Cited by 417Lipoproteins and Cardiovascular HealthAcute Myocardial Infarction ResearchHealth Promotion and Cardiovascular Prevention

The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.

A Test in Context

Open access

Ridker, Paul M·2016·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2015.11.037

Open this paper in CoChat — free account Open PDF

Abstract

The inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) adds prognostic information on cardiovascular risk comparable to blood pressure or cholesterol. Values <1, 1 to 3, and >3 mg/l indicate lower, average, or higher relative cardiovascular risk, respectively. Global risk algorithms that include hsCRP outperform those solely using Framingham covariates. Although diet, exercise, and smoking cessation are first steps for patients with a proinflammatory response, JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial data demonstrate that statins reduce by 47% the rate of first myocardial infarction, stroke, or confirmed cardiovascular death when given to patients with low-density lipoprotein-C levels of <130 mg/dl and hsCRP of >2 mg/l (hazard ratio: 0.53; 95% confidence interval: 0.40 to 0.69; p < 0.00001). In current U.S. guidelines, hsCRP carries a class IIb assessment and is most appropriate in primary prevention when clinical decisions to initiate statin therapy are uncertain. Ongoing multinational trials are pursuing whether reducing inflammation will decrease vascular event rates.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jacc.2015.11.037

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674
Self-citation
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Self-citation
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Self-citation
Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes
Cannon, C. P., Blazing, M. A., Giugliano, R. P., McCagg, A., White, J. A., Theroux, P., Darius, H., Lewis, B. S., Ophuis, T. O., Jukema, J. W., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1410489 · Cited by 4,487
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Progress and challenges in translating the biology of atherosclerosis
Libby, P., Ridker, P. M., & Hansson, G. K. (2011) · Nature · doi:10.1038/nature10146 · Cited by 4,010
Self-citation
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J. J., Gotto, A. M., Kastelein, J. J. P., Köenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344393.60303.0a · Cited by 3,641
Self-citation
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604
Self-citation

Show all 64 references

Sorted by citations

Items 201–300 of 417

Role of interleukin 1 in the development of atherosclerosis
Nasonov, E. L., & Попкова, Т. В. (2019) · Rheumatology Science and Practice · doi:10.14412/1995-4484-2018-28-34 · Cited by 9
ARNIs: balancing “the good and the bad” of neuroendocrine response to HF
Ferrari, R., Cardoso, J., Fonseca, M., Aguiar, C., Moreira, J. I., Fucili, A., & Rapezzi, C. (2019) · Clinical Research in Cardiology · doi:10.1007/s00392-019-01547-2 · Cited by 9
C-Reactive Protein Level and the Genetic Variant rs1130864 in the CRP Gene as Prognostic Factors for 10-Year Cardiovascular Outcome
Schulz, S., Rehm, S., Schlitt, A., Lierath, M., Lüdike, H., Hofmann, B., Bitter, K., & Reichert, S. (2023) · Cells · doi:10.3390/cells12131775 · Cited by 9
The therapeutic potential of Honeysuckle in cardiovascular disease: an anti-inflammatory intervention strategy
Zhao, Y. (2024) · American Journal of Translational Research · doi:10.62347/njmj7853 · Cited by 8
Recent Trends in Hydrogel-Based Biosensor Technology for the Diagnosis of Neurodegenerative Diseases
Ayçiçek, S., Cevher, Ş. C., & Acar, S. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00420 · Cited by 9
Association of neutrophil-to-lymphocyte ratio with clinical outcomes after percutaneous coronary intervention
Oliva, A., Vogel, B., Sartori, S., Cao, D., Smith, K. F., Bay, B., Sweeny, J. M., Muro, F. M. D., Danias, M., Moreno, P., et al. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf597 · Cited by 8
Self-citation
Inverted U‐Shaped Association of Plasma Resolvin D2 With Atherosclerotic Cardiovascular Disease and the Mediation Effects of Serum Cholesterol: A Chinese Community‐Based Study
