The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Pathophysiology of Takotsubo Syndrome
Open accessAbstract
Takotsubo syndrome (TTS) has been a recognized clinical entity for 31 years, since its first description in 1990. TTS is now routinely diagnosed in patients who present with acute chest pain, electrocardiographic changes, troponin elevation, unobstructed coronary arteries, and a typical pattern of circumferential left ventricular wall motion abnormalities that usually involve the apical and midventricular myocardium. Increasing understanding of this intriguing syndrome stems from wider recognition, possible increasing frequency, and a rising number of publications focused on the pathophysiology in clinical and laboratory studies. A comprehensive understanding of TTS pathophysiology and evidence-based treatments are lacking, and specific and effective treatments are urgently required. This paper reviews the pathophysiology of this fascinating syndrome; what is known from both clinical and preclinical studies, including review of the evidence for microvascular dysfunction, myocardial beta-adrenergic signaling, inflammation, and electrophysiology; and where focused research needs to fill gaps in understanding TTS.
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Cites
Fourth universal definition of myocardial infarction (2018)
Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., ESC Scientific Document Group, Thygesen, K., Alpert, J. S., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehy462 · Cited by 5,880
Self-citationNeurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,110
Ghadri, J.-R., Wittstein, I. S., Prasad, A., Sharkey, S., Dote, K., Akashi, Y. J., Cammann, V. L., Crea, F., Galiuto, L., Desmet, W., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy076 · Cited by 1,600
Self-citationBybee, K. A., Kara, T., Prasad, A., Lerman, A., Barsness, G. W., Wright, R. S., & Rihal, C. S. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00010 · Cited by 1,507
Lyon, A. R., Bossone, E., Schneider, B., Sechtem, U., Citro, R., Underwood, S. R., Sheppard, M. N., Figtree, G. A., Parodi, G., Akashi, Y. J., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.424 · Cited by 1,214
Self-citationGhadri, J.-R., Wittstein, I. S., Prasad, A., Sharkey, S., Dote, K., Akashi, Y. J., Cammann, V. L., Crea, F., Galiuto, L., Desmet, W., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy077 · Cited by 899
Self-citationLyon, A. R., Rees, P. S., Prasad, S., Poole-Wilson, P. A., & Harding, S. E. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1066 · Cited by 865
Self-citationEitel, I., von Knobelsdorff-Brenkenhoff, F., Bernhardt, P., Carbone, I., Muellerleile, K., Aldrovandi, A., Francone, M., Desch, S., Gutberlet, M., Strohm, O., et al. (2011) · JAMA · doi:10.1001/jama.2011.992 · Cited by 814
Paur, H., Wright, P. T., Sikkel, M. B., Tranter, M. H., Mansfield, C., O'Gara, P., Stuckey, D. J., Nikolaev, V. O., Diakonov, I., Pannell, L., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.111591 · Cited by 767
Self-citationPathophysiology of Takotsubo Syndrome
Pelliccia, F., Kaski, J. C., Crea, F., & Camici, P. G. (2017) · Circulation · doi:10.1161/circulationaha.116.027121 · Cited by 732
Metadata
- Authors
- Lyon, A. R., Citro, R., Schneider, B., Morel, O., Ghadri, J. R., Templin, C., & Omerovic, E.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 77
- Issue
- 7
- Pages
- 902-921
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W3130395385
- Cited by
- 394
- References
- 77
- FWCI
- 32.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lyon, A. R., Citro, R., Schneider, B., Morel, O., Ghadri, J. R., Templin, C., & Omerovic, E. (2021). Pathophysiology of Takotsubo Syndrome. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2020.10.060
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
