Benefit of anticoagulation unlikely in patients with atrial fibrillation and a CHA2DS2-VASc score of 1
Open accessAbstract
Background Patients with atrial fibrillation (AF) and ≥1 point on the stroke risk scheme CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category) are considered at increased risk for future stroke, but the risk associated with a score of 1 differs markedly between studies.Objectives The goal of this study was to assess AF-related stroke risk among patients with a score of 1 on the CHA2DS2-VASc.Methods We conducted this retrospective study of 140,420 patients with AF in Swedish nationwide health registries on the basis of varying definitions of "stroke events."Results Using a wide "stroke" diagnosis (including hospital discharge diagnoses of ischemic stroke as well as unspecified stroke, transient ischemic attack, and pulmonary embolism) yielded a 44% higher annual risk than if only ischemic strokes were counted. Including stroke events in conjunction with the index hospitalization for AF doubled the long-term risk beyond the first 4 weeks. For women, annual stroke rates varied between 0.1% and 0.2% depending on which event definition was used; for men, the corresponding rates were 0.5% and 0.7%.Conclusions The risk of ischemic stroke in patients with AF and a CHA2DS2-VASc score of 1 seems to be lower than previously reported.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rates of stroke and thromboembolism vary considerably in patients with CHA2DS2-VASc scores of 1 or 2 due to differences in outcomes, populations, and anticoagulation status.
“The rates of stroke and thromboembolism vary considerably in patients with CHA 2 DS 2 -VASc scores of 1 or 2 due to differences in outcomes, populations, and anticoagulation status (Web Addenda Table 1).371,376,377,1041”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [376]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H. G., Cigarroa, J. E., Cleveland, J. C., CONTI, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000041 · Cited by 7,119 · see citing works
Lip, G. Y. H., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. G. M. (2010) · Chest · doi:10.1378/chest.09-1584 · Cited by 6,879 · see citing works
Guidelines for the management of atrial fibrillation
Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq278 · Cited by 5,875 · see citing works
External review and validation of the Swedish national inpatient register
Ludvigsson, J. F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.-L., Reuterwall, C., Heurgren, M., & Olausson, P. O. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-450 · Cited by 5,055 · see citing works
2012 focused update of the ESC Guidelines for the management of atrial fibrillation
Authors Task Force Members, Camm, A. J., Lip, G. Y. H., Caterina, R. D., Savelieva, I., Atar, D., Hohnloser, S. H., Hindricks, G., Kirchhof, P. F., Bax, J. J., et al. (2012) · EP Europace · doi:10.1093/europace/eus305 · Cited by 3,814 · see citing works
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
January, C. T., Wann, L. S., Alpert, J. S., Calkins, H., Cigarroa, J. E., Cleveland, J. C., Conti, J. B., Ellinor, P. T., Ezekowitz, M. D., Field, M. E., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.022 · Cited by 2,955 · see citing works
Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805 · see citing works
Olesen, J. B., Lip, G. Y. H., Hansen, M. L., Hansen, P. R., Tolstrup, J. S., Lindhardsen, J., Selmer, C., Ahlehoff, O., Olsen, A.-M. S., Gislason, G. H., et al. (2011) · BMJ · doi:10.1136/bmj.d124 · Cited by 1,428 · see citing works
Friberg, L., Rosenqvist, M., & Lip, G. Y. H. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr488 · Cited by 1,192 · see citing works
Self-citationFuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,157 · see citing works
Antithrombotic Therapy for Atrial Fibrillation
You, J. J., Singer, D. E., Howard, P. A., Lane, D. A., Eckman, M. H., Fang, M. C., Hylek, E. M., Schulman, S., Go, A. S., Hughes, M., et al. (2012) · CHEST Journal · doi:10.1378/chest.11-2304 · Cited by 924 · see citing works
A transient ischaemic attack clinic with round-the-clock access (SOS-TIA): feasibility and effects
Lavallée, P. C., Meseguer, E., Abboud, H., Cabrejo, L., Olivot, J., Simon, O., Mazighi, M., Nifle, C., Niclot, P., Lapergue, B., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70248-x · Cited by 664 · see citing works
The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation
