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Cited by 438

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Diuretic Therapy for Patients With Heart Failure

Open access
Felker, G. Michael, Ellison, David H., Mullens, Wilfried, Cox, Zachary L., Testani, Jeffrey M.·2020·Journal of the American College of Cardiology

Abstract

Expansion of extracellular fluid volume is central to the pathophysiology of heart failure. Increased extracellular fluid leads to elevated intracardiac filling pressures, resulting in a constellation of signs and symptoms of heart failure referred to as congestion. Loop diuretics are one of the cornerstones of treatments for heart failure, but in contrast to other therapies, robust clinical trial evidence to guide the use of diuretics is sparse. A nuanced understanding of renal physiology and diuretic pharmacokinetics is essential for skillful use of diuretics in the management of heart failure in both the inpatient and outpatient settings. Diuretic resistance, defined as an inadequate quantity of natriuresis despite an adequate diuretic regimen, is a major clinical challenge that generally portends a poor prognosis. In this review, the authors discuss the fundamental mechanisms and physiological principles that underlie the use of diuretic therapy and the available data on the optimal use of diuretics.

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Metadata

Authors
Felker, G. M., Ellison, D. H., Mullens, W., Cox, Z. L., & Testani, J. M.
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2020-03
Volume
75
Issue
10
Pages
1178-1195
ISSN
0735-1097 (ISSN-L)
OpenAlex
W3010099281
Cited by
438
References
101
FWCI
23.74
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Diuretic Therapy for Patients With Heart Failure. https://app.cochat.ai/papers/10.1016/j.jacc.2019.12.059
The paper
Felker, G. M., Ellison, D. H., Mullens, W., Cox, Z. L., & Testani, J. M. (2020). Diuretic Therapy for Patients With Heart Failure. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2019.12.059

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.