The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis
Abstract
The body of evidence from the past three decades demonstrates that oxidative stress can be involved in several diseases. This study aims to summarise the current state of knowledge on the association between oxidative stress and the pathogenesis of some characteristic to the biological systems diseases and aging process. This review also presents the effect of physical activity on redox homeostasis. There is strong evidence from studies for participation of reactive oxygen and nitrogen species in pathogenesis of acute and chronic diseases based on animal models and human studies. Elevated levels of pro-oxidants and various markers of the oxidative stress and cells and tissues damage linked with pathogenesis of cancer, atherosclerosis, neurodegenerative diseases hypertension, diabetes mellitus, cardiovascular disease, atherosclerosis, reproductive system diseases, and aging were reported. Evidence confirmed that inflammation contributes widely to multiple chronic diseases and is closely linked with oxidative stress. Regular moderate physical activity regulates oxidative stress enhancing cellular antioxidant defence mechanisms, whereas acute exercise not preceded by training can alter cellular redox homeostasis towards higher level of oxidative stress. Future studies are needed to clarify the multifaceted effects of reactive oxygen/nitrogen species on cells and tissues and to continue study on the biochemical roles of antioxidants and physical activity in prevention of oxidative stress-related tissue injury.
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Cites
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Cited by
Exercise-induced oxidative stress: Friend or foe?
Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M. P., & Hyatt, H. (2020) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.04.001 · Cited by 655
Structures of Astaxanthin and Their Consequences for Therapeutic Application
Brotosudarmo, T. H. P., Limantara, L., Setiyono, E., & Heriyanto (2020) · International Journal of Food Science · doi:10.1155/2020/2156582 · Cited by 167
Oslan, S. N. H., Tan, J. S., Oslan, S. N., Matanjun, P., Mokhtar, R. A. M., Shapawi, R., & Huda, N. (2021) · Molecules · doi:10.3390/molecules26216470 · Cited by 121
Ayaz, A., Zaman, W., Radák, Z., & Gu, Y. (2024) · Antioxidants · doi:10.3390/antiox13040437 · Cited by 26
Physical Exercise and Metabolic Reprogramming
Batatinha, H. P., Lira, F. S., Kruger, K., & Rosa Neto, J. C. (2022) · Essential Aspects of Immunometabolism in Health and Disease · doi:10.1007/978-3-030-86684-6_12 · Cited by 5
Metadata
- Authors
- Kruk, J., Aboul-Enein, H. Y., Kładna, A., & Bowser, J. E.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2019-05-04
- Volume
- 53
- Issue
- 5
- Pages
- 497-521
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2943822791
- Cited by
- 284
- References
- 225
- FWCI
- 16.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kruk, J., Aboul-Enein, H. Y., Kładna, A., & Bowser, J. E. (2019). Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis. Free Radical Research. https://doi.org/10.1080/10715762.2019.1612059
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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