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The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy

Open access
Honigberg, Michael C., Zekavat, Seyedeh Maryam, Aragam, Krishna, Klarin, Derek, Bhatt, Deepak L., Scott, Nandita S., Peloso, Gina M., Natarajan, Pradeep·2019·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2019.09.052
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Abstract

BACKGROUND: History of a hypertensive disorder of pregnancy (HDP) among women may be useful to refine atherosclerotic cardiovascular disease risk assessments. However, future risk of diverse cardiovascular conditions in asymptomatic middle-aged women with prior HDP remains unknown. OBJECTIVES: The purpose of this study was to examine the long-term incidence of diverse cardiovascular conditions among middle-aged women with and without prior HDP. METHODS: Women in the prospective, observational UK Biobank age 40 to 69 years who reported ≥1 live birth were included. Noninvasive arterial stiffness measurement was performed in a subset of women. Cox models were fitted to associate HDP with incident cardiovascular diseases. Causal mediation analyses estimated the contribution of conventional risk factors to observed associations. RESULTS: Of 220,024 women included, 2,808 (1.3%) had prior HDP. The mean age at baseline was 57.4 ± 7.8 years, and women were followed for median 7 years (interquartile range: 6.3 to 7.7 years). Women with HDP had elevated arterial stiffness indexes and greater prevalence of chronic hypertension compared with women without HDP. Overall, 7.0 versus 5.3 age-adjusted incident cardiovascular conditions occurred per 1,000 women-years for women with versus without prior HDP, respectively (p = 0.001). In analysis of time-to-first incident cardiovascular diagnosis, prior HDP was associated with a hazard ratio (HR) of 1.3 (95% CI: 1.04 to 1.60; p = 0.02). HDP was associated with greater incidence of CAD (HR: 1.8; 95% CI: 1.3 to 2.6; p < 0.001), heart failure (HR: 1.7; 95% CI: 1.04 to 2.60; p = 0.03), aortic stenosis (HR: 2.9; 95% CI: 1.5 to 5.4; p < 0.001), and mitral regurgitation (HR: 5.0; 95% CI: 1.5 to 17.1; p = 0.01). In causal mediation analyses, chronic hypertension explained 64% of HDP's association with CAD and 49% of HDP's association with heart failure. CONCLUSIONS: Hypertensive disorders of pregnancy are associated with accelerated cardiovascular aging and more diverse cardiovascular conditions than previously appreciated, including valvular heart disease. Cardiovascular risk after HDP is largely but incompletely mediated by development of chronic hypertension.

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Metadata

Authors
Honigberg, M. C., Zekavat, S. M., Aragam, K., Klarin, D., Bhatt, D. L., Scott, N. S., Peloso, G. M., & Natarajan, P.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2019-12
Volume
74
Issue
22
Pages
2743-2754
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2019.09.052
OpenAlex
W2983944226
Cited by
319
References
46
FWCI
23.81
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy. https://app.cochat.ai/papers/10.1016/j.jacc.2019.09.052
The paper
Honigberg, M. C., Zekavat, S. M., Aragam, K., Klarin, D., Bhatt, D. L., Scott, N. S., Peloso, G. M., & Natarajan, P. (2019). Long-Term Cardiovascular Risk in Women With Hypertension During Pregnancy. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2019.09.052

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.