High-sensitivity C-reactive protein, inflammation, and cardiovascular risk: From concept to clinical practice to clinical benefit
Abstract
Advances in vascular biology have shown that inflammation plays an integral role in the development of cardiovascular disease. Extensive study of high-sensitivity C-reactive protein (hs-CRP) has demonstrated that this measure of inflammation predicts cardiovascular risk not reflected by traditional risk factors, adds prognostic information to traditional risk assessment, and predicts long-term cardiovascular risk in individuals with no prior evidence of cardiovascular disease. Patients with elevated hs-CRP levels in the absence of elevated cholesterol appear to derive preventive benefit from statin therapy that is similar in magnitude to that in patients with elevated cholesterol. The large-scale Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosvastatin (JUPITER) trial represents a critical study to determine the utility of a strategy for targeting statin therapy to prevent incident cardiovascular disease in patients at increased cardiovascular risk on the basis of elevated hs-CRP who would not be considered candidates for therapy on the basis of hypercholesterolemia or traditional risk assessment. Inclusion of hs-CRP measurement in risk screening and use of this information to guide preventive therapy could result in a marked improvement in prevention of cardiovascular morbidity and mortality.
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APOE genotyping was performed with allele-specific PCR with universal molecular beacons, and DNA sequencing of positive control DNA samples was completed to assure correct assignment of alleles.
“Genotyping of APOE polymorphisms rs7412 and rs429358 was performed at PreventionGenetics (www.preventiongenetics.com) with an array tape [58] using allele-specific PCR with universal molecular beacons [59, 60]. DNA sequencing of positive control DNA samples were completed to assure correct assignment of alleles.”
From Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial (2016) · cites this paper as [59]
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- Authors
- Ridker, P. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Ridker, Paul M
- ORCID
- Ridker, Paul M
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 148
- Issue
- 1
- Pages
- S19-S26
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2084102521
- Cited by
- 290
- References
- 21
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 3 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 19 · 2012: 15
- FWCI
- 26.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- high-sensitivity C-reactive protein, inflammation, cardiovascular risk, cardiovascular disease prevention, statin therapy, rosuvastatin, JUPITER trial, primary prevention, cardiovascular risk assessment, hypercholesterolemia, risk screening
- MeSH terms
- Anticholesteremic Agents, C-Reactive Protein, Cardiovascular Diseases, Clinical Trials as Topic, Humans, Inflammation, Lipids, Cholesterol, LDL, Myocardial Infarction, Risk, Risk Factors, Stroke, Metabolic Syndrome
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