Singer, D. E., Chang, Y., Fang, M. C., Borowsky, L. H., Pomernacki, N. K., Udaltsova, N., & Go, A. S. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-5-200909010-00003 · Cited by 655 · see citing works
Identifying Patients at High Risk for Stroke Despite Anticoagulation
Lip, G. Y. H., Frison, L., Halperin, J. L., & Lane, D. A. (2010) · Stroke · doi:10.1161/strokeaha.110.590257 · Cited by 493 · see citing works
Friberg, L., Rosenqvist, M., & Lip, G. Y. H. (2012) · Circulation · doi:10.1161/circulationaha.111.055079 · Cited by 454 · see citing works
Self-citationLip, G., Lindhardsen, J., Lane, D., Ahlehoff, O., Hansen, M., Raunsø, J., Tolstrup, J., Hansen, P., Gislason, G., Torp-Pedersen, C., et al. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0364 · Cited by 428 · see citing works
The Validity of a Diagnosis of Heart Failure in a Hospital Discharge Register
Ingelsson, E., Ärnlöv, J., Sundström, J., & Lind, L. (2005) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.12.007 · Cited by 412 · see citing works
Eckman, M. H., Singer, D. E., Rosand, J. M., & Greenberg, S. M. (2010) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.110.958108 · Cited by 276 · see citing works
Smith, J. G., Platonov, P. G., Hedblad, B., Engström, G., & Melander, O. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-009-9404-1 · Cited by 275 · see citing works
Friberg, L., Benson, L., Rosenqvist, M. A., & Lip, G. Y. H. (2012) · BMJ · doi:10.1136/bmj.e3522 · Cited by 265 · see citing works
Kakkar, A. K., Mueller, I., Bassand, J., Fitzmaurice, D. A., Goldhaber, S. Z., Goto, S., Haas, S. K., Hacke, W., Lip, G. Y. H., Mantovani, L. G., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.09.011 · Cited by 234 · see citing works
Asplund, K., Åsberg, K. H., Appelros, P., Bjarne, D., Eriksson, M., Johansson, Å., Jonsson, F., Norrving, B. G., Stegmayr, B., Terént, A., et al. (2010) · International Journal of Stroke · doi:10.1111/j.1747-4949.2010.00557.x · Cited by 221 · see citing works
Coppens, M., Eikelboom, J. W., Hart, R. G., Yusuf, S., Lip, G. Y. H., Dorian, P., Shestakovska, O., & Connolly, S. J. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs314 · Cited by 185 · see citing works
Huisman, M. V., Lip, G. Y. H., Diener, H., Dubner, S., Halperin, J. L., Chang, S., Rothman, K. J., Teutsch, C., Zint, K., Ackermann, D., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.12.006 · Cited by 148 · see citing works
Piccini, J. P., Fraulo, E. S., Ansell, J., Fonarow, G. C., Gersh, B. J., Go, A. S., Hylek, E. M., Kowey, P. R., Mahaffey, K. W., Thomas, L. E., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.07.001 · Cited by 147 · see citing works
Refinement of Swedish Administrative Registers to Monitor Stroke Events on the National Level
Köster, M., Asplund, K., Johansson, Å., & Stegmayr, B. (2013) · Neuroepidemiology · doi:10.1159/000345953 · Cited by 114 · see citing works
Differences among western European countries in anticoagulation management of atrial fibrillation
Ammentorp, B., Darius, H., Caterina, R. D., SCHILLING, R. J., Schmitt, J., Zamorano, J. L., Kirchhof, P. F., & Heuzey, J. L. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-12-1007 · Cited by 108 · see citing works
Olesen, J. B., Fauchier, L., Lane, D. A., Taillandier, S., & Lip, G. Y. H. (2011) · CHEST Journal · doi:10.1378/chest.11-0862 · Cited by 107 · see citing works
Guo, Y., Apostolakis, S. Z., Blann, A. D., Wang, H., Zhao, X., Zhang, Y., Zhang, D., Ma, J., Wang, Y., & Lip, G. Y. H. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.052 · Cited by 80 · see citing works
Stroke Risk Stratification in a “Real-World” Elderly Anticoagulated Atrial Fibrillation Population
Poli, D., Lip, G. Y. H., Antonucci, E., Grifoni, E., & Lane, D. A. (2010) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2010.01858.x · Cited by 78 · see citing works
Healey, J. S., Parkash, R., Pollak, T., Tsang, T. S. M., & Dorian, P. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.11.015 · Cited by 71 · see citing works
Apostolakis, S. Z., Zubaid, M., Rashed, W. A., Alsheikh-Ali, A. A. A., Almahmeed, W. A., Shehab, A., Sulaiman, K., AlQudaimi, A., Asaad, N., Amin, H., et al. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.02.003 · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Lip GY, Frison L, Halperin JL, Lane DA. Identi- fying patients at high risk for stroke despite anti- coagulation: a comparison of contemporary stroke risk stratification schemes in an anticoagulated atrial fibrillation cohort. Stroke 2010;41:2731-8.
