The DOI matches its Crossref record; 115 of the 116 references it cites were found in a registry or an index.
Clinical Use of High-Sensitivity Cardiac Troponin in Patients With Suspected Myocardial Infarction
Open accessAbstract
High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction 7 years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt, the most important indication of hs-cTn assays, these simple, inexpensive, and highly reproducible tools complement detailed clinical assessment including chest pain characteristics and the electrocardiogram. Hs-cTn assays for the first time allowed the precise quantification of cardiomyocyte injury around the 99th percentile and thereby substantially increased the accuracy of MI detection from blood obtained at presentation to the emergency department (ED). Higher accuracy at ED presentation enabled the development and extensive validation of early hs-cTn-based diagnostic algorithms, which substantially reduced the time required for the safe rule-out or rule-in of MI. This review summarizes key principles underlying the safe and effective use of hs-cTn in the ED in patients with suspected MI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“cTnI forms the inhibitory subunit of the cTn complex (cTnI–cTnT–TnC; Supplementary Fig. 1) and is released into the bloodstream following cardiac injury23–25 where it circulates with low abundance (typically < 50 ng/mL)26 and in myriad proteoforms (e.g., phosphorylated, acetylated, oxidized, and truncated), making detection and analysis extremely challenging.”
From Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum (2020) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization
Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E., & Hsu, C.-Y. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041031 · Cited by 11,369
Roffi, M., Patrono, C., Collet, J.-P., Mueller, C., Valgimigli, M., Andreotti, F., Bax, J. J., Borger, M. A., Brotons, C., Chew, D. P., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv320 · Cited by 8,261
Self-citationAuthors Task Force Members, Steg, P. G., James, S. K., Atar, D., Badano, L. P., Lundqvist, C. B., Borger, M. A., Mario, C. D., Dickstein, K., Ducrocq, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs215 · Cited by 6,890
Third universal definition of myocardial infarction
the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Thygesen, K., Alpert, J. S., Jaffe, A. S., Simoons, M. L., CHAITMAN, B. R., & White, H. D. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.122 · Cited by 6,585
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O’Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C.-T., Fesmire, F. M., Franklin, B. A., et al. (2012) · Circulation · doi:10.1161/cir.0b013e3182742cf6 · Cited by 4,802
2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes
Amsterdam, E. A., Wenger, N. K., Brindis, R. G., Casey, D. E., Ganiats, T. G., Holmes, D. R., Jaffe, A. S., Jneid, H., Kelly, R. F., Kontos, M. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.017 · Cited by 3,595
The TIMI Risk Score for Unstable Angina/Non–ST Elevation MI
Antman, E. M., Cohen, M. C., Bernink, P. J. L. M., McCabe, C. H., Horacek, T., Papuchis, G., Mautner, B., Corbalán, R., Radley, D. R., & Braunwald, E. (2000) · JAMA · doi:10.1001/jama.284.7.835 · Cited by 3,221
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O'Gara, P. T., Kushner, F. G., Ascheim, D. D., Casey, D. E., Chung, M. K., de Lemos, J. A., Ettinger, S. M., Fang, J. C., Fesmire, F. M., Franklin, B. A., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.019 · Cited by 2,625
Third Universal Definition of Myocardial Infarction
Thygesen, K. A., Alpert, J. S., Jaffe, A. S., Simoons, M. L., CHAITMAN, B. R., White, H. D., Thygesen, K. A., Alpert, J. S., White, H. D., Jaffe, A. S., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.001 · Cited by 2,619
Relation between Renal Dysfunction and Cardiovascular Outcomes after Myocardial Infarction
Anavekar, N. S., McMurray, J. J. V., Velazquez, E. J., Solomon, S. D., Køber, L., Rouleau, J. L., White, H. D., Nordlander, R., Maggioni, A. P., Dickstein, K., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041365 · Cited by 1,923
Research works printed but not linked: 2
