernández, S., Gallego, P., Vilchez, J. A., Valdés, M., Vicente, V., & Lip, G. Y. H. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.1623 · Cited by 190
Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores
Kimura, T., Takatsuki, S., Inagawa, K., Katsumata, Y., Nishiyama, T., Nishiyama, N., Fukumoto, K., Aizawa, Y., Tanimoto, Y., Tanimoto, K., et al. (2013) · Heart Rhythm · doi:10.1016/j.hrthm.2013.01.036 · Cited by 176
Chao, T., Lin, Y., Tsao, H.-M., Tsai, C.-F., Lin, W., Chang, S., Lo, L., Hu, Y., Tuan, T., Suenari, K., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.045 · Cited by 163
Chang, C., Lee, Y., Tsai, C., Chang, S., Chung, Y., Lin, M.-S., Lin, J., & Lai, M. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.036 · Cited by 131
Lin, L.-J., Cheng, M.-H., Lee, C., Wung, D.-C., Cheng, C., & Yang, Y. K. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.09.010 · Cited by 131
Lin, L., Lee, C., Yu, C., Tsai, C., Lai, L.-P., Hwang, J., Chen, P., & Lin, J.-L. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.033 · Cited by 124
Olesen, J. B., Fauchier, L., Lane, D. A., Taillandier, S., & Lip, G. Y. H. (2011) · CHEST Journal · doi:10.1378/chest.11-0862 · Cited by 107
Potpara, T., Polovina, M. M., Licina, M. M., Marinković, J., Prostran, M. S., & Lip, G. Y. H. (2012) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.111.966713 · Cited by 102
Ogawa, S., Aonuma, K., Tse, H., Huang, D., Huang, J., Kalman, J. M., Kamakura, S., Nair, M., Shin, D., Stiles, M. K., et al. (2013) · Journal of Arrhythmia · doi:10.1016/j.joa.2013.03.002 · Cited by 83
Atrial Fibrillation and the Risk of Ischemic Stroke
Chao, T., Liu, C., Chen, S., Wang, K.-L., Lin, Y., Chang, S., Lo, L., Hu, Y., Tuan, T., Wu, T.-J., et al. (2012) · Stroke · doi:10.1161/strokeaha.112.667865 · Cited by 83
Guo, Y., Apostolakis, S. Z., Blann, A. D., Wang, H., Zhao, X., Zhang, Y., Zhang, D., Ma, J., Wang, Y., & Lip, G. Y. H. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.052 · Cited by 80
The management of atrial fibrillation: summary of updated NICE guidance
Jones, C., Pollit, V., Fitzmaurice, D. A., Cowan, C., & On behalf of the Guideline Development Group (2014) · BMJ · doi:10.1136/bmj.g3655 · Cited by 74
Anandasundaram, B., Lane, D. A., Apostolakis, S. Z., & Lip, G. Y. H. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12177 · Cited by 57
Dental scaling and atrial fibrillation: A nationwide cohort study
Chen, S., Liu, C., Chao, T., Wang, K.-L., Chen, T., Chou, P., Wang, F., Lin, S., & Chiang, C. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.01.192 · Cited by 41
Chao, T., Lin, Y., Chang, S., Lo, L., Hu, Y., Tuan, T., Liao, J., Chung, F., HSIEH, M., & Chen, S. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.01.005 · Cited by 21
The Evolving Role of Stroke Prediction Schemes for Patients With Atrial Fibrillation
Ha, A. C. T., & Healey, J. S. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2013.06.001 · Cited by 13
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Metadata
- Authors
- Chao, T.-F., Liu, C.-J., Wang, K.-L., Lin, Y.-J., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Tuan, T.-C., Chen, T.-J., Lip, G. Y. H., & Chen, S.-A.
- Affiliations
- Taipei Veterans General Hospital (TW)
- Birmingham City Hospital (GB)
- Corresponding author
- Chen, Shih-Ann
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 65
- Issue
- 7
- Pages
- 635-642
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2022880742
- Cited by
- 258
- References
- 43
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 16 · 2023: 8 · 2022: 9 · 2021: 18 · 2020: 24 · 2019: 30 · 2018: 40 · 2017: 28 · 2016: 46 · 2015: 24
- FWCI
- 33.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Science Council (NSC98-2410-H-010-003-MY2)
- Taipei Veterans General Hospital (V100D-002-3, V101D-001-2, V102B-025, V99A-153, V99C1-140)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- atrial fibrillation, CHA2DS2-VASc score, oral anticoagulation, ischemic stroke risk, stroke risk stratification, sex differences, hypertension, vascular disease, diabetes mellitus, congestive heart failure
- MeSH terms
- Administration, Oral, Age Factors, Aged, Anticoagulants, Atrial Fibrillation, Ischemic Attack, Transient, Female, Humans, Hypertension, Male, Middle Aged, Retrospective Studies, Risk Factors, Sex Factors, Taiwan, Risk Assessment, Stroke, Diabetes Complications
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