Cardiac Sarcoidosis
Open accessAbstract
Clinically manifest cardiac involvement occurs in perhaps 5% of patients with sarcoidosis. The 3 principal manifestations of cardiac sarcoidosis (CS) are conduction abnormalities, ventricular arrhythmias, and heart failure. An estimated 20% to 25% of patients with pulmonary/systemic sarcoidosis have asymptomatic cardiac involvement (clinically silent disease). In 2014, the first international guideline for the diagnosis and management of CS was published. In patients with clinically manifest CS, the extent of left ventricular dysfunction seems to be the most important predictor of prognosis. There is controversy in published reports as to the outcome of patients with clinically silent CS. Despite a paucity of data, immunosuppression therapy (primarily with corticosteroids) has been advocated for the treatment of clinically manifest CS. Device therapy, primarily with implantable cardioverter-defibrillators, is often recommended for patients with clinically manifest disease.
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- Authors
- Birnie, D. H., Nery, P. B., Ha, A. C., & Beanlands, R. S. B.
- Affiliations
- Ottawa Heart Institute (CA)
- University Health Network (CA)
- Corresponding author
- Birnie, David H.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 68
- Issue
- 4
- Pages
- 411-421
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W4205862288
- Semantic Scholar
- 5405de3916d6cee318f7ebd2c3e6873a88384b61
- Cited by
- 569
- References
- 71
- Citations by year
- 2026: 37 · 2025: 67 · 2024: 69 · 2023: 69 · 2022: 76 · 2021: 58 · 2020: 67 · 2019: 54 · 2018: 37 · 2017: 33 · 2016: 1
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Sarcoidosis and Beryllium Toxicity Research
- Health Sciences › Medicine › Physiology › Histiocytic Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
- Keywords
- cardiac sarcoidosis, conduction abnormalities, ventricular arrhythmias, heart failure, left ventricular dysfunction, prognosis, corticosteroid immunosuppression, implantable cardioverter-defibrillator, device therapy
- MeSH terms
- Diagnostic Imaging, Electrocardiography, Humans, Cardiomyopathies, Prognosis, Sarcoidosis, Magnetic Resonance Imaging, Cine, Positron-Emission Tomography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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