Liu, B., Zhang, J., Zhang, K., Li, M., Jing, Y., Gu, S., Ding, H., Liang, Y., Zhou, H., & Dong, C. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.032588 · Cited by 8
Association of high-sensitivity C-reactive protein and hematologic-inflammatory indices with risk of cardiovascular diseases: a population-based study with partial least squares structural equation modeling approach
Hafezi, S. G., Ahari, R. K., Saberi‐Karimian, M., Giski, Z. E., Mansoori, A., Ferns, G. A., Ebrahimi, M., Heidari‐Bakavoli, A., Moohebati, M., Yousefian, S., et al. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05122-w · Cited by 8
Inflammatory Biomarkers of Cardiometabolic Risk in Obese Egyptian Type 2 Diabetics
Barakat, L. A. A., Shora, H., El‐Deen, I. M., & El-Sayed, E.-S. (2017) · Medical Sciences · doi:10.3390/medsci5040025 · Cited by 8
Identification of risk factors for sepsis-associated mortality by gene expression profiling analysis
Yan, Q., Chen, X., Wu, N., Ma, C., Cui, X., & Liu, Z. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8491 · Cited by 8
A comparison study between wide‐range and high‐sensitivity C‐reactive protein assays (Roche Cobas c702) for low C‐reactive protein concentration in patients with cardiovascular risk
Li, R., Xue, Y., Wang, T., Gong, L., Peng, P., Xiong, P., Dai, M., Shao, T., Hu, Y., & Ye, X. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22957 · Cited by 8
A New Biomarker in Patients with Vitiligo: A Case-Control Study
Ghaderi, R. (2016) · MOJ Immunology · doi:10.15406/moji.2016.03.00106 · Cited by 8
Predictive ability of C-reactive protein for stroke.
Ahangar, A. A. (2016) · PubMed Central · Cited by 8
Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study
Tian, W., Zhang, T., Wang, X., Zhang, J., Ju, J., & Xu, H. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2309317 · Cited by 7
Temporal Relationship Between Visceral Fat and Inflammation, and Their Joint Effect on Cardiometabolic Diseases: Evidence from the China Health and Retirement Longitudinal Study (CHARLS)
Lin, M., Zhou, Y., Wu, R., Li, S., Ni, X., Xiao, J., Han, S., Tang, H., Huang, J., Wen, J., et al. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s539644 · Cited by 7
C-Reactive Protein and Fatty Acids
Norde, M. M., Oki, É., & Rogero, M. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811297-7.00009-3 · Cited by 7
Biomarkers associated with atherogenesis: current status and promising areas
Magruk, M. A., Mosikian, A. A., & Babenko, A. Y. (2019) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2019-12-148-152 · Cited by 7
C-reactive protein in traditional melanesians on Kitava
Carrera‐Bastos, P., Fontes‐Villalba, M., Gurven, M., Muskiet, F. A. J., Åkerfeldt, T., Lindblad, U., Råstam, L., Frostegård, J., Shapira, Y., Shoenfeld, Y., et al. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-020-01812-7 · Cited by 10
Cross-sectional associations between accelerometry-measured physical activity, left atrial size, and indices of left ventricular diastolic dysfunction: The Tromsø Study
Heitmann, K. A., Løchen, M., Hopstock, L. A., Stylidis, M., Welde, B., Schirmer, H., & Morseth, B. (2020) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2020.101290 · Cited by 8
Younger women are more susceptible to inflammation: A longitudinal examination of the role of aging in inflammation and depressive symptoms
Kuhlman, K. R., Irwin, M. R., Ganz, P. A., Cole, S. W., Manigault, A. W., Crespi, C. M., & Bower, J. E. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.019 · Cited by 8
Post-PCI Risk Assessment by Inflammation Activity According to Disease Acuity and Time from Procedure
Song, H., Ahn, J., Kang, M. G., Kim, K., Bae, J. S., Cho, S. Y., Koh, J., Park, Y., Hwang, S., Cho, E. J., et al. (2023) · Thrombosis and Haemostasis · doi:10.1055/a-2011-8426 · Cited by 7
Low protein Z plasma level is a risk factor for acute myocardial infarction in coronary atherosclerosis disease patients
Liu, B., Li, Y., Luo, J., Dai, L., Zhao, J., Li, H., Jie, Q., Wang, D., Huang, X., & Wei, Y. (2016) · Thrombosis Research · doi:10.1016/j.thromres.2016.10.010 · Cited by 7
C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women
