The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Large-Artery Stiffness in Health and Disease
Open accessAbstract
A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and protects the microvasculature from potentially harmful fluctuations in pressure and blood flow. Large artery (aortic) stiffening, which occurs with aging and various pathologic states, impairs this cushioning function and has important consequences on cardiovascular health, including isolated systolic hypertension, excessive penetration of pulsatile energy into the microvasculature of target organs that operate at low vascular resistance, and abnormal ventricular-arterial interactions that promote left ventricular remodeling, dysfunction and failure. Large artery stiffness independently predicts cardiovascular risk and represents a high-priority therapeutic target to ameliorate the global burden of cardiovascular disease. We provide an overview of key physiologic and biophysical principles related to arterial stiffness, the impact of aortic stiffening on target organs, non-invasive methods for the measurement of arterial stiffness, mechanisms leading to aortic stiffening, therapeutic approaches to reduce it, and clinical applications of arterial stiffness measurements.
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Cites
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An Energy Budget for Signaling in the Grey Matter of the Brain
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Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction
Ben-Shlomo, Y., Spears, M., Boustred, C., May, M., Anderson, S. G., Benjamin, E. J., Boutouyrie, P., Cameron, J., Chen, C.-H., Cruickshank, J. K., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.09.063 · Cited by 1,835
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Sympathetic Overactivity in Patients with Chronic Renal Failure
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Cited by
Arterial Stiffness Preceding Diabetes: A Longitudinal Study
Zheng, M., Zhang, X., Chen, S., Song, Y., Zhao, Q., Gao, X., & Wu, S. (2020) · Circulation Research · doi:10.1161/circresaha.120.317950 · Cited by 259
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction
Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., Mentz, R. J., Borlaug, B. A., Simon, M. A., Chirinos, J. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.014 · Cited by 184
Self-citationDregan, A., Rayner, L., Davis, K. A. S., Bakolis, I., Arias de la Torre, J., Das-Munshi, J., Hatch, S. L., Stewart, R., & Hotopf, M. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.4712 · Cited by 132
Renal Sympathetic Denervation in Patients With Heart Failure With Preserved Ejection Fraction
Kresoja, K.-P., Rommel, K.-P., Fengler, K., von Roeder, M., Besler, C., Lücke, C., Gutberlet, M., Desch, S., Thiele, H., Böhm, M., et al. (2021) · Circulation: Heart Failure · doi:10.1161/circheartfailure.120.007421 · Cited by 96
Clayton, Z. S., Rossman, M. J., Mahoney, S. A., Venkatasubramanian, R., Maurer, G. S., Hutton, D. A., VanDongen, N. S., Greenberg, N. T., Longtine, A. G., Ludwig, K. R., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21392 · Cited by 84
“34 The cellular and molecular mechanisms underlying increased intrinsic aortic wall stiffness with age largely involve remodeling of the composition of structural compounds within the ECM of the aortic wall.”
Background
Metadata
- Authors
- Chirinos, J. A., Segers, P., Hughes, T., & Townsend, R.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 74
- Issue
- 9
- Pages
- 1237-1263
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2971164718
- Cited by
- 1,001
- References
- 6
- FWCI
- 57.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chirinos, J. A., Segers, P., Hughes, T., & Townsend, R. (2019). Large-Artery Stiffness in Health and Disease. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2019.07.012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