- Freeman, 2000, Ten things emergency physicians should not do: unless they want to become defendants, Foresight, 49, 1
- Gregg RE, 2010, Combining Sgarbossa and Selvester ECG criteria to improve STEMI detection in the presence of LBBB, Comput Cardiol, 37, 277
Cited by
Sorted by citations
Fourth universal definition of myocardial infarction (2018)
Thygesen, K. A., Alpert, J. S., Jaffe, A. S., CHAITMAN, B. R., Bax, J. J., Morrow, D. A., White, H. D., ESC Scientific Document Group, Thygesen, K., Alpert, J. S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy462 · Cited by 5,989
Self-citation2023 ESC Guidelines for the management of acute coronary syndromes
Byrne, R. A., Rossello, X., Coughlan, J. J., Barbato, E., Berry, C., Chieffo, A., Claeys, M. J., Dan, G.-A., Dweck, M. R., Galbraith, M., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad191 · Cited by 5,333
Self-citationFourth Universal Definition of Myocardial Infarction (2018)
Thygesen, K. A., Alpert, J. S., Jaffe, A. S., CHAITMAN, B. R., Bax, J. J., Morrow, D. A., & White, H. D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.1038 · Cited by 4,238
Fourth Universal Definition of Myocardial Infarction (2018)
Thygesen, K. A., Alpert, J. S., Jaffe, A. S., CHAITMAN, B. R., Bax, J. J., Morrow, D. A., & White, H. D. (2018) · Circulation · doi:10.1161/cir.0000000000000617 · Cited by 4,037
Gulati, M., Levy, P. D., Mukherjee, D., Amsterdam, E. A., Bhatt, D. L., Birtcher, K. K., Blankstein, R., Boyd, J. H., Bullock-Palmer, R. P., Conejo, T., et al. (2021) · Circulation · doi:10.1161/cir.0000000000001029 · Cited by 1,684
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain
Gulati, M., Levy, P. D., Mukherjee, D., Amsterdam, E. A., Bhatt, D. L., Birtcher, K. K., Blankstein, R., Boyd, J. H., Bullock-Palmer, R. P., Conejo, T., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.053 · Cited by 849
Fourth Universal Definition of Myocardial Infarction (2018)
Thygesen, K. A., Alpert, J. S., Jaffe, A. S., CHAITMAN, B. R., Bax, J. J., Morrow, D. A., & White, H. D. (2018) · Global Heart · doi:10.1016/j.gheart.2018.08.004 · Cited by 473
Gulati, M., Levy, P. D., Mukherjee, D., Amsterdam, E. A., Bhatt, D. L., Birtcher, K. K., Blankstein, R., Boyd, J. H., Bullock-Palmer, R. P., Conejo, T., et al. (2021) · Circulation · doi:10.1161/cir.0000000000001030 · Cited by 436
Pudil, R., Mueller, C. E., Čelutkienė, J., Henriksen, P. A., Lenihan, D. J., Dent, S. F., Barac, A., Stanway, S., Moslehi, J. J., Suter, T. M., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.2017 · Cited by 382
Self-citationApplication of High-Sensitivity Troponin in Suspected Myocardial Infarction
Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., Anand, A., Boeddinghaus, J., Nestelberger, T., Badertscher, P., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1803377 · Cited by 346
Self-citation2023 ESC Guidelines for the management of acute coronary syndromes
Byrne, R. A., Rosselló, X., Coughlan, J. J., Barbato, E., Berry, C., Chieffo, A., Claeys, M. J., Dan, G., Dweck, M. R., Galbraith, M., et al. (2023) · European Heart Journal Acute Cardiovascular Care · doi:10.1093/ehjacc/zuad107 · Cited by 373
Self-citationStroke-heart syndrome: clinical presentation and underlying mechanisms
Scheitz, J. F., Nolte, C. H., Doehner, W., Hachinski, V., & Endres, M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30336-3 · Cited by 319
Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction
Twerenbold, R., Neumann, F., Sörensen, N. A., Ojeda, F., Karakas, M., Boeddinghaus, J., Nestelberger, T., Badertscher, P., Giménez, M. R., Puelacher, C., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.040 · Cited by 222
Self-citationOutcome of Applying the ESC 0/1-hour Algorithm in Patients With Suspected Myocardial Infarction
Twerenbold, R., Costabel, J. P., Nestelberger, T., Campos, R., Wussler, D. N., Arbucci, R., Cortes, M. M., Boeddinghaus, J., Baumgartner, B., Nickel, C. H., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.05.046 · Cited by 204
Self-citationMeijers, W. C., Bayés‐Genís, A., Mebazaa, A., Bauersachs, J. K., Cleland, J. G. F., Coats, A. J. S., Januzzi, J. L., Maisel, A. S., McDonald, K., Mueller, T., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2346 · Cited by 206