Cited by
Sorted by citations
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellá, M., Diener, H., Heidbuchel, H., Hendriks, J., et al. (2016) · Europace · doi:10.1093/europace/euw295 · Cited by 4,465 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Collet, J.-P., Thiele, H., Barbato, E., Barthélémy, O., Bauersachs, J., Bhatt, D. L., Dendale, P., Dorobantu, M., Edvardsen, T., Folliguet, T., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehaa575 · Cited by 5,037 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia
Herrmann, J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0348-1 · Cited by 747 · see citing works
Andrade, J. G., Aguilar, M., Atzema, C. L., Bell, A., Cairns, J. A., Cheung, C. C., Cox, J. L., Dorian, P., Gladstone, D. J., Healey, J. S., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.09.001 · Cited by 568 · see citing works
Yao, X., Abraham, N. S., Alexander, G. C., Crown, W. H., Montori, V. M., Sangaralingham, L. R., Gersh, B. J., Shah, N. D., & Noseworthy, P. A. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.003074 · Cited by 452 · see citing works
Doherty, J. U., Gluckman, T. J., Hucker, W. J., Januzzi, J. L., Ortel, T. L., Saxonhouse, S. J., & Spinler, S. A. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.024 · Cited by 445 · see citing works
Kamel, H., & Healey, J. S. (2017) · Circulation Research · doi:10.1161/circresaha.116.308407 · Cited by 435 · see citing works
Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
Ko, D., Rahman, F., Schnabel, R. B., Yin, X., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.45 · Cited by 353 · see citing works
2020 Clinical guidelines for Atrial fibrillation and atrial flutter
Arakelyan, M., Bockeria, L., Vasilieva, E., Golitsyn, S., Golukhova, E., Gorev, M., Davtyan, K., Drapkina, O., Kropacheva, E., Kuchinskaya, E. A., et al. (2021) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2021-4594 · Cited by 11 · see citing works
van den Ham, H. A., Klungel, O. H., Singer, D. E., Leufkens, H. G. M., & van Staa, T. P. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.08.033 · Cited by 205 · see citing works
Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation
Schnabel, R. B., Pecen, L., Ojeda, F., Lucerna, M., Rzayeva, N., Blankenberg, S., Darius, H., Kotecha, D., Caterina, R. D., & Kirchhof, P. F. (2017) · Heart · doi:10.1136/heartjnl-2016-310406 · Cited by 179 · see citing works
Fox, K. A. A., Lucas, J. E., Pieper, K. S., Bassand, J., Camm, A. J., Fitzmaurice, D. A., Goldhaber, S. Z., Goto, S., Haas, S. K., Hacke, W., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017157 · Cited by 152 · see citing works
Lee, S. S., Kong, K. A., Kim, D., Lim, Y.-M., Yang, P., Yi, J., Kim, M., Kwon, K., Pyun, W. B., Joung, B., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx316 · Cited by 142 · see citing works
Atrial Fibrillation and Ventricular Arrhythmias
Gillis, A. M. (2017) · Circulation · doi:10.1161/circulationaha.116.025312 · Cited by 132 · see citing works
Wide Variation in Reported Rates of Stroke Across Cohorts of Patients With Atrial Fibrillation
Quinn, G. R., Severdija, O. N., Chang, Y., & Singer, D. E. (2016) · Circulation · doi:10.1161/circulationaha.116.024057 · Cited by 128 · see citing works
Forslund, T., Wettermark, B., & Hjemdahl, P. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1983-z · Cited by 121 · see citing works
Leung, M., van Rosendael, P. J., Abou, R., Marsan, N. A., Leung, D. Y., Delgado, V., & Bax, J. J. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx736 · Cited by 116 · see citing works