de Santis, I. P., Lindenau, J. D., Ramos, R. B., Silva, T. R., Casanova, G. K., Oppermann, K., & Spritzer, P. M. (2020) · Women s Midlife Health · doi:10.1186/s40695-020-00051-2 · Cited by 7
Prognostic value of C-reactive protein predicting all-cause and cause-specific mortality: a prospective cohort study in Shanghai, China
Ke, J., Liu, Q., Liu, X., Wu, K., Qiu, H., Song, J., Ruan, X., & Zhou, Y. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-101532 · Cited by 8
Association of C-reactive protein-triglycerides-glucose index-waist to height ratio and cardiometabolic multimorbidity in middle-aged and older adults: a nationwide cohort study
Du, J., Man, Z., Bai, X., Luo, D., Guo, Q., Wang, Y., Yan, Y., Su, X., & Zheng, W. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03151-x · Cited by 6
High‐sensitivity C‐reactive protein to high‐density lipoprotein cholesterol ratio predicts long‐term adverse outcomes in patients who underwent percutaneous coronary intervention: A prospective cohort study
Dai, X., Xue, Z.-K., Wang, X., Chen, K., Hu, S., Tse, G., Rha, S., & Liu, T. (2024) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13919 · Cited by 6
Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome
Aarsetoey, R., Ueland, T., Aukrust, P., Michelsen, A. E., de la Fuente, R. L., Grundt, H., Staines, H., Nygaard, O. K., & Nilsen, D. W. T. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02306-w · Cited by 6
Undiagnosed Pediatric Elevated Blood Pressure Is Characterized by Induction of Proinflammatory and Cytotoxic Mediators
Thürmann, L., Bauer, M., Ferland, M., Messingschlager, M., Schikowski, T., Berg, A. V., Heinrich, J., Herberth, G., Lehmann, I., Standl, M., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21489 · Cited by 6
Clonal Hematopoiesis and Cardiovascular Risk: Atherosclerosis, Thrombosis, and beyond
Izzi, B., & Fuster, J. J. (2024) · Hämostaseologie · doi:10.1055/a-2219-6410 · Cited by 6
γ′ fibrinogen levels are associated with blood clot strength in traumatic brain injury patients
Farrell, D. H., Rick, E. A., Dewey, E. N., Schreiber, M. A., & Rowell, S. (2019) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2019.12.028 · Cited by 6
Markers of Cardiovascular Disease among Adults Exposed to Smoke from the Hazelwood Coal Mine Fire
Betts, J. M., Dewar, E. M., Stub, D. A., Gao, C. X., Brown, D. W., Ikin, J. F., Zeleke, B. M., Biswas, S., Abramson, M. J., & Liew, D. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041587 · Cited by 6
Effect of compliance during periodontal maintenance therapy on c‐reactive protein levels: a 6‐year follow‐up
Costa, F. O., Esteves Lima, R. P., Cortelli, S. C., Costa, A. M., Cortelli, J. R., & Cota, L. O. M. (2021) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13407 · Cited by 5
Assessment of Cardiovascular Risk Factors in Women Having Female Pattern Hair Loss
Verma, D., Mendiratta, V., Garg, T., Tripathi, S., & Tomer, S. (2024) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_104_23 · Cited by 5
Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects
Bertolami, A., Júnior, J. C. D. L., Cintra, R. M. R., de Carvalho, L. S. F., Gonzaga, C. C., Sulzbach, M. L., Petisco, A. C. G. P., Barbosa, J. E. M., Faludi, A. Á., Plutzky, J., et al. (2017) · Clinical Endocrinology · doi:10.1111/cen.13540 · Cited by 5
Clinical utility of inflammatory and genetic biomarkers for cardiovascular disease prevention, categorization, and treatment
Mewborn, E. K., Wright, D. B., & Wicks, M. (2023) · Journal of the American Association of Nurse Practitioners · doi:10.1097/jxx.0000000000000901 · Cited by 4
Blood Biomarkers as a Non-Invasive Method for the Assessment of the State of the Fontan Circulation
Wittczak, A., Mazurek-Kula, A., Banach, M., Piotrowski, G., & Bielecka-Dabrowa, A. M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020496 · Cited by 6
Large HDL2 combined with inflammatory factors as superior predictors for coronary artery disease than small HDL3
Wu, X., He, Z., Sun, R., Xie, X., Chen, Q., Wang, J., Bao, J., Huang, J., Jiang, Y., Zhang, Y., et al. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-948 · Cited by 4
Low-density lipoprotein cholesterol in oldest old with acute myocardial infarction: Is lower the better?