Self-citationBlood Biomarkers for Stroke Diagnosis and Management
Tatuene, J. K., & Jickling, G. C. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08530-0 · Cited by 179
Ouyang, M., Tu, D., Tong, L., Sarwar, M., Bhimaraj, A., Li, C.-Z., Coté, G. L., & Carlo, D. D. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112621 · Cited by 175
0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction
Twerenbold, R., Badertscher, P., Boeddinghaus, J., Nestelberger, T., Wildi, K. S., Puelacher, C., Sabti, Z., Giménez, M. R., Tschirky, S., de Lavallaz, J. D. F., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.028901 · Cited by 173
Self-citationEarly Diagnosis of Myocardial Infarction With Point-of-Care High-Sensitivity Cardiac Troponin I
Boeddinghaus, J., Nestelberger, T., Koechlin, L., Wussler, D. N., López‐Ayala, P., Walter, J. E., Troester, V., Ratmann, P. D., Seidel, F., Zimmermann, T., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.065 · Cited by 177
Self-citationRecommendations for Institutions Transitioning to High-Sensitivity Troponin Testing
Januzzi, J. L., Mahler, S. A., Christenson, R. H., Rymer, J. A., Newby, L. K., Body, R. M., Morrow, D. A., & Jaffe, A. S. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.046 · Cited by 164
Stępińska, J., Lettino, M., Ahrens, I., Bueno, H., Garcı́a-Castrillo, L., Khoury, A., Lancellotti, P., Mueller, C. E., Münzel, T. F., Oleksiak, A., et al. (2020) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872619885346 · Cited by 163
Self-citationGulati, M., Levy, P. D., Mukherjee, D., Amsterdam, E. A., Bhatt, D. L., Birtcher, K. K., Blankstein, R., Boyd, J. H., Bullock-Palmer, R. P., Conejo, T., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.052 · Cited by 152
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain
Gulati, M., Levy, P. D., Mukherjee, D., Amsterdam, E. A., Bhatt, D. L., Birtcher, K. K., Blankstein, R., Boyd, J. H., Bullock-Palmer, R. P., Conejo, T., et al. (2021) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2021.11.009 · Cited by 138
Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays
Mueller, C. E., Twerenbold, R., & Reichlin, T. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.298638 · Cited by 132
Self-citationBoeddinghaus, J., Nestelberger, T., Twerenbold, R., Neumann, F., Lindahl, B., Giannitsis, E., Sörensen, N. A., Badertscher, P., Jann, J., Wussler, D. N., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy514 · Cited by 130
Self-citationCardiac Troponin Elevation in Patients Without a Specific Diagnosis
Eggers, K. M., Jernberg, T., & Lindahl, B. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.082 · Cited by 117
From Atherosclerotic Plaque to Myocardial Infarction—The Leading Cause of Coronary Artery Occlusion
Młynarska, E., Czarnik, W., Fularski, P., Hajdys, J., Majchrowicz, G., Stabrawa, M., Rysz, J., & Franczyk, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137295 · Cited by 143
Miranda, D., Lobo, A. S., Walsh, B., Sandoval, Y. B., & Smith, S. W. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.11.011 · Cited by 109
Myocardial Infarction Risk Stratification With a Single Measurement of High-Sensitivity Troponin I
Sandoval, Y. B., Nowak, R. M., deFilippi, C. R., Christenson, R. H., Peacock, W. F., McCord, J., Limkakeng, A. T., Sexter, A., & Apple, F. S. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.05.058 · Cited by 100
High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction
Boeddinghaus, J., Nestelberger, T., Twerenbold, R., Koechlin, L., Meier, M., Troester, V., Wussler, D. N., Badertscher, P., Wildi, K. S., Puelacher, C., et al. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.300061 · Cited by 89
Self-citationFourth universal definition of myocardial infarction (2018)
Thygesen, K., Alpert, J. S., Jaffe, A. S., CHAITMAN, B. R., Bax, J. J., Morrow, D. A., White, H. D., Joint European Society of Cardiology (ESC), American College of Cardiology (ACC), American Heart Association (AHA), et al. (2018) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2018.11.011 · Cited by 85
Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum
Tiambeng, T. N., Roberts, D. S., Brown, K. A., Zhu, Y., Chen, B., Wu, Z., Mitchell, S. D., Guardado-Alvarez, T. M., Jin, S., & Ge, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-17643-1 · Cited by 76
