Obesity, cigarette smoking, and telomere length in women
Abstract
Obesity and smoking are important risk factors for many age-related diseases. Both are states of heightened oxidative stress, which increases the rate of telomere erosion per replication, and inflammation, which enhances white blood cell turnover. Together, these processes might accelerate telomere erosion with age. We therefore tested the hypothesis that increased body mass and smoking are associated with shortened telomere length in white blood cells. We investigated 1122 white women aged 18-76 years and found that telomere length decreased steadily with age at a mean rate of 27 bp per year. Telomeres of obese women were 240 bp shorter than those of lean women (p=0.026). A dose-dependent relation with smoking was recorded (p=0.017), and each pack-year smoked was equivalent to an additional 5 bp of telomere length lost (18%) compared with the rate in the overall cohort. Our results emphasise the pro-ageing effects of obesity and cigarette smoking.
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Because LTL is also affected by other risk factors for CAD such as oxidative stress, it has been unclear whether the association of shorter LTL with CAD is primary or secondary.
“Because LTL is also affected by other risk factors for CAD such as oxidative stress27–29, it has been unclear whether the association of shorter LTL with CAD is primary or secondary.”
From Identification of seven loci affecting mean telomere length and their association with disease (2013) · cites this paper as [28]
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Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Faner, R., Rojas, M., MacNee, W., & Agustí, A. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201202-0282pp · Cited by 268 · see citing works
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Mediterranean diet and telomere length in Nurses' Health Study: population based cohort study
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Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
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Self-citationChildhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder
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Telomere length predicts poststroke mortality, dementia, and cognitive decline
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The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome
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Obesity May Accelerate the Aging Process
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Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial
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Self-citationObesity and ageing: Two sides of the same coin
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Telomeres and lifestyle factors: Roles in cellular aging.
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SIRT1 contributes to telomere maintenance and augments global homologous recombination
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Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample
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Andrew, T., Aviv, A., Falchi, M., Surdulescu, G. L., Gardner, J. P., Lu, X., Kimura, M., Kato, B. S., Valdes, A. M., & Spector, T. D. (2006) · The American Journal of Human Genetics · doi:10.1086/500052 · Cited by 252 · see citing works
Self-citation
- Authors
- Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T.
- Affiliations
- St Thomas' Hospital (GB)
- University of Medicine and Dentistry of New Jersey (US)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 366
- Issue
- 9486
- Pages
- 662-664
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2147991226
- Cited by
- 1,363
- References
- 6
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 46 · 2023: 47 · 2022: 59 · 2021: 63 · 2020: 65 · 2019: 81 · 2018: 62 · 2017: 80 · 2016: 89 · 2015: 75 · 2014: 98 · 2013: 80 · 2012: 100
- FWCI
- 29.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Healthcare Foundation of New Jersey
- Grant Healthcare Foundation
- Wellcome Trust
- Korea Institute of Machinery and Materials
- National Institutes of Health
- National Institute on Aging (R01AG021593, AG021593)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- obesity, cigarette smoking, telomere length, leukocytes, oxidative stress, inflammation, aging, pack-years, women, body mass index
- MeSH terms
- Adolescent, Adult, Aged, Aging, Female, Humans, Middle Aged, Obesity, Risk Factors, Smoking, Telomere
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