Liu, H., Zhang, M., Chen, R., Zhou, J., Qian, J., Dou, K., Yan, H., & Li, J. (2022) · Age and Ageing · doi:10.1093/ageing/afac202 · Cited by 5
Unequally Unequal? Contextual-level status inequality and social cohesion moderating the association between individual-level socioeconomic position and systemic chronic inflammation
Oberndorfer, M., Leyland, A. H., Pearce, J. R., Grabovac, I., Hannah, M. K., & Dorner, T. E. (2023) · Social Science & Medicine · doi:10.1016/j.socscimed.2023.116185 · Cited by 5
C-reactive protein, pharmacological treatments and diet: how to target your inflammatory burden
Bay, B., Arnold, N., & Waldeyer, C. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000922 · Cited by 5
Prognostic role of serum high mobility group box 1 concentration in cardiac surgery
Kim, N., Lee, S., Lee, J. R., Kwak, Y. L., Jun, J.-H., & Shim, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-63051-2 · Cited by 5
Prognostic Impact of Statins on Patients With Peripheral Artery Disease With Elevated C-Reactive Protein Levels
Shibahashi, E., Jujo, K., Mizobuchi, K., Nakao, M., Uchigata, Y., & Yamaguchi, J. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.09.018 · Cited by 6
Casting NETs to predict cardiovascular outcomes
Kithcart, A. P., & Libby, P. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318766413 · Cited by 5
A new comprehensive parameter combining residual C-reactive protein and neutrophil risk predicting adverse events in Chinese patients after percutaneous coronary intervention: A multi-center prospective cohort study
Yang, F., Yu, M., Yuan, Y., Xu, J., Liu, M., Nie, S., Xiong, Y., Yu, L., Long, Q., Zhu, Z., et al. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003885 · Cited by 4
Phase angle is associated with inflammatory parameters in young adults and adults with metabolic syndrome in a population-based study
Gabiatti, M. P., Longo, G. Z., Hauschild, D. B., Pinto, L. G., & Hansen, F. (2025) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2025.104028 · Cited by 4
Lipoprotein(a) elevation independently associates with incident atrial fibrillation irrespective of inflammatory status
Li, L., Hu, Z., Wu, L., WU, L., Liu, L., Zhou, L., Peng, X., Xu, M., Zhang, T., Zhao, M., et al. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.08.001 · Cited by 4
Clinical impact of systemic inflammation across different high-sensitivity C-reactive protein cutoffs in patients undergoing percutaneous coronary intervention
Oliva, A., Shneyderman, M., Gitto, M., Sartori, S., Vogel, B., Bay, B., Smith, K. F., Moreno, P., Sweeny, J. M., Muro, F. M. D., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120523 · Cited by 4
A CRISPR/Cas12a-based aptasensor enhanced by functionalized AuNPs for sensitive full-range C-reactive protein detection
Wang, S., Guan, X., & Sun, S. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01727k · Cited by 4
Evaluation of atherosclerotic risk in rosacea patients through serum fetuin‐A and carotid intima media thickness
Kulaklı, S., Yıldırmak, S., Oğuz, I. D., Usta, M., Tosun, A., & Akşan, B. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16094 · Cited by 4
PCSK9 inhibitors ameliorate arterial stiffness in ACS patients: evidences from Mendelian randomization, a retrospective study and basic experiments
Xu, L., Wang, L., Wang, Y., Wang, Y., Jiang, Y., Du, P., Cheng, J., Zhang, C., Wang, R., Jiao, T., et al. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1408760 · Cited by 4
