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The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Reverse Myocardial Remodeling Following Valve Replacement in Patients With Aortic Stenosis

Open access
Treibel, Thomas A., Kozor, Rebecca, Schofield, Rebecca, Benedetti, Giulia, Fontana, Marianna, Bhuva, Anish N., Sheikh, Amir, López, Begoña, González, Arantxa, Manisty, Charlotte, Lloyd, Guy, Kellman, Peter, Díez, Javier, Moon, James C.·2018·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2017.12.035
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Abstract

Left ventricular (LV) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis). This study sought to investigate whether human myocardial interstitial fibrosis in aortic stenosis (AS) is plastic and can regress. Patients with symptomatic, severe AS (n = 181; aortic valve area index 0.4 ± 0.1 cm2/m2) were assessed pre–aortic valve replacement (AVR) by echocardiography (AS severity, diastology), cardiovascular magnetic resonance (CMR) (for volumes, function, and focal or diffuse fibrosis), biomarkers (N-terminal pro–B-type natriuretic peptide and high-sensitivity troponin T), and the 6-min walk test. CMR was used to measure the extracellular volume fraction (ECV), thereby deriving matrix volume (LV mass × ECV) and cell volume (LV mass × [1 − ECV]). Biopsy excluded occult bystander disease. Assessment was repeated at 1 year post-AVR. At 1 year post-AVR in 116 pacemaker-free survivors (age 70 ± 10 years; 54% male), mean valve gradient had improved (48 ± 16 mm Hg to 12 ± 6 mm Hg; p < 0.001), and indexed LV mass had regressed by 19% (88 ± 26 g/m2 to 71 ± 19 g/m2; p < 0.001). Focal fibrosis by CMR late gadolinium enhancement did not change, but ECV increased (28.2 ± 2.9% to 29.9 ± 4.0%; p < 0.001): this was the result of a 16% reduction in matrix volume (25 ± 9 ml/m2 to 21 ± 7 ml/m2; p < 0.001) but a proportionally greater 22% reduction in cell volume (64 ± 18 ml/m2 to 50 ± 13 ml/m2; p < 0.001). These changes were accompanied by improvement in diastolic function, N-terminal pro–B-type natriuretic peptide, 6-min walk test results, and New York Heart Association functional class. Post-AVR, focal fibrosis does not resolve, but diffuse fibrosis and myocardial cellular hypertrophy regress. Regression is accompanied by structural and functional improvements suggesting that human diffuse fibrosis is plastic, measurable by CMR and a potential therapeutic target. (Regression of Myocardial Fibrosis After Aortic Valve Replacement; NCT02174471)

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Metadata

Authors
Treibel, T. A., Kozor, R., Schofield, R., Benedetti, G., Fontana, M., Bhuva, A. N., Sheikh, A., López, B., González, A., Manisty, C., Lloyd, G., Kellman, P., Díez, J., & Moon, J. C.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2018-02
Volume
71
Issue
8
Pages
860-871
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2017.12.035
OpenAlex
W2792450684
Cited by
384
References
48
FWCI
29.25
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Reverse Myocardial Remodeling Following Valve Replacement in Patients With Aortic Stenosis. https://app.cochat.ai/papers/10.1016/j.jacc.2017.12.035
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Treibel, T. A., Kozor, R., Schofield, R., Benedetti, G., Fontana, M., Bhuva, A. N., Sheikh, A., López, B., González, A., Manisty, C., Lloyd, G., Kellman, P., Díez, J., & Moon, J. C. (2018). Reverse Myocardial Remodeling Following Valve Replacement in Patients With Aortic Stenosis. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2017.12.035

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.