Stroke risk assessment in atrial fibrillation: risk factors and markers of atrial myopathy
Calenda, B. W., Fuster, V., Halperin, J. L., & Granger, C. B. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.106 · Cited by 116 · see citing works
Aspberg, S., Chang, Y., Atterman, A., Bottai, M., Go, A. S., & Singer, D. E. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw077 · Cited by 111 · see citing works
Skjøth, F., Nielsen, P., Larsen, T. B., & Lip, G. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-07-0565 · Cited by 106 · see citing works
Performance and Validation of a Novel Biomarker-Based Stroke Risk Score for Atrial Fibrillation
Oldgren, J., Hijazi, Z., Lindbäck, J., Alexander, J. H., Connolly, S. J., Eikelboom, J. W., Ezekowitz, M. D., Granger, C. B., Hylek, E. M., Lópes, R. D., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.022802 · Cited by 105 · see citing works
Ischemic Stroke Risk in Patients With Atrial Fibrillation and CHA 2 DS 2 -VASc Score of 1
Joundi, R. A., Cipriano, L. E., Sposato, L. A., & Saposnik, G. (2016) · Stroke · doi:10.1161/strokeaha.115.012609 · Cited by 106 · see citing works
Atrial high-rate episodes and stroke prevention
Camm, A. J., SIMANTIRAKIS, E. N., Goette, A., Lip, G. Y. H., Vardas, P. E., Calvert, M., CHLOUVERAKIS, G. I., Diener, H., & Kirchhof, P. F. (2016) · EP Europace · doi:10.1093/europace/euw279 · Cited by 103 · see citing works
Nielsen, P. B., Larsen, T. B., Skjøth, F., Overvad, T. F., & Lip, G. Y. H. (2016) · Scientific Reports · doi:10.1038/srep27410 · Cited by 102 · see citing works
Noseworthy, P. A., Yao, X., Deshmukh, A. J., Houten, H. V., Sangaralingham, L. R., Siontis, K. C., Piccini, J. P., Asirvatham, S. J., Friedman, P. A., Packer, D. L., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002597 · Cited by 91 · see citing works
Stærk, L., Fosbøl, E. L., Lip, G. Y. H., Lamberts, M., Bonde, A. N., Torp-Pedersen, C. T., Ozenne, B., Gerds, T. A., Gislason, G., & Olesen, J. B. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw496 · Cited by 91 · see citing works
Direct‐acting oral anticoagulants: pharmacology, indications, management, and future perspectives
Gómez‐Outes, A., Suárez‐Gea, M. L., Lecumberri, R., Terleira‐Fernández, A. I., & Vargas, E. (2015) · European Journal Of Haematology · doi:10.1111/ejh.12610 · Cited by 91 · see citing works
Verberk, W., Omboni, S., Kollias, A., & Stergiou, G. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.182 · Cited by 89 · see citing works
Kim, I., Yang, P., Lee, J., Yu, H. T., Kim, T., Uhm, J., Pak, H., Lee, M., & Joung, B. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.12.048 · Cited by 79 · see citing works
Chao, T., Lip, G. Y. H., Lin, Y., Chang, S., Lo, L., Hu, Y., Tuan, T., Liao, J., Chung, F., Chen, T., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy837 · Cited by 77 · see citing works
Atrial Fibrillation, Type 2 Diabetes, and Non–Vitamin K Antagonist Oral Anticoagulants
Plitt, A., McGuire, D. K., & Giugliano, R. P. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2016.5224 · Cited by 69 · see citing works
Ablation of Atrial Fibrillation
Link, M. S., Haı̈ssaguerre, M., & Natale, A. (2016) · Circulation · doi:10.1161/circulationaha.116.021727 · Cited by 64 · see citing works
Forslund, T., Wettermark, B., Andersen, M. T., & Hjemdahl, P. (2017) · EP Europace · doi:10.1093/europace/euw416 · Cited by 60 · see citing works
Stroke risk in atrial fibrillation: Do we anticoagulate CHADS2 or CHA2DS2-VASc ≥1, or higher?