Chesnaye, N. C., Szummer, K. E., Barany, P. F., Heimbürger, O., Mağın, H., Almquist, T., Uhlin, F., Dekker, F. W., Wanner, C., Jager, K. J., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013091 · Cited by 73
Валерьевич, А. О., HARUTYUNYAN, G., Duplyakov, D. V., Константинова, Е. В., Konstantinova, N. N., Shakhnovich, R. M., Yavelov, I. S., Yakovlev, A. N., Sa, A., Alekyan, B. G., et al. (2025) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2025-6306 · Cited by 86
Discrepancy between Cardiac Troponin Assays Due to Endogenous Antibodies
Lam, L., Aspin, L., Heron, R. C., Ha, L., & Kyle, C. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvz032 · Cited by 71
The Circulating Biomarkers League: Combining miRNAs with Cell-Free DNAs and Proteins
Felekkis, K. N., & Papaneophytou, C. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063403 · Cited by 73
Kimenai, D. M., Janssen, E. B. N. J., Eggers, K. M., Lindahl, B., den Ruijter, H. M., Bekers, O., Appelman, Y., & Meex, S. J. R. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.286781 · Cited by 70
Hemmig, E. A., Temiz, Y., Gökçe, O., Lovchik, R. D., & Delamarche, E. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03792 · Cited by 68
Boeddinghaus, J., Twerenbold, R., Nestelberger, T., Koechlin, L., Wussler, D. N., Meier, M., Troester, V., Zimmermann, T., Badertscher, P., Wildi, K. S., et al. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2019.304725 · Cited by 65
Self-citationDelta Checks in the clinical laboratory
Randell, E. W., & Yenice, S. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2018.1540536 · Cited by 66
Comparison of fourteen rule-out strategies for acute myocardial infarction
Wildi, K. S., Boeddinghaus, J., Nestelberger, T., Twerenbold, R., Badertscher, P., Wussler, D. N., Giménez, M. R., Puelacher, C., de Lavallaz, J. D. F., Dietsche, S., et al. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.11.140 · Cited by 61
Self-citationEvaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease
Regan, B., Boyle, F., O’Kennedy, R. J., & Collins, D. (2019) · Sensors · doi:10.3390/s19163485 · Cited by 61
Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm
López‐Ayala, P., Nestelberger, T., Boeddinghaus, J., Koechlin, L., Ratmann, P. D., Strebel, I., Gehrke, J., Meier, S., Walter, J. E., Giménez, M. R., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.052982 · Cited by 61
Self-citationCardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges
Campu, A., Muresan, I., Craciun, A.-M., Cainap, S. S., Aştilean, S., & Focşan, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147728 · Cited by 59
Li, Y., Wang, Y.-C., Wang, Y., Liu, J., Lee, C., Chen, C., Hsieh, C., Kuo, F. Y., Huang, W., Sung, S., et al. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.06.002 · Cited by 57
Villalonga, A., Estabiel, I., Pérez-Calabuig, A. M., Mayol, B., Parrado, C., & Villalonga, R. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113203 · Cited by 55
Chiang, C., Chiang, C., Lee, G. H., Gi, W., Wu, Y.-K. A., Huang, S., Yeo, Y. H., Giannitsis, E., & Lee, C. (2020) · Heart · doi:10.1136/heartjnl-2019-316343 · Cited by 56
Maroules, C. D., Rybicki, F. J., Ghoshhajra, B. B., Batlle, J. C., Branch, K. R., Chinnaiyan, K. M., Hamilton-Craig, C. R., Hoffmann, U., Litt, H. I., Meyersohn, N. M., et al. (2022) · Journal of cardiovascular computed tomography · doi:10.1016/j.jcct.2022.09.003 · Cited by 55
Nestelberger, T., Boeddinghaus, J., Greenslade, J. H., Parsonage, W. A., Than, M. P., Wussler, D. N., López‐Ayala, P., Zimmermann, T., Meier, M., Troester, V., et al. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2019.305193 · Cited by 50
Self-citationAcute Myocardial Infarction Biosensor: A Review From Bottom Up
Reyes-Retana, J. A., & Duque-Ossa, L. C. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100739 · Cited by 51
Regan, B. K., O’Kennedy, R., & Collins, D. (2018) · Biosensors · doi:10.3390/bios8040114 · Cited by 47
Diagnosis of acute myocardial infarction in the presence of left bundle branch block
Nestelberger, T., Cullen, L., Lindahl, B., Reichlin, T., Greenslade, J. H., Giannitsis, E., Christ, M., Morawiec, B., Miró, Ò., Martín‐Sánchez, F. J., et al. (2019) · Heart · doi:10.1136/heartjnl-2018-314673 · Cited by 44