Are circadian rest–activity rhythms sex‐specific markers of frailty risk in older adults? A narrative review
Kim, J., Kirkman, D. L., Lü, J., Sargent, L. J., & Kim, Y. (2025) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.70110 · Cited by 4
The Effect of Emergency Department Visits and Inflammatory Markers on One-Year Mortality in Patients with Heart Failure
Köse, A., Çelik, A., Altınsoy, K. E., Bozkurt, S., & Erdoğan, S. (2020) · Cardiovascular Toxicology · doi:10.1007/s12012-020-09594-2 · Cited by 4
The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis
Liu, X., Xie, H., Zheng, G., & Liu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-89905-x · Cited by 4
Weight underestimation and weight nonregulation behavior may be related to weak grip strength
Lee, K. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.12.016 · Cited by 4
Inflammatory Markers and Risk of Cardiovascular Events in Ischemic Stroke
Boghozian, R., Falcione, S. R., & Jickling, G. C. (2023) · Stroke · doi:10.1161/strokeaha.123.042584 · Cited by 4
A cross-sectional study of the relationship between physical activity, diet quality, and high-sensitivity C-reactive protein in US adults
Xu, F., Earp, J. E., Delmonico, M. J., Lofgren, I. E., & Riebe, D. A. (2024) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2023.12.021 · Cited by 3
The Metabolic Outcomes of Obstructive Sleep Apnea Surgery: A Scoping Review
Kutler, R. B., Caplan, I. F., Jelić, S., St‐Onge, M., & Cai, Y. (2025) · The Laryngoscope · doi:10.1002/lary.32255 · Cited by 3
The effects of estimated glucose disposal rate and high sensitivity C-reactive protein on risk of incident cardiovascular diseases in middle-aged and elderly Chinese adults: a nationwide prospective cohort study
Xu, L., Ma, J., & Xu, Y. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02653-z · Cited by 3
A prometabolite strategy inhibits cardiometabolic disease in an ApoE–/– murine model of atherosclerosis
Beckman, T. N., Volpatti, L. R., de Matos, S. N., Slezak, A. J., Reda, J. W., Weinstock, A., Ziolkowski, L. M., Turk, A., Budina, E., Cao, S., et al. (2025) · JCI Insight · doi:10.1172/jci.insight.191090 · Cited by 3
Association of the monocyte-to-albumin ratio with cardiovascular disease and with all-cause and cardiovascular mortality in the general population
Jin, Y., Wang, X., Chen, Y., Li, X., Wu, X., Tian, Y., & Li, J. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1645793 · Cited by 3
High Urine Albumin-to-Creatinine Ratio is Associated with Increased Arterial Stiffness in Diabetes: A Chinese Cross-Sectional Study
Guo, K., Zhu, Y., Yu, Q., Chen, H., Cheng, W., Zhang, X., Zhang, X., Liu, B., Zhou, Z., & Kuang, X. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s457883 · Cited by 3
The impact of elevated C-reactive protein levels on long-term outcomes of patients undergoing transcatheter aortic valve replacement
Brunner, S., Moccetti, F., Loretz, L., Conrad, N., Bossard, M., Attinger‐Toller, A., Kurmann, R., Cuculi, F., Wolfrum, M., & Toggweiler, S. (2024) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2024.07.002 · Cited by 3
Influence of circadian alignment and sleep timing variability on sex-specific inflammatory markers in healthy adults
Shafer, B. M., McAuliffe, K., Kogan, S. A., Davis, M. C., Shea, S. A., Olson, R., & McHill, A. W. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00735.2025 · Cited by 3
