Cited by 511Lipoproteins and Cardiovascular HealthCardiovascular Health and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

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Impact of Lipids on Cardiovascular Health

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Ference, Brian A., Graham, Ian, Tokgozoglu, Lale, Catapano, Alberico L.·2018·Journal of the American College of Cardiology

DOI 10.1016/j.jacc.2018.06.046

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Abstract

People who maintain ideal cardiovascular heath have a low lifetime risk of cardiovascular disease. Therefore, encouraging people to achieve ideal cardiovascular health represents an important opportunity to improve the prevention of cardiovascular disease. However, preventing cardiovascular disease by promoting ideal cardiovascular health requires shifting the focus from treating disease after it develops to preventing cardiovascular events before they happen by slowing the progression of atherosclerosis. Because atherogenic lipoproteins play a central causal role in the initiation and progression of atherosclerosis, maintaining optimal lipid levels is necessary to achieve ideal cardiovascular health. This review describes the cumulative effect of lipid-carrying lipoproteins on the risk of cardiovascular disease, estimates the magnitude of the clinical benefit that can be achieved by maintaining optimal lipid levels, identifies the most effective timing for implementing strategies designed to achieve optimal lipid levels, and provides a clinical pathway to help people achieve the lipid levels necessary for ideal cardiovascular health.

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Authors: Ference, B. A., Graham, I., Tokgozoglu, L., & Catapano, A. L.
Affiliations: University of Cambridge (GB)
Trinity College Dublin (IE)
University of Milan (IT)
Corresponding author: Catapano, Alberico L.
ORCID: Graham, Ian
Catapano, Alberico L.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 2018-09
Volume: 72
Issue: 10
Pages: 1141-1156
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/j.jacc.2018.06.046
OpenAlex: W2889378692
Cited by: 511
References: 62
Citations by year: 2026: 65 · 2025: 75 · 2024: 82 · 2023: 80 · 2022: 68 · 2021: 76 · 2020: 35 · 2019: 29 · 2018: 1
FWCI: 7.83
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Hacettepe University Institutional Repository (hacettepe.edu.tr) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: ideal cardiovascular health, cardiovascular disease prevention, atherosclerosis, atherogenic lipoproteins, serum lipids, cardiovascular risk, care pathways
MeSH terms: Hypolipidemic Agents, Cardiovascular Diseases, Diet, Health Promotion, Humans, Lipids, Cholesterol, LDL, Primary Prevention, Genetic Variation, Exercise, Disease Progression, Genetic Predisposition to Disease, Atherosclerosis, Plaque, Atherosclerotic

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