Olesen, J. B., & Torp-Pedersen, C. T. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-02-0154 · Cited by 59 · see citing works
Fauchier, L., Lecoq, C., Clémenty, N., Bernard, A. B., Angoulvant, D., Ivanés, F., Babuty, D., & Lip, G. Y. H. (2015) · CHEST Journal · doi:10.1378/chest.15-1622 · Cited by 58 · see citing works
Sulzgruber, P., Waßmann, S., Semb, A. G., Doehner, W., Widimský, P., Gremmel, T., Kaski, J. C., Savarese, G., Rosano, G. M. C., Borghi, C., et al. (2019) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvz016 · Cited by 58 · see citing works
Nielsen, P. B., & Overvad, T. F. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1710014 · Cited by 51 · see citing works
The risks of risk scores for stroke risk assessment in atrial fibrillation
Chao, T., & Nielsen, P. B. (2015) · Thrombosis and Haemostasis · doi:10.1160/th15-03-0210 · Cited by 50 · see citing works
Lip, G. Y. H., Skjøth, F., Nielsen, P. B., Kjældgaard, J. N., & Larsen, T. B. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.1883 · Cited by 49 · see citing works
Komen, J. J., Pottegård, A., Mantel-Teeuwisse, A. K., Forslund, T., Hjemdahl, P., Wettermark, B., Hallas, J., Olesen, M. S., Bennie, M., Mueller, T., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac111 · Cited by 50 · see citing works
Zeballos-Palacios, C. L., Hargraves, I. G., Noseworthy, P. A., Branda, M. E., Kunneman, M., Burnett, B., Gionfriddo, M. R., McLeod, C. J., Gorr, H. S., Brito, J. P., et al. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.08.030 · Cited by 48 · see citing works
Macle, L., Cairns, J. A., Andrade, J. G., Mitchell, L. B., Nattel, S., Verma, A., Verma, A., Macle, L., Andrade, J. G., Atzema, C. L., et al. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.06.005 · Cited by 47 · see citing works
Risk stratification for stroke in atrial fibrillation: a critique
Killu, A. M., Granger, C. B., & Gersh, B. J. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy731 · Cited by 47 · see citing works
Lévy, S., Steinbeck, G., Santini, L., Nabauer, M., Maceda, D. P., Kantharia, B., Saksena, S., & Cappato, R. (2022) · Journal of interventional cardiac electrophysiology · doi:10.1007/s10840-022-01195-z · Cited by 46 · see citing works
Registries in Atrial Fibrillation: From Trials to Real-Life Clinical Practice
Mazurek, M., Huisman, M. V., & Lip, G. Y. H. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.09.012 · Cited by 46 · see citing works
van Doorn, S., Debray, T. P. A., Kaasenbrood, F., Hoes, A. W., Rutten, F. H., Moons, K. G. M., & Geersing, G. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13690 · Cited by 48 · see citing works
Chinese guidelines for the diagnosis and management of atrial fibrillation
Ma, C., Wu, S., Liu, S., & Han, Y. (2024) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.14920 · Cited by 47 · see citing works
Allan, V., Banerjee, A., Shah, A. D., Patel, R. S., Denaxas, S., Casas, J. P., & Hemingway, H. (2016) · Heart · doi:10.1136/heartjnl-2016-309910 · Cited by 45 · see citing works
Risk of ischemic stroke and utility of CHA2DS2‐VASc score in women and men with atrial fibrillation
Tomasdottir, M., Friberg, L., Hijazi, Z., Lindbäck, J., & Oldgren, J. (2019) · Clinical Cardiology · doi:10.1002/clc.23257 · Cited by 43 · see citing works
Anjum, M., Ariansen, I., Hjellvik, V., Selmer, R. M., Kjerpeseth, L. J., Skovlund, E., Myrstad, M., Ellekjær, H., Christophersen, I. E., Tveit, A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad659 · Cited by 41 · see citing works
Guideline-Adherent Antithrombotic Treatment Improves Outcomes in Patients With Atrial Fibrillation
