The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Basic Biology of Oxidative Stress and the Cardiovascular System
Open accessAbstract
The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human biology. However, when ROS generation exceeds endogenous antioxidant capacity, oxidative stress arises. If unchecked, ROS production and oxidative stress mediate tissue and cell damage that can spiral in a cycle of inflammation and more oxidative stress. This article is Part 1 of a 3-part series covering The Role of Oxidative Stress in Cardiovascular Disease. The broad theme of this first paper is the mechanisms and biology of oxidative stress. Specifically, we review the basic biology of oxidative stress, relevant aspects of mitochondrial function, and stress-related cell death pathways (apoptosis and necrosis) as they relate to the heart and cardiovascular system. We then explore telomere biology and cell senescence. As important regulators and sensors of oxidative stress, telomeres are segments of repetitive nucleotide sequence at each end of a chromosome that protect the chromosome ends from deterioration.
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Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
The role of senescent cells in ageing
van Deursen, J. M. (2014) · Nature · doi:10.1038/nature13193 · Cited by 2,623
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524
Obesity, cigarette smoking, and telomere length in women
Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363
Cited by
Wang, Y., Li, L., Zhao, W., Dou, Y., An, H., Tao, H., Xu, X., Jia, Y., Lu, S., Zhang, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02037 · Cited by 361
Oxidative Stress and Cardiovascular Risk: Obesity, Diabetes, Smoking, and Pollution
Niemann, B., Rohrbach, S., Miller, M. R., Newby, D. E., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.043 · Cited by 353
Self-citationLi, Z., Zhu, S., Liu, Q., Wei, J., Jin, Y., Wang, X., & Zhang, L. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115025 · Cited by 301
Kruk, J., Aboul-Enein, H. Y., Kładna, A., & Bowser, J. E. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1612059 · Cited by 284
Obas, V., & Vasan, R. S. (2018) · Clinical Science · doi:10.1042/cs20171156 · Cited by 148
Metadata
- Authors
- Sack, M. N., Fyhrquist, F. Y., Saijonmaa, O. J., Fuster, V., & Kovacic, J. C.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 70
- Issue
- 2
- Pages
- 196-211
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2732112239
- Cited by
- 240
- References
- 49
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sack, M. N., Fyhrquist, F. Y., Saijonmaa, O. J., Fuster, V., & Kovacic, J. C. (2017). Basic Biology of Oxidative Stress and the Cardiovascular System. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2017.05.034
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
