Cited by 255Acute Myocardial Infarction ResearchCardiac Imaging and DiagnosticsClinical Reasoning and Diagnostic Skills

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Clinical Use of High-Sensitivity Cardiac Troponin in Patients With Suspected Myocardial Infarction

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Twerenbold, Raphael, Boeddinghaus, Jasper, Nestelberger, Thomas, Wildi, Karin, Rubini Gimenez, Maria, Badertscher, Patrick, Mueller, Christian·2017·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2017.07.718

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Abstract

High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction 7 years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt, the most important indication of hs-cTn assays, these simple, inexpensive, and highly reproducible tools complement detailed clinical assessment including chest pain characteristics and the electrocardiogram. Hs-cTn assays for the first time allowed the precise quantification of cardiomyocyte injury around the 99th percentile and thereby substantially increased the accuracy of MI detection from blood obtained at presentation to the emergency department (ED). Higher accuracy at ED presentation enabled the development and extensive validation of early hs-cTn-based diagnostic algorithms, which substantially reduced the time required for the safe rule-out or rule-in of MI. This review summarizes key principles underlying the safe and effective use of hs-cTn in the ED in patients with suspected MI.

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Authors: Twerenbold, R., Boeddinghaus, J., Nestelberger, T., Wildi, K., Rubini Gimenez, M., Badertscher, P., & Mueller, C.
Affiliations: University of Basel (CH)
Corresponding author: Mueller, Christian
ORCID: Twerenbold, Raphael
Boeddinghaus, Jasper
Nestelberger, Thomas
Wildi, Karin
Badertscher, Patrick
Mueller, Christian
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2017-08
Volume: 70
Issue: 8
Pages: 996-1012
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2017.07.718
OpenAlex: W2749133321
Cited by: 255
References: 116
Citations by year: 2026: 18 · 2025: 18 · 2024: 19 · 2023: 25 · 2022: 25 · 2021: 29 · 2020: 43 · 2019: 39 · 2018: 32 · 2017: 7
FWCI: 4.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Bristol-Myers Squibb
AstraZeneca
Alere
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (P300PB-167803/1, 167803)
Schweizerische Herzstiftung
Stiftung für Kardiovaskuläre Forschung Basel
Abbott Diagnostics
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
Keywords: high-sensitivity troponin, myocardial infarction, emergency department, early diagnosis, diagnostic algorithm, rule-in and rule-out, cardiomyocyte injury, chest pain
MeSH terms: Algorithms, Humans, Myocardial Infarction, Biomarkers, Troponin I, Troponin T, Early Diagnosis

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Clinical Use of High-Sensitivity Cardiac Troponin in Patients With Suspected Myocardial Infarction

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