Plaque vulnerability and adverse outcomes: The long road to fight atherosclerosis
Bonaventura, A., Liberale, L., Carbone, F., Vecchié, A., & Montecucco, F. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13253 · Cited by 3
The impact of a comprehensive pharmaceutical care intervention in addition to cardiac rehabilitation program on outcomes of post-acute coronary syndrome patients: A pilot study
Casper, E. A., Wakeel, L. M. E., Saleh, M. A., & El‐Hamamsy, M. (2022) · Patient Education and Counseling · doi:10.1016/j.pec.2022.06.004 · Cited by 3
Proteína C reactiva ultrasensible como marcador proinflamatorio y su asociación con la obesidad
Greene, E. J. D., Siu, P. Y. A., Benítez, L. F. B., Jiménez, V. V., Fuentes, A. K. R., Pacheco, S. T., Arredondo, D. A. S., & Reyes, P. A. S. (2023) · Acta Médica Grupo Ángeles · doi:10.35366/109021 · Cited by 3
Exploration of Inflammatory Biomarkers and Psychological Cardiovascular Disease Risk Factors Among Community Dwelling Adults: A Gender Comparison Study
Hung, H., Chen, M.-F., Lee, H., & Wang, H. (2023) · Biological Research For Nursing · doi:10.1177/10998004231197845 · Cited by 3
Effect of Serum IL-6 Levels on the Progression of Non-Target Lesions in Patients after Coronary Stenting
Sha, X., Wang, W., Qiu, J., & Wang, R. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2507234 · Cited by 3
The correlation between stable angina and inflammatory factors and blood lipids: a case-control study
Xiang, L. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1443450 · Cited by 3
Effect of high sensitivity C-reactive protein on uric acid-related cardiometabolic risk in patients with coronary artery disease—a large multicenter prospective study
Song, Y., Cai, W., Jiang, L., Xu, J., Yao, Y., Xu, N., Wang, X., Liu, Z., Zhang, Z., Zhang, Y., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-75508-9 · Cited by 3
C-reactive protein and its associations with сardiometabolic risk factors and echocardiographic indicators of heart failure: results of “Know your heart” study in Arkhangelsk
Алексеевна, М. О., Kudryavtsev, A. V., Семчугова, Э. О., Malyutina, S. K., & Ryabikov, A. N. (2020) · Kardiologiia · doi:10.18087/cardio.2020.9.n975 · Cited by 3
The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting
Gao, M., Fan, K.-J., Yu, W., Liu, H., Wei, Y., & Yu, Y. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02168-2 · Cited by 3
C-reactive protein as an indicator of polymorbidity in patients with arterial hypertension
Sevostyanova, E. V., Nikolaev, Y. A., Митрофанов, И. М., & Polyakov, V. Y. (2022) · Сибирский научный медицинский журнал · doi:10.18699/ssmj20220209 · Cited by 3
Mechanisms of Hypercoagulation and Aberrant Clot Lyses in Type 2 Diabetes
Pretorius, E. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_17 · Cited by 3
Oxidative Stress Reduction (Prong-3)
DePace, N. L., & Colombo, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-17016-5_5 · Cited by 3
Colchicine Use in Acute Coronary Syndromes: An Update
Tapoi, L. C., Benchea, L.-C., Siriopol, D. C., Kanbay, M., & Covic, A. C. (2021) · Angiology · doi:10.1177/0003319720985644 · Cited by 3
Integrated CT-derived fractional flow reserve and perivascular fat attenuation index: a multimodal approach to predict in-stent restenosis
Zhao, W., Huang, L., Zhu, M., Li, X., Liu, X., Zhang, W., Shao, C., & Li, Y. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1703044 · Cited by 2
