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Cited by 432

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Present Status of Brugada Syndrome

Open access
Brugada, Josep, Campuzano, Oscar, Arbelo, Elena, Sarquella-Brugada, Georgia, Brugada, Ramon·2018·Journal of the American College of Cardiology

Abstract

The Brugada syndrome is an inherited disorder associated with risk of ventricular fibrillation and sudden cardiac death in a structurally normal heart. Diagnosis is based on a characteristic electrocardiographic pattern (coved type ST-segment elevation ≥2 mm followed by a negative T-wave in ≥1 of the right precordial leads V1 to V2), observed either spontaneously or during a sodium-channel blocker test. The prevalence varies among regions and ethnicities, affecting mostly males. The risk stratification and management of patients, principally asymptomatic, still remains challenging. The current main therapy is an implantable cardioverter-defibrillator, but radiofrequency catheter ablation has been recently reported as an effective new treatment. Since its first description in 1992, continuous achievements have expanded our understanding of the genetics basis and electrophysiological mechanisms underlying the disease. Currently, despite several genes identified, SCN5A has attracted most attention, and in approximately 30% of patients, a genetic variant may be implicated in causation after a comprehensive analysis.

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Metadata

Authors
Brugada, J., Campuzano, O., Arbelo, E., Sarquella-Brugada, G., & Brugada, R.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2018-08
Volume
72
Issue
9
Pages
1046-1059
ISSN
0735-1097 (ISSN-L)
OpenAlex
W2888481150
Cited by
432
References
87
FWCI
26.49
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Present Status of Brugada Syndrome. https://app.cochat.ai/papers/10.1016/j.jacc.2018.06.037
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Brugada, J., Campuzano, O., Arbelo, E., Sarquella-Brugada, G., & Brugada, R. (2018). Present Status of Brugada Syndrome. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2018.06.037

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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