Self-citationKatz, D. H., & Gavin, M. C. (2019) · Annals of Internal Medicine · doi:10.7326/aitc201908060 · Cited by 49
Bojer, A. S., Sørensen, M. H., Vejlstrup, N. G., Goetze, J. P., Gæde, P., & Madsen, P. L. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01160-y · Cited by 43
Recent advances in cardiac biomarkers detection: From commercial devices to emerging technologies
Savonnet, M., Rolland, T., Cubizolles, M., Roupioz, Y., & Buhot, A. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113777 · Cited by 42
Sandoval, Y. B., Apple, F. S., Saenger, A. K., Collinson, P. O., Wu, A. H. B., & Jaffe, A. S. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa158 · Cited by 41
Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain
Levsky, J. M., Haramati, L. B., Spevack, D. M., Menegus, M. A., Chen, T., Mizrachi, S., Brown‐Manhertz, D., Selesny, S., Lerer, R., White, D. J., et al. (2018) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2018.03.024 · Cited by 38
Value of Prehospital Troponin Assessment in Suspected Non-ST-Elevation Acute Coronary Syndrome
van Dongen, D. N., Fokkert, M. J., Tolsma, R. T., Badings, E., van der Sluis, A., Slingerland, R. J., Hof, A. W. J. V. ’., & Ottervanger, J. P. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.07.037 · Cited by 41
Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology
Calderón‐Domínguez, M., Belmonte, T., Quezada-Feijoó, M., Ramos, M., Fernández‐Armenta, J., Pérez-Navarro, M. A., César, S., Peña-Peña, L., Vea, À., Llorente‐Cortés, V., et al. (2019) · Translational research · doi:10.1016/j.trsl.2019.08.007 · Cited by 36
Xu, H., Brook, R. D., Wang, T., Song, X., Feng, B., Yi, T., Liu, S., Wu, R., Chen, J., Zhang, Y., et al. (2019) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000078 · Cited by 36
Trending Cardiac Biomarkers During Pregnancy in Women With Cardiovascular Disease
Chang, S. A., Khakh, P., Janzen, M. L., Lee, T., Kiess, M. C., Rychel, V., & Grewal, J. (2022) · Circulation Heart Failure · doi:10.1161/circheartfailure.121.009018 · Cited by 33
Natarajan, S., Su, F., Joseph, J., Shah, M. I., & Huang, Y. (2019) · The Analyst · doi:10.1039/c9an01382b · Cited by 32
Chest Pain Risk Stratification in the Emergency Department: Current Perspectives
Yukselen, Z., Majmundar, V., Dasari, M., Kumar, P. A., & Singh, Y. (2024) · Open Access Emergency Medicine · doi:10.2147/oaem.s419657 · Cited by 31
Jing, W., Wang, Y., Chen, C., Zhang, F., Yang, Y., Ma, G., Yang, E. H., Snozek, C., Tao, N. J., & Wang, S. (2020) · ACS Sensors · doi:10.1021/acssensors.0c01681 · Cited by 31
Lind, L., Zanetti, D., Högman, M., Sundman, L., & Ingelsson, E. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241558 · Cited by 29
Koechlin, L., Boeddinghaus, J., López‐Ayala, P., Reber, C., Nestelberger, T., Wildi, K. S., Spagnuolo, C., Strebel, I., Glaeser, J., Bima, P., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.05.056 · Cited by 30
Self-citationHow to best use high-sensitivity cardiac troponin in patients with suspected myocardial infarction
Twerenbold, R., Boeddinghaus, J., Nestelberger, T., Wildi, K. S., Giménez, M. R., Badertscher, P., & Mueller, C. E. (2017) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2017.12.006 · Cited by 28
Self-citationWalter, J. E., de Lavallaz, J. D. F., Koechlin, L., Zimmermann, T., Boeddinghaus, J., Honegger, U., Strebel, I., Twerenbold, R., Amrein, M., Nestelberger, T., et al. (2020) · Annals of Internal Medicine · doi:10.7326/m19-0080 · Cited by 28
Self-citationMahler, S. A., Ashburn, N. P., Paradee, B. E., Stopyra, J. P., O’Neill, J. C., & Snavely, A. C. (2024) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.123.010270 · Cited by 27
Mueller, D. L., Puelacher, C., Honegger, U., Walter, J. E., Badertscher, P., Schaerli, N., Strebel, I., Twerenbold, R., Boeddinghaus, J., Nestelberger, T., et al. (2018) · Clinical Chemistry · doi:10.1373/clinchem.2018.286971 · Cited by 27
Self-citationAssociation of comorbidities with clinical outcomes in patients after acute myocardial infarction
Baechli, C., Koch, D., Bernet, S., Gut, L., Wagner, U., Müeller, B., Schüetz, P., & Kutz, A. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100558 · Cited by 26