Mazurek, M., Shantsila, E., Lane, D. A., Wolff, A., Proietti, M., & Lip, G. Y. H. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.023 · Cited by 40 · see citing works
Lip, G. Y. H., & Nielsen, P. B. (2016) · Circulation · doi:10.1161/circulationaha.115.016713 · Cited by 40 · see citing works
2025 Clinical practice guidelines for Atrial fibrillation and flutter
Golukhova, E., Golitsyn, S., Mikhailov, E., Revishvili, A., Arakelyan, M., Vasilyeva, E., Davtyan, K., Drapkina, O., Drozdova, L., Kropacheva, E., et al. (2026) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6668 · Cited by 36 · see citing works
Overvad, T. F., Nielsen, P. B., & Lip, G. Y. H. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvw022 · Cited by 37 · see citing works
Dalgaard, F., Pieper, K. S., Verheugt, F. W. A., Camm, A. J., Fox, K. A. A., Kakkar, A. K., Pallisgaard, J. L., Rasmussen, P. V., van Weert, H. C. P. M., Lindhardt, T. B., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2019-033283 · Cited by 37 · see citing works
Friberg, L., & Oldgren, J. (2017) · Open Heart · doi:10.1136/openhrt-2017-000682 · Cited by 33 · see citing works
Mazurek, M., Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H., Dubner, S., Halperin, J. L., Zint, K., França, L. R., et al. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.03.024 · Cited by 33 · see citing works
Atrial fibrillation in the elderly population: Challenges and management considerations
Salih, M., Abdel-Hafez, O., Ibrahim, R., & Nair, R. C. (2021) · Journal of Arrhythmia · doi:10.1002/joa3.12580 · Cited by 32 · see citing works
Permanent Percutaneous Carotid Artery Filter to Prevent Stroke in Atrial Fibrillation Patients
Reddy, V. Y., Neužil, P., Potter, T. J. R. D., der Heyden, J. V., Tromp, S. C., Rensing, B. J. W. M., Jirešová, E., Dujka, L., & Lekešová, V. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.04.035 · Cited by 30 · see citing works
Cardiovascular Care of Masters Athletes
Churchill, T. W., & Baggish, A. L. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-09987-2 · Cited by 29 · see citing works
Potpara, T., Lip, G. Y. H., Dagres, N., Crijns, H. J. G. M., Boriani, G., Kirchhof, P. F., Arbelo, E., Savelieva, I., Lenarczyk, R., Fauchier, L., et al. (2020) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcaa050 · Cited by 28 · see citing works
Lip, G. Y. H., Skjøth, F., Rasmussen, L. H., Nielsen, P. B., & Larsen, T. B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.05.044 · Cited by 27 · see citing works
Torp-Pedersen, C. T., Goette, A., Nielsen, P. B., Potpara, T., Fauchier, L., Camm, A. J., Arbelo, E., Boriani, G., Skjoeth, F., Rumsfeld, J. S., et al. (2019) · EP Europace · doi:10.1093/europace/euz210 · Cited by 27 · see citing works
Anticoagulation Therapy for Non-valvular Atrial Fibrillation: A Mini-Review
Wu, J. H., Zhang, Y., Liao, X., & Lei, Y. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00350 · Cited by 27 · see citing works
Collet, J., Thiele, H., Barbato, E., Barthélémy, O., Bauersachs, J. K., Bhatt, D. L., Dendale, P., Dorobanţu, M., Edvardsen, T., Folliguet, T. A., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.12.024 · Cited by 28 · see citing works
Kim, M. H., Yu, H. T., Kim, J., Kim, T., Uhm, J., Joung, B., Lee, M., & Pak, H.-N. (2020) · EP Europace · doi:10.1093/europace/euaa235 · Cited by 26 · see citing works
Denas, G., Gennaro, N., Ferroni, E., Fedeli, U., Saugo, M., Zoppellaro, G., Jose, S. P., Costa, G., Corti, M. C., Andretta, M., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.09.029 · Cited by 26 · see citing works
Shah, S. J., Eckman, M. H., Aspberg, S., Go, A. S., & Singer, D. E. (2018) · Annals of Internal Medicine · doi:10.7326/m17-2762 · Cited by 25 · see citing works