Integrative Transcriptomic and Bioinformatics Approaches Combined With Transformer Models Identify Key Gene Networks in Atherosclerosis
Yan, D., Li, W., Xing, E., Wang, P., & Zhang, Z. (2026) · The FASEB Journal · doi:10.1096/fj.202503988r · Cited by 2
The joint effect of cardiometabolic index and high-sensitivity C-reactive protein on incident cardiovascular disease: A prospective cohort study
Zhou, J., Li, Z., Du, L.-L., Oyang, Y.-L., & Gao, Y. (2026) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2026.104566 · Cited by 2
A quantitative method to estimate free interleukin-6 among patients treated with the interleukin-6 ligand inhibitor ziltivekimab: comparison to C-reactive protein with implications for the ZEUS, HERMES, and ARTEMIS cardiovascular outcomes trials
Nolain, P., Fugger, M., Hellinghus, B. T., Hilgendorf, I., Højen, J. F., Libby, P., Liuzzo, G., Matter, C. M., Tuttle, K. R., & Ridker, P. M. (2026) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2026.120742 · Cited by 2
Self-citation
Targeting Inflammation in Atherosclerotic Cardiovascular Disease: Mechanisms and Emerging Therapies
Spindler, M. P., Libby, P., & Ridker, P. M. (2026) · Immunological Reviews · doi:10.1111/imr.70151 · Cited by 3
Self-citation
High-sensitivity C-reactive protein as a prognostic marker in patients undergoing valve surgery
Duchnowski, P., Szymański, P., Kuśmierczyk, M., & Hryniewiecki, T. (2020) · Polish Journal of Cardio-Thoracic Surgery · doi:10.5114/kitp.2020.94185 · Cited by 2
The relationship between the level of Lр(а) and the prevalence of atherosclerosis among young patients
Александровна, К. Е., Afanasieva, O. I., Sherstyuk, E. E., Tmoyan, N. A., Андреевна, Р. О., Tyurina, A. V., Afanasieva, M. I., Владиславович, Е. М., & Pokrovsky, S. N. (2022) · Terapevticheskii arkhiv · doi:10.26442/00403660.2022.04.201454 · Cited by 2
Rivaroxaban in patients with abdominal aortic aneurysm and high-sensitivity C-reactive protein elevation (BANBOO): study protocol for a randomized, controlled trial
Li, J., Ma, S., Jia, X. J., Bu, Y., Zhou, T., Zhang, L., Qiu, M., & Wang, X. (2023) · Trials · doi:10.1186/s13063-023-07461-3 · Cited by 2
Deep Learning and Single‐Cell Sequencing Analyses Unveiling Key Molecular Features in the Progression of Carotid Atherosclerotic Plaque
Zhang, H., Wang, Y., Liu, M., Yao, Q., Shen, S., Gang, Q., Jiang, H., Lun, Y., & Zhang, J. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70220 · Cited by 2
Low-grade inflammation in prognosis in patients undergoing coronary artery bypass grafting: The importance of neutrophil-to-lymphocyte ratio and growth differentiation factor 15
Анатольевна, Г. А., Андреевна, К. Е., Tukish, O. V., & Repin, A. N. (2025) · Russian Open Medical Journal · doi:10.15275/rusomj.2025.0107 · Cited by 2
The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury
Halma, M. T. J., Vottero, P., Thorp, J. A., Peers, T., Tuszyński, J. A., & Marik, P. E. (2025) · Advances in Virology · doi:10.1155/av/7990876 · Cited by 2
Metabolic syndrome and weight status may modify the inverse association between handgrip strength and C-reactive protein in Korean adults
Lee, K. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.12.002 · Cited by 2
Circunferencia de la cintura como predictor de factores de riesgo de enfermedad cardiovascular en residentes costarricenses de 60 años y más.