López‐Ayala, P., Boeddinghaus, J., Koechlin, L., Nestelberger, T., & Mueller, C. E. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa226 · Cited by 26
Self-citationKavsak, P. A., Andruchow, J. E., McRae, A. D., & Worster, A. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1476141 · Cited by 27
Song, E., Kim, I., Jeon, C. S., & Pyun, S. H. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108962 · Cited by 25
Sex-Related Aspects of Biomarkers in Cardiac Disease
Mingels, A. M. A., & Kimenai, D. M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-77932-4_33 · Cited by 23
Update on high-sensitivity cardiac troponin in patients with suspected myocardial infarction
Twerenbold, R., Boeddinghaus, J., & Mueller, C. E. (2018) · European Heart Journal Supplements · doi:10.1093/eurheartj/suy020 · Cited by 23
Self-citationBardajı́, A., Bonet, G., Carrasquer, A., González‐Del‐Hoyo, M., Vásquez‐Nuñez, K., Ali, S. A., Boqué, C., & Cediel, G. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.11.037 · Cited by 23
Burgos, L. M., Trivi, M., & Costabel, J. P. (2020) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872620935399 · Cited by 23
Ullah, A., Sajid, S., Qureshi, M., Kamran, M., Anwaar, M. A., Naseem, M. A., Zaman, M. U., Mahmood, F., Rehman, A., Shehryar, A., et al. (2023) · Cureus · doi:10.7759/cureus.42081 · Cited by 22
Clinical implications of high‐sensitivity cardiac troponins
Holzmann, M. J. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12779 · Cited by 21
Obesity paradox and perioperative myocardial infarction/injury in non-cardiac surgery
for the BASEL-P.M.I. Investigators, Hidvegi, R., Puelacher, C., Gualandro, D. M., Lampart, A., Buse, G. L., Hammerer‐Lercher, A., Walter, J. E., Liffert, M., Bolliger, D., et al. (2020) · Clinical Research in Cardiology · doi:10.1007/s00392-020-01605-0 · Cited by 21
Self-citationClinical risk assessment of biotin interference with a high-sensitivity cardiac troponin T assay
Mumma, B. E., Diercks, D. B., Twerenbold, R., Valcour, A., Ziegler, A., Schützenmeister, A., Kasapic, D., & Tran, N. K. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0962 · Cited by 21
Self-citationRopii, B., Bethasari, M., Anshori, I., Koesoema, A. P., Shalannanda, W., Satriawan, A., Setianingsih, C., Akbar, M. R., Aditama, R., Fahmi, F., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0302475 · Cited by 20
McCarthy, C. P., Neumann, F., Michelhaugh, S. A., Ibrahim, N. E., Gaggin, H. K., Sörensen, N. A., Schaefer, S., Zeller, T., Magaret, C. A., Barnes, G., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.017221 · Cited by 20
Use of cardiac troponin in the early diagnosis of acute myocardial infarction
Muzyk, P., Twerenbold, R., Morawiec, B., López‐Ayala, P., Boeddinghaus, J., Nestelberger, T., Mueller, C. E., & Kawecki, D. (2020) · Kardiologia Polska · doi:10.33963/kp.15585 · Cited by 20
Self-citationLee, T., Chen, L.-C., Wang, E., Wang, C.-C., Lin, Y., & Chen, W. (2021) · Biosensors · doi:10.3390/bios11070210 · Cited by 19
Jaakkola, S., Paana, T., Nuotio, I. O., Kiviniemi, T., Pouru, J.-P., Porela, P., Biancari, F., & Airaksinen, J. K. E. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111963 · Cited by 18
Kim, S., Yoo, S. J., & Kim, J. (2020) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2020.02.005 · Cited by 17
Zeljković, I., Knecht, S., Pavlović, N., Celikyrut, U., Spies, F., Burri, S., Mannhart, D., Peterhans, L., Reichlin, T., Schaer, B. A., et al. (2019) · Open Heart · doi:10.1136/openhrt-2018-000949 · Cited by 17
Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome
de Lavallaz, J. D. F., Puelacher, C., Buse, G. L., Bolliger, D., Germanier, D., Hidvegi, R., Walter, J. E., Twerenbold, R., Strebel, I., Badertscher, P., et al. (2018) · Heart · doi:10.1136/heartjnl-2018-313876 · Cited by 16
Self-citationEarly kinetics of cardiac troponin in suspected acute myocardial infarction
Giménez, M. R., Wildi, K. S., Wussler, D. N., Koechlin, L., Boeddinghaus, J., Nestelberger, T., Badertscher, P., Sedlmayer, R., Puelacher, C., Zimmermann, T., et al. (2020) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2020.04.008 · Cited by 16
Self-citationMyocardial injury after non-cardiac surgery: a perioperative affair?
