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Impact of Lipids on Cardiovascular Health
Open accessAbstract
People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after it develops to preventing cardiovascular events before they happen by slowing the progression of atherosclerosis. Because atherogenic lipoproteins play a central causal role in the initiation and progression of atherosclerosis, maintaining optimal lipid levels is necessary to achieve ideal cardiovascular health. This review describes the cumulative effect of lipid-carrying lipoproteins on the risk of cardiovascular disease, estimates the magnitude of the clinical benefit that can be achieved by maintaining optimal lipid levels, identifies the most effective timing for implementing strategies designed to achieve optimal lipid levels, and provides a clinical pathway to help people achieve the lipid levels necessary for ideal cardiovascular health.
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“ApoB-containing lipoproteins retained in the arterial wall provoke a complex process that leads to lipid deposition and the initiation of an atheroma [43].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [43]
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Metadata
- Authors
- Ference, B. A., Graham, I., Tokgozoglu, L., & Catapano, A. L.
- Affiliations
- University of Cambridge (GB)
- Trinity College Dublin (IE)
- University of Milan (IT)
- Corresponding author
- Catapano, Alberico L.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 72
- Issue
- 10
- Pages
- 1141-1156
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2889378692
- Cited by
- 511
- References
- 62
- Citations by year
- 2026: 65 · 2025: 75 · 2024: 82 · 2023: 80 · 2022: 68 · 2021: 76 · 2020: 35 · 2019: 29 · 2018: 1
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- ideal cardiovascular health, cardiovascular disease prevention, atherosclerosis, atherogenic lipoproteins, serum lipids, cardiovascular risk, care pathways
- MeSH terms
- Hypolipidemic Agents, Cardiovascular Diseases, Diet, Health Promotion, Humans, Lipids, Cholesterol, LDL, Primary Prevention, Genetic Variation, Exercise, Disease Progression, Genetic Predisposition to Disease, Atherosclerosis, Plaque, Atherosclerotic
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