Fernández, E. A., & Carballo-Alfaro, A. M. (2021) · UNED Research Journal · doi:10.22458/urj.v13i1.3398 · Cited by 2
High-Sensitivity C-Reactive Protein
Feldman, D. I., Blumenthal, R. S., & Gluckman, T. J. (2022) · Contemporary cardiology · doi:10.1007/978-3-030-98824-1_17 · Cited by 2
High‐sensitivity C‐reactive protein is a predictor of all‐cause mortality in a rural Japanese population
Kawamoto, R., Kikuchi, A., Niomiya, D., & Kumagi, T. (2024) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.25015 · Cited by 2
The Relationship of the Concentration of Lipoprotein(a) and Markers of Inflammation with Multifocal Atherosclerosis in Women
Afanasieva, O. I., Tmoyan, N. A., Александровна, К. Е., Андреевна, Р. О., Владиславович, Е. М., Afanasieva, M. I., & Pokrovsky, S. N. (2019) · Kardiologiia · doi:10.18087/cardio.2019.10.n520 · Cited by 2
Relationship between plasma high-sensitivity C-reactive protein and traditional cardiovascular risk factors among active-duty military personnel in the Republic of Serbia
Ratković, N., Pandrc, M. S., Perić, V., Stojanović, M., & Rančić, N. (2021) · Vojnosanitetski pregled · doi:10.2298/vsp210122030r · Cited by 2
A Devotion to Never Feeling Satisfied
Fuster, V. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.025 · Cited by 2
Beyond LDL-C: Triangulating residual risk via lipoprotein(a), remnant cholesterol, and vascular inflammation
Kalra, D. K. (2026) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2026.06.002 · Cited by 2
Baseline inflammatory status affects the prognostic impact of statins in patients with peripheral arterial disease
Jujo, K., Ueshima, D., Abe, T., Shimazaki, K., Fujimoto, Y., Tanaka, T., Murata, T., Miyazaki, T., Matsumoto, M., Tokuyama, H., et al. (2024) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2024.100481 · Cited by 1
Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review
Александровна, С. Н., Сергеевна, Г. А., Kravchenko, E. E., Vishnyakov, V. A., & Mokin, E. I. (2025) · Cardiosomatics · doi:10.17816/cs640894 · Cited by 1
Determinants of lack of atherosclerosis progression in adult patients with elevated lipoprotein (a): results from the STAR-Lp(a) study
Sosnowska, B., Bytyçi, I., Lewek, J., Bielecka-Dabrowa, A. M., Burzyńska, M., Jankowski, P., Chudzik, M., & Banach, M. (2025) · Archives of Medical Science · doi:10.5114/aoms/209946 · Cited by 3
Long-term effects on cardiac function and symptoms in patients with myocarditis following COVID-19 vaccination: the ECHOVID-19 Long-term Study
Ramadan, M. N., Davidovski, F. S., Espersen, C., Al‐Rubai, A. H., Khoraizat, A., Johansen, N. D., Skaarup, K. G., Lassen, M. C. H., Hviid, A. P., Grove, T., et al. (2025) · Open Heart · doi:10.1136/openhrt-2025-003584 · Cited by 2
Association of disability and inflammation: Potential risks to a vulnerable population
Liu-Galvin, R. E., Orlando, F. A., & Mainous, A. G. (2025) · Disability and health journal · doi:10.1016/j.dhjo.2025.101969 · Cited by 1

Authors: Ridker, P. M.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Ridker, Paul M
ORCID: Ridker, Paul M
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2016-02
Volume: 67
Issue: 6
Pages: 712-723
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2015.11.037
OpenAlex: W2264523161
Cited by: 414
References: 64
Citations by year: 2026: 54 · 2025: 51 · 2024: 45 · 2023: 47 · 2022: 35 · 2021: 35 · 2020: 48 · 2019: 34 · 2018: 30 · 2017: 19 · 2016: 16
FWCI: 6.54
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
AstraZeneca
American College of Cardiology Foundation
National Heart, Lung, and Blood Institute (U01HL101422)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
Keywords: high-sensitivity C-reactive protein, inflammation, cardiovascular risk, cardiovascular risk prediction, statins, rosuvastatin, JUPITER trial, primary prevention, Framingham risk factors, LDL cholesterol, myocardial infarction, stroke, cardiovascular mortality
MeSH terms: C-Reactive Protein, Cardiovascular Diseases, Humans, Predictive Value of Tests, Global Health, Reproducibility of Results, Biomarkers, Incidence, Survival Rate, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Test in Context

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks