Circulating angiogenic factors and the risk of preeclampsia

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101 · see citing works

A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer

Yang, J. C., Haworth, L. R., Sherry, R. M., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Steinberg, S. M., Chen, H. X., & Rosenberg, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021491 · Cited by 2,681 · see citing works

Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal Cancer

Kabbinavar, F. F., Hurwitz, H. I., Fehrenbacher, L., Meropol, N. J., Novotny, W. F., Liebérman, G., Griffing, S., & Bergsland, E. K. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2003.10.066 · Cited by 1,711 · see citing works

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

Eremina, V., Sood, M. M., Haigh, J. J., Nagy, A., Lajoie, G., Ferrara, N., Gerber, H. P., Kikkawa, Y., Miner, J. H., & Quaggin, S. E. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17423 · Cited by 1,308 · see citing works

Pathogenesis and genetics of pre-eclampsia

Roberts, J., & Cooper, D. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03577-7 · Cited by 1,279 · see citing works

Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome?

Zhou, Y., Damsky, C. H., & Fisher, S. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119388 · Cited by 937 · see citing works

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

Zhou, Y., McMaster, M., Woo, K., Janatpour, M. J., Perry, J., Kärpänen, T., Alitalo, K. K., Damsky, C. H., & Fisher, S. J. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62567-9 · Cited by 639 · see citing works

Trial of Calcium to Prevent Preeclampsia

Levine, R. J., Hauth, J. C., Curet, L. B., Sibai, B. M., Catalano, P. M., Morris, C. D., DerSimonian, R., Esterlitz, J. R., Raymond, E. G., Bild, D. E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370201 · Cited by 634 · see citing works

Pre-eclampsia

Walker, J. J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02800-2 · Cited by 519 · see citing works

Overexpression of the Soluble Vascular Endothelial Growth Factor Receptor in Preeclamptic Patients: Pathophysiological Consequences

Tsatsaris, V., Goffin, F., Munaut, C., Brichant, J.-F., Pignon, M.-R., Noël, A., Schaaps, J., CABROL, D., Frankenne, F., & Foidart, J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030528 · Cited by 461 · see citing works

Longitudinal serum concentrations of placental growth factor: Evidence for abnormal placental angiogenesis in pathologic pregnancies

Taylor, R. N., Grimwood, J., Taylor, R. S., McMaster, M., Fisher, S. J., & North, R. A. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.111 · Cited by 410 · see citing works

Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia

Koga, K., Osuga, Y., Yoshino, O., Hirota, Y., Ruimeng, X., Hirata, T., Takeda, S., Yano, T., Tsutsumi, O., & Taketani, Y. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021942 · Cited by 403 · see citing works

Birth-Weight-for-Gestational-Age Patterns by Race, Sex, and Parity in the United States Population

Zhang, J. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00142-e · Cited by 297 · see citing works

Preeclampsia is associated with reduced serum levels of placenta growth factor

Torry, D. S., Wang, H., Wang, T., Caudle, M. R., & Torry, R. J. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70021-3 · Cited by 286 · see citing works

Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia

Page, N., Woods, R. J., Gardiner, S. M., Lomthaisong, K., Gladwell, R. T., Butlin, D., Manyonda, I., & Lowry, P. J. (2000) · Nature · doi:10.1038/35015579 · Cited by 250 · see citing works

Disturbed Feto-Maternal Cell Traffic in Preeclampsia

Holzgreve, W., GHEZZI, F., NARO, E. D., GÄNSHIRT, D., MAYMON, E., & HAHN, S. (1998) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(98)00068-4 · Cited by 247 · see citing works

Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia

Tidwell, S., Ho, H., Chiu, W.-H., Torry, R. J., & Torry, D. S. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.113129 · Cited by 231 · see citing works

Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia

Polliotti, B. (2003) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(03)00338-7 · Cited by 225 · see citing works

Glomerular endotheliosis in normal pregnancy and pre-eclampsia

Strevens, H., Wide‐Swensson, D., Hansen, A., Horn, T. D., Ingemarsson, I., Larsen, S., Willner, J., & Olsen, S. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2003.02162.x · Cited by 176 · see citing works

Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function

Cockell, A., Learmont, J. G., Smárason, A. K., Redman, C. W. G., Sargent, I. L., & Poston, L. (1997) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1997.tb11052.x · Cited by 171 · see citing works

Plasma placenta growth factor levels in midtrimester pregnancies

Tjoa, M. L. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01497-1 · Cited by 103 · see citing works

Expression and Function of Placenta Growth Factor: Implications for Abnormal Placentation

Torry, D., Mukherjea, D., Arroyo, J. A., & Torry, R. J. (2003) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(03)00048-0 · Cited by 102 · see citing works

Decreased Maternal Serum Placenta Growth Factor in Early Second Trimester and Preeclampsia

Su, Y. N., Lee, C., Cheng, W., Shau, W. Y., Chow, S. N., & Hsieh, F. J. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(01)01341-2 · Cited by 89 · see citing works

Trial of calcium for preeclampsia prevention (CPEP): Rationale, design, and methods

Levine, R. J., Esterlitz, J., Raymond, E. G., DerSimonian, R., Hauth, J. C., Curet, L. B., Sibai, B. M., Catalano, P. M., Morris, C. D., Clemens, J. D., et al. (1996) · Controlled Clinical Trials · doi:10.1016/s0197-2456(96)00106-7 · Cited by 74 · see citing works

Vascular Endothelial Growth Factor: Basic Science and Clinical Progress

Ferrara, N. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0027 · Cited by 3,707 · see citing works

VEGF receptor signalling ? in control of vascular function

Olsson, A.-K., Dimberg, A., Kreuger, J., & Claesson-Welsh, L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1911 · Cited by 3,122 · see citing works

Untitled work

Rana (2019) · doi:10.1161/circresaha.118.313276 · Cited by 2,095 · see citing works

Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management Recommendations for International Practice

Brown, M. A., Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C. E., Adoyi, G., & Ishaku, S. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10803 · Cited by 2,089 · see citing works

Preterm labor: One syndrome, many causes

Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984 · see citing works

Soluble endoglin contributes to the pathogenesis of preeclampsia

Venkatesha, S., Toporsian, M., Lam, C., Hanai, J.-I., Mammoto, T., Kim, Y. M., Bdolah, Y., Lim, K.-H., Yuan, H.-T., Libermann, T. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1429 · Cited by 1,855 · see citing works

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

Zeisler, H., Llurba, E., Chantraine, F., Vatish, M., Staff, A. C., Sennström, M., Olovsson, M., Brennecke, S. P., Stepan, H., Allegranza, D., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1414838 · Cited by 1,820 · see citing works

Pre-eclampsia

Sibai, B. M., Dekker, G., & Kupferminc, M. J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17987-2 · Cited by 1,815 · see citing works

Soluble Endoglin and Other Circulating Antiangiogenic Factors in Preeclampsia

Levine, R. J., Lam, C., Qian, C., Yu, K. F., Maynard, S. E., Sachs, B. P., Sibai, B. M., Epstein, F. H., Romero, R. J., Thadhani, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055352 · Cited by 1,804 · see citing works

Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies

Shibuya, M. (2011) · Genes & Cancer · doi:10.1177/1947601911423031 · Cited by 1,778 · see citing works

The Inconsistency of “Optimal” Cutpoints Obtained using Two Criteria based on the Receiver Operating Characteristic Curve

Perkins, N. J., & Schisterman, E. F. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj063 · Cited by 1,753 · see citing works

The effects of oxidative stress on female reproduction: a review

Agarwal, A. K., Aponte, A., Premkumar, B. J., Shaman, A. A., & Gupta, S. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-49 · Cited by 1,674 · see citing works

Pre-eclampsia

Mol, B. W., Roberts, C. T., Thangaratinam, S., Magee, L. A., de Groot, C. J. M., & Hofmeyr, G. J. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00070-7 · Cited by 1,619 · see citing works

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

Brosens, I., Pijnenborg, R., Vercruysse, L., & Romero, R. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.08.009 · Cited by 1,568 · see citing works

VEGF Inhibition and Renal Thrombotic Microangiopathy

Eremina, V., Jefferson, J. A., Kowalewska, J., Höchster, H. S., Haas, M., Weisstuch, J., Richardson, C., Kopp, J. B., Kabir, M. G., Backx, P. H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707330 · Cited by 1,500 · see citing works

The International Federation of Gynecology and Obstetrics ( FIGO ) initiative on pre‐eclampsia: A pragmatic guide for first‐trimester screening and prevention

Poon, L. C., Shennan, A. H., Hyett, J. A., Kapur, A., Hadar, E., Divakar, H., McAuliffe, F. M., Costa, F. D. S., von Dadelszen, P., McIntyre, D. H., et al. (2019) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.12802 · Cited by 1,343 · see citing works

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

Phipps, E. A., Thadhani, R., Benzing, T. R., & Karumanchi, S. A. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0119-6 · Cited by 1,255 · see citing works

Pre-eclampsia: pathophysiology and clinical implications

Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019) · BMJ · doi:10.1136/bmj.l2381 · Cited by 1,250 · see citing works

The hypertensive disorders of pregnancy: ISSHP classification, diagnosis & management recommendations for international practice

Brown, M. A., Magee, L. A., Kenny, L. C., Karumanchi, S. A., McCarthy, F. P., Saito, S., Hall, D. R., Warren, C., Adoyi, G., & Ishaku, S. (2018) · Pregnancy Hypertension · doi:10.1016/j.preghy.2018.05.004 · Cited by 1,089 · see citing works

Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis

Shibuya, M., & Claesson, L. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.012 · Cited by 1,057 · see citing works

Endothelial cells and VEGF in vascular development

Coultas, L., Chawengsaksophak, K., & Rossant, J. (2005) · Nature · doi:10.1038/nature04479 · Cited by 1,016 · see citing works

Pre-eclampsia

Chappell, L. C., Cluver, C. A., Kingdom, J. C., & Tong, S. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32335-7 · Cited by 977 · see citing works

Preeclampsia, a Disease of the Maternal Endothelium

Powe, C. E., Levine, R. J., & Karumanchi, S. A. (2011) · Circulation · doi:10.1161/circulationaha.109.853127 · Cited by 972 · see citing works

Pre-eclampsia part 1: current understanding of its pathophysiology

Chaiworapongsa, T., Chaemsaithong, P., Yeo, L., & Romero, R. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.102 · Cited by 956 · see citing works

The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions

Takahashi, H., & Shibuya, M. (2005) · Clinical Science · doi:10.1042/cs20040370 · Cited by 950 · see citing works

Properties of the Glomerular Barrier and Mechanisms of Proteinuria

Haraldsson, B. S., Nystrom, J. C., & Deen, W. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00055.2006 · Cited by 919 · see citing works

Revisiting biomarker discovery by plasma proteomics

Geyer, P. E., Holdt, L. M., Teupser, D., & Mann, M. (2017) · Molecular Systems Biology · doi:10.15252/msb.20156297 · Cited by 917 · see citing works

Placental Origins of Preeclampsia

Huppertz, B. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.107607 · Cited by 899 · see citing works

Inflammation and Pregnancy

Challis, J. R., Lockwood, C. J., Myatt, L., Norman, J. E., Strauss, J. F., & Petraglia, F. (2009) · Reproductive Sciences · doi:10.1177/1933719108329095 · Cited by 893 · see citing works

The biology of vascular endothelial growth factors

Tammela, T., Enholm, B., Alitalo, K. K., & Paavonen, K. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.002 · Cited by 838 · see citing works

The Placenta: A Multifaceted, Transient Organ

Burton, G. J., & Fowden, A. L. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0066 · Cited by 833 · see citing works

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

Shibuya, M. (2012) · The Journal of Biochemistry · doi:10.1093/jb/mvs136 · Cited by 796 · see citing works

Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface

Red‐Horse, K., Zhou, Y., Genbačev, O., Prakobphol, A., Foulk, R. A., McMaster, M., & Fisher, S. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422991 · Cited by 785 · see citing works

VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature

Kamba, T., Tam, B. Y. Y., Hashizume, H., Haskell, A., Sennino, B., Mancuso, M. R., Norberg, S. M., O’Brien, S., Davis, R. B., Gowen, L. C., et al. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00133.2005 · Cited by 773 · see citing works

Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease

Wang, X. L., & Khalil, R. A. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.002 · Cited by 758 · see citing works

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

Lohela, M. K., Bry, M., Tammela, T., & Alitalo, K. K. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.012 · Cited by 731 · see citing works

Pathogenesis of Preeclampsia

Young, B. C., Levine, R. J., & Karumanchi, S. A. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102149 · Cited by 722 · see citing works

Inflammation, Immunity, and Hypertensive End-Organ Damage

McMaster, W. G., Kirabo, A., Madhur, M. S., & Harrison, D. G. (2015) · Circulation Research · doi:10.1161/circresaha.116.303697 · Cited by 708 · see citing works

Preeclampsia: Recent Insights

Roberts, J. M., & Gammill, H. S. (2005) · Hypertension · doi:10.1161/01.hyp.0000188408.49896.c5 · Cited by 693 · see citing works

Corneal avascularity is due to soluble VEGF receptor-1

Ambati, B. K., Nozaki, M., Singh, N., Takeda, A., Jani, P. D., Suthar, T., Albuquerque, R., Richter, E. R., Sakurai, E., Newcomb, M. T., et al. (2006) · Nature · doi:10.1038/nature05249 · Cited by 686 · see citing works

A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate

Romero, R. J., Nien, J. K., Espinoza, J., Todem, D., Fu, W., Chung, H., Kusanovic, J. P., Gotsch, F., Erez, O., Mazaki‐Tovi, S., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701830480 · Cited by 675 · see citing works

Preeclampsia and the Risk of End-Stage Renal Disease

Vikse, B. E., Irgens, L. M., Leivestad, T., Skjærven, R., & Iversen, B. M. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706790 · Cited by 673 · see citing works

Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia

Rana, S., Powe, C. E., Salahuddin, S., Verlohren, S., Perschel, F. H., Levine, R. J., Lim, K.-H., Wenger, J. B., Thadhani, R., & Karumanchi, S. A. (2012) · Circulation · doi:10.1161/circulationaha.111.054361 · Cited by 668 · see citing works

Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines

Phipps, E., Prasanna, D., Brima, W., & Jim, B. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12081115 · Cited by 633 · see citing works

Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis

Shibuya, M. (2006) · BMB Reports · doi:10.5483/bmbrep.2006.39.5.469 · Cited by 623 · see citing works

The two-stage placental model of preeclampsia: An update

Staff, A. C. (2019) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2019.07.004 · Cited by 613 · see citing works

RETIRED: Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy

Magee, L. A., Helewa, M. E., Rey, É., Cardew, S., Côté, A., Douglas, M. J., Firoz, T., Gibson, P., Gruslin, A., Lange, I. R., et al. (2008) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)32776-1 · Cited by 580 · see citing works

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

Patten, I. S., Rana, S., Shahul, S. S., Rowe, G. C., Jang, C., Liu, L., Hacker, M. R., Rhee, J. S., Mitchell, J., Mahmood, F. U., et al. (2012) · Nature · doi:10.1038/nature11040 · Cited by 570 · see citing works

Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction

Gilbert, J. S., Ryan, M. J., LaMarca, B. B., Sedeek, M. H., Murphy, S., & Granger, J. P. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01113.2007 · Cited by 553 · see citing works

Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis

Wang, A., Rana, S., & Karumanchi, S. A. (2009) · Physiology · doi:10.1152/physiol.00043.2008 · Cited by 552 · see citing works

Relaxin family peptides and their receptors

Bathgate, R. A. D., Halls, M. L., van der Westhuizen, E. T., Callander, G. E., Kocan, M., & Summers, R. J. (2013) · Physiological Reviews · doi:10.1152/physrev.00001.2012 · Cited by 534 · see citing works

Elevated Placental Soluble Vascular Endothelial Growth Factor Receptor-1 Inhibits Angiogenesis in Preeclampsia

Ahmad, S., & Ahmed, A. (2004) · Circulation Research · doi:10.1161/01.res.0000147365.86159.f5 · Cited by 516 · see citing works

Biology and therapeutic targeting of vascular endothelial growth factor A

Pérez, L., & Ferrara, N. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00631-w · Cited by 515 · see citing works

Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction

Girardi, G., Yarilin, D. A., Thurman, J. M., Holers, V. M., & Salmon, J. E. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061022 · Cited by 507 · see citing works

Diagnostic Accuracy of Placental Growth Factor in Women With Suspected Preeclampsia

Chappell, L. C., Duckworth, S., Seed, P. T., Griffin, M., Myers, J., Mackillop, L. H., Simpson, N., Waugh, J. J. S., Anumba, D. O. C., Kenny, L. C., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.003215 · Cited by 501 · see citing works

Monocytes and Macrophages in Pregnancy and Pre-Eclampsia

Faas, M. M., Spaans, F., & de Vos, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00298 · Cited by 495 · see citing works

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

Schwartz, A. L., & Ciechanover, A. J. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.051208.165340 · Cited by 491 · see citing works

Prospective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics

Haggstrom, A. N., Drolet, B. A., Baselga, E., Chamlin, S. L., Garzón, M. C., Horii, K. A., Lucky, A. W., Mancini, A. J., Metry, D. W., Newell, B. D., et al. (2007) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.12.003 · Cited by 484 · see citing works

Angiogenic Factors and Preeclampsia

Maynard, S. E., & Karumanchi, S. A. (2011) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.10.004 · Cited by 482 · see citing works

Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy

Magee, L. A., Pels, A., Helewa, M. E., Rey, É., & von Dadelszen, P. (2014) · Pregnancy Hypertension · doi:10.1016/j.preghy.2014.01.003 · Cited by 479 · see citing works

Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice

Zhou, C. C., Zhang, Y., Irani, R. A., Zhang, H., Mi, T., Popek, E. J., Hicks, J. M., Ramin, S. M., Kellems, R. E., & Xia, Y. (2008) · Nature Medicine · doi:10.1038/nm.1856 · Cited by 470 · see citing works

First-Trimester Prediction of Hypertensive Disorders in Pregnancy

Poon, L. C., Kametas, N. A., Maíz, N., Akolekar, R., & Nicolaides, K. H. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127977 · Cited by 465 · see citing works

Shared and disparate components of the pathophysiologies of fetal growth restriction and preeclampsia

Ness, R. B., & Sibai, B. M. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.07.049 · Cited by 460 · see citing works

Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis

Shibuya, M. (2006) · Angiogenesis · doi:10.1007/s10456-006-9055-8 · Cited by 443 · see citing works

Epidemiology of preeclampsia: impact of obesity

Jeyabalan, A. (2013) · Nutrition Reviews · doi:10.1111/nure.12055 · Cited by 440 · see citing works

IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia?

Redman, C. W. G., Sargent, I. L., & Staff, A. C. (2014) · Placenta · doi:10.1016/j.placenta.2013.12.008 · Cited by 437 · see citing works

Placental Productions and Expressions of Soluble Endoglin, Soluble fms-Like Tyrosine Kinase Receptor-1, and Placental Growth Factor in Normal and Preeclamptic Pregnancies

Gu, Y., Lewis, D. F., & Wang, Y. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1550 · Cited by 434 · see citing works

Pre-eclampsia: its pathogenesis and pathophysiolgy

Gathiram, P., & Moodley, J. (2016) · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa · doi:10.5830/cvja-2016-009 · Cited by 433 · see citing works

The placenta in preeclampsia

Roberts, J. M., & Escudero, C. (2012) · Pregnancy Hypertension · doi:10.1016/j.preghy.2012.01.001 · Cited by 430 · see citing works

An automated method for the determination of the sFlt-1/PIGF ratio in the assessment of preeclampsia

Verlohren, S., Galindo, A., Schlembach, D., Zeisler, H., Herraı̀z, I., Moertl, M. G., Pape, J., Dudenhausen, J. W., Denk, B., & Stepan, H. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.09.016 · Cited by 429 · see citing works

Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives

Lee, C., Kim, M., Kumar, A., Lee, H., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 427 · see citing works

Uterine artery Doppler at 11 + 0 to 13 + 6 weeks in the prediction of pre‐eclampsia

Plasencia, W., Maiz, N., Bonino, S., Kaihura, C., & Nicolaides, K. H. (2007) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.5157 · Cited by 425 · see citing works

Negative Regulation of Soluble Flt-1 and Soluble Endoglin Release by Heme Oxygenase-1

Cudmore, M., Ahmad, S., Al‐Ani, B., Fujisawa, T., Coxall, H., Chudasama, K., Devey, L. R., Wigmore, S. J., Abbas‐Hanif, A., Hewett, P. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.660134 · Cited by 421 · see citing works

Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways

Redman, C. W. G., Staff, A. C., & Roberts, J. M. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.09.047 · Cited by 411 · see citing works

Circulating Angiogenic Factors in the Pathogenesis and Prediction of Preeclampsia

Lam, C. S., Lim, K.-H., & Karumanchi, S. A. (2005) · Hypertension · doi:10.1161/01.hyp.0000187899.34379.b0 · Cited by 406 · see citing works

Induction of Neutrophil Extracellular DNA Lattices by Placental Microparticles and IL-8 and Their Presence in Preeclampsia

Gupta, A. K., Hasler, P., Holzgreve, W., Gebhardt, G., & Hahn, S. (2005) · Human Immunology · doi:10.1016/j.humimm.2005.11.003 · Cited by 403 · see citing works

Molecular Evidence of Placental Hypoxia in Preeclampsia

Soleymanlou, N., Jurišica, I., Nevo, O., Ietta, F., Zhang, X., Zamudio, S., Post, M., & Caniggia, I. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0078 · Cited by 394 · see citing works

Oxidative stress: Normal pregnancy versus preeclampsia

Chiarello, D. I., Abad, C., Rojas, D., Toledo, F., Vázquez, C. M., Mate, A., Sobrevía, L., & Marı́n, R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.005 · Cited by 394 · see citing works

Placental trophoblast cell differentiation: Physiological regulation and pathological relevance to preeclampsia

Ji, L., Brkić, J., Liu, M., Fu, G., Peng, C., & Wang, Y. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.008 · Cited by 386 · see citing works

Liver disease in pregnancy

Joshi, D., James, A., Quaglia, A., Westbrook, R. H., & Heneghan, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61495-1 · Cited by 385 · see citing works

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Kanasaki, K., Palmsten, K., Sugimoto, H., Ahmad, S., Hamano, Y., Xie, L., Parry, S., Augustin, H. G., Gattone, V. H., Folkman, J., et al. (2008) · Nature · doi:10.1038/nature06951 · Cited by 381 · see citing works

Tracking placental development in health and disease

Aplin, J., Myers, J., Timms, K., & Westwood, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0372-6 · Cited by 381 · see citing works

Redefining Preeclampsia Using Placenta-Derived Biomarkers

Staff, A. C., Benton, S. J., von Dadelszen, P., Roberts, J. M., Taylor, R. N., Powers, R. W., Jones, D. S., & Redman, C. W. G. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00250 · Cited by 375 · see citing works

New Gestational Phase–Specific Cutoff Values for the Use of the Soluble fms-Like Tyrosine Kinase-1/Placental Growth Factor Ratio as a Diagnostic Test for Preeclampsia

Verlohren, S., Herraı̀z, I., Lapaire, O., Schlembach, D., Zeisler, H., Calda, P., Sabrià, J., Markfeld-Erol, F., Galindo, A., Schoofs, K., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01787 · Cited by 375 · see citing works

Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity

Redman, C. W. G., & Staff, A. C. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.003 · Cited by 373 · see citing works

Hypertension in Pregnancy and Later Cardiovascular Risk

Romundstad, P., Magnussen, E. B., Smith, G. D., & VATTEN, L. J. (2010) · Circulation · doi:10.1161/circulationaha.110.943407 · Cited by 372 · see citing works

Pre‐eclampsia‐like syndrome induced by severe COVID‐19: a prospective observational study

Mendoza, M., García-Ruiz, I., Maíz, N., Rodó, C., García‐Manau, P., Serrano, B., Lopez‐Martinez, R., Balcells, J., Fernández‐Hidalgo, N., Carreras, E., et al. (2020) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16339 · Cited by 372 · see citing works

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

Kumasawa, K., Ikawa, M., Kidoya, H., Hasuwa, H., Saito‐Fujita, T., Morioka, Y., Takakura, N., Kimura, T., & Okabe, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011293108 · Cited by 366 · see citing works

Prospective Study of Placental Angiogenic Factors and Maternal Vascular Function Before and After Preeclampsia and Gestational Hypertension

Noori, M., Donald, A. E., Angelakopoulou, A., Hingorani, A. D., & Williams, D. J. (2010) · Circulation · doi:10.1161/circulationaha.109.895458 · Cited by 361 · see citing works

Spontaneous Coronary Artery Dissection Associated With Pregnancy

Tweet, M. S., Hayes, S. N., Codsi, E., Gulati, R., Rose, C. H., & Best, P. J. M. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.055 · Cited by 360 · see citing works

Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia

Chaiworapongsa, T., Romero, R., Kim, Y. M., Kim, G. J., Kim, M. R., Espinoza, J., Bujold, E., Gonçalves, L., Gomez, R., Edwin, S., et al. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050400028816 · Cited by 359 · see citing works

Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum

von Versen‐Höynck, F., Schaub, A. M., Chi, Y.-Y., Chiu, K.-H., Liu, J., Lingis, M., Williams, R. S., Rhoton-Vlasak, A. S., Nichols, W. W., Fleischmann, R. R., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12043 · Cited by 354 · see citing works

Diagnosis and management of atypical preeclampsia-eclampsia

Sibai, B. M., & Stella, C. L. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.07.048 · Cited by 353 · see citing works

Placental growth factor and pre-eclampsia

Chau, K., Hennessy, A., & Makris, A. (2017) · Journal of Human Hypertension · doi:10.1038/jhh.2017.61 · Cited by 352 · see citing works

Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1

Nevo, O., Soleymanlou, N., Wu, Y., Xu, J., Kingdom, J. C., Many, A., Zamudio, S., & Caniggia, I. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00794.2005 · Cited by 351 · see citing works

Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

Rana, S., Burke, S. D., & Karumanchi, S. A. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.10.022 · Cited by 351 · see citing works

Pilot Study of Extracorporeal Removal of Soluble Fms-Like Tyrosine Kinase 1 in Preeclampsia

Thadhani, R., Kisner, T., Hagmann, H., Boßung, V., Noack, S., Schaarschmidt, W., Jank, A., Kribs, A., Cornely, O. A., Kreyssig, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.034793 · Cited by 347 · see citing works

Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia

Boeldt, D. S., & Bird, I. M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0340 · Cited by 346 · see citing works

Elevated Blood Pressure in Pregnancy and Subsequent Chronic Disease Risk

Männistö, T. I., Mendola, P., Vääräsmäki, M., Järvelin, M., Hartikainen, A., Pouta, A. M., & Suvanto, E. T. J. (2013) · Circulation · doi:10.1161/circulationaha.112.128751 · Cited by 342 · see citing works

Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor–Associated Hypertension and Vascular Disease

Pandey, A. K., Singhi, E. K., Arroyo, J. P., Ikizler, T. A., Gould, E. R., Brown, J. D., Beckman, J. A., Harrison, D. G., & Moslehi, J. J. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.10271 · Cited by 342 · see citing works

Angiogenic factors in maternal circulation and preeclampsia with or without fetal growth restriction

VATTEN, L. J., Åsvold, B. O., & Eskild, A. (2012) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2012.01516.x · Cited by 34 · see citing works

Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies

Powers, R. W., Jeyabalan, A., Clifton, R. G., Van Dorsten, P., Hauth, J. C., Klebanoff, M. A., Lindheimer, M. D., Sibai, B., Landon, M., Miodovnik, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013263 · Cited by 162 · see citing works

Circulating soluble fms-like tyrosine kinase 1 (sFlt1) is increased in high-risk women who develop preeclampsia

Simas, T. A. M., Solitro, M. J., Frost, S., Nadkarni, S., Crawford, S. L., Meyer, B. A., & Maynard, S. E. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.10.438

Changes in circulating concentrations of soluble fms-like tyrosine kinase-1 and placental growth factor measured by automated electrochemiluminescence immunoassays methods are predictors of preeclampsia

Leaños‐Miranda, A., Campos-Galicia, I., Isordia‐Salas, I., Rivera‐Leaños, R., Romero-Arauz, J. F., Méndez, J. A. A., & Ulloa‐Aguirre, A. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328357c0c9 · Cited by 52 · see citing works

First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia

Thadhani, R., Mutter, W. P., Wolf, M., Levine, R. J., Taylor, R. N., Sukhatme, V. P., Ecker, J. L., & Karumanchi, S. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031244 · Cited by 453 · see citing works