Proietti, M., & Lip, G. Y. H. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.03.024 · Cited by 24 · see citing works
Anticoagulation in Atrial Fibrillation – Current Concepts
Katritsis, D. G., Gersh, B. J., & Camm, A. J. (2015) · Arrhythmia & Electrophysiology Review · doi:10.15420/aer.2015.04.02.100 · Cited by 26 · see citing works
Choi, S. Y., Kim, M. H., Lee, K. M., Cho, Y., Park, J. S., Yun, S., & Lip, G. Y. H. (2020) · Thrombosis and Haemostasis · doi:10.1055/a-1336-0476 · Cited by 24 · see citing works
Zoppellaro, G., Zanella, L., Denas, G., Gennaro, N., Ferroni, E., Fedeli, U., Jose, S. P., Costa, G., Corti, M. C., Andretta, M., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.04.117 · Cited by 23 · see citing works
Singleton, M. J., Ahmad, M. I., Kamel, H., O’Neal, W. T., Judd, S. E., Howard, V. J., Howard, G., Soliman, E. Z., & Bhave, P. D. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016380 · Cited by 24 · see citing works
Taha, A., Nielsen, S. J., Franzén, S., Rezk, M., Ahlsson, A., Friberg, L., Björck, S., Jeppsson, A., & Bergfeldt, L. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024703 · Cited by 23 · see citing works
Atrial fibrillation and use of antithrombotic medications in older people: A population-based study
Ding, M., Fratiglioni, L., Johnell, K., Fastbom, J., Ljungdahl, M., & Qiu, C. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.07.012 · Cited by 23 · see citing works
Maeda, T., Nishi, T., Funakoshi, S., Tada, K., Tsuji, M., Satoh, A., Kawazoe, M., Yoshimura, C., & Arima, H. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014574 · Cited by 23 · see citing works
Hung, Y., Chao, T., Liu, C., Tuan, T., Lin, Y., Chang, S., Lo, L., Hu, Y., Liao, J., Chung, F., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003839 · Cited by 22 · see citing works
Resuming anticoagulant therapy after intracerebral bleeding
Becattini, C., Sembolini, A., & Paciaroni, M. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.05.012 · Cited by 22 · see citing works
Cardiomyopathies and Arrhythmias Induced by Cancer Therapies
Romitan, D.-M., Rădulescu, D., Berindan‐Neagoe, I., Stoicescu, L., Grosu, A. I., Rădulescu, L., Gulei, D., & Ciuleanu, T. (2020) · Biomedicines · doi:10.3390/biomedicines8110496 · Cited by 23 · see citing works
New Oral Anticoagulants in Nonvalvular Atrial Fibrillation
Fatima, U., Kulkarni, A., Stapleton, D. D., & Kaluski, E. (2016) · Clinical Cardiology · doi:10.1002/clc.22582 · Cited by 19 · see citing works
Lip, G. Y. H., Potpara, T., Boriani, G., & Blomström‐Lundqvist, C. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12468 · Cited by 19 · see citing works
Komen, J. J., Hjemdahl, P., Mantel-Teeuwisse, A. K., Klungel, O. H., Wettermark, B., & Forslund, T. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1603 · Cited by 20 · see citing works
Abdel-Qadir, H. M., Singh, S. M., Pang, A., Austin, P. C., Jackevicius, C. A., Tu, K., Dorian, P., & Ko, D. T. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.1232 · Cited by 18 · see citing works
Anticoagulation in Atrial Fibrillation Cardioversion: What Is Crucial to Take into Account
Lucà, F., Giubilato, S., Fusco, S. A. D., Piccioni, L., Rao, C. M., Iorio, A., Cipolletta, L., D’Elia, E., Gelsomino, S., Rossini, R., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153212 · Cited by 19 · see citing works
Integrated care of patients with atrial fibrillation: the 2016 ESC atrial fibrillation guidelines
Kirchhof, P. F. (2017) · Heart · doi:10.1136/heartjnl-2016-310843 · Cited by 18 · see citing works
Østergaard, L., Olesen, J. B., Petersen, J. K., Nielsen, L. S., Kristensen, S. L., Schou, M., Køber, L., & Fosbøl, E. L. (2023) · Circulation · doi:10.1161/circulationaha.123.066477 · Cited by 17 · see citing works
Impact of age on thromboembolic events in patients with non‐valvular atrial fibrillation
Kim, Y. G., Choi, J., Boo, K. Y., Kim, D. Y., Hong, Y., Kim, M. S., Lee, K., Shim, J., Kim, J. S., & Kim, Y. (2019) · Clinical Cardiology · doi:10.1002/clc.23293 · Cited by 17 · see citing works
Potpara, T., Dagres, N., Mujović, N. M., Vasić, D., Ašanin, M., Nedeljkovic, M. A., Marín, F. R., Fauchier, L., Blomström‐Lundqvist, C., & Lip, G. Y. H. (2016) · Advances in Therapy · doi:10.1007/s12325-016-0458-7 · Cited by 16 · see citing works
Clinical conundrums in antithrombotic therapy management: A Delphi Consensus panel
Colonna, P., Andreotti, F., Ageno, W., Pengo, V., & Marchionni, N. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.09.159 · Cited by 16 · see citing works
Jackson, L. R., Kim, S., Fonarow, G. C., Freeman, J. V., Gersh, B. J., Go, A. S., Hylek, E. M., Kowey, P. R., Mahaffey, K. W., Singer, D. E., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.008764 · Cited by 16 · see citing works
Adding Rigor to Stroke Risk Prediction in Atrial Fibrillation
Singer, D. E., & Ezekowitz, M. D. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.11.013 · Cited by 15 · see citing works
Chinese Guidelines for the Diagnosis and Management of Atrial Fibrillation
Ma, C., Wu, S., Liu, S., & Han, Y. (2024) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2024.03.009 · Cited by 16 · see citing works
Savino, J. A., & Halperin, J. L. (2016) · Circulation · doi:10.1161/circulationaha.115.016715 · Cited by 14 · see citing works
Thromboembolic risk stratification in atrial fibrillation—beyond clinical risk scores
Wan, D., Andrade, J. G., & Laksman, Z. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2202042 · Cited by 15 · see citing works
Mao, Y., Ma, M., Yang, Y., Yu, C., Wang, Y., Jiang, R., & Jiang, C. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.02.031 · Cited by 14 · see citing works
Adding Rigor to Stroke Rate Investigations in Patients With Atrial Fibrillation
Nielsen, P. B., & Lip, G. Y. H. (2017) · Circulation · doi:10.1161/circulationaha.116.025944 · Cited by 14 · see citing works
van den Dries, C. J., van Doorn, S., Souverein, P. C., Pajouheshnia, R., Moons, K. G. M., Hoes, A. W., Geersing, G., & van den Ham, H. A. (2020) · TH Open · doi:10.1055/s-0040-1721499 · Cited by 13 · see citing works
Kwon, S., Kim, T. J., Choi, E., Ahn, H., Lee, E., Lee, S., Ko, S., Oh, S., & Lip, G. Y. H. (2021) · Heart Rhythm · doi:10.1016/j.hrthm.2021.01.016 · Cited by 13 · see citing works
- Authors
- Friberg, L., Skeppholm, M., & Terént, A.
- Affiliations
- Danderyds sjukhus (SE)
- Uppsala University Hospital (SE)
- Corresponding author
- Friberg, Leif
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 65
- Issue
- 3
- Pages
- 225-232
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2101501864
- Cited by
- 207
- References
- 32
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 22 · 2019: 17 · 2018: 18 · 2017: 29 · 2016: 43 · 2015: 28
- FWCI
- 28.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bristol-Myers Squibb
- AstraZeneca
- Sanofi
- Stockholms Läns Landsting
- Svenska Läkaresällskapet
- St. Jude Medical
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- atrial fibrillation, CHA2DS2-VASc score, stroke risk, ischemic stroke, anticoagulation, sex differences, long-term stroke risk
- MeSH terms
- Aged, Anticoagulants, Atrial Fibrillation, Brain Ischemia, Female, Humans, Male, Registries, Retrospective Studies, Sweden, Warfarin, Risk Assessment, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