Miccichè, V., Baldi, C., ROBERTIS, E. D., & Piazza, O. (2018) · Minerva Anestesiologica · doi:10.23736/s0375-9393.18.12537-5 · Cited by 15
Mullins, K., & Christenson, R. H. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01350-w · Cited by 15
Sandesara, P. B., O’Neal, W. T., Tahhan, A. S., Hayek, S. S., Lee, S. K., Khambhati, J., Topel, M. L., Hammadah, M., Alkhoder, A. A., Ko, Y., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.02.039 · Cited by 14
Walter, J. E., Nestelberger, T., Boeddinghaus, J., Twerenbold, R., Croton, L., Badertscher, P., Wildi, K. S., Wussler, D. N., de Lavallaz, J. D. F., Mueller, C. E., et al. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.04.088 · Cited by 14
Self-citationChen, R., Pang, M., Yu, H., Luo, F., Zhang, X., Su, L., Li, Y., Zhou, S., Xu, R., Gao, Q., et al. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae247 · Cited by 13
Acute Kidney Injury and High-Sensitivity Cardiac Troponin T Levels in the Emergency Department
Cyon, L., Kadesjö, E., Edgren, G., & Roos, A. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.19602 · Cited by 13
Evaluating patients with chest pain in the emergency department
Bellolio, F., Gottlieb, M. A., Body, R. M., Than, M. P., & Hess, E. P. (2025) · BMJ · doi:10.1136/bmj.r136 · Cited by 14
Suthahar, N., Meems, L. M. G., van Veldhuisen, D. J., Walter, J. E., Gansevoort, R. T., Heymans, S. R. B., Schroen, B. L. M., van der Harst, P., Kootstra‐Ros, J. E., van Empel, V. P. M., et al. (2020) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.01.017 · Cited by 13
Self-citationRicci, F., Neumann, F., Rübsamen, N., Sörensen, N. A., Ojeda, F., Cataldo, I., Zeller, T., Schäfer, S., Hartikainen, T. S., Golato, M., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.895421 · Cited by 13
Metadata
- Authors
- Twerenbold, R., Boeddinghaus, J., Nestelberger, T., Wildi, K., Rubini Gimenez, M., Badertscher, P., & Mueller, C.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Mueller, Christian
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 70
- Issue
- 8
- Pages
- 996-1012
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2749133321
- Cited by
- 255
- References
- 116
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 19 · 2023: 25 · 2022: 25 · 2021: 29 · 2020: 43 · 2019: 39 · 2018: 32 · 2017: 7
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Bristol-Myers Squibb
- AstraZeneca
- Alere
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (P300PB-167803/1, 167803)
- Schweizerische Herzstiftung
- Stiftung für Kardiovaskuläre Forschung Basel
- Abbott Diagnostics
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Keywords
- high-sensitivity troponin, myocardial infarction, emergency department, early diagnosis, diagnostic algorithm, rule-in and rule-out, cardiomyocyte injury, chest pain
- MeSH terms
- Algorithms, Humans, Myocardial Infarction, Biomarkers, Troponin I, Troponin T, Early Diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
