The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Cardiorespiratory Fitness and Mortality in Healthy Men and Women
Open accessAbstract
BACKGROUND There is a well-established inverse relationship between cardiorespiratory fitness (CRF) and mortality. However, this relationship has almost exclusively been studied using estimated CRF. OBJECTIVES This study aimed to assess the association of directly measured CRF, obtained using cardiopulmonary exercise (CPX) testing with all-cause, cardiovascular disease (CVD), and cancer mortality in apparently healthy men and women. METHODS Participants included 4,137 self-referred apparently healthy adults (2,326 men, 1,811 women; mean age: 42.8 ± 12.2 years) who underwent CPX testing to determine baseline CRF. Participants were followed for 24.2 ± 11.7 years (1.1 to 49.3 years) for mortality. Cox-proportional hazard models were performed to determine the relationship of CRF (ml·kg-1·min-1) and CRF level (low, moderate, and high) with mortality outcomes. RESULTS During follow-up, 727 participants died (524 men, 203 women). CPX-derived CRF was inversely related to all-cause, CVD, and cancer mortality. Low CRF was associated with higher risk for all-cause (hazard ratio [HR]: 1.73; 95% confidence interval [CI]: 1.20 to 3.50), CVD (HR: 2.27; 95% CI: 1.20 to 3.49), and cancer (HR: 2.07; 95% CI: 1.18 to 3.36) mortality compared with high CRF. Further, each metabolic equivalent increment increase in CRF was associated with a 11.6%, 16.1%, and 14.0% reductions in all-cause, CVD, and cancer mortality, respectively. CONCLUSIONS Given the prognostic ability of CPX-derived CRF for all-cause and disease-specific mortality outcomes, its use should be highly considered for apparently healthy populations as it may help to improve the efficacy of the individualized patient risk assessment and guide clinical decisions.
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Cites
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114
Kodama, S. (2009) · JAMA · doi:10.1001/jama.2009.681 · Cited by 3,035
Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486
Self-citationFletcher, G. F., Ades, P. A., Kligfield, P., Arena, R., Balady, G. J., Bittner, V. A., Coke, L. A., Fleg, J. L., Forman, D. E., Gerber, T. C., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829b5b44 · Cited by 2,235 · cited 2×
“The results of this study align with recommendations of recent scientific and policy statements (1,15,17) that regard CRF as a clinical vital sign and highlight the importance of accurately quantifying CRF in apparently healthy adults given its diagnostic and prognostic capabilities.”
BackgroundResultFitness versus physical activity patterns in predicting mortality in men
Myers, J., Kaykha, A., George, S., Abella, J., Zaheer, N., Lear, S., Yamazaki, T., & Froelicher, V. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.06.047 · Cited by 521
Reference Standards for Cardiorespiratory Fitness Measured With Cardiopulmonary Exercise Testing
Kaminsky, L. A., Arena, R., & Myers, J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.07.026 · Cited by 461
Self-citationLongitudinal Algorithms to Estimate Cardiorespiratory Fitness
Artero, E. G., Jackson, A. S., Sui, X., Lee, D.-C., O’Connor, D. P., Lavie, C. J., Church, T. S., & Blair, S. N. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.008 · Cited by 128
Cardiorespiratory fitness and health outcomes: a call to standardize fitness categories.
Kokkinos, P., Myers, J., Franklin, B., Narayan, P., Lavie, C. J., & Faselis, C. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.10.011 · Cited by 65
Cited by
Mortality reduction with physical activity in patients with and without cardiovascular disease
Jeong, S.-W., Kim, S.-H., Kang, S.-H., Kim, H.-J., Yoon, C.-H., Youn, T.-J., & Chae, I.-H. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz564 · Cited by 320
Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension
Musci, R., Hamilton, K., & Linden, M. (2019) · Sports · doi:10.3390/sports7070170 · Cited by 73
Healthy Vascular Aging Is Associated With Higher Cardiorespiratory Fitness
Fleenor, B. S., Carlini, N. A., Kaminsky, L. A., Whaley, M. H., Peterman, J. E., & Harber, M. P. (2021) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000530 · Cited by 20
Self-citationFranklin, B. A., Arena, R., Kaminsky, L. A., Peterman, J. E., Kokkinos, P., & Myers, J. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaa094 · Cited by 15
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Metadata
- Authors
- Imboden, M. T., Harber, M. P., Whaley, M. H., Finch, W. H., Bishop, D. L., & Kaminsky, L. A.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 72
- Issue
- 19
- Pages
- 2283-2292
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2898631899
- Cited by
- 276
- References
- 9
- FWCI
- 27.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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