Cited by 229Vitamin D Research StudiesHeart Failure Treatment and ManagementCardiovascular Function and Risk Factors

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Effects of Vitamin D on Cardiac Function in Patients With Chronic HF

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Witte, Klaus K., Byrom, Rowena, Gierula, John, Paton, Maria F., Jamil, Haqeel A., Lowry, Judith E., Gillott, Richard G., Barnes, Sally A., Chumun, Hemant, Kearney, Lorraine C., Greenwood, John P., Plein, Sven, Law, Graham R., Pavitt, Sue, Barth, Julian H., Cubbon, Richard M., Kearney, Mark T.·2016·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2016.03.508PMC PMC4893154

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Abstract

BACKGROUND: Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D. Low vitamin D levels are associated with a worse prognosis. OBJECTIVES: The VINDICATE (VitamIN D treatIng patients with Chronic heArT failurE) study was undertaken to establish safety and efficacy of high-dose 25 (OH) vitamin D3 (cholecalciferol) supplementation in patients with chronic HF due to LVSD. METHODS: We enrolled 229 patients (179 men) with chronic HF due to LVSD and vitamin D deficiency (cholecalciferol <50 nmol/l [<20 ng/ml]). Participants were allocated to 1 year of vitamin D3 supplementation (4,000 IU [100 μg] daily) or matching non-calcium-based placebo. The primary endpoint was change in 6-minute walk distance between baseline and 12 months. Secondary endpoints included change in LV ejection fraction at 1 year, and safety measures of renal function and serum calcium concentration assessed every 3 months. RESULTS: One year of high-dose vitamin D3 supplementation did not improve 6-min walk distance at 1 year, but was associated with a significant improvement in cardiac function (LV ejection fraction +6.07% [95% confidence interval (CI): 3.20 to 8.95; p < 0.0001]); and a reversal of LV remodeling (LV end diastolic diameter -2.49 mm [95% CI: -4.09 to -0.90; p = 0.002] and LV end systolic diameter -2.09 mm [95% CI: -4.11 to -0.06 p = 0.043]). CONCLUSIONS: One year of 100 μg daily vitamin D3 supplementation does not improve 6-min walk distance but has beneficial effects on LV structure and function in patients on contemporary optimal medical therapy. Further studies are necessary to determine whether these translate to improvements in outcomes. (VitamIN D Treating patIents With Chronic heArT failurE [VINDICATE]; NCT01619891).

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Lowry, 2015, Vitamin d supplementation improves the size and function of the left ventricle in patients with heart failure, Eur Heart J, 36, A665

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Reply
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VITAMIN D AND ITS RELATIONSHIP WITH CARDIOVASCULAR DISEASES
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Vitamina D e prevenzione cardiovascolare
Lullo, L. D., Rivera, R. F., Floccari, F., Bàrbera, V., Bellasi, A., Pascalis, A. D., Russo, D., Russo, L., Santoboni, F., & Ronco, C. (2016) · Giornale di Clinica Nefrologica e Dialisi · doi:10.33393/gcnd.2016.750
The effect of vitamin D therapy in the improvement of cardiac performance and exercise capacity in patients with heart failure: A double-blind, randomized, placebo-controlled trial.
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Authors: Witte, K. K., Byrom, R., Gierula, J., Paton, M. F., Jamil, H. A., Lowry, J. E., Gillott, R. G., Barnes, S. A., Chumun, H., Kearney, L. C., Greenwood, J. P., Plein, S., Law, G. R., Pavitt, S., Barth, J. H., Cubbon, R. M., & Kearney, M. T.
Affiliations: University of Leeds (GB)
Leeds Teaching Hospitals NHS Trust (GB)
Corresponding author: Witte, Klaus K.
ORCID: Witte, Klaus K.
Gierula, John
Paton, Maria F.
Jamil, Haqeel A.
Lowry, Judith E.
Greenwood, John P.
Plein, Sven
Law, Graham R.
Pavitt, Sue
Barth, Julian H.
Cubbon, Richard M.
Kearney, Mark T.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2016-06
Volume: 67
Issue: 22
Pages: 2593-2603
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2016.03.508
PMC: PMC4893154
OpenAlex: W2338797564
Cited by: 229
References: 45
Citations by year: 2026: 7 · 2025: 10 · 2024: 18 · 2023: 23 · 2022: 21 · 2021: 23 · 2020: 26 · 2019: 22 · 2018: 34 · 2017: 30 · 2016: 14
FWCI: 30.30
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Journal of the American College of Cardiology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Lincoln Repository (University of Lincoln) (acceptedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Institute for Health and Care Research (HCS DRF-2014-05-006)
British Heart Foundation (RG/09/010/28087, FS/12/80/29821, FS/10/028/28252)
University of Leeds
National Institutes of Health
Medical Research Council (MR/J00281X/1)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: vitamin D supplementation, chronic heart failure, left ventricular systolic dysfunction, vitamin D deficiency, 25-hydroxyvitamin D3, vitamin D3, left ventricular ejection fraction, left ventricular remodeling, 6-minute walk distance, renal function, serum calcium
MeSH terms: Walk Test, Aged, Calcifediol, Calcitriol, Cholecalciferol, Double-Blind Method, Echocardiography, Female, Heart Failure, Heart Ventricles, Humans, Male, Middle Aged, Stroke Volume, Systole, Vitamins, Ventricular Dysfunction, Left, Magnetic Resonance Imaging, Cine, Ventricular Remodeling

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Effects of Vitamin D on Cardiac Function in Patients